3.

Male Reproductive System -

19
HISTOLOGY
INTRODUCTION

• For a species to survive, it has to have

a form of creating a new generation of
reproductively-capable individuals of
the same species. In order to do this,
it has to employ a certain way of
reproducing. In the case of humans,
we reproduce through sexual
reproduction. This consists of 2 cells
fusing through fertilization. In this
trans, we’re going to look at one of
the organ system that produce one of
the cells required for reproduction, the
male reproductive system.

Lecture Outline
1. Male Reproductive System TESTES
2. Component Organs
3. Origin of Gametes • Oval organ
4. Meiosis • Encased by scrotum
5. Spermatogenesis • Size: 4.5 cm x 3 cm x 2 cm
6. Testis • Weight: about 14 g
• Functions:
7. Epididymis & Vas deferens
o produce spermatozoa or sperm
8. Urethra
cells
9. Accessory Glands/Organs
o produce male hormone,
a. Prostate
testosterone
b. Seminal Vesicle • Tunica albuginea
c. Bulbourethral Gland o Tough, fibrous capsule
o Dense irregular connective
tissue
o Mediastinum testis
MALE REPRODUCTIVE SYSTEM
§ Thickened area at
• Produce male gametes (sperm cells; posterior surface of testis
spermatozoa) & deliver these to the § Entry and exit of blood
female genital tract and lymphatic vessels
• Produce testosterone (male hormone § Exit of ductuli efferentes
responsible for physical and • Septulae testis
physiological characteristics of males) o From t. albuginea at
mediastinum testis
COMPONENT ORGANS o Incompletely divide organ into
lobules
• Testes • Lobules (lobuli testis)
• Duct system of each testis o About 250/ testis
• Copulatory organ (penis) o Each contains 1-4 seminiferous
• Accessory glands tubules
§ Highly-coiled tubes

TRANSCRIBERS: Group 12A (David Martin’s Group) 1

SUBTRANSHEAD: RJ BELTRAN
 § Sites of spermatogenesis frequently and some
differentiate

SPERMATOGENESIS

• Site: seminiferous tubules

• From puberty until old age
• Each testis produces 94.6 X 106
spermatozoa/day
• Stages:

ORIGIN OF GAMETES

PRIMORDIAL
GERM CELLS

OOGONIA (IN SPERMATOGONIA

OVARY OF (IN TESTES OF
FEMALSES MALES

SPERMATOZOA
• Types of spermatogonia (in sexually
mature males):
Primordial germ cells o Dark type A (type Ad)
o Stem cells for male and female § Small (12 mm) with dark
gametes nucleus
o 2nd-8th weeks of intrauterine life § Dormant, reserve cell
(IUL), arise from endoderm of that rarely divides
yolk sac § Divides to renew
o 4th week IUL, start to migrate numbers or to
to developing gonads differentiate to type Ap
o 5th week IUL, start to reach spermatogonium
developing gonads o Pale type A (type Ap)
• Spermatogonia § Looks like type Ad
o Divide infrequently before spermatogonium except
puberty nucleus is paler
o At puberty, with release of LH & § Divides actively to renew
FSH by pituitary, divide more numbers or to

TOPIC: 3. Male Reproductive System- HISTOLOGY 2

LECTURER: Dr. Ed Gonzales
 differentiate to type B o Migrates to adluminal
spermatogonia compartment of seminiferous
§ Mitosis into type B tubules
spermatogonia features MEIOSIS
incomplete cytokinesis
hence, daughter cells • Involves 2 successive cell divisions:
connected to each other Meiosis I and II
by cytoplasmic bridges • During this process the chromosomes
§ Cytoplasmic bridges replicate only once
severed only just before
spermatozoa are released MEIOSIS I: diploid primary
into lumen of spermatocyte → two haploid cells
seminiferous (secondary spermatocyte) - which is
o Type B composed of 46 duplicated chromosomes but
§ Resemble type Ap 23 kinds
Spermatogonium except MEIOSIS II: secondary spermatocyte →
nucleus is more rounded two haploid cells (spermatids) each
§ Connected to sister type which are no longer duplicated.
B spermatogonia by
cytoplasmic bridges MEISOSIS I
§ Undergoes mitosis,
PRIMARY SPERMATOCYTE
before all progenies
• diploid cell, has 22 pairs of
increase in size and
homologous somatic
differentiate to primary
chromosomes and a pair of
spermatocytes
male sex chromosomes (X and
Y)

