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Herpes Viruses: Clinical Features

The herpes family of viruses includes HSV-1, HSV-2, VZV, EBV, CMV, and other human herpes viruses. HSV-1 and HSV-2 cause oral and genital herpes and can result in an initial primary infection followed by recurrent outbreaks from viral reactivation. Symptoms of primary herpes infection may include painful sores in the mouth or on the genitals. Recurrent outbreaks commonly cause cold sores or lesions. Diagnosis involves biopsy, culture, or antibody testing and treatment utilizes antiviral medications.

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67 views4 pages

Herpes Viruses: Clinical Features

The herpes family of viruses includes HSV-1, HSV-2, VZV, EBV, CMV, and other human herpes viruses. HSV-1 and HSV-2 cause oral and genital herpes and can result in an initial primary infection followed by recurrent outbreaks from viral reactivation. Symptoms of primary herpes infection may include painful sores in the mouth or on the genitals. Recurrent outbreaks commonly cause cold sores or lesions. Diagnosis involves biopsy, culture, or antibody testing and treatment utilizes antiviral medications.

Uploaded by

Moka Mohsen
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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HERPES VIRUSES

The herpes family of viruses consists of the following:


1. Herpes simplex virus 1 (HSV-1)
2. Herpes simplex virus 2 (HSV-2)
3. Varicella-zoster virus (VZV)
4. Epstein-Barr virus (EBV)
5. Cytomegalovirus (CMV)
6. Other human herpes virus (HHV-6, HHV-7,
HHV-8)

 Herpes Simplex Virus:


There are two types:
1. Herpes simplex virus 1 (HSV-1)
2. Herpes simplex virus 2 (HSV-2)

Clinical features:
*Patients infected with HSV-1 or HSV-2 experience:
1. An initial primary infection.
2. Experience repeated recurrences\secondary of
the infection occurs with reactivation of the virus.

CLINICAL FEATURES:
1) Acute herpetic gingival-stomatitis (primary
herpes)
 is the most common pattern of symptomatic primary
HSV infection
 The manifestations vary from mild to severely
debilitating.

2 3

Figure 2 Acute herpetic gingivostomatitis , Widespread yellowish mucosal ulcerations.

Figure 1 Acute herpetic gingivostomatitis, Numerous coalescing, irregular, and yellowish ulcerations of the
dorsal surface of the tongue.

4 5

Figure 4 Acute herpetic gingivostomatitis. Painful, enlarged, and erythematous palatal gingiva.

Figure 5 Acute herpetic gingivostomatitis. Painful, enlarged, and erythematous facial gingiva. Note erosions of
the free gingival margin.

2) Secondary\Recurrent Oral Herpes Simplex:


The two main clinical types of recurrent oral herpes
simplex infections
(1) Recurrent herpes labialis.
-A cluster of vesicles and shallow ulcers, Affects the
Lips, Most common form of recurrent HSV infections.

A B
Figure 2 Recurrent herpes labialis. A) Early stages consisting of fluid-filled viral vesicles. B) Late

Stage demonstrating brownish crusted lesions.

(2) Recurrent intraoral herpes.


-intraoral cluster of symptomatic shallow punctate
ulcers, involves the palate or maxillary gingiva.
-Relatively uncommon.

A B
Figure 3 Recurrent intraoral herpes. A) Common intraoral site on posterior palate over greater

Palatine foramina. B) Occasionally encountered gingival lesions.


3) Neonatal Herpes Simplex Virus:
-Neonatal HSV infection is infrequent.
-Much more frequent in infants born to mothers
experiencing a primary HSV infection.
4) HERPETIC WHITLOW:
- A primary or secondary herpes simplex infection
-Lesions are usually vesicular or pustular, surrounded
by a wide zone of erythema, Localized to the hands or
fingers, Acquired by direct contact with an active
lesion.

Figure 4 herpetic whitlow. ( Painful, inflamed herpetic lesion on finger).

Diagnosis: 1) Biopsy. 2) Cytology Smear.

3) Culture. 4) Fluorescent antibody.


Treatment: -Anti viral medications.

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