PT19421327 Report 2 PDF
PT19421327 Report 2 PDF
DEPARTMENT OF HORMONES
FREE T3/ FREE T4
FREE T3 3.25 pg/ml 1.5 - 5.0 pg/ml
Pregnant Women
Notes:
Tri-iodothyronine (T3) normally represents only approximately 5% of the thyroid hormone and like thyroxine is almost entirely bound to the carrier proteins,
with only 0.25% of the total being in the free state. Measurement of free tri-iodothyronine is of value in confirming the diagnosis of hyperthyroidism, when an
elevated free or total thyroxine level is found. Abnormal total and free tri-iodothyronine concentrations may appear in T3 toxicosis, in the presence of normal
thyroxine levels. Free T3 levels are unaffected by carrier protein variation.
Free T4 may be indicated when binding globulin (TBG) problems are perceived, or when conventional test results seem inconsistent with clinical observations.
It is normal in subjects with high TBG binding who are euthyroid (ie, free thyroxine should be normal in nonthyroidal diseases).Increased free T4 levels may
occur with nonthyroid illnesses especially during the recovery period.
Test: TSH. Sample: Serum. Method: CLIA.(TSH3ULTRA Kit)
TSH (Thyroid Stimulating Hormone or Thyrotropin) is produced by Anterior pituitary in response to its stimulation by TRH (Thyrotropin Releasing Hormone)
released from hypothalamus.TSH and TRH releases are regulated by Thyroid hormones through a feedback mechanism.
There are several causes that can lead to Thyroid gland dysfunction or dysregulation which eventualy results in Hyperthyroidism or Hypothyroidism.Based on
the thyroid hormones and TSH levels it can be classified as subclinical,primary or central.
Apart from this,certain other conditions can also leads to diagnostic confusions in the interpretation of a Thyroid function test, and they are Pregnancy,
Levothyroxine therapy, certain other drug therapy,assay interference, alterations in thyroid hormone binding protein's concentration and its binding capacity,
conditions of non-thyroidal illness and certain genetic conditions. TSH secretion exhibits a diurinal pattern , so its advisable to check it during morning.
Measurement of TSH alone may be misleading , in conditions like Recent treatment for thyrotoxicosis ,TSH-assay interference,Central
hypothyroidism,TSH-secreting pituitary adenoma, Resistance to Thyroid hormone,and Disorders of thyroid hormone transport or metabolism.
TSH receptor present in Thyroid gland can be stimulated or inhibited by auto-antibodies produced during autoimmune thyroid disorders, which can lead to
functional abnormalities of thyroid gland.
The American Thyroid Association determined that only TSH assays with third generation functional sensitivity (sensitivity=0.01mIU/L) are sufficient for use
as screening tests for hyperthyroidism;their recommendation is consistent with the National Academy of Clinical Biochemistry Laboratory Medicine Practice
Guideline for assessment of thyroid function.
Note : TSH value <0.03 mIU/L can be due to the presence of TSH variant,in some individuals.So,if not clinically correlating,kindly inform the lab,so that
necessary responsible action can be taken in time (within 2 days-if possible) to ensure diagnosis of TSH variant in the particular individual,if present.
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DEPARTMENT OF HORMONES
ABHITHA .B
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DEPT. OF HORMONES
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