Spermatogonia are in basal area of

seminiferous tubules

• Primary Spermatocyte
o Largest cell in male germ cell
lineage

TOPIC: 3. Male Reproductive System- HISTOLOGY 3

LECTURER: Dr. Ed Gonzales
 and sex move a little further
from each other
INTERPHASE
• Pre-leptotene stage II. METAPHASE
• Not part of MEIOSIS • Homologous and sex pairs of
• Primary spermatocyte’s chromosomes chromosomes align themselves in
replicate resulting in the production of parallel fashion at the center of the
two sister chromatids per cell
chromosome (marks the start of
meiosis I)
III. ANAPHASE
I. PROPHASE • The homologous and sex pairs of
• Has 5 stages chromosomes move to opposite poles
• About 22 days. but the sister chromatids of each
chromosome stay together
1. Leptotene
- Chromatin material starts to IV. TELOPHASE
form fine threads within nucleus • Each group of chromosome acquires a
nuclear envelop
2. Zygotene • Cytoplasm divides equally between
- Chromatin material condenses two daughter cells but they remain
further connected by cytoplasmic bridges
- The homologous and sex because cytokinesis is incomplete
chromosome approach each • Equal but incomplete cytokinesis
other to form 23 pairs resulting to two secondary
spermatocyte connected by
3. Pachytene cytoplasmic bridges.
-first evidence that
chromosomes have replicated Secondary Spermatocyte
-Each pair of homologous - Half the size of a primary
chromosome are seen as two spermatocyte
pairs of sister chromatids - One daughter cell: 22 somatic
(tetrads) chromosome + Y chromosome
- Chromosomes become thicker - Another daughter cell: 22 somatic
by condensing even further, chromosome + X chromosome
rendering the sister chromatids - These chromosomes come in
recognizable as distinct entities duplicate pairs called chromatids
- Crossing-over or genetic
recombination: corresponding MEIOSIS II
segments of non-sister
chromatids of each pair of • Produce two haploid spermatids
homologous chromosomes are from secondary spermatocytes
exchanged • Secondary spermatocytes start second
meiosis after they are formed
4. Diplotene • Complete meiosis after in a matter of
- The homologous but altered hours, hence, hard to find in section
chromosomes begin to separate
I. PROPHASE II
5. Diakinesis • Chromosome condenses
-Chromosomes moves further • Two sister chromatids of a
from each other chromosome are still coupled
- The nuclear membrane
disappears and the homologous II. METAPHASE II
• Chromosome move to equatorial plane

