Vince John B.

Sevilla Drugstudy

Drug Classificati Dosage Mechanism of Action Indications Contraindication Side Effects Nursing Responsibilities
on
cholinestera Mild to moderate binds and reversibly indicated for the treatment of  neuroleptic  nausea  May be administered
Donepezil se inhibitors  5 mg PO qHS inactivates the dementia of the Alzheimer's malignant  diarrhea without regard to food.
initially, may cholinesterases, thus type. Efficacy has been syndrome.  not sleeping well Swallow capsules
increase to 10 inhibiting hydrolysis of demonstrated in patients  a reaction  vomiting whole; do not open,
mg/day after 4-6 acetylcholine. This with mild, moderate, and characterized by  muscle cramps
weeks if increases acetylcholine severe Alzheimer's disease. crush, or chew.
fever.  tiredness Capsules may be
warranted concentrations at  muscle rigidity  not wanting to
Moderate to severe cholinergic synapses and confusion. opened, sprinkled on
eat or having a
 5 mg PO qHS  atrioventricular applesauce, and
poor appetite
initially, may swallowed; do not
block.  bruising
increase to 10 
mg qDay after
a type of slow  weight loss chew. Entire contents of
heart rhythm  Slow heart rate each capsule should be
4-6 weeks; may disorder.
further increase and fainting consumed; do not divide
 torsades de  Stomach ulcers dose.
to 23 mg/day pointes.
after 3 months if and bleeding,  Emphasize the
 a type of symptoms can
warranted importance of taking
abnormal heart include:
rhythm. donepezil daily, as
 heartburn
 sick sinus  stomach pain
directed. Missed doses
syndrome. should be skipped and
that won’t go
away regular schedule
 nausea or returned to the
vomiting following day. Do not
 blood in your take more than
vomit, or dark- prescribed; higher doses
colored vomit do not increase effects
that looks like but may increase side
coffee grounds
effects.
 Inform patient/family
that it may take wk
before improvement in
baseline behavior is
observed.
Vince John B. Sevilla Drugstudy
 Caution patient and
caregiver that
donepezil/memantine
may cause drowsiness
and dizziness. Caution
patient to avoid
activities requiring
alertness.