Active Series

For Skin Care

Improved Skin Health
With the “Grant Touch”

Grant Industries, Inc.

 Grant’s Active Series

If you are familiar with Grant Industries because of our silicone expertise
and the “Grant Touch”, then you may be surprised to learn that we also
offer a new series of active delivery systems that include peptides,
vitamins, botanical extracts, hydration polymers and wrinkle reducers.

For decades, Grant Industries has been the leading supplier of specialty silicone elastomers
to the beauty care market. We take pride in listening to our customers and are always
striving to provide products and solutions that exceed expectations. Our company is
focused and optimized to rapidly develop custom products. We accomplish this by drawing
upon technology from our existing product line and combining this with unique solutions
derived from innovative sources outside our company.

“We Listen, We Explore, We Create”

“Nos Audio , Nos Rimor , Nos Partum”(latin version)

The initial feel of a product is critical to consumer appeal. Grant has mastered the art of elegant
texture and product performance, while integrating ease of formulation into all product categories.

Our Active Series of cosmetic materials include breakthrough technology from our
talented chemists and supply partners. Some of the external technologies include peptides,
retinoids, InvisaSkin®, glycoconjugates, GABA and an extensive line of bioconverted
botanicals.

Grant’s Active Series are available for the following skin care
areas:

Color: Foundations, Concealers, Powders and Primers

Skin Care: Anti-aging, Anti-acne, Creams, Lotions, Actives,
Intensive Hydration Products and Daily Wear

Need a custom Grant Active Series product?

A product meeting your specific requirement is just an email or phone call away.
 Active Series Summary
Product Description INCI NAME Application
Instant Wrinkle Reduction
GRANT-X Cyclopentasiloxane (and) Water (and) Anti-Aging
A multi-ingredient “performance matrix” that instantly Polysilicone-11 (and) Amino Butyric Acid (and) Daily Wear
reduces the appearance of wrinkles. Clinical test results Barium Sulfate (and) Panax Ginseng Root Color Cosmetics
show rapid improvement in achieving a smooth healthy look Extract (and) Portulaca Oleracea Extract (and) Wrinkle Treatment
in all participants via nerve synapse interactions (GABA & Centella Asiatica Extract Face Lift Products
botanicals), soft-focus optics and line-filling silicone
polymers.

Peptides

InvisaSkin™ Matrix Rebuilder-O Water (and) Butylene Glycol (and) Anti-Aging

An anti-aging skin care complex combining the activity of Ethoxydiglycol (and) Daily Wear
palmitoyl hexapeptide-14 and the botanically derived Dimethylacrylamide/Acrylic Acid/ Polystyrene Color Cosmetics
glycoconjugates (goji berry extract) with a rehydrating Ethyl Methacrylate Copolymer (and) Palmitoyl
(InvisaSkin) polymer for a maximum synergistic effect Hexapeptide-14 (and) Lycium Barbarum Fruit
rebuilding skin’s extra cellular matrix. Extract (Goji Berry)

Granactive AGE Water (and) Butylene Glycol (and) Anti-Aging

An anti-aging skin care complex combining the activity of Ethoxydiglycol (and) Palmitoyl Hexapeptide-14 Daily Wear
palmitoyl hexapeptide-14 and glycoconjugates from goji (and) Lycium Barbarum Fruit Extract (Goji Color Cosmetics
berry extract for a maximum synergistic effect rebuilding Berry) Wrinkle Treatment
skin’s extra cellular matrix. Face Lift Products

Granactive Hexapeptide Cyclopentasiloxane (and) Polysilicone-11 (and) Color Cosmetics

An anhydrous anti-aging delivery complex combining the Ethoxydiglycol (and) Palmitoyl Hexapeptide-14 Daily Wear
matrix-fibroblast stimulation power of palmitoyl Anti-Aging
hexapeptide-14 with the line-filling silicone elastomer.

Granactive Powder-168 Mica (and) Silica (and) Water (and) Pressed Powders
A mineral based powder with catalytic anti-aging complex Ethoxydiglycol (and) Barium Sulfate (and) Peat Daily Wear
especially designed to stimulate cellular turnover and Extract (and) Palmitoyl Hexapeptide-14 (and) Anti-Aging
improve skin appearance. Gold Loose Powders
Granactive™ ACNE Water (and) Butylene Glycol (and) Oryza Anti-Acne
A botanical complex containing a patented antimicrobial Sativa (Rice) Bran Extract (and) Boswellia Daily Wear
peptide (Oligopeptide-10) for use in products associated Serrata Extract (and) Honey Extract (and) Toners
with treating acne symptoms. Synergistic with salicylic acid Oligopeptide-10
for those desiring anti-acne claims.

Granactive Oligopeptide-10 Cyclopentasiloxane (and) Dimethicone (and) Anti-Acne

An elastomer matrix featuring a patented anti-microbial, Water (and) Polysilicone-11 (and) Butylene Daily Wear
anti-acne peptide from plant amino acids use in a toner or Glycol (and) Decyl Glucoside (and) Toners
other product to promote healthy skin tone. Oligopeptide-10

Retinoic Ester (Bioavailable Vitamin-A for Cosmetics)

Granactive RD-101 Cyclopentasiloxane (and) Stearoxymethicone/ Acne Treatment
Our flagship anhydrous delivery matrix containing 1% dimethcone copolymer (and) Dimethyl Daily Wear
hydroxypinacolone retinoate in DMI and polysilicone Isosorbide (and) Dimethicone (and) Anti-Aging
elastomers gel for outstanding skin aesthetics and anti- Hydroxypinacolone Retinoate
aging performance.

Granactive Retinoid Fluid Dimethyl Isosorbide (and) Hydroxypinacolone Acne Treatment

Concentrated and easily formulated anhydrous matrix Retinoate Daily Wear
containing 10% of the pinacolyl ester of all-trans retinoic Anti-Aging
acid (tretinoin) in a premium delivery solvent.

