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Molecular Biology (19043) : Second Assignment

This document contains a list of 9 student names and sections for a Molecular Biology second assignment due on July 16, 2020 to Dr. Fawzi Al-Razem. It also contains two questions about silent mutations in DNA and codon usage bias. The second question asks for a clinical implication of a silent mutation that affects phenotype. A brief response is provided describing the molecular characteristics of one such example.

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Lara Masri
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40 views2 pages

Molecular Biology (19043) : Second Assignment

This document contains a list of 9 student names and sections for a Molecular Biology second assignment due on July 16, 2020 to Dr. Fawzi Al-Razem. It also contains two questions about silent mutations in DNA and codon usage bias. The second question asks for a clinical implication of a silent mutation that affects phenotype. A brief response is provided describing the molecular characteristics of one such example.

Uploaded by

Lara Masri
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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‫)‪Molecular Biology (19043‬‬

‫‪Second Assignment‬‬

‫‪July 16, 2020‬‬


‫‪Dr. Fawzi Al-Razem‬‬

‫‪180017‬‬ ‫(شعبة ‪)2‬‬ ‫عرين عياد محمد ابو فارة‬


‫‪190069‬‬ ‫(شعبة ‪)3‬‬ ‫فاطمة سليم عبدهللا حجاج‬
‫‪180053‬‬ ‫(شعبة ‪)1‬‬ ‫الرا محمد يوسف المصري‬
‫‪190084‬‬ ‫(شعبة ‪)3‬‬ ‫نور مازن يوسف عوض‬
‫‪180057‬‬ ‫(شعبة ‪)2‬‬ ‫رهف مجدي خليل جعبري‬
‫‪180141‬‬ ‫(شعبة ‪)3‬‬ ‫راما صبحي احمد ابو دانين‬
‫‪180029‬‬ ‫(شعبة ‪)3‬‬ ‫سجى موسى خليل ابو عالية‬
‫‪190096‬‬ ‫(شعبة ‪)1‬‬ ‫سماح احمد ابراهيم مرعي‬
‫‪180061‬‬ ‫(شعبة ‪)3‬‬ ‫شهيرة طلب طالب مناصرة‬

‫‪Silent mutations that occur in DNA are quite common in living cells and usually‬‬
‫‪involve no effects on phenotype‬‬

‫?‪a. Define the silent mutation in DNA‬‬


b. What is the codon usage bias?

Codon usage bias relates to variations in the extent at which similar codons appear in DNA
coding. The genetic code that contains the codon acts as a guide for deciding whether the
DNA-encoded genes are decoded into proteins.
The association between the codon in messenger RNA and the anticodon in an aminoacyl-
transfer RNA is a critical association in protein synthesis. Codon usage bias exists when
different organisms have differences in the frequency of synonymous codons found in their
DNA coding, implying that some codons are rarely utilized while other codons are
commonly used in a particular organism.

c. Provide one example of a clinical implication of a “silent mutation” that proven to


have an effect on the phenotype and provide a brief description of its molecular
characteristics?

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