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CHAPTER V II PDF

This study investigated the antihyperglycemic potential of Syzygium aqueum leaf extract in decreasing blood glucose levels in albino mice. Literature showed diabetes is a leading cause of death in the Philippines. The extract was tested on hyperglycemic mice at different concentrations and time intervals, and was found to lower blood sugar levels most effectively at 250mg/kg. Both the extract and metformin showed similar effects, with blood sugar decreasing more after 60 minutes. The extract was only effective for hyperglycemic mice. The study concluded the extract lowers blood glucose but more research is needed to improve reliability and test other parts of the plant.

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45 views2 pages

CHAPTER V II PDF

This study investigated the antihyperglycemic potential of Syzygium aqueum leaf extract in decreasing blood glucose levels in albino mice. Literature showed diabetes is a leading cause of death in the Philippines. The extract was tested on hyperglycemic mice at different concentrations and time intervals, and was found to lower blood sugar levels most effectively at 250mg/kg. Both the extract and metformin showed similar effects, with blood sugar decreasing more after 60 minutes. The extract was only effective for hyperglycemic mice. The study concluded the extract lowers blood glucose but more research is needed to improve reliability and test other parts of the plant.

Uploaded by

Eddie Kim Caño
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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CHAPTER V

SUMMARY, FINDINGS, CONLUSIONS AND RECOMMENDATIONS

The following chapter presents the summary of the research and emphasizes the
significant findings discovered from the study. This part also concludes the paper and provides
recommendations for further research.

SUMMARY

This study investigated on the antihyperglycemic potential of Syzygium aqueum in


decreasing the blood glucose levels of albino mice. The literature review was focused on the
statistics regarding the number of people suffering from Diabetes mellitus. It was discovered in
2017 that the mentioned disease was the fifth leading cause of death in the Philippines. The
reviewed literature also highlights various herbal plants as well as processes in producing plant
extracts and the ways on how treatments can be administered to the test subjects. Studies on
this area were minimized on various plants assessed for their capability to lower blood sugar
levels and on the antidiabetic potential of S. aqueum through examining its flavonoid contents
whereas, no related studies were found to have tested it on animal subjects.
The research was conducted on 12 male Albino mice which was observed and given
40% glucose solution to increase their blood sugar levels for the intention of imitating the effects
of Type 2 Diabetes. After 7 days, treatments were given and the test animals’ blood glucose
levels were obtained, monitored, and observed 30, 60 and 90 minutes after they were given the
plant extracts to evaluate its effectiveness in Regional Animal Disease and Diagnostic
Laboratory in Camalig, Albay. The research design employed is the experimental research
design to assess the differences among the groups which received treatment from the plant
extract and from the commercial drug for the control.
Consistent lowering pattern of blood sugar levels were observed on the albino mouse
whose initial blood sugar levels were above normal while the mice which blood glucose levels
lies on and below normal exhibited unusual patterns whereas some went up and some went
down.
Specifically, it sought answers to the following questions: 1.How effective is the
Syzygium aqueum leaf extract in lowering the blood sugar levels of diabetic Albino mice in
terms of: a. Concentration of leaf extract; b. Extent of effectiveness; 2. What is the difference of
Metformin and the extract coming from Syzygium aqueum?

FINDINGS

Based on the results, the findings from the study are the following:
1. The different concentrations of Syzygium aqueum mainly the 500 mg/kg, and 750
mg/kg were not effective in lowering the blood sugar levels of non-diabetic mice
however, in different time intervals, 250mg/kg became the most efficient dosage to
lower the increased blood glucose levels of mice. The extract is only effective on the
test animal which is initially hyperglycemic.

2. Comparing the commercial drug and the Syzygium aqueum leaf extract’s
effectiveness’ in treating hyperglycemic mice, it was discovered that no significant
difference in the blood sugar levels of test animals were observed in the different
time intervals.
3. The extent of the effectiveness of the plant extract did not last longer as time
passes by, except for the test animal that is hyperglycemic before the experiment.
Most of the recorded blood sugar levels dropped after 60 minutes but rose after 90
minutes.

CONCLUSION

After all the analysis and evaluation conducted and based from the findings of the study,
the researchers concluded the following:
1. The Syzygium aqueum leaf extract is effective in lowering the blood glucose levels
of albino mice on a descriptive basis, only if the receiver of the extract is proven
hyperglycemic before intake of each dosage. This information supports the study of
U.D. Palasinamy and T. Manaharan which by then only tested the potential of
Syzygium aqueum through examining its leaf extracts' flavonoid content (4-
hydroxybenzaldehyde, myricetin-3-O-rhamnoside, europetin-3-O- rhamnoside,
phloretin, myragalone-G, and myrigalone-B) which have hypoglycemic potential.

2. The effect of the leaf extract and the control drug, (Metformin) does not vary too
much from each other. Both showed an increase in blood sugar level.

3. The S. aqueum leaf extract fed to the diabetic mouse showed a consistent
lowering of blood sugar, which amounted to 40mg/dL decrease after 90 minutes.
However, a trend showing an increase then a decrease in blood sugar level is
present on test animals that aren’t diabetic.

RECOMMENDATIONS

After acquiring the conclusions based on the experimental results, the researchers have
therefore arrived at the following recommendations to improve the study:
1. Ensure that the mice have reached the blood glucose level that is considered
hyperglycemic, to increase the reliability of the testing of the leaf extract.

2. Test the leaf extract in comparison to other generic drugs (i.e. Acarbose).

3. Determine the extent of effectiveness of the extract induced by prolonging the


period of recording the blood sugar levels.

4. Study other parts of S. aqueum for antidiabetic potential, especially the fruit, flower
and the roots and compare which is more effective in terms of lowering blood sugar
level.

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