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Protogyl PDF

1. Protogyl is an antiamoebic drug that contains metronidazole and/or diloxanide furoate in various formulations for treating intestinal parasites like Entamoeba histolytica. 2. Metronidazole works against both trophozoites and cysts forms of the parasite by interfering with their DNA, while diloxanide furoate directly kills trophozoites in the intestines. 3. Protogyl is prescribed for different stages of amoebiasis and giardiasis, with dosages varying based on the formulation and patient age or weight. Side effects are generally mild gastrointestinal issues.

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389 views

Protogyl PDF

1. Protogyl is an antiamoebic drug that contains metronidazole and/or diloxanide furoate in various formulations for treating intestinal parasites like Entamoeba histolytica. 2. Metronidazole works against both trophozoites and cysts forms of the parasite by interfering with their DNA, while diloxanide furoate directly kills trophozoites in the intestines. 3. Protogyl is prescribed for different stages of amoebiasis and giardiasis, with dosages varying based on the formulation and patient age or weight. Side effects are generally mild gastrointestinal issues.

Uploaded by

pushkar078
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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PROTOGYL

PRESENTATION:

PROTOGYL SUSPENSION
Each 5ml contains:
Metronidazole Benzoate equivalent to Metronidazole IP 100 mg
Flavored Syrup base q.s.

Available in 50 ml Bottle Pack

PROTOGYL FORTE SUSPENSION


Each 5ml contains:
Metronidazole Benzoate equivalent to Metronidazole IP 200 mg
Flavored Syrup base q.s.

Available in 50 ml Bottle Pack

PROTOGYL FORTE TABLETS:


Each film coated tablet contains Metronidazole BP 400mg

Available as 10 Tablets x 25 Blister Pack

PROTOGYL DF TABLETS
Each film coated tablet contains:
Metronidazole BP 400mg
Diloxanide Furoate BP 500mg

Available as 30 Tablets x 10 Blister Pack

PROTOGYL DF SUSPENSION
Each 5ml contains:
Metronidazole Benzoate equivalent to Metronidazole IP 100mg
Diloxanide Furoate BP 125mg

Available in 50ml Bottle Pack

CATEGORY: Antiamoebic

AMOEBIASIS CAUSE & CYCLE:

Amoebiasis has a world wide distribution. Poor environmental sanitation & low socioeconomic
status are important factors in spread of the disease, which occurs due to fecal contamination of
food & water.
Amoebic cyst reaching the intestine transforms into trophozoites. They live on the surface of
colonic mucosa as commensals & pass into stools; serving to propagate the disease.
Occasionally, the trophozoites pass into blood streams & reach liver via portal vein and can
cause amoebic liver abscess.

PHARMACOKINETICS:
Metronidazole
Absorption: Rapid & complete absorption
Distribution: Body tissue & fluids
Metabolism: Liver
Onset of Action: Within few hours
Duration of Action: 8 hours
Diloxanide Furoate
Absorption: Rapid
Excretion: Urine

INDICATIONS:
 Asymptomatic cyst passers
 Active amoebic infection (dysentry)
 Amoebic Hepatitis
 Amoebic Liver abscess
 Giardiasis
 Chronic intestinal amoebiasis
 Intestinal amoebiasis
 Postoperative anaerobic infection (Prophylaxsis: Metronidazole)

DF is very effective luminal amoebicide used alone for cyst passer or usually with MZ
for other forms of amoebic infections.

[MZ: For both trophozoites & cysts ]

MECHANISM OF ACTION:

MZ
In anaerobic microorganism MZ is converted to active form by reduction of its nitro group. This
gets bound to DNA & prevents nucleic acid formation.

DF
It directly kills trophozoites, responsible for production of cyst. No systemic antiamoebic activity
is evident despite its absorption. It is a drug of choice for mild intestinal & asymtomatic
amoebiasis.

NOTE:
Metronidazole is also used in:
 Trichomonas vaginalis
 Giardia lumbia
 Bacteroides fragilis

Metronidazole was initially introduced as well tolerated effective agent for Trichomonas
vaginalis & later found to be highly active amoebicide.

DOSAGE:

PROTOGYL DF

Adult: 1 Protogyl DF tablet is usually recommended for 5-10 days or as directed by the
physician.
Children: One teaspoonful 3 times daily for 5 days or as directed by the physician.

PROTOGYL

Amoebiasis:
Adult: 400-800mg 3 times daily for 5-10 days
Children: 36-50 mg/Kg/day in 3 divided doses for 10 days or as directed by the physician

Giardiasis:
Adult: 2gm once daily for 3 days or as directed by the physician
Children: 25-35 mg/Kg/day in 2 divided doses for 5-10 days or as directed by the
physician

SIDE EFFECTS:
MZ
 Nausea, vomiting, diarrhea
 Metallic taste
 Headache, dry mouth
 Abdominal distress
 Urticaria, pruritus
 Ataxia, vertigo, dizziness, drowsiness
DF
 Nausea, flatulence
 Itching, Skin rash
 Anorexia

WARNING:
Metronidazole has been shown to be carcinogenic in mice & possibly carcinogenic in rats.
UNNECESSARY USE SHOULD THEREFORE BE AVOIDED.
PRECAUTIONS:
MZ
 Severe renal dysfunction
 Severe obstructive hepatic disease
 Alcoholic cirrhosis
Pregnancy: Use only if clearly needed, NOT RECOMMENDED for first trimester in pregnancy
Lactation: Use with caution, should not be breast feed during treatment

DF [Not active in hepatic amoebiasis]


Pregnancy: [Contraindicated ]
Lactation: [Use with caution ]

CONTRAINDICATIONS:

MZ
 Active CNS disease
 Blood dyscrasias
 Hypersensitivity

DF
 Children under 2 years age

DRUG INTERACTIONS AND/OR RELATED PROBLEMS:

 Warfarin & other coumarin anticoagulant

[Potentiates anticoagulant effect, increasing prothrombin time by Metronidazole]


 Alcohol

[A disufram like reaction occurs: Abdominal cramps, nausea, vomiting, headache &
flushing]

 Disulfram

[Acute psychotic reaction or confusion state]

 Lithium

[Increase Lithium level]

 Phenobarbitone & Phenytoin

[Increase metabolism of Metronidazole]

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