Granactive Powder-101 Mica (and) Silica (and) Water (and) Dimethyl Pressed Powders
A hydroxypinacolone retinoate anti-aging mineral powder Isosorbide (and) Barium Sulfate (and) Daily Wear
complex especially designed to stimulate cellular turnover Hydroxypinacolone Retinoate (and) Peat Anti-Aging
and improve skin appearance. Extract (and) Gold Loose Powders
 Grant-X Instantaneous Wrinkle Eliminator

Polysilicone-11 Instant Wrinkle Reduction Matrix

A multi-ingredient “performance matrix” that instantly reduces the appearance of
wrinkles. Clinical test results show rapid improvement in achieving a smooth
healthy look in all participants via nerve synapse interactions (GABA & botanicals),
soft-focus optics and line-filling silicone polymers. Visible anti-aging results can be
seen in reduction of lines and wrinkles along with an improvement in skin
Features and Benefits: appearance. In a cosmetic cream, Grant-X was clinically proven to reduce
the appearance of facial lines and wrinkles by over 50% in all 15
• Enhanced GABA Synapse panelists tested after just one ten minute application! Grant-X instantly
Properties
improves the skin feel perception during payout and transitions to that sought after
• Fine Line Elimination or powdery silicone-elastomer “Gransil Touch” with a soft-focus matte appearance.
Reduction Many users will experience a pleasant tingling sensation during
application, which positively reinforces skin activity and supports brand
• Botanical-Ion Channel
loyalty!
Interaction
Ingredient Contribution to Wrinkle/Fine Line Reduction
• Instantaneous Wrinkle
Reduction As shown below, each individual ingredient has been selected to contribute a
different mechanism for wrinkle reduction and together they provide a highly
• Analogous Performance
to “Freeze-type” effective regimen for skin smoothing.
Products Gamma Amino Butyric Acid (GABA)
• A known inhibitory neurotransmitter. Action potentials are triggered by a threshold
INCI Name: level of depolarization
Cyclopentasiloxane (and) Water • Causes the opening of chemically regulated gated channels for Cl- and
(and) Polysilicone-11 (and) Amino hyperpolarization (inhibitory postsynaptic potential)
Butyric Acid (and) Barium Sulfate • The final effect is relaxation of the facial nerve that can reduce wrinkles.
(and) Panax Ginseng Root Extract
(and) Portulaca Oleracea Extract Portulaca Oleracea (Purslane) Extract
(and) Centella Asiatica Extract • Possesses unique skeletal muscle relaxant properties, which do not appear to
involve interference with acetylcholine mechanisms.
• Extract may involve interference with Ca2+ mobilization in skeletal muscle or inhibition
Recommended Use Levels:
of the release of calcium from stores in the sarcoplasmic reticulum.
10 – 40%
(Grant’s clinical’s based on 35% use level)
• The final effect is relaxation of the muscle that can reduce wrinkles.

Safety: Panax Ginseng Extract

Non-irritating, Non-sensitizing • Ginseng saponins, major active ingredients of ginseng root, produce multiple
pharmacological responses, including reversible blocking of Na+ channels
Non-mutagenic
• Ginseng is considered an adaptogenic herb - which help the body adapt to stresses of
various kinds.
Availability: • Contributes to wrinkle reduction
Globally
Centella Asiatica Extract
Applications: • Centella extract stimulates collagen synthesis, reduces fine lines and wrinkles and
• Anti-aging assists in eliminating dark under eye circles.
• After Sun
• Daily Wear Cyclomethicone and Polysilicone-11
• A premium silicone-elastomer gel system with leading consumer sensory acceptance,
wrinkle filling capability, matte appearance and oil absorption.

Barium Sulfate
• A fine inorganic particle of a discrete particle size and exact refractive index for soft
focus optical effects in silicone gel systems.
 Wrinkle Eliminator F-1245
Grant-X was clinically proven, in the following cosmetic cream, to gently
improve the appearance of facial fine lines and wrinkles by over 50% in all of
15 panelists tested. Results available upon request.

Part Ingredient INCI Name % (wt)

A Deionized Water Water 36.6
1,3 Butylene Glycol Butylene Glycol 5.00
Germazide C Chlorphenesin 0.30
Amphisol K Potassium Cetyl Phosphate 2.00
TEA Triethanolamine 0.20
B Luvitol EHO Cetearyl Ethylhexanote 5.00
Grant-X Cyclopentasiloxane (and) 35.00
Water (and) Polysilicone-11 Great for all ages and
(and) Amino Butyric Acid (and)
Barium Sulfate (and) Panax skin types!
Ginseng Root Extract (and)
Portulaca Oleracea Extract
(and) Centella Asiatica Extract GRANT-X includes active
Carnauba Wax Copernecia Cerifera 1.90 ingredients that reversibly
(Carnauba) Wax
Phoenotaine C-35 Sodium Cocamidopropyl PG- 3.00
interact with wrinkle causing
Dimonium Chloride Phosphate mechanisms, without relying
Ceteth-20 Ceteth-20 1.00 on the acetylcholine switch
Biophilic-H (Lucas Hydrogenated Lecithin (and) 3.00
Meyer) C12-16 Alcohols (and) Palmitic
as related to Botox®.
Botox is a registered trademark of Allergan, Inc.
Acid
C Gransil PSQ Polymethylsilsesquioxane 5.00
Granthix APP Isohexadecane (and) 0.40
Ammonium
Polyacryloyldimethyl Taurate
(and) Polysorbate-80
Glyceryl Behenate Glyceryl Behenate 1.00
Preservative qs
Total 100.00

Procedure:
1. Mix part A well, heat to 75° - 80° C.
2. Heat part B to 85° - 90° C. Mix well.
3. Add part A to part B under homogenization
4. Add part C to part AB
5. Mix for 15 minutes at 85° - 90° C.
6. Cool batch to 25° C under mixing.

