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Tugas Sediaan Steril

This document contains calculations to determine the volume of isotonic diluent and amount of sodium chloride needed to make intravenous injections of various drugs isotonic. It provides examples for ketamine HCl 10 mg/ml, morphine HCl 10 mg/ml, imipramine HCl 13.5 mg/ml, and methadone HCl 10 mg/ml injections. The calculations use the drug concentration, osmotic coefficient, and formula to determine the volume of isotonic diluent based on the drug weight. The remaining volume that is non-isotonic is then calculated and used to determine the amount of sodium chloride needed to make the full volume isotonic.

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0% found this document useful (0 votes)
35 views3 pages

Tugas Sediaan Steril

This document contains calculations to determine the volume of isotonic diluent and amount of sodium chloride needed to make intravenous injections of various drugs isotonic. It provides examples for ketamine HCl 10 mg/ml, morphine HCl 10 mg/ml, imipramine HCl 13.5 mg/ml, and methadone HCl 10 mg/ml injections. The calculations use the drug concentration, osmotic coefficient, and formula to determine the volume of isotonic diluent based on the drug weight. The remaining volume that is non-isotonic is then calculated and used to determine the amount of sodium chloride needed to make the full volume isotonic.

Uploaded by

esterina
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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1.

R/ Ketamin HCL 10 mg/ml


m.f inj. Da in ampul 1 ml
dtd. No. III
Jawab :
 Ketamin HCl = 10mg/ml = 1g/100ml = 1%
 E 1% Ketamin HCl = 0,21 (FI IV HAL 1246)
 W = 1g/100ml
V = W x E x 111,1
V = 1 x 0,21 x 111,1
= 23,331 ml (Volume Isotonis)
 Pelarut yang belum isotonis = 100 ml – 23,331ml
= 76,669ml
1
Dalam1 ml= x 76,669 ml
100
= 0,77 ml
0,9
 NaCl yang ditambahkan= x 0,77 ml=0,0069 g=6,9 mg/ml
100

2. R/ Morfin HCL 10mg/ml


m.f. injeksi da in ampul 1 ml
dtd no. III
Jawab :
 Morfin HCl = 10mg/ml = 1g/100ml = 1%
 E 1% = 0,086
 W = 1g
V = W x E x 111,1
= 1 x 0,086 x 111,1
= 9,55 ml (Volume Isotonis)

 Pelarut yang belum isotonis = 100ml – 9,55ml


= 90,45 ml
1 ml
Dalam1 ml= x 90,45ml=0,9045 ml
100 ml
0,9 g
 NaCl yang perlu ditambahkan= x 0,9045 ml=0,0081 g /ml = 8,1g/ml
100 ml
3. R/imipramine Hcl 13,5 mg/ml
m.f inj da in vial 5 ml
dtd no. II
Jawab :
 Imipramin HCl = 13,5mg/ml = 1,35mg/100ml = 1,3%
 E 2% Imipramin HCl = 0,20
 W = 1,35g
V = W x E x 111,1
= 1,35 x 0,20 x 111,1
= 29,99ml (Volume Isotonis)
 Pelarut yang isotonis = 100ml – 29,99ml
= 70,01
5
Dalam5 ml= x 70,01=3,5 ml
100
0,9 g
 NaCl yang ditambahkan= x 3,5 ml=0,0315 g=31,5 mg/ml
100 ml

4. R/Methadon Hcl 10 mg/ml


m.f. isotonis cum nacl ad 10 ml
da in vial 5 ml
dtd. No. III
Jawab :
 Methadon HCl = 10mg/ml = 1g/100ml = 1%
 E 1% Methadon HCl = 0,18
1g
 W =Methadon= x 10 ml=0,1 gram
100ml
V = W x E x 111,1
= 0,1 x 0,18 x 111,1
= 1,99ml
 Volume yang belum isotonis = 10ml – 1,99ml
= 8,01ml
5
dalam 5 ml = x 8,01=4,00 ml
10
0,9 g
 NaCl ditambahkan = x 4,00 ml=0,036 g/ml = 36mg/ml
100 ml

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