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Comparative Study of Commercial Antacids: Objective

The document describes a comparative study of commercial antacids. It involves standardizing hydrochloric acid and sodium hydroxide solutions, then using these solutions to titrate powdered samples of different antacid tablets against each other. This determines the amount of hydrochloric acid each antacid sample can neutralize. The results show that OCID 20 is the most effective antacid as it neutralizes the highest volume of hydrochloric acid.

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116 views

Comparative Study of Commercial Antacids: Objective

The document describes a comparative study of commercial antacids. It involves standardizing hydrochloric acid and sodium hydroxide solutions, then using these solutions to titrate powdered samples of different antacid tablets against each other. This determines the amount of hydrochloric acid each antacid sample can neutralize. The results show that OCID 20 is the most effective antacid as it neutralizes the highest volume of hydrochloric acid.

Uploaded by

shikzzz
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Comparative Study of Commercial Antacids

OBJECTIVE :
To analyze the given samples of commercial antacids by
determining the amount of hydrochloric acid they can
neutralize.

REQUIREMENTS :
Burettes, pipettes, titration flasks, measuring flasks, beakers,
weight box, fractional weights, sodium hydroxide, sodium
carbonate, hydrochloric acid, phenolphthalein.

PROCEDURE :
1. Prepare 1 litre of approximately  HCl solution by diluting
10 ml of the concentrated acid for one litre.
2. Similarly, make 1 litre of approximately NaOH solution by
dissolving4.0g of NaOH to prepare one litre of solution.
3. Prepare  Na2CO3 solution by weighing exactly 1.325 g of
anhydrous sodium carbonate and then dissolving it in water to
prepare exactly 0.25 litres (250 ml) of solution.
4. Standardize the HCl solution by titrating it against the
standard Na2CO3 solution using methyl orange as indicator.
5. Similarly, standardize NaOH solution by titrating it against
standardized HCl solution using phenolphthalein as indicator.
6. Powder the various samples of antacid tablets and weigh
1.0 g of each.
7. Add a specific volume of standardised HCl to each of the
weighed sample is taken in conical flasks. The acid should be
in slight excess, so that it can neutralize all the alkaline
component of the tablet.
8. Add 2 drops of phenolphthalein and warm the flask till
most of powder dissolves. Filter off the insoluble material.
9. Titrate this solution against the standardised NaOH
solution, till a permanent pinkish tinge is obtained. Repeat this
experiment with different antacids.

OBSERVATIONS AND CALCULATIONS :


Standardisation of HCl solution :
Volume of Na2CO3 solution taken = 20.0 ml
S No. of Burette readings Volume of acid
obs. used
Initial Final
1. 0 ml          15.0 ml 15.0 ml

2. 0 ml          15.1 ml 15.1 ml

3. 0 ml          15.0 ml 15.0 ml

4. 0 ml          15.0 ml 15.0 ml

5. 0 ml          15.0ml 15.0 ml

Concordant volume = 15.0 ml


Applying normality equation,
N1V1 = N2V2
N1 x 15.0 =  N2 x 20
Normality of HCl, N1 = = 0.133 N
Standardisation of NaOH solution :
Volume of the given NaOH solution taken = 20.0 ml
S No. of Burette readings Volume of acid
obs. Initial Final used

1. 0 ml          26.5 ml 26.5 ml

2. 0 ml          26.8 ml 26.8 ml

3. 0 ml          26.6 ml 26.6 ml

4. 0 ml          26.6 ml 26.6 ml

5. 0 ml          26.6ml 26.6 ml

Concordant volume = 26.6 ml


Applying normality equation,
N1V1 = N2V2
0.133 x 26.6 = N2 x 20
Normality of NaOH, 2 = = 0.176 N

Analysis of antacid tablet :


Weight of antacid tablet powder = 1.0 g
Volume of HCl solution added = 20.0 ml
Antacid Vol. Of NaOH Vol. Of HCl soln.
soln. Used to Used to neutralise 1.0
neutralise unused g of antacid matter
HCl
1. Gelusil 12.1 ml 12.0 ml
2. Digene 16.0 ml 16.2 ml

3. Aludrox 19.3 ml 18.9 ml

4. Logas 24.3 ml 24.4 ml

5. Ranitidine 21.4 ml 21.7 ml

6. Ocid 20 22.7 ml 21.9 ml

CONCLUSION :
The antacid which has maximum volume of HCl is used for
neutralizing i.e. OCID 20 is more effective.

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