GABA and Ion Channel

Mechanism

Grant-X
InvisaSkin® Matrix Rebuilder-O Restore and Rejuvenate

Patent pending Anti-Wrinkle Palmitoyl Hexapeptide-14 composition

with plant derived glycoconjugates
InvisaSkin Matrix Rebuilder-O is an anti-aging skin care complex combining the activity of
Palmitoyl Hexapeptide-14 and plant derived glycoconjugates (Goji berry extract) for a
maximum synergistic effect rebuilding skin’s extra cellular matrix. Multiple rebuilding
pathways are activated including: collagen biosynthesis, fibroblast proliferation and
inhibition of destructive matrix metalloproteinases. Anti-aging visible results can be seen
in reduction of lines and wrinkles along with a large improvement in skin’s elasticity. This
ingredient utilizes InvisaSkin™ delivery technology to maximized efficacy and hydration.
Intracellular Matrix Function
Palmitoyl Hexapeptide-14: Enhanced anti-wrinkle and lifting
A short bioactive peptide effect by stimulation of fibroblast
consisting of six naturally and collagen synthesis and
occurring amino acids with a inhibition of MMP-9. Includes
palmitoyl lipid attached for glycoconjugates and a peptide
enhanced skin penetration having immuno-modulatory
functions that boost host gene
expression, act as messengers,
and induce chemokine
production. Left side: untreated Right side: Matrix Rebuilder
Live Fibroblast Cells
INCI Name: Mechanism
Water (and) Butylene Glycol
(and) Ethoxydiglycol (and) The presence of this anti-aging
Dimethylacrylamide/Acrylic Acid peptide and Goji berry glyco-
Polystyrene Ethyl Methacrylate conjugate triggers specific natural
Copolymer (and) Palmitoyl intracellular messengers to up-
Hexapeptide-14 (and) Lycium regulate desired cellular activities
Barbarum Fruit Extract (Goji that tend to otherwise diminish
Berry) with age. The primary
characteristic is a dermal
fibroblast scaffolding effect that
increases three-dimensional cell
proliferation leading to Sulforhodimine stained fibroblast cells. 3-D structure in center
dramatically increased skin (treated area) vs monolayer on edges (untreated area)
Recommended Use Level:
elasticity and reduction of
10%
wrinkles.
Targeted Effect and Delivery
Activates the growth of fibroblast
cells and collagen production.
Patent Status: Formulated so actives penetrate
Patented Composition and the epidermis and remain
Patent Pending Applications hydrated. Fibroblast messaging
continues for up to 24-hours via
the deliver package of peptide
and glycoconjugate in a hydrated
polymer matrix co-formulated
Safety: with a penetration enhancing
Non-cytotoxic, Non-irritating, emollient.
Non-sensitizing, Non-mutagenic
 MMP-9 Inhibition
Availability:
Globally Matrix Metalloproteinase
Inhibition

Collagenase activity was

measured with a Enzchek kit
from Molecular Probes (Invitro-
Applications:
gen) using quenched
Wrinkle treatment, anti-aging
fluorescent gelatin and human
and face lift products in serum,
metallo-proteinase-9
gel cream and lotion forms.
preparation. The release of the
digested, fluorescent gelatin in
the presence of different test
materials was measured at
excitation/emission
wavelengths 485/530nm with
Millipore fluorometer.

Formulation: The combination of palmitoyl-

Water Dispersible hexapeptide-14 and goji berry
extract significantly inhibited
MMP-9.

Skin Toning and Elasticity

Increased elastin production

Demo Formulation: firms up skin and helps in
Available by Request recovery from aging, stress and
UV damage. Skin firmness and
resiliency are assessed by
cutometry, which measures the
elastic response of the skin over
time. A higher degree of
elasticity helps lift sags and
Tibetian Goji Berry improve the overall tone of the
skin, resulting in a more youthful
appearance

Matrix Rebuilder-O

Exhibits a statistically relevant

elasticity improvement in only
four weeks in AMA lab clinical
test.

InvisaSkin® Matrix Rebuilder-O

 Anti-Aging Peptide Complex
Granactive AGE
Patent pending Anti-Wrinkle Palmitoyl Hexapeptide-14 Composition
with Plant-derived Glycoconjugates
Granactive AGE is an anti-aging skin care complex combining the activity of
Palmitoyl Hexapeptide-14 and plant derived glycoconjugates (Goji berry extract)
for a maximum synergistic effect rebuilding skin’s extra cellular matrix. Multiple
rebuilding pathways are activated including: collagen biosynthesis, fibroblast
proliferation and inhibition of destructive matrix metalloproteinases. Anti-aging
visible results can be seen in reduction of lines and wrinkles along with an
improvement in skin’s elasticity. This ingredient can be combined with InvisaSkin
DS for increased delivery efficacy and other sensory benefits.
Intracellular Matrix Function
Palmitoyl Hexapeptide-14: Enhanced anti-wrinkle and lifting
A short bioactive peptide consisting of six effect by stimulation of fibroblast
naturally occurring amino acids with a and collagen synthesis and
palmitoyl lipid attached for enhanced skin inhibition of MMP-9. Includes
penetration glycoconjugates and a peptide
having immuno-modulatory
functions that boost host gene
INCI Name: expression, act as messengers, Untreated Granactive AGE Treated
Water (and) Butylene Glycol (and) and induce chemokine production. Live Fibroblast Cells
Ethoxydiglycol (and) Palmitoyl
Hexapeptide-14 (and) Lycium Barbarum Mechanism
Fruit Extract (Goji Berry) (and) Sodium The presence of this anti-aging
Benzoate peptide and goji berry glyco-
conjugate triggers specific natural
intracellular messengers to up-
Recommended use level: regulate desired cellular activities
5% (Typical) that tend to otherwise diminish
with age. The primary
characteristic is a dermal fibroblast
scaffolding effect that increases Sulforhodimine stained fibroblast cells. 3-D
three-dimensional cell proliferation structure in center (treated area) vs monolayer on
leading to dramatically increased edges (untreated area)
skin elasticity and reduction of
wrinkles.
Targeted Effect and Delivery
Activates the growth of
fibroblast cells and collagen
production. Formulated so
actives penetrate the epidermis
and remain hydrated. Fibroblast
messaging continues for up to
24-hours via the deliver package
of peptide and glycoconjugate in
a hydrated polymer matrix co-
formulated with a penetration
enhancing emollient.

