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Drug Biotransformation Quiz

This document contains a 10 question pharmacology quiz about drug biotransformation. The questions cover topics like the consequences of phase 1 biotransformation, accelerating urinary excretion of drugs like aspirin, induction of drug metabolizing enzymes leading to increased drug metabolism, biotransformation reactions that convert drugs to toxic vs. active metabolites, and factors that increase drug half-life like chronic alcoholism or renal disease.

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Maxine Lepatan
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253 views3 pages

Drug Biotransformation Quiz

This document contains a 10 question pharmacology quiz about drug biotransformation. The questions cover topics like the consequences of phase 1 biotransformation, accelerating urinary excretion of drugs like aspirin, induction of drug metabolizing enzymes leading to increased drug metabolism, biotransformation reactions that convert drugs to toxic vs. active metabolites, and factors that increase drug half-life like chronic alcoholism or renal disease.

Uploaded by

Maxine Lepatan
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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PHARMACOLOGY LAB QUIZ 27 August, 2020

“DRUG BIOTRANSFORMATION”

1. ONE OF THESE IS NOT A CONSEQUENCE OF PHASE 1


BIOTRANSFORMATION. *
a. FORMATION OF INACTIVE METABOLITES
a. PRODUCTION OF GLUCORONIDES
b. PRODUCTION OF ACTIVE METABOLITES
c. FORMATION OF TOXIC METABOLITES

2. A PATIENT WAS RUSHED TO THE EMERGENCY ROOM HAVING JUST


INGESTED A LARGE DOSE OF ASPIRIN (A SALICYLATE). WHICH OF THE
FOLLOWING IS TRUE ? *
a. URINARY EXCRETION CAN BE ACCELERATED BY ADMINISTRATION OF
AMMONIUM CHLORIDE
b. THIS DRUG IS MAINLY EXCRETED BY GLOMERULAR EXCRETION
a. URINARY EXCRETION COULD BE ACCELERATED BY ADMINISTRATION OF
SODIUM BICARBONATE
c. URINARY EXCRETION IS ACCELERATED BY GIVING NACL

3. A PATIENT WAS SEEN IN THE E.R DUE TO ADRUG OVERDOSE ,IN ORDER TO
INCREASE URINARY EXCRETION, THE PATIENT WAS GIVEN AMMONIUM
CHLORIDE. WHICH OF THE FOLLOWING IS THE SUSPECTED AGENT THAT
THE PATIENT OVERDOSE . *
a. ASPIRIN
b. HEROIN
c. PHENOBARBITAL
a. METHAMPHETAMINE
4. INDUCTION OF THE DMMS WILL LEAD TO ALLOF THE FOLLOWING EXCEPT
: *
a. THERE IS DIMINISHING EFFECT OF THE DRUG
d. THERE IS A DIMINISHING EFFECT OF DRUGS WHO HAVE THE SAME
BIOTRANSFORMATION PATHWAY OF THE INDUCER
e. THERE IS INCREASE METABOLISM OF OTHER DRUGS TAKEN
SIMULTANEOUSLY WITH THE INDUCER
b. THERE IS INCREASE IN THE HALF LIFE OF THE DRUG TAKEN
SIMULTANEOUSLY WITH THE INDUCER

5. THIS OXIDATION REACTION CONVERTS A DRUG INTO A TOXIC


METABOLITE . *
a. DEHALOGENATION
c. EPOXIDATION
f. AMIDE HYDROLYSIS
g. REDOX RECYCLING

6. THE BIOTRANSFORMATION REACTION CONVERTS AN ACTIVE DRUG TO AN


ACTIVE METABOLITE *
a. ESTER HYDROLYSIS OF ASPIRIN
h. GLUCURONIDATION OF DIAZEPAM
d. N-DEALKYLATION OF DIAZEPAM
i. PEPTIDE HYDROLYSIS OF PROINSULIN

7. WHICH OF THIS BIOTRANSFORMATION REACTION CONVERTS AN ACTIVE


DRUG INTO A TOXIC METABOLITE ? *
a. REDOX RECYCLING OF BLEOMYCIN
j. PEPTIDE HYDROLYSIS OF PROINSULIN
e. N-DEALKYLATION OF DIAZEPAM
k. ESTER HYDROLYSIS OF ACETYLCHOLINE
8. CLINICAL SITUATIONS RESULTING IN INCREASE HALF LIFE INCLUDES ALL
EXCEPT : *
a. WHEN A SECOND DRUG DISPLACES THE FIRST DRUG FROM ITS ALBUMIN
BINDING.
f. HEMORRHAGE
l. CHRONIC ALCOHOLISM
m. RENAL DISEASE

9. ONE OF THESE WILL NOT PROMOTE TUBULAR REABSORPTION *


a. MORE LIPID SOLUBLE DRUGS
g. ALKALINE DRUG IN AN ACIDIC TUBULAR FILTRATE
n. ONE OF THESE WILL NOT PROMOTE TUBULAR REABSORPTION
o. ACIDIC DRUGS IN AN ACIDIC TUBULAR FILTRATE

10. INHIBITORS SUCH AS OMEPRAZOLE WHEN TAKEN WITH WARFARIN WILL


RESULT IN : *
a. INCREASE METABOLISM OF WARFARIN
p. DECREASE IN THE HALF LIFE OF WARFARIN
q. DECREASE IN THE PLASMA CONCENTRATION OF WARFARIN
h. INCREASE THE RISK OF THE SIDE EFFECTS OF WARFARIN

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