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CP 1 (Eliminasi) : Time C (NG/ML) LNC C' C' - C LN (C'-C)

This document contains pharmacokinetic data from a drug trial with measurements of drug concentration (C) in ng/ml over time. It includes the natural log of the concentrations and derived parameters C' and the change from the measured concentration C. Graphical analyses were performed determining the elimination rate constant (K) and absorption rate constant (Ka) from the slope and intercept of lines of best fit.

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Rania Risna
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31 views3 pages

CP 1 (Eliminasi) : Time C (NG/ML) LNC C' C' - C LN (C'-C)

This document contains pharmacokinetic data from a drug trial with measurements of drug concentration (C) in ng/ml over time. It includes the natural log of the concentrations and derived parameters C' and the change from the measured concentration C. Graphical analyses were performed determining the elimination rate constant (K) and absorption rate constant (Ka) from the slope and intercept of lines of best fit.

Uploaded by

Rania Risna
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLSX, PDF, TXT or read online on Scribd
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Time C (ng/ml) Ln C C' C' - C Ln (C'-C)

0 0 0 0 0 0
0.25 51.33 3.938275 105.2249 53.8949 3.987036 Cp 1 (elimina
0.5 74.05 4.304741 100.444 26.394 3.273137
3
0.75 82.91 4.417756 95.88025 12.97025 2.562658 2.5
1 85.11 4.443945 2 f(x) = − 0.1859684814599
1.5 R² = 0.999999728311886
1.5 81.76 4.403788 Axis Title
1
2 75.51 4.324265 0.5
3 62.98 4.142817 0
10 12 14 16 18 20 22 24 26
4 52.32 3.957379
6 36.08 3.585739 Axis Title
8 24.88 3.214064
12 11.83 2.470639 slope (K)
18 3.88 1.355835 intercept (B)
24 1.27 0.239017

C' → Cp= intersept x 𝑒^(𝑘.


𝑡)
T max Ka/K
k.t = -0.0465 -0.093 -0.1395 Ln (Ka/K)
exp (k.t)= 0.954565 0.911194 0.869793 Ka-K
C' = 105.2249 100.444 95.88025 Tmax →

12 2.470639 0.25 3.987036


18 1.355835 0.5 3.273137
24 0.239017 0.75 2.562658
Cp 1 (eliminasi) Cp 2 (absorbsi)
3 5
2.5 4
2 f(x) = − 0.185968481459983 x + 4.70259624364502 f(x) = − 2.84875516075803 x + 4.69865452663234
R² = 0.999999728311886 Column B 3 Column E
1.5 R² = 0.999998077534137
Linear (Column B) Axis Title 2 Linear (Column E)
1
0.5 1
0 0
10 12 14 16 18 20 22 24 26 0.2 0.3 0.4 0.5 0.6 0.7 0.8
Axis Title Axis Title

→ -0.186 Slope (Ka ) → -2.8488


→ 110.2334 intercept (A) → 109.8043

15.31613
2.728906
2.6628 -2.6628
1.024826
bsorbsi)

16075803 x + 4.69865452663234
7534137 Column E
Linear (Column E)

0.7 0.8

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