Patent Status:
Patented Composition and Patent Pending
Applications
 MMP-9 Inhibition
Safety:
Non-cytotoxic, Non-irritating, Matrix Metalloproteinase
Non-sensitizing, Non-mutagenic Inhibition
Collagenase activity was
measured with Enzchek kit from
Molecular Probes (Invitrogen)
Availability: using quenched fluorescent
Globally gelatin and human metallo-
proteinase-9 preparation. The
release of the digested,
fluorescent gelatin in the
Applications: presence of different test
Wrinkle treatment, anti-aging and face lift materials was measured at
products in serum, gel cream and lotion excitation/emission wavelengths
forms. 485/530nm with Millipore
fluorometer. The combination of
Pamitoyl-hexapeptide-14 and
Goji berry extract significantly
Formulation: inhibited MMP-9
Water Dispersible
(May combine with InvisaSkin DS for added
hydration) Skin Toning and Elasticity

Increased elastin production

firms up skin and helps in
Demo Formulation: recovery from aging, stress and
Available by Request UV damage. Skin firmness and
resiliency are assessed by
cutometry, which measures the
elastic response of the skin over
time. A higher degree of
elasticity helps lift sags and
improve the overall tone of the
skin, resulting in a more youthful
appearance

Granactive AGE exhibits a

statistically relevant elasticity
improvement in only four weeks
in AMA lab clinical testing.

Tibetian Goji Berry

Clinical anti-wrinkle effect

A twelve-week human panel

test of 29 subjects
demonstrated that Palmitoyl
Hexapeptide-14 is equivalent to
RENOVA® (0.05% treretinoin)
in reducing the appearance of
fine lines and wrinkles with
none of the irritation and
redness caused by retinoid
drugs.

Granactive AGE
 Granactive Youthful Appearance
Hexapeptide And “Gransil Touch”

Anti-Aging Silicone Polymer Matrix

Granactive™ Hexapeptide is a designer peptide based anti-aging

complex that combines the matrix-fibroblast stimulation of palmitoyl
hexapeptide-14 with polysilicone-11 which will instantly improves
the skin feel perception during payout and transitions to that much
sought after powdery silicone-elastomer “Gransil Touch”.
Palmitoyl hexapeptide-14 is a short bioactive peptide modified with
palmitoyl for enhanced delivery and has proven to be a superb
ingredient for stimulating collagen production and proliferating
fibroblast cells while inhibiting MMPs. Granactive™ Hexapeptide
can be used in both emulsions and anhydrous based systems for
comprehensive anti-aging function of reducing the appearance of
fine lines and wrinkles, while eliminating dull and dry skin by
Features and Benefits: rebuilding the extra-cellular matrix.

• Maximized skin regenerative

properties
PEPTIDE GEL vs RENOVA® WRINKLE/FINE
• Clinical study proven wrinkle LINE COMPARATIVE STUDY
reduction
Study Aim:
• Great sensorial aesthetics A 12-week split-face, double-blind study comparing the efficacy of a
palmitoyl hexapeptide-14 gel with tretinoin (retinoic acid) cream
• World class “Gransil Touch” (0.05%) in the correction of fine lines and wrinkles.

• Improved skin health

INCI Name:
Cyclopentasiloxane (and) Polysilicone-11 (and)
Ethoxydiglycol (and) Palmitoyl Hexapeptide-14

Recommended Use Levels:

5 -10%

Safety:
Non-irritating, Non-sensitizing
Non-mutagenic

Availability:
Globally
Results:
Applications: All of the five investigators rated the peptide equal to or more
• Color Cosmetics effective than tretinoin cream in regard to therapy for fine lines and
• Daily Wear wrinkles of the periorbital region.
• Anti-Aging
Granactive Powder-168 Anti-Aging Powder

Peptide Powder for Youthful Skin

Granactive Powder 168 is a powdered anti-aging complex that
combines the matrix-fibroblast stimulation and collagen growth of
palmitoyl hexapeptide-14 with plant derived fulvic acid (peat extract) to
maximize the restorative powers of the skin’s extra-cellular matrix. It
includes 24 carat colloidal gold to facilitate the electrolytic transfer
between trace minerals and the skin’s natural metallic-based
electrolytes.
Granactive Powder-168 is a catalytic anti-aging complex especially
designed to stimulate cellular turnover and improve skin appearance in
loose and pressed powder applications.

