FISIOLOGÍA DEL MÚSCULO Y SU
PAPEL EN LA SALUD Y ENFERMEDAD
Henry Humberto León Ariza.
Licenciado en Educación Física
Médico Cirujano
Aspirante a Doctor en Biociencias
EVOLUCIÓN Y
OBESIDAD
Wells JC, Fewtrell MS. Measuring body composition. Arch Dis Child 2006;91(7):612-7.
RABDOMIOCITO VS ADIPOCITO
Zea-Robles AC, et al. [University students cardiovascular risk factors and their relationship with
body composition]. Rev Salud Publica (Bogota ) 2014 Aug;16(4):505-15.
EL TEJIDO ADIPOSO COMO
ÓRGANO ENDOCRINO
Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease.
Nature 2006 Dec 14;444(7121):875-80.
EL MÚSCULO COMO
ÓRGANO ENDOCRINO
Nieman DC, Henson DA, Smith LL, Utter AC, Vinci DM, Davis JM, Kaminsky DE, Shute M. Cytokine
changes after a marathon race. J Appl Physiol 2001;91(1):109-14.
EL MÚSCULO COMO
ÓRGANO ENDOCRINO
“The recent discovery of myokines
– that is, cytokines that are
produced and secreted by skeletal
muscle cells – sheds light on the
association between exercise and
inflammation’”
Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic
disease. Nature 2008 Jul 24;454(7203):463-9.
EL MÚSCULO COMO
ÓRGANO ENDOCRINO
“Skeletal muscle: not simply an
organ for locomotion and energy
storage”
Lancaster GI, Febbraio MA. Skeletal muscle: not simply an organ for locomotion and energy
storage. J Physiol 2009 Feb 1;587(Pt 3):509-10.
EL MÚSCULO COMO
ÓRGANO ENDOCRINO
Benatti FB, Pedersen BK. Exercise as an anti-inflammatory therapy for rheumatic diseases-
myokine regulation. Nat Rev Rheumatol 2015 Feb;11(2):86-97.
Resultado de 73
diferentes
estudios
realizados (800
sujetos), con
diferentes formas
de ejercicio.
Pedersen BK, Febbraio MA. Muscle as an Endocrine Organ: Focus on Muscle-Derived
Interleukin-6. Physiol Rev 2008;88:1379-406.
Pedersen BK, Febbraio MA. Muscle as an Endocrine Organ: Focus on Muscle-Derived
Interleukin-6. Physiol Rev 2008;88:1379-406.
INTERLEUCINA 15 (IL-15)
N. G. Barra, S. Reid, R. MacKenzie et al., “Interleukin-15 contributes to the regulation of murine
adipose tissue and human adipocytes,” Obesity, vol. 18, no. 8, pp. 1601–1607, 2010.
Factor Neurotrópico
Derivado del Cerebro (BDNF)
Pedersen BK, Pedersen M, Krabbe KS, Bruunsgaard H, Matthews VB, Febbraio MA. Role of
exercise-induced brain-derived neurotrophic factor production in the regulation of energy
homeostasis in mammals. Exp Physiol. 2009 94(12):1153-60.
Stefano Schiaffino, Carlo Reggiani, Fiber Types in Mammalian Skeletal Muscles, Physiological
Reviews 2011 91 (4), 1447-1531
Fuerza y adaptaciones
mitocondriales
Porter C., P. T. Reidy, N. Bhattarai, L. S. Sidossis, and B. B. Rasmussen. Resistance Exercise Training
Alters Mitochondrial Function in Human Skeletal Muscle. Med. Sci. Sports Exerc., 47 (9) 1922–
1931, 2015
Artero EG, Lee D, Lavie CJ, España-Romero V, Sui X, et al. (2012) Effects of muscular strength on
cardiovascular risk factors and prognosis. J Cardiopulm Rehabil Prev 2012;32:351-358
Leon Ariza HH, Melo Moreno CA, Ramírez Villada JF. Papel de la producción de miokinas a través
del ejercicio. Journal of Sport and Health Research 2012;4(2):157-66.
BIBLIOGRAFÍA
Wells JC, Fewtrell MS. Measuring body composition. Arch Dis Child 2006;91(7):612-7.
Zea-Robles AC, León-Ariza HH, Botero-Rosas DA, Afanador-Castaneda HD, Pinzon-Bravo LA. [University students
cardiovascular risk factors and their relationship with body composition]. Rev Salud Publica (Bogota ) 2014
Aug;16(4):505-15.
Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011
Feb;11(2):85-97.
Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004
Sep;92(3):347-55.
Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006 Dec
14;444(7121):875-80.
Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature
2008 Jul 24;454(7203):463-9.
Lancaster GI, Febbraio MA. Skeletal muscle: not simply an organ for locomotion and energy storage. J Physiol 2009
Feb 1;587(Pt 3):509-10.
Benatti FB, Pedersen BK. Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation. Nat
Rev Rheumatol 2015 Feb;11(2):86-97.
Pedersen BK, Febbraio MA. Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6. Physiol Rev
2008;88:1379-406.
León Ariza HH, Melo Moreno CA, Ramírez Villada JF. Papel de la producción de miokinas a través del ejercicio.
Journal of Sport and Health Research 2012;4(2):157-66.
Stefano Schiaffino, Carlo Reggiani, Fiber Types in Mammalian Skeletal Muscles, Physiological
Reviews 2011 91 (4), 1447-1531
HENRY HUMBERTO LEON ARIZA
[email protected]
[email protected]
[email protected]
www. Basemedica.co
@sportphysiology
