Diarrhea

Diarrhea

An electron micrograph of rotavirus, the cause of nearly 40%

of hospitalizations from diarrhea in children under 5.
ICD-10 A09., K59.1
ICD-9 787.91
DiseasesDB 3742
eMedicine ped/583
MeSH D003967

Diarrhea (from the Greek, διὰρροια meaning "a flowing through"), also spelled diarrhoea, is the condition of
having three or more loose or liquid bowel movements per day. It is a common cause of death in developing
countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea
can cause dehydration and electrolyte imbalances. In 2009 diarrhea was estimated to have caused 1.1 million
deaths in people aged 5 and over and 1.5 million deaths in children under the age of 5. Oral rehydration salts
and zinc tablets are the treatment of choice and have been estimated to have saved 50 million children in the
past 25 years.

Definition
Diarrhea is defined by the World Health Organization as having 3 or more loose or liquid stools per day, or as
having more stools than is normal for that person.

Secretory

Secretory diarrhea means that there is an increase in the active secretion, or there is an inhibition of absorption.
There is little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that
stimulates the secretion of anions, especially chloride ions. Therefore, to maintain a charge balance in the
lumen, sodium is carried with it, along with water. In this type of diarrhea intestinal fluid secretion is isotonic
with plasma even during fasting.

Osmotic

Osmotic diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion
(e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water.
 Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing
water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can
produce osmotic diarrhea and distention of the bowel. A person who has lactose intolerance can have difficulty
absorbing lactose after an extraordinarily high intake of dairy products. In persons who have fructose
malabsorption, excess fructose intake can also cause diarrhea. High-fructose foods that also have a high glucose
content are more absorbable and less likely to cause diarrhea. Sugar alcohols such as sorbitol (often found in
sugar-free foods) are difficult for the body to absorb and, in large amounts, may lead to osmotic diarrhea.

Exudative

Exudative diarrhea occurs with the presence of blood and pus in the stool. This occurs with inflammatory bowel
diseases, such as Crohn's disease or ulcerative colitis, and other severe infections.

Motility-related

Motility-related diarrhea is caused by the rapid movement of food through the intestines (hypermotility). If the
food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be
absorbed. This can be due to a vagotomy or diabetic neuropathy, or a complication of menstruation.
Hyperthyroidism can produce hypermotility and lead to pseudodiarrhea and occasionally real diarrhea. Diarrhea
can be treated with antimotility agents (such as loperamide). Hypermotility can be observed in patients who
have had portions of their bowel removed, allowing less total time for absorption of nutrients.

Inflammatory

Inflammatory diarrhea occurs when there is damage to the mucosal lining or brush border, which leads to a
passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. Features of all three of the
other types of diarrhea can be found in this type of diarrhea. It can be caused by bacterial infections, viral
infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be
caused by tuberculosis, colon cancer, and enteritis.

Dysentery

Generally, if there is blood visible in the stools, it is not diarrhea, but dysentery. The blood is trace of an
invasion of bowel tissue. Dysentery is a symptom of, among others, Shigella, Entamoeba histolytica, and
Salmonella.

Differential diagnosis
 Diagram of the human gastrointestinal tract.

Diarrhea is most commonly due to viral gastroenteritis with rotavirus accounting for 40% of cases in children
under five. (p. 17) In travelers however bacterial infections predominate.[6]

It can also be the part of the presentations of a number of medical conditions such as: Crohn's disease or
mushroom poisoning.

Infections

There are many causes of infectious diarrhea, which include viruses, bacteria and parasitesNorovirus is the most
common cause of viral diarrhea in adults, but rotavirus is the most common cause in children under five years
old. Adenovirus types 40 and 41, and astroviruses cause a significant number of infections.

The bacterium campylobacter is a common cause of bacterial diarrhea, but infections by salmonellae, shigellae
and some strains of Escherichia coli (E.coli) are frequent. In the elderly, particularly those who have been
treated with antibiotics for unrelated infections, a toxin produced by Clostridium difficile often causes severe
diarrhea.

Parasites do not often cause diarrhea except for the protozoan Giardia, which can cause chronic infections if
these are not diagnosed and treated with drugs such as metronidazole, and Entamoeba histolytica.[15][16]

Other infectious agents such as parasites and bacterial toxins also occur. In sanitary living conditions where
there is ample food and a supply of clean water, an otherwise healthy person usually recovers from viral
infections in a few days. However, for ill or malnourished individuals, diarrhea can lead to severe dehydration
and can become life-threatening.