A human panel test

Clinical Anti-aging Study
using the powder
formula
demonstrates
visible anti-aging
results can be
Features and Benefits: observed in just 4
weeks.
• Maximized skin regenerative
properties The chart shows a
• Clinical study proven wrinkle pronounced
reduction and skin brightening reduction of lines
• Great sensorial aesthetics and wrinkles.
• Improved skin health Researchers also
noted improved skin
INCI Name: brightening.
Mica (and) Silica (and) Water (and)
Ethoxydiglycol (and) Barium Sulfate (and)
Peat Extract (and) Palmitoyl Hexapeptide-14 Anti-Wrinkle Peptide Powder
(and) Gold Part Wt (%)
Ingredient
A Soft Talc 70.0
Recommended Use Levels:
5 -10% Mica LTM-102 10.0
Zinc Stearate 2.0
Safety: Granpowder USQ 5.0
(Polymethylsilsesquioxane (and) HDI/Trimethylol
Non-irritating, Non-sensitizing Hexyllactone Crosspolymer)
Non-mutagenic SXI-5 1.5
(Mica (and) Dimethicone (and) Silica - US Cosmetics)
Availability: Red Iron Oxide 0.3
Globally Yellow Iron Oxide 1.0
Black Iron Oxide 0.1
Applications: Granactive Powder-168 5.0
• Pressed Powders (Mica (and) Silica (and) Water (and) Ethoxydiglycol
• Daily Wear (and) Barium Sulfate (and) Peat Extract (and)
Palmitoyl Hexapeptide-14 (and) Gold
• Anti-Aging
• Loose Powders B Coco Caprylate/Caprate 3.0
Isopropyl Isostearate 2.0
Preservative qs
Total 100.0
“An absolute first…
Procedure:
…loose powders providing a 1) Grind part A until consistent color and texture
clinical level of peptide activity” 2) Add part B to part A and continue grinding until smooth texture.
 Clear Healthy
Granactive ACNE Skin Products

New Approach to Treating Acne

Oligopeptide-10
A short bioactive peptide consisting The unique combination of botanicals and anti-microbial peptide offers a gentle approach
of fifteen naturally occurring amino to treating the symptoms of acne.
acids that provides anti-microbial
activity against p-acne bacterium
Patent Pending Antimicrobial Oligopeptide-10
Botanical Complex for Acne Treatment
INCI Name:
Water (and) Butylene Glycol (and)
Granactive ACNE is botanical complex containing a patented antimicrobial peptide for
Oryza Sativa (Rice) Bran Extract use in products associated with treating acne symptoms. This product can be formulated
(and) Boswellia Serrata extract with an approved OTC acne ingredient, like salicylic acid or simply used in a toner or
(and) Honey Extract (and) other product for maintenance of the skin. Oligopeptide-10 is an anti-microbial peptide
Oligopeptide-10 derived from plant amino acids that is highly synergistic with salicylic acid. This allows
salicylic acid to be effectively formulated at 0.5%, the lowest permissible level as defined
in CFR Vol. 56, No.159 §333.310c, the monograph for acne treatments. In comparison,
Use Level: 5% other products formulated near the 2% salicylic acid level are more irritating. Salicylic
acid is comedolytic as it opens up the infected pores to allow oxygen in. This action
allows access of oligopeptide-10 into the pores for a maximum bacteriostatic effect.
Patent Status: Oligopeptide-10 has broad-spectrum activity against many types of organisms, including
Patent Pending Application the p. acne bacterium. Rice bran, boswellia serrata and honey botanical extracts are
included to soothe and smooth the skin.

Safety: Targeted Effect and Delivery

Non-cytotoxic, Non-mutagenic,
Non-irritating, Non-sensitizing Human skin is comprised of two major Innate immunity peptides such as
classes of innate immunity peptide, β- defensins and LL-37 are known for
defensins and cathelicidins (LL-37). binding and neutralizing bacterial debris.
Availability: Globally This effect down regulates pro-
inflammatory cytokines, thereby reducing
Inflammation is often associated with skin irritation potential.
conditions that have bacterial involvement,
Applications: Consistent with this LL-37 has also been
which is in part due to lipopolysaccharide
Anti-acne* therapy products in shown to modulate the toll-like receptor
(LPS) released from the outer membrane of
serum, gel cream and lotion forms. (TLR) mediated inflammatory response.
gram-negative bacteria, and lipotechoic acid
Oligopeptide-10 is a synthetic peptide
(LTA) released from gram-positive bacteria.
designed to bind LTA.
Formulation:
Water Dispersible Synergy Between Salicylate and Antimicrobial Peptide

A study of sodium salicylate added to oligo-

peptide-10 solutions found the salicylate was
Maximum Bacteria instrumental in synergistically lowering the
(P. acne) Kill minimum inhibitory concentration
Including antibiotic resistant requirement for the peptide. In other words,
bacterium
0.5% salicylate is all that is required to meet
the FDA guidelines and still cause an 8X
decrease in the amount of peptide required
Non-drying, Fast acting
to kill over 50% of the bacteria. This study
Aesthetically Pleasant Coverage
exhibits the efficacy and value possible in
using salicylates with a peptide level of >2
ug/ml.
Non-comedogenic
*must be co-formulated with an approved anti-acne active as subject to regional codes and laws.
 Anti-Acne and
Granactive Oligopeptide-10 Daily Wear

High Performance Polymer Matrix For Anti-acne

Granactive Oligopeptide-10 is a silicone-elastomer matrix featuring a patented

anti-microbial peptide from plant amino acids. Granactive Oligopeptide-10 can
be formulated with an approved OTC acne ingredient, like salicylic acid, or simply
used in a toner or other product for healthy maintenance of the skin. While it has
excellent activity against the p-acne bacterium, it was found to be highly effective
in combination with salicylic acid. This allows salicylic acid to be synergistically
Oligopeptide-10 (the peptide INCI
name) is a short bioactive peptide formulated near the 0.5% level, the lowest permissible use level for ACNE
consisting of naturally occurring amino treatment. In comparison, other products formulated near the 2% salicylic acid
acids that provides anti-microbial
activity against p-acne bacterium level are much higher in irritation. Salicylic acid is comedolytic, opening up the
infected pores to allow oxygen in. This action enables Oligopeptide-10 free access
Features and Benefits:
• Ready to dilute into an active into the pores for a maximum bacteriostatic effect. Promotes healthy skin tone
containing water phase or
improving an existing o/w while treating the consumer to a sophisticated skin feel.
emulsion