TOPIC: 3. Male Reproductive System- HISTOLOGY 4

LECTURER: Dr. Ed Gonzales
III. ANAPHASE II MATURATION PHASE
• Sister chromatids of each
chromosome are pulled apart to • Spermatid has completely
opposite poles by spinal transformed into the Spermatozoon.
• Release of the spermatozoon into the
IV. TELOPHASE II fluid filled lumen of the seminiferous
• Each set of chromatids acquires a tubules.
nuclear envelope around each nucleus • Cytoplasm bridges are severed.
• Equal and incomplete cytokinesis • Anatomical mature spermatozoon
forming two spermatids connected by but physiologically immature.
cytoplasmic bridges
Spermatozoon
Spermatids • Head
• Daughter cells produced after second o Made up of an elongated, highly
meiosis condensed nucleus that is
• Round or ovoid cells with darkly- covered on its anterior 2/3rds
staining nucleus by the acrosome.
• Contain 23 chromosomes but none is o Contains hydrolytic enzymes
identical from the original primary involved in fertilization.
spermatocyte due to crossing over § Disperse cells of the
• Located near the lumen of corona radiate
seminiferous tubules § Digest the zona pellucida
• Smallest and most numerous of the that surround the ovum.
immature gametes. • Tail
o Necl/ Connecting piece
SPERMATOGENESIS § Segment that is attached
to the head.
Three stages to spermiogenesis o Middle piece
1. Golgi Phase § Distal to the neck
2. Acrosomal Phase § Surrounded by the
3. Maturation Phase mitochondrial sheath
o Principal piece
GOLGI PHASE § Distal to the middle piece
§ Thinner and much longer
• Golgi complex makes proacrosomal (50um)
granules. which later join to form the o End piece
acrosomal vesicle § Short
• Centrioles move toward the surface § Terminal segment of the
of the cell opposite the acrosomal tail
vesicle. These elongate to form a § Not enclosed by fibrous
Flagellum. sheath

ACROSOMAL PHASE TESTIS

• Acrosomal vesicle transforms to the
• Site of spermatogenesis
acrosome.
• Synthesizes testosterone
• Nucleus elongates further as the
• Pair of oval bodies that are lodged in
chromatin material condenses as the
the scrotum
tail lengthens
• Enclosed by Tunica albuginea
• Cytoplasm migrates with the
o Tough fibrous capsule
mitochondria to surround the first part
o Dense irregular CT
of the tail and forms the middle
• Tunica albuginea thickens at the
piece.
posterior surface of the testes forming
the mediastinu of the testis.

TOPIC: 3. Male Reproductive System- HISTOLOGY 5

LECTURER: Dr. Ed Gonzales
 o Entrance of blood and lymphatic • It’s walls consist of:
vessels. o Outer fibrous sheath
o Exit of the ductuli eferentes § Myoid Cells
o Sends the septulae testis which • Contractile cells
divide the organ into lobules. o Inner Epithelium
§ Stratified whose cells
Testicular Lobules consist of spermatogenic
• Occupied by the seminiferous tubules cells and supporting
supported by stroma. Sertoli cells.
• This also contains the Insterstitial Sertoli cells
cells of Leydig.
− Large, tall cells with broad bases that
Insterstitial cells of Leydig rest on basal lamina
• Large ovoid cells that exhibit a round o Tapers as they extend into the
nucleus that contains fine chromatin free surface of epithelium
and one or two peripherally located − Elongated nucleus positioned at a
nucleoli right angle to basement membrane
• Cytoplasm is eosiniphilic o Visible nucleolus in routine
• Contains lipid and elongated histologic preparations
crystals of Reinke − Cytoplasm exhibits crystal inclusions
• Produces Testosterone o Similar to those found in the
o Maintenance of seminiferous interstitial cells of Leydig
tubules − Well supplied with cytoplasmic
o Controls spermatogenesis organelles
o Proper functioning of accessory o Abundant mitochondria and
glands lysosomes
o Secondary sexual o Well-developed Golgi complex
characteristics o Extensive smooth endoplasmic
o Regulated by LH produced by reticulum
pituitary gland. − Apices project toward the lumen of the
seminiferous tubule
o Contains spermatozoa that are
ready for spermiation
− Lateral surfaces form folds that
partially enclose the developing male
gametes
o Developing gametes form four
to eight layers of cells
§ Spermatogonia occupy
the basal compartment of
the seminiferous tubules
§ Progenies move towards
the lumen as they
differentiate, eventually
occupying successively
Seminiferous Tubules higher folds
• Small but long and highly coiled − Forms tight junctions with each other
tubules that are filled with fluid o Divides the lumen of the
• Start as blind or as anastomosing seminiferous tubules into two
tubes at the base and terminate at the compartments
apical portion of the lobule § Basal compartment
• Site for the production of male ð Contains
gametes. spermatogonia
ð Site of

