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9 - Smooth Muscle

This document outlines the learning objectives for a lecture on smooth muscle physiology: 1) It will contrast the structures and functions of smooth and skeletal muscles. 2) It will describe the ion channels in smooth muscle cells and excitation-contraction coupling. 3) Excitation-contraction coupling in smooth muscle can occur without action potentials via G protein coupled receptors and calcium sensitization. 4) It will compare the length-tension and force-velocity relationships between smooth and skeletal muscles.

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tylermed
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96 views

9 - Smooth Muscle

This document outlines the learning objectives for a lecture on smooth muscle physiology: 1) It will contrast the structures and functions of smooth and skeletal muscles. 2) It will describe the ion channels in smooth muscle cells and excitation-contraction coupling. 3) Excitation-contraction coupling in smooth muscle can occur without action potentials via G protein coupled receptors and calcium sensitization. 4) It will compare the length-tension and force-velocity relationships between smooth and skeletal muscles.

Uploaded by

tylermed
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Unit 3: Skeletal and Smooth Muscle Physiology

Lecture 9: Smooth Muscle Structure, Contraction, and


Relationships

Learning Objectives:

1. Contrast skeletal and smooth muscles.


2. Name/Describe all channels on the smooth muscle cell (and
contrast with skeletal muscle cell).
3. Describe excitation-contraction coupling in the smooth muscle.
4. Contrast and describe the length-tension and force-velocity
relationships.

1
Unit 3: Skeletal and Smooth Muscle Physiology
Lecture 9: Smooth Muscle Structure, Contraction, and
Relationships

Learning Objectives:

1. Contrast skeletal and smooth muscles.


2. Name/Describe all channels on the smooth muscle cell (and
contrast with skeletal muscle cell).
3. Describe excitation-contraction coupling in the smooth muscle.
4. Contrast and describe the length-tension and force-velocity
relationships.

2
3
1) Skeletal vs. Smooth

4
1) Skeletal vs. Smooth
Autonomic Nervous System
Varicosities – No transverse tubules

5
1) Skeletal vs. Smooth

6
1) Multi-Unit vs. Single-Unit

7
1) Multi-Unit vs. Single-Unit

8
1) Phasic Contraction

single-unit
smooth muscle

Time

9
1) Phasic Activation (Purple/Red)

10
1) Pacemaker Potentials

11
1) Phasic vs. Tonic Contraction

single-unit
smooth muscle

multi-unit
smooth muscle

Time
12
1) Tonic Activation (Green/Blue)

13
No Yes

14
Unit 3: Skeletal and Smooth Muscle Physiology
Lecture 9: Smooth Muscle Structure, Contraction, and
Relationships

Learning Objectives:

1. Contrast skeletal and smooth muscles.


2. Name/Describe all channels on the smooth muscle cell (and
contrast with skeletal muscle cell).
3. Describe excitation-contraction coupling in the smooth muscle.
4. Contrast and describe the length-tension and force-velocity
relationships.

15
2) Calcium
From SR (very few compared to skeletal)

16
No Yes

17
Unit 3: Skeletal and Smooth Muscle Physiology
Lecture 9: Smooth Muscle Structure, Contraction, and
Relationships

Learning Objectives:

1. Contrast skeletal and smooth muscles.


2. Name/Describe all channels on the smooth muscle cell (and
contrast with skeletal muscle cell).
3. Describe excitation-contraction coupling in the smooth muscle.
4. Contrast and describe the length-tension and force-velocity
relationships.

18
3) Smooth Muscle Myosin

19
3) Excitation-Contraction Coupling

20
3) Excitation-Contraction Coupling
Smooth muscle contraction may occur in the absence of an action potential.

Actin?
21
3) Latch State
Unique property of smooth muscle

Tension maintained

ATPase activity very low

Shortening velocity, phosphorylation and Ca2+ levels are low

22
No Yes

23
Unit 3: Skeletal and Smooth Muscle Physiology
Lecture 9: Smooth Muscle Structure, Contraction, and
Relationships

Learning Objectives:

1. Contrast skeletal and smooth muscles.


2. Name/Describe all channels on the smooth muscle cell (and
contrast with skeletal muscle cell).
3. Describe excitation-contraction coupling in the smooth muscle.
4. Contrast and describe the length-tension and force-velocity
relationships.

24
4) Force-Velocity Relationship

25
No Yes

26
4) Force-Velocity Relationship

27
4) Length-Tension Relationship
smooth muscle skeletal muscle

28

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