• Immediate perceptible difference Oligopeptide-10 Acne Treatment Formula

in skin feel – smooth feeling initial
then transitions to powdery soft
“Gransil Touch” Part Ingredient INCI Name wt %
• Contains Oligopeptide-10, an Deionized Water Water 59.05
antimicrobial peptide originally Natrosol 250M Hydroxyethylcellulose 0.10
designed as a co-ingredient for Butylene Glycol Butylene Glycol 15.00
healing and acne treatments Tween-20 Polysorbate 20 0.15
Plantaren 2000 Decyl Glucoside 0.20
• Cold processable in water based
Salicylic Acid Salicylic Acid 0.50
high performance systems
Diocide Caprylyl Glycol (and) Phenoxyethanol (and) 0.50
INCI Name: Hexylene Glycol
Cyclopentasiloxane (and) Dimethicone Granthix APP Isohexadecane (and) Ammonium 4.50
(and) Water (and) Polysilicone-11 Polyacryloyldimethyl Taurate (and)
(and) Butylene Glycol (and) Decyl Polysorbate 80
Glucoside (and) Oligopeptide-10
B Granactive Cyclopentasiloxane (and) Dimethicone (and) 20.00
Oligopeptide-10 Water (and) Polysilicone-11 (and) Butylene
Recommended Use Levels: Glycol (and) Decyl Glucoside (and)
10 - 30 % Oligopeptide-10
Total: 100.00
Safety:
Non-irritating, Non-sensitizing
Non-mutagenic
Procedure:
1. Add ingredients of part A, mix with side sweep agitation.
Availability: 2. Add part B to part A with side sweep agitation, mix for 30 min.
Globally

Applications: Note: If you are interested in a non-silicone based ACNE treatment, consider
• Anti-Acne* Granactive ACNE, an aqueous solution containing the proven anti-microbial
• Daily Wear peptide (INCI name oligopeptide–10) for use in products associated with the
• Toners treatment of acne. We recommend co-formulating this product with salicylic
acid and InvisaSkin® DS for optimal performance, delivery and treatment.
Formulation Advice:
Easily formulated in water systems *must be co-formulated with an approved anti-acne active as subject to
at 60°C or below. regional codes and laws.
 Contains The Most Active
Granactive RD-101 Form Of Cosmetic Grade
Vitamin-A

Mild Retinoic Ester Technology for

Anti-Aging and Anti-Acne* Products

The prescriptive drug active Tretinoin is the all-trans isomer of retinoic acid and is a
topical form of delivering vitamin-A. It helps the skin to renew itself more quickly and
therefore reduces pimple and blackhead formation, and may improve the appearance
Granactive RD-101 and texture of skin.
A mixture containing 1% pure
pinacolyl ester of trans- Retin-A® is Tretinoin topically used to treat acne. The Renova® brand of Tretinoin topical
retinoic acid. Designed for is used to reduce the appearance of fine wrinkles and mottled skin discoloration, fix age
high stability, low irritation spots and make rough facial skin feel smoother. All of these products are exclusively in
and effective activity and the acid form and can peel/irritate the skin and increase the skins sensitivity to sun
dermal delivery in skin care exposure. (TM Ortho Dermatological)
applications.
In comparison, Granactive RD-101 is a formulated cosmetic raw material that includes
Cosmetic Level 1% of a pure ester form of Tretinoin that works similar to Retin-A, but without the
Retinoic Acid Receptor irritation of Tretinoin. It also does not require a prescription to use. This delivery
form significantly reduces the irritation potential, without diminishing the cosmetic
(RAR) Binding Activity
treatment potential. Granactive RD-101 in cosmetics decreases the effects of sunlight-
induced aging and is a useful ingredient in anti-acne* preparations. Unlike Tretinoin,
• Inhibits Synthesis Of
the improved mildness allows Granactive RD-101 to be co-formulated with anti-acne
Matrix Proteases
products like salicylic acid and it's salts, so long as the retinoic ester is protected in the
oil phase of an emulsion.
• Increases Synthesis Of
Collagen
*must be co-formulated with an approved anti-acne active as subject to regional codes and laws.

• Stimulates Division Of Clinical Age-Spot Reduction

Keratinocytes And
Dermal Fibroblasts
A formula containing 0.1%
• Stimulates Synthesis
Hydroxypinacolone-Retinoate and
Of Extracellular Matrix
1% Magnesium Ascorbyl
Phosphate (MAP) was graded for
INCI Name: age spot reduction over one
Cyclopentasiloxane (and) month of study on 5 subjects.
Stearoxymethicone/ This formula essentially included
dimethicone copolymer (and) a minimum level of MAP to qualify
Dimethyl Isosorbide (and) for products requiring skin-
Dimethicone (and) lightening claims.
Hydroxypinacolone Retinoate
As shown on the right, this
combination is very effective in
Appearance: achieving a 50% improvement in
Viscous Bright Yellow Gel the grade of discolored skin in
With Characteristic just one month. MAP can be
Vitamin-A Odor difficult to formulate, so a 50%
use level reduction is always
preferred.
Recommended Use Surface Roughness and Overall Skin Condition Improvements
Level
1% to 10%

Significant skin surface

roughness improvements
Patent Status: occurred within one or two
US 4,885,311 and weeks of using this product.
Patent Pending Applications
About 50% improvement was
noted.
Safety:
Non-irritating, Non-mutagenic During the ending survey,
and Non-sensitizing 100% of participates responded
that skin roughness, dryness,
tone, radiance, softness,
firmness, tightness, elasticity
and overall skin condition were
significantly improved.