TOPIC: 3. Male Reproductive System- HISTOLOGY 6

LECTURER: Dr. Ed Gonzales
 spermatocytogene inhibin
sis § Inhibin has a negative
ð Primary feedback effect on the
spermatocytes pituitary gland
then migrate into § Commands the gland to
the adluminal reduce FSH secretion
compartment − Stimulated by follicle-stimulating
§ Adluminal compartment hormone (FSH)
ð Contains primary o FSH is secreted by the pituitary
spermatocytes that gland
have migrated − Target cells of testosterone
from the basal
compartment BLOOD SUPPLY AND LYMPHATICS
ð Site of further − Arterial supply
development of o Right and left testes are
primary supplied by the left and right
spermatocytes to testicular arteries
become § Arise from the abdominal
spermatozoa aorta, below the origins
ð More mature of the renal arteries
gametes are o Branches of the testicular artery
located closer to before reaching the testes:
the lumen of the § Supplies the epididymis
seminiferous § Anastomose with
tubules branches of the artery of
o Acts as the blood-testes barrier the ductus deferens and
§ Presumably prevents cremasteric artery
cells in adluminal § Penetrates the tunica
compartment from albuginea at the
getting in contact with, mediastinum testis and
and being attacked by, enter the testis
the cells of the immune ð Course towards the
system rete testis, which
§ Note that cells in the they supply with
adluminal compartment capillaries
are antigenically different ð Follow connective
from somatic cells tissues elements
− Additional functions: through
o Nutritional support and interlobular areas
protection of developing and break up into
gametes intertubular
o Production of the fluid that fills capillaries in the
the lumen of the seminiferous connective tissue
tubules stroma
§ Fluid facilitates transport − Venous drainage
of spermatozoa through o Venules that drain the
excretory ducts capillaries form collecting
o Phagocytosis of excess venules that:
cytoplasm § Drain into veins in the
§ Shed by spermatids tunica albuginea
during spermiogenesis § Empty into venous
o Synthesis and secretion of plexuses associated with
proteins and the hormone the rete testis

TOPIC: 3. Male Reproductive System- HISTOLOGY 7

LECTURER: Dr. Ed Gonzales
 o Veins converge and exit at the canals with irregular
mediastinum testis lumens within
o Veins form pampiniform plexus mediastinum testis
of veins that surround the § Epithelium:
ductus deferens in the ð Simple epithelium
spermatic cord with squamous or
o Pampiniform plexus empties cuboidal cells
into two to three larger veins ð Cells rest on well-
which later fuse to form a single developed basal
testicular vein lamina and are
§ Right testicular vein darkly staining
drains in inferior vena ð Enveloped
cava externally by
§ Left testicular vein joins vascular
left renal vein connective tissue
− Lymphatics that blends with
o Begin at intertubular areas connective tissue
o Unite with other lymphatic of mediastinum
vessels at the interlobular testis
connective tissue, that drain o Ductuli efferentes
into larger lymphatic vessels in § 12 to 20 fine tubules in
the capsule which canals of the rete
o Ultimately converge and exit at testis drain
the mediastinum testis § Penetrate the tunica
DUCTS OF THE TESTIS albuginea and exit the
− Intratesticular genital ducts testis at its
o Tubuli recti posterosuperior surface
§ Immediate continuation ð Distal segment is
of the seminiferous actually
tubules extratesticular
§ Short, narrow, straight § Become highly torturous
tubes in the mediastinum immediately after leaving
testis the testis
§ Epithelium: § Travel towards the head
ð Simple epithelium of the epididymis to
ð Initial segment: merge and form a single
Sertoli cells with tube (ductus epididymis)
no associated § Epithelium:
gametes ð “Scalloped appearance”
ð Distal segment: due to the cells that line
columnar or the duct in an irregularly
cuboidal cells with alternating manner
numerous ð Two cell types:
microvilli on their o Columnar ciliated:
luminal surface help propel spermatozoa
ð supported into epididymis as their
externally by ciliary beat is towards the
dense irregular epididymis
connective tissue o Cuboidal non-
§ Empties into the rete ciliated but with
testis microvilli: endocytose
o Rete testes some of the fluid that
§ Network of anastomosing bathe the spermatozoa

