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1098D Pharm 313 Mabbayad-John-Nikko PDF

1) Herbal processing involves extraction methods like infusion, decoction, and tinctures, while drug manufacture uses complex purification and chemical/semi-synthesis. 2) Assays for herbal processing include component identification, cell studies, and animal tests, while drug tests are more standardized like content uniformity and dissolution. 3) Verification of effects for herbal processing involves pre-clinical and cell-based studies, while drug tests require clinical trials and in vivo animal studies.

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87 views2 pages

1098D Pharm 313 Mabbayad-John-Nikko PDF

1) Herbal processing involves extraction methods like infusion, decoction, and tinctures, while drug manufacture uses complex purification and chemical/semi-synthesis. 2) Assays for herbal processing include component identification, cell studies, and animal tests, while drug tests are more standardized like content uniformity and dissolution. 3) Verification of effects for herbal processing involves pre-clinical and cell-based studies, while drug tests require clinical trials and in vivo animal studies.

Uploaded by

Nikko Mabbayad
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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ETHNOPHARMACOLOGY AND NATURAL PRODUCTS

Comparison between herbal processing and drug manufacturing


John Nikko B. Mabbayad

Parameter of Herbal processing Drug manufacture


comparison
Method of extraction/ • Infusion • Complex Purification
Method of production • Decoction • Chemical synthesis
• Blanching • Semi-synthesis via
• Bruising intermediate of a
• Tincture product
• Smudging
Assay for screening/ • Component identification • Pharmacopeial test
tests used o Phytochemical analysis (tablets and capsule)
o Phenotypic screening o Absolute drug
• Cell studies content test
• Mechanism analysis o Uniformity of weight
• Transcriptional profiling test
o Uniformity of
content
o Disintegration test
o Dissolution test

• Non-pharmacopoeial
test
o Tablet hardness or
crushing strength
test
o Friability test
o Tablet thickness

• Other test
o Sterility test
Verification of • Pre-clinical toxicity testing of • In vitro models using
pharmacologic effect. herbs extracts
• Cell-based cytotoxicity • Pre-clinical trials
• Herbal toxicokinetics • Clinical trial (I, II, III, IV)
• DNA microarrays
• Proteomics • In vivo studies
• Metabonomics o Dog blood pressure
• Animal test preparation
o Ocular/skin irritancy test o Cat superior cervical
o Neurotoxicity test ganglia preparation
o Genotoxicity test
ETHNOPHARMACOLOGY AND NATURAL PRODUCTS
Comparison between herbal processing and drug manufacturing
John Nikko B. Mabbayad
o Reproductive/developmental o Dog chorda tympani-
toxicity test wharton’s duct
preparation
o Rabbit sciatic nerve-
gastronemicus
muscle preparation

References

Exposito, O., Bonfill, M., Moyano, E., Onrubia, M., Mirjalili, M., Cusido, R., & Palazon, J. (2009). Biotechnological
Production of Taxol and Related Taxoids: Current State and Prospects. Anti-Cancer Agents in Medicinal Chemistry,
9(1), 109–121. doi:10.2174/187152009787047761

Long, J. P., & Chiou, C. Y. (1970). Pharmacological Testing Methods for Drugs Acting on the Peripheral Nervous
System. Journal of Pharmaceutical Sciences, 59(2), 133–148. doi:10.1002/jps.2600590202

Ifeoma, O., & Oluwakanyinsol, S. (2013). Screening of Herbal Medicines for Potential Toxicities. New Insights into
Toxicity and Drug Testing. doi:10.5772/54493

Quality Control Tests for Tablets. (2020, March 31). Retrieved September 07, 2020, from
https://www.pharmapproach.com/quality-control-tests-for-tablets/

Philippine national Formulary

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