Overall Skin Condition Improvements

Significant Improvements were

noted in skin surface scaling,
otherwise a potential indicator
of irritation and dryness.

The method of formulating

Granactive RD-101 yields an
Availability: effective and winning formula
Globally without dryness or irritation.

Applications:
Anti-aging and anti-acne* 80% of the panelist responded
therapy products in serum, that this formula significantly
gel, cream and lotion forms. reduced fine lines and wrinkles,
diminished the appearance of
*must be co-formulated with an age spots, skin discolorations
approved anti-acne active as subject and freckles and improved sun
to regional codes and laws.
damaged skin.

Formulation:
Oil Dispersible

Granactive RD-101
 Granactive Retinoid Clear and Beautiful Skin

Fluid
Unique Vitamin-A Delivery for Skin Health

Granactive Retinoid Fluid is a concentrated and easily formulated anhydrous matrix

containing 10% of the pinacolyl ester of all-trans retinoic acid (tretinoin) in a premium
delivery solvent (DMI). This source of vitamin-A may be the most bio-available, non-
prescription form sold to the cosmetics industry. It is intended for use in anti-aging and anti-
acne beauty treatments. It provides low irritation, effective activity and high dermal delivery
in daily maintenance skin care applications.

The activity of Granactive Retinoid Fluid is based on the pure ester form of tretinoin that
works similar to Retin-A® (TM Ortho Dermatological), but without the irritation of tretinoin. It also
does not require a prescription to use. This esterified delivery form significantly reduces the
irritation potential, without diminishing the cosmetic treatment potential. Granactive
Retinoid Fluid in cosmetics decreases the effects of sunlight-induced aging and is a useful
ingredient in acne related preparations. The improved mildness allows Granactive Retinoid
Fluid to be co-formulated with many interesting actives for skin health and acne therapy.

Surface Roughness and Overall Skin Condition Improvements

INCI Name:
Dimethyl Isosorbide (and)
Significant skin surface roughness
Hydroxypinacolone Retinoate
improvements occurred within one
or two weeks of using this product.
Recommended Use About 50% improvement was
Level: noted.
1% or lower
During the ending survey, 100% of
Safety: participates responded that skin
Non-cytotoxic, Non- roughness, dryness, tone,
radiance, softness, firmness,
mutagenic, Non-irritating,
tightness, elasticity and overall skin
Non-sensitizing condition were significantly
improved
Availability:
Globally
Overall Skin Condition Improvements
Applications:
Anti-Aging and Anti-acne*
therapy products in serum, Significant Improvements were
gel, cream and lotion forms. noted in skin surface scaling,
otherwise a potential indicator of
irritation and dryness.
*must be co-formulated with an
approved anti-acne active as subject The method of formulating
to regional codes and laws. Granactive Retinoid Fluid yields an
effective and winning formula
without dryness or irritation.

80% of the panelist responded

that this formula significantly
reduced fine lines and wrinkles,
diminished the appearance of age
spots, skin discolorations and
freckles and improved sun
damaged skin.
Granactive Powder-101 Healthy Skin Powders

Healthy Skin Matrix Powder

Granactive Powder-101 is a powdered anti-aging complex that combines 1%

of a pure ester form of tretinoin (that works similar to Retin-A® (TM Ortho Dermatological)

without the irritation), with plant derived fulvic acid (peat extract) to maximize
the restorative powers of the skin’s extra-cellular matrix. It includes 24 carat
colloidal gold to facilitate the electrolytic transfer between trace minerals and the
skin’s natural metallic-based electrolytes. Granactive Powder-101 will
decrease the effects of sunlight-induced aging and is a catalytic anti-aging
complex especially designed to stimulate cellular turnover and improve skin
appearance in loose and pressed powder applications.
Features and Benefits:
• Catalytic anti-aging complex
• Great sensorial aesthetics Anti Aging & Skin Lightening Pressed Powder (G101-611-1)
• Improved skin health
Part Ingredient Wt.%
INCI Name: A Mica & Hydrogenated Lecithin 52.10
Mica (and) Silica (and) Water (and) Dimethyl
Sericite & Hydrogeneted Lecithin 10.00
Isosorbide (and) Barium Sulfate (and)
Hydroxypinacolone Retinoate (and) Peat Zinc Myristate 7.00
Extract (and) Gold Kaolin & Dimethicone 5.00
Silica & Dimethicone 6.00
Recommended Use Levels: Granactive Powder-101 10.00
5 -10% (Mica (and) Silica (and) Water (and) Dimethyl Isosorbide (and)
Barium Sulfate (and) Hydroxypinacolone Retinoate (and) Peat
Extract (and) Gold
Safety:
Red Iron Oxide & Triethoxycaprylylsilane 0.30
Non-irritating, Non-sensitizing
Non-mutagenic Yellow Iron Oxide & Triethoxycaprylylsilane 1.00
Black Iron Oxide & Triethoxycaprylylsilane 0.10
Availability: B Octyldodecyl Lactate 4.50
Globally Isopropyl Isostearate 3.00
Preservative (Jeecide Cap-5) 1.00
Applications: 100.00
• Pressed Powders
• Daily Wear Procedure:
• Anti-Aging
• Loose Powders 1) Mix part A until consistent color and texture
2) Add part B to part A and continue mixing until smooth texture.
 Patents

Peptide Compositions with Palmitoyl Hexapeptide-14

US20070166267
Anti-wrinkle composition

Peptide Compositions with Oligopeptide-10

US20070207112
Anti-acne composition

US6,875,744
Short Bioactive Peptides

Granactive Powders

Patent Applied for

Anti-wrinkle composition

Hydroxypinacolone Retinoate

US 4,885,311

Dimethylacrylamide/Acrylic Acid/ Polystyrene Ethyl Methacrylate

Copolymer

US 5,942,243
Mucoadhesive Composition…

US20040143026
Bioadhesive Composition…
Additional Active Series Information:

CONTAINS NO ALLERGENS: Per the Cosmetics Directive (76/768/EEC) or

annex II, III

BSE/TSE STATEMENT: No animal product or by-product was used in making

these materials.