TOPIC: 3. Male Reproductive System- HISTOLOGY 8

LECTURER: Dr. Ed Gonzales
 (fluid is produced by Ductus epididymis
Sertoli cells)
ð Supported externally by a
thin layer of circularly-
arranged smooth muscle
cells
− Extratesticular ducts
o Ductus epididymis
o Ductus deferens
o Ejaculatory ducts
o Urethra

EPIDIDYMIS & VAS DEFERENS

EPIDIDYMIS
- Is a c-shaped structure
- occupies an area about 7.5 cm in
length on the superior and posterior
surface of the testis - Long but highly coiled tube
- has three parts: - When uncoiled, it is more than 6
o thick head meters long, but its diameter is only 1
§ associated with the mm
superior pole of the testis - Its wall is formed by a
§ contains the distal pseudostratified columnar epithelium
portion of the ductuli that is surrounded externally by
efferentes and the initial smooth muscle and connective tissue
segment of the highly elements
coiled ductus epididymis - Its pseudostratified epithelium has
into which the ductuli two types:
efferentes drain o Principal cells
o slender body § More numerous than
§ associated with the basal cells
posterior surface of the § Tall columnar in initial
testis segment but become
§ (body and tail) contain cuboidal terminally
the rest of the ductus § With stereocilia (microvilli
epididymis that are as long as cilia
o short tail but nonmotile
§ associated with the § Absorbing as much as
inferior pole of the testis 90% of fluid from
§ (body and tail) contain seminiferous tubule
the rest of the ductus (secreted by Sertoli cells)
epididymis § Secretory cells but
secretion is not well-
studied; may aid in
maturation of sperm
o Basal cells
§ Small, rounded or
pyramidal cells that rest
on basal lamina

TOPIC: 3. Male Reproductive System- HISTOLOGY 9

LECTURER: Dr. Ed Gonzales
 § Between the bases of the § The structures are
principal cells enveloped by three layers
§ Pale-staining cytoplasm of tough dense
and coarse nuclear connective tissue:
material 1. Internal spermatic
§ Have few cytoplasmic fascia
organelles that serve as 2. Cremasteric fascia –
stem cells for principal conatians cremaster
cells muscle
3. External spermatic
- Smooth muscles cells progressively
fascia
become more numerous along the
duct
o Initially: thin circularly arranged
o Distally: inner and outer
longitudinally arranged, middle
circularly arranged
- Serves for accumulation and storage
of spermatozoa
- Main site for absorption of excess fluid
from seminiferous tubule
- Sperm cells stay 2-6 days in ductus
epididymis
- Spermatozoa fully motile when they
leave
o Still needs to undergo
capacitation before it can
fertilize an ovum
o Able to cover distance between
vagina and abdominal cavity in
15 minutes

DUCTUS DEFERENS (VAS DEFERENS)

Ductus deferens

- Fibromuscular tube
- 45 cm long
- Continuation of ductus epididymis - Walls of ductus deferens consists of
- From initial segment to exit from deep three histologic layers:
inguinal ring, embedded in spermatic o Mucosa
cord § Forms longitudinal folds
o Spermatic cord § Terminal dilated segment
§ Consist of structures that (ampulla-simple
enter/leave testis columnar), forms more
§ Constituents ductus numerous, deeper and
deferens( and its artery complex folds
and vein), testicular § Composed of
artery, pampiniform pseudostratified columnar
plexus of veins, (with stereocilia)
lymphatic vessels, nerves epithelium; shorter than
of testes in ductus epididymis
TOPIC: 3. Male Reproductive System- HISTOLOGY 10
LECTURER: Dr. Ed Gonzales
 § Lamina propria is made Ejaculatory Duct
up of loose connective
- Union of ductus deferens and duct
tissue with elastic fibers
of seminal vesicles
- 2 cm in length
- Penetrates substance of the prostate
gland
- Empties into posterior part of the
prostatic urethra

