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Rajiv Gandhi University of Health Sciences, Karnataka: Q.P. CODE: 2604

This document contains exam questions for a Pharmaceutical Organic Chemistry course. It includes long essay questions, short essay questions, and short answer questions covering various topics in organic chemistry including reaction mechanisms, functional groups, isomerism, and named reactions. Students are asked to discuss reaction mechanisms such as nitration and chlorination of benzene, benzoin and aldol condensations, and electrophilic addition. Other questions cover concepts like carbenes, Williamson synthesis, isomerism, Beckmann rearrangement, properties of functional groups, stability of conjugated dienes, and more.

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VISHNU RAJ V
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123 views1 page

Rajiv Gandhi University of Health Sciences, Karnataka: Q.P. CODE: 2604

This document contains exam questions for a Pharmaceutical Organic Chemistry course. It includes long essay questions, short essay questions, and short answer questions covering various topics in organic chemistry including reaction mechanisms, functional groups, isomerism, and named reactions. Students are asked to discuss reaction mechanisms such as nitration and chlorination of benzene, benzoin and aldol condensations, and electrophilic addition. Other questions cover concepts like carbenes, Williamson synthesis, isomerism, Beckmann rearrangement, properties of functional groups, stability of conjugated dienes, and more.

Uploaded by

VISHNU RAJ V
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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2604_9999_9_S226

Rajiv Gandhi University of Health Sciences, Karnataka


I Year B.Pharm Degree Examination – NOVEMBER 2015
Time: Three Hours Max. Marks: 70 Marks

PHARMACEUTICAL ORGANIC CHEMISTRY – I


(Revised Scheme 3)
Q.P. CODE: 2604
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks


1. Discuss the mechanism involved in the (A) Nitration and (B) Chlorination of Benzene
2. Discuss the mechanism involved in the following reactions
(A) Benzoin condensation (B) Aldol condensation
3. Write the mechanism of Electrophilic addition. Write about the reaction of hydrogen halides
with alkenes. Write the effect of peroxide on the above reaction

SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks


4. What are carbenes? Discuss the mechanism involved in the reaction between phenol and
chloroform in the presence of sodium hydroxide
5. What is Williamson’s synthesis? Give its limitations
6. What is Isomerism? Explain different types of isomerism with examples
7. Discuss the mechanism involved in Beckmann rearrangement
8. Comment, phenol is acidic but not ethanol
9. Explain the factor affecting the nucleophilic aliphatic substitution reaction
10. What are dienes? Discuss the stability of conjugated dienes
11. Give reasons, amino group is activating and ortho, para directing in electrophilic aromatic
substitution

SHORT ANSWERS 10 x 2 = 20 Marks


12. Define with examples (a) Electrophile (b) Nucleophile
13. Explain how allyl carbocation is stabilized?
14. Propene is treated with chlorine at about 5000 C. Write the reaction
15. Compare and contrast E1 versus E2 reactions (Any four points)
16. What do you mean by hydride shift? Give one example
17. Explain Hoffmann’s elimination with an example
18. Write down the structures of the following
(A) Acetophenone (B) Ethyl acetoacetate
19. How do you convert Benzoic acid to Benzamide
20. Complete the reaction with chemical structures. Aniline is treated with acetic anhydride in
presence of acetic acid and the compound obtained is then treated with nitrating mixture
21. What is Grignard reagent? Give any one example
*****

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