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Cyclomix DPI Leaflet 2020

The Cyclomix is a high shear blender suitable for blending dry powder inhaler formulations. It uses impact and shear mixing via an agitator inside a conical vessel to homogeneously blend active ingredients into lactose carriers. The Cyclomix applies precise mechanical energy to break up particles without over-mixing. It is available in various sizes from R&D to production scale and is suitable for blending as well as coating processes.

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Lakhlef Selma
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Download as PDF, TXT or read online on Scribd
31 views

Cyclomix DPI Leaflet 2020

The Cyclomix is a high shear blender suitable for blending dry powder inhaler formulations. It uses impact and shear mixing via an agitator inside a conical vessel to homogeneously blend active ingredients into lactose carriers. The Cyclomix applies precise mechanical energy to break up particles without over-mixing. It is available in various sizes from R&D to production scale and is suitable for blending as well as coating processes.

Uploaded by

Lakhlef Selma
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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CYCLOMIX

high shear blender for DPI formulations.


CYCLOMIX FOR BLENDING DPI FORMULATIONS
Blending formulations for dry powder blender, the product is rotated by an By adjusting the mixing speed and time
inhalers is a delicate matter. In order to agitator with paddles and a knife blade. the Cyclomix will show its versatility by
disperse the active ingredients in the The rotational movement will apply performing other processes like coating,
lactose carriers one needs to break up the centrifugal forces onto the powder bonding, rounding or densification.
cohesive forces between the fine particles particles. This force moves the particles
which requires a certain mechanical upwards along the wall of the conical The blending process of the Cyclomix is
energy. vessel. scalable based on constant tip speed. The
mixing time is scaled based on constant
However, if the energy applied to the At the top of the cone, the specially energy per kilogram of product.
formulation is too high, the adhesive shaped dome guides the particles
forces between the carrier and the actives downwards again through the centre of Key benefits
will also be too high, limiting the the vessel. This flow pattern is combined  The central bottom outlet and the
separation during inhalation. Finding the with a rotational pattern. conical shape of the vessel result in a
right balance for the required mixing complete discharge, assisted by a slow
energy is a critical issue and calls for a very Most of the mechanical energy is applied rotation of the agitator if necessary;
efficient mixer. by the paddles at the wall of the vessel  Top driven agitator without seals and
using the total cone surface. This large bearings in the product zone. Various
Delivering a fully homogeneous blend, surface area in relation to the product seal configurations are possible;
without deterioration of the particles is a volume makes the Cyclomix a very  Various options for contained
prerequisite. The Cyclomix has proven to efficient mixer compared with other high charging and discharging possible;
be perfectly suitable for this application. shear blenders resulting in a  Fully compliant with applicable
Besides powder blending processes, the homogeneous blend with minimum input guidelines and regulations.
Cyclomix proved to be suitable for coating of mechanical energy.
processes as well, for example coating The Cyclomix is available in many sizes,
lactose with magnesium stearate. By jacketing the vessel and the cover the from R&D to production scale, based on
product can be cooled at the location one of three platforms to choose from.
The Cyclomix uses a combination of where the shear energy is introduced,
impact mixing and shear mixing. Inside the resulting in good temperature control.

We have Cyclomix systems


in various sizes available for
testing or renting.
Contact us for details!

Contact us
For further questions, please contact Bert
Dekens: phone +31 314 373 376
e-mail [email protected]

02 | HOSOKAWA MICRON
R&D SCALE

Features
 Drive unit with ancillaries Mini
 Exchangeable product bowls of 100 ml, 1 or 2 litres Cyclomix
 Easy connection of bowls, without tools
100 ml, 1 or
 Separate charging and discharging in dispensary 2 litres
 1 and 2 litre bowls are suitable for water cooling
 Straightforward control system with data output

MID-RANGE

Features
 One drive unit with ancillaries
 Exchangeable product bowls of 5 or 15 litres
 Lift for easy changing of bowls
Cyclomix
 cGMP design
5 or 15 litres
 21 CFR part 11 compliant

Options
 Contained charging and discharging
 CIP skid
 Cooling by tap water or water chiller
 Stand alone or ‘through the wall’ design

LARGE SCALE

Features
> Integrated system
> Jacketed vessel/cover with cooling sytem
Cyclomix
> 21 CFR part 11 compliant
50, 75 or
100 litres
Options

> Contained charging and discharging


> CIP skid
> Lift system for drum manipulation

HOSOKAWA MICRON | 03
PLENTY OF REASONS TO GIVE US A CALL

Combined advantage Vast experience R&D/test facilities Worldwide service

The Hosokawa Group has Hosokawa has decades of Hosokawa has extensive Hosokawa has a very
several technology centres, experience in providing research and test facilities responsive and smoothly
each expert in one or more solutions for processing in Doetinchem, the operating service depart-
specific powder processing pharmaceutical powders. Netherlands, perfectly ment. Our Service Team
technologies. Combining We have references all outfitted to assist clients carries out repair and
this knowledge gives you over the world, including determining what the best maintenance services
the benefit of having just the biggest names in the system solution is for their onsite or in one of our
one supplier and contact. industry. specific process. fully-equipped workshops.

Hosokawa Micron B.V.


Team Pharma
Gildenstraat 26
7005 BL Doetinchem
Netherlands

tel. +31 314 373 461


[email protected]
www.hosokawamicron.nl

HMBV.CLX.ENG.20.09

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