o Muscularis
§ Very thick
§ Composed of smooth
muscle arranged in 3
layers :
• Outer and inner:
longitudinally
oriented
• Middle: circularly - Mucosa
oriented o Exhibits folds that project into
o Adventitia lumen
§ Composed of connective o Simple columnar
tissue with blood, lymph - Muscularis
vessels and nerves o Initial segment is surrounded by
thin layer of smooth muscle
o Within the prostate, it has no
muscular layer
§ mucosa is surrounded by
fibromuscular tissue (part
of stroma of prostate
gland)

TOPIC: 3. Male Reproductive System- HISTOLOGY 11

LECTURER: Dr. Ed Gonzales
 URETHRA – The skin has no hair follicles and
contains a limited number of sweat glands
PENIS
– Male copulatory organ – Glands of Tyson
– Consists of 3 cylindrical masses o Sebaceous glands found in the
(cavernous bodies) undersurface of the prepuce and the
o Two (2) Corpora proximal portion of the
Cavernosa penis glans penis.
● Structurally identical o It secretes smegma in uncircumcised
● They occupy the dorsum penis
of the penis where they
lie side by side
o One (1) Corpus
Spongiosum penis
● Lies on the median plane
● Ventral to the cavernosa
penis
● Enlarged distal portion:
glans penis
● Covered by a fold of
skin: prepuce
● Central portion is
occupied by spongy
urethra

– Tunica Albuginea ACCESSORY GLANDS OF THE MALE

o Tough layer of dense regular REPRODUCTIVE SYSTEM
connective tissue
o Account for most of the volume of male
o Binds the three cavernous bodies
ejaculate (semen)
o Flaccid: 2mm thick
● Averages 2-5 ml per ejaculation
o Erect: 0.5 mm thick
● 20 to 250 million spermatozoa per
– Cavernous bodies are made up of
ml
erectile tissue
● Cells of the ejaculate: 10%
o Labyrinthine system of anastomosing
● Seminal vesicle secretion: 60%
blood channels
● Prostate secretion: 30%
o Lined by endothelium (unfenestrated)
● Bulbourethral secretion: insignificant
o Separated from each other by
(only a drop)
connective tissue that contains elastic
and smooth muscle fibers
PROSTATE GLAND
o Vascular channels are ordinarily – Chestnut shaped
collapsed Vertical diameter: 3cm
o But in the presence of erotic stimuli, AP diameter: 2 cm
they rapidly fill up with blood – Largest accessory gland
– External to the tunica albuginea is loose – Lies immediately under the apex of the
connective tissue that serves as urinary bladder
hypodermis of the skin that envelops – Traversed by the prostatic urethra
the skin

TOPIC: 3. Male Reproductive System- HISTOLOGY 12

LECTURER: Dr. Ed Gonzales
 – Stroma: consists of dense irregular
connective tissue that is richly
supplied with smooth muscle fibers
● Forms capsule
● Gives off septa
● Subdivide the prostate into
poorly defined lobules
– Parenchyma:
o Main prostatic glands
● Comprise the bulk of the
prostate (2/3)
● About 20 ducts open
independently of each other
into the prostatic sinuses
o Submucosal glands
● Occupy the whole inner third of
the prostate
● Ducts also open into prostatic
sinuses
o Mucosal glands
● Small group of glands that
SEMINAL VESICLE
occupy innermost area
● Ducts open directly on the
luminal surface of the prostatic
urethra