Malabsorption

Malabsorption is the inability to absorb food, mostly in the small bowel but also due to the pancreas.
 Causes include:

 enzyme deficiencies or mucosal abnormality, as in food allergy and food intolerance, (e.g. celiac disease
(gluten intolerance), lactose intolerance (intolerance to milk sugar, common in non-Europeans), fructose
malabsorption)
 pernicious anemia (impaired bowel function due to the inability to absorb vitamin B12),
 loss of pancreatic secretions (may be due to cystic fibrosis or pancreatitis),
 structural defects, like short bowel syndrome (surgically removed bowel) and radiation fibrosis (usually
following cancer treatment and other drugs, including agents used in chemotherapy).

Inflammatory bowel disease

Main article: Inflammatory bowel disease

The two overlapping types here are of unknown origin:

 Ulcerative colitis is marked by chronic bloody diarrhea and inflammation mostly affects the distal colon
near the rectum.
 Crohn's disease typically affects fairly well demarcated segments of bowel in the colon and often affects
the end of the small bowel.

Irritable bowel syndrome

Another possible cause of diarrhea is irritable bowel syndrome (IBS) which usually presents with abdominal
discomfort relieved by defecation and unusual stool (diarrhea or constipation) for at least 3 days a week over the
previous 3 months. There is no direct treatment for IBS, however symptoms can be managed through a
combination of dietary changes, soluble fiber supplements, and/or medications.

Other causes

 Diarrhea can be caused by chronic ethanol ingestion.

 Ischemic bowel disease. This usually affects older people and can be due to blocked arteries.
 Hormone-secreting tumors: some hormones (e.g., serotonin) can cause diarrhea if excreted in excess
(usually from a tumor).
 Chronic mild diarrhea in infants and toddlers may occur with no obvious cause and with no other ill
effects; this condition is called toddler's diarrhea.

Pathophysiology
Evolution

According to two researchers, Nesse and Williams, diarrhea may function as an evolved expulsion defense
mechanism. As a result, if it is stopped, there might be a delay in recovery. They cite in support of this
argument research published in 1973 which found that treating Shigella with the anti-diarrhea drug (Lomotil)
caused people to stay feverish twice as long as those not so treated. The researchers indeed themselves observed
that: "Lomotil may be contraindicated in shigellosis. Diarrhea may represent a defense mechanism".

Diagnostic approach
The following types of diarrhea may indicate further investigation is needed:

 In infants
 Moderate or severe diarrhea in young children
 Associated with blood
 Continues for more than two days
 Associated non-cramping abdominal pain, fever, weight loss, etc
 In travelers
 In food handlers, because of the potential to infect others;
 In institutions such as hospitals, child care centers, or geriatric and convalescent homes.

A severity score is used to aid diagnosis in children.

Prevention
A rotavirus vaccine has the potential to decrease rates of diarrhea.

Management
In many cases of diarrhea, replacing lost fluid and salts is the only treatment needed. This is usually by mouth –
oral rehydration therapy – or, in severe cases, intravenously. Diet restrictions such as the BRAT diet are no
longer recommended. Research does not support the limiting of milk to children as doing so has no effect on
duration of diarrhea.

Medications such as loperamide (Imodium), bismuth subsalicylate may be beneficial, however they may be
contraindicated in certain situations.

Medications

Antibiotics

While antibiotics are beneficial in certain type of acute diarrhea they are usually not used except in specific
situations.[26][27] There are concerns that antibiotic may increase the risk of hemolytic uremic syndrome in people
infected with Escherichia coli O157:H7. In resource poor countries treatment with antibiotics may be beneficial.

Anti motility agents

Anti motility agents like loperamide are effective at reducing the duration of diarrhea.

Bismuth compounds

While bismuth compounds (Pepto-Bismol) decreased the number of bowel movements in those with travelers'
diarrhea it does not decrease the length of illness. These agents should only be used if bloody diarrhea is not
present.
 Alternative therapies

The probiotic lactobacillus can help prevent antibiotic associated diarrhea in adults but possibly not children.
For those who suffer from lactose intolerance, taking digestive enzymes containing lactase when consuming
dairy products is recommended.

Epidemiology

Disability-adjusted life year for diarrhea per 100,000 inhabitants in 2004.

no data      < 500      500-1000      1000-1500      1500-2000      2000-2500      2500-3000      3000-3500      3500-4000
4000-4500      4500-5000      5000-6000      > 6000

World wide in 2004 approximately 2.5 billion cases of diarrhea occurred which results in 1.5 million deaths
among children under the age of five. Greater than half of these were in Africa and South Asia This is down
from a death rate of 5 million per year two decades agoDiarrhea remains the second leading cause of death
(16%) after pneumonia (17%) in this age group