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Group Discussion Second Year Cardiovascular System

Case 1 describes a 50-year-old diabetic patient with abnormal lipid levels including high total cholesterol, low HDL, high LDL, and high triglycerides. Case 2 is about a 62-year-old man taking an HMG-CoA reductase inhibitor, indicating a diagnosis of high cholesterol or familial hypercholesterolemia. Case 3 asks to identify which cardiac enzyme markers would be ordered at 3 hours, 24 hours, and 72 hours to assist in diagnosing a patient with chest pain, explaining how the enzymes may be elevated at different stages of a heart attack.

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65 views2 pages

Group Discussion Second Year Cardiovascular System

Case 1 describes a 50-year-old diabetic patient with abnormal lipid levels including high total cholesterol, low HDL, high LDL, and high triglycerides. Case 2 is about a 62-year-old man taking an HMG-CoA reductase inhibitor, indicating a diagnosis of high cholesterol or familial hypercholesterolemia. Case 3 asks to identify which cardiac enzyme markers would be ordered at 3 hours, 24 hours, and 72 hours to assist in diagnosing a patient with chest pain, explaining how the enzymes may be elevated at different stages of a heart attack.

Uploaded by

ola nagar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Case 1:

A 50 year old diabetic went for a routine health


checkup.His lab findings were:
- T.Cholesterol : 310 mg/dl
- HDL : 30 mg/dl
- LDL : 200 mg/dl
- Triglycerides : 210 mg/dl
.Please write your biochemical report on this case

Case 2:
A 62-year-old man is prescribed a pharmaceutical agent that inhibits
the activity of the enzyme HMG-CoAreductase. This patient most
likely has which of the following conditions?
a. Chronic inflammation
b. Familialhypercholesterolemia
c. Hypertension
d. Hyperuricemia
e. Type 2diabetes

Case 3:
A patient with ischemic chest discomfort. Which enzymes from
Cardiac markers would you order to assist in making the diagnosis?
Compare and contrast the enzyme patterns if the pathologic process
was of 3 hours duration, or 24 hours duration, or 72 hours duration?
You should be able to explain the various enzymes which might be

elevated during the course of the infarction.


Case 4:
A 22-year-old woman presents with a fusiform swelling of the
Achilles tendon, which, when biopsied, shows cholesterol-laden
macrophages (foam cells) dispersed among the collagen fibers. She
had been troubled with joint pains for several years. Both her mother
and father developed arthritis associated with production of
xanthomas, but their first symptoms occurred in middle age. She was
referred to a nutritionist and treated with an enzyme inhibitor. Which
of the following is most likely elevated in the blood of this woman?
A. Chylomicron remnants
B. Chylomicrons
C. High density lipoproteins (HDL)
D. Low density lipoproteins (LDL)
E. Very low density lipoproteins (VLDL)

Case 5:
A 48 year old male with a history of hypertension and high cholesterol
presents to the emergency department with chest pains for 60
minutes. He describes a substernal chest pressure “like an elephant on
my chest” associated with shortness of breath and diaphoresis. His
ECG shows ST elevations consistent with myocardial infarction.
Which of the following laboratory results would be expected?
A. Elevated myoglobin, elevated troponin I, and elevated CKMB
B. Normal myoglobin, elevated troponin I, and normal CK-MB
C. Elevated myoglobin, normal troponin I, and normal CK-MB
D. Normal myoglobin, normal troponin I, and elevated CK-MB
E. Normal myoglobin, normal troponin I, and normal CK-MB

Case 6:
Liver cells in culture were kept at 0 C and treated with trypsin to
digest the receptors on the cell surface. The temperature was then
raised to 37.0 and radioactive LDL was added to the culture media.
Several hours later, the labeled LDL was found to be inside the cells.
This specific process of LDL uptake is
F. active transport
G. facilitated diffusion
H. phagocytosis
I. pinocytosis
J. receptor-mediated endocytosis

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