– Epithelium of the alveoli

● Often simple columnar
● Sometimes simple squamous, simple,
cuboidal, or pseudostratified columnar
● Some contains prostatic concretions or
corpora amylacea

– Secretes alkaline fluid that contains:

● Alkaline fluid
● Enzymes
● Fibrinolysin
● Prostaglandins compound with Figure 1.0 Seminal vesicles
antibiotic properties. • Pair of sac-like structures about 5 cm
long
• Lie between fundus of urinary bladder
and the rectum, and above prostate
gland on either side of midline
• Each Seminal vesicle consists of a long
10-15cm, narrow tube that is coiled

TOPIC: 3. Male Reproductive System- HISTOLOGY 13

LECTURER: Dr. Ed Gonzales
I. CAPSULE: B. MUSCULARIS

o Very vascular connective tissue

o Sends connective tissue elements
into organ that binds and support
coils of the seminal vesicle

II. HISTIOLOGIC LAYERS

A. MUCOSA

Figure 3.0. Muscular layer of Seminal

vesicle

• Inner: circularly-arranged (thin layer)

• Outer: longitudinally-arranged (thick
layer)
C. ADVENTITIA

Figure 2.0. Mucosa of Seminal vesicles

• Forms intricately branched folds

• Lumen looks like a maze
1. Epithelium

o Nonciliated pseudostratified columnar/

cuboidal epithelium
o Cells comprising the epithelim,
columnar or cuboidal principal cells -
contain lipochrome pigments in the
Figure 4.0. Adventitia of Seminal vesicle
cytoplasm
o Columnar/ cuboidal principal cells • Connective tissue with elastic elements
produce secretion that contains:
o Fructose – source of energy of BULBOURETHRAL GLAND
spermatozoa
• Pair of pea-sized, yellowish organs
o Prostaglandins
• Diameter: 1cm
o Fibrinogen
• Behind and lateral to membranous
o In between bases of these cells, stem
Urethra
cells – few small, round cells
• Embedded in fibers of sphincter Urethrae
2. Lamina Propria
muscle
• Compound tubuloalveolar, mucus
secreting gland
• Secretion: clear, viscous fluid that is
discharged at or a little before onset of

TOPIC: 3. Male Reproductive System- HISTOLOGY 14

LECTURER: Dr. Ed Gonzales
 ejaculation (to lubricate the Urethra for REFERENCES:
easier passage of spermatozoa
1. Lecture Notes
2. Recordings
3. PPT
4. Doc Ed’s book

Figure 5.0 Bulbourethral gland

I. CAPSULE

o Thin connective tissue

o Contains collagenous and elastic That’s just how special you are to Him. That
to begin with, before we’re even born, He
fibers and some smooth and striated
loves us that intensely. Since He knows you
muscle cells
since you were born, then He himself also
II. SEPTA
wrote your life story. Every single detail of it.
o Arise from capsule Every single one of those good moments and
o Divide gland into small lobules even the seemingly not-so-good times. But
III. LOBULES want to know what the not-so-good times
are for? It’s to build you up. It’s to transform
A. ALVEOLI you to that man or woman and of course,
•Simple cuboidal epithelium future Doctor that God designed you to be!
:D So take heart, future doctor! And just
•Nucleus of the epithelial cells –
trust that He is doing great things in your
typically displaced towards the base
life! :D LABAN 2020! :D
of the cell (because of the presence
of secretory granules in the
cytoplasm)
B. DUCTS

• Proximally: Simple tall cuboidal/

columnar epithelium that contains
patches of mucus-secreting cells
• Confluence of duct gives rise to à
Main excretory duct: Pseudostratified
columnar epithelium also contain
patches of mucus-secreting cells
o Relatively long
o Opens into the proximal part of
the Spongy Urethra

TOPIC: 3. Male Reproductive System- HISTOLOGY 15

LECTURER: Dr. Ed Gonzales