HEAVY METALS AND PESTICIDES: All Products Certified to Meet < 5ppm
heavy metals and be pesticide free.

GMO STATEMENT: No Genetically Modified Organism or plant used in any

feedstock.

LATEX STATEMENT: No Latex derived material used in any feedstock.

HYDROXYPINACOLONE RETINOATE (and most Vitamin-A Derivatives):

In accordance to the Prop 65 labeling guidelines, formulating this substance at

0.1% by weight on an active basis into a cosmetic preparation WILL NOT subject
the cosmetic to prop.65 labeling requirements or CMR labelling since the daily
dosage would be considerably under the 10,000 IU daily dose limit as applied to
retinol/retinyl esters.

This upper recommended use levels for Granactive Retinoid Fluid, Granactive RD-
101 and Granactive Powder-101 are designed to provide 0.1% (or less) retinoate
ester in the cosmetic. This would equate to 2400 IU / g retinol equivalent or less.
Any warnings on the MSDS apply to the concentrated Grant Industries raw
material prior to dilution into a cosmetic and apply to worker safety. Please
contact the Grant Industries Regulatory dept for additional questions about
standard industry practices for safely formulating retinoids.

ANIMALS WERE NOT USED IN ANY WAY IN THE DEVELOPMENT OR

TESTING OF THESE PRODUCTS

SAMPLES, SPECIFICATION SHEETS, MSDS’S and OTHER REGULATORY INFORMATION AVAILABLE

UPON REQUEST
Other Recent Product Innovations:

Gransil SiW Series

Gransil SiW-026 is surprisingly easy to add to aqueous phases, it provides significant energy savings in
production, especially when incorporating it into a cold mix formula. This value added delivery form
produces a modern silicone feel, without relying on heavy emulsifiers that could otherwise mask sensory
properties or increase irritation or decrease active performance.

Gransil SiW-043 enables the formulator to rapidly develop world-class creams and lotions with the
“Gransil Touch”. We also add just the right amount of octyldodecyl lactate to this product to serve a
performance booster for sunscreens and actives for daily wear cosmetics. This perfect combination of
elastomer gel and emollients balances initial feel, texture, play and active performance.

Gransil SiW-050-IS includes the moisture retaining InvisaSkin® polymer to provide the ultimate
performance in skin feel and enduring hydration. It imparts a highly unique cushioning sensory benefit
beyond that of the traditionally used silicone based products. This premium polysilicone
elastomer/isododecane matrix maximizes the effective balance between initial and continuous sensory
performance during payout and long-term wear.

Gransil SiW-HA-IS delivers vegetable derived sodium hyaluronate, an enduring moisturize retaining
substance that is widely distributed in the extra-cellular medium of connective tissue. It contains the
InvisaSkin® polymer which imparts a consistent increase in re-hydration and a highly unique,
cushioning feel. The product shows exceptional sensorial aesthetics due to our Polysilicone-11 silicone-
elastomer infused into a micro-dispersion that allows for quick and easy addition to the aqueous part of
emulsions.

Gransil SiW-TiO2 and Gransil SiW-ZnO are derived from our UV-Cut series of concentrated
sunscreen micro-dispersions which yield high SPF values and maximize transparency on skin. This value
added micro-dispersion delivery form produces a high SPF value, yields a uniform transparent film,
provides great sensorial aesthetics and dramatically decreases the time it takes to develop an elegant,
consumer acceptable product.

Gransil SiW-CRT is a concentrated micro-dispersion of almost 90% oil phase contained in a thickened aqueous
external phase. The oil phase contains a significant amount of the copolymer of isobutylmethacrylate and
dimethiconol in volatile isoparaffin. This product can be diluted in aqueous formulas including leave-on glazes,
serums and conditioners. As the solvent vaporizes, the solution polymer dries quickly on hair to form a clear, glossy
film that is flexible and breathable. The film exhibits outstanding adhesion and color retention properties to maintain
the highest degree of vibrant color.

Gransil SiW-PCA-10 is designed for easy addition into leave-on lotions, shampoos, rinse off
conditioners and body cleansers. The pyrrolidone carboxylic acid group (an isomer of the natural
moisturizing factor "PCA") is covalently bonded to a silicone polymer to improve compatibility between
silicones and keratinatous protein. The PCA group tenaciously holds moisture and forms ionic bonds with
any free amino group on hair or skin. The final effect is a product that is easier to formulate at lower
temperatures while providing a higher degree of slip, volume and conditioned hair.

Grant Industries, Inc.

103 MAIN AVENUE
ELMWOOD PARK, NJ 07407
Tel. (201) 791-8700
FAX: (201) 791-3887
www.grantinc.com Bulletin: GAS 6-08-1 copyright 2008

Disclaimer: Although the information is presented in good faith and believed to be correct, Grant Industries makes no representations or warranties as to the completeness or
accuracy of Information. Information is supplied upon the condition that the persons receiving same will make their own determination as to its suitability for their purposes prior
to use. In no event will Grant Industries be responsible or liable for any loss of profits, lost goodwill, direct, special, indirect, incidental, or consequential damages of any nature
whatsoever, including without limitation lost revenues, resulting from the use of or reliance upon Information or the product to which Information refers. No representations or
warranties, either express or implied, of merchantability, fitness for a particular purpose or of any other nature are made hereunder with respect to information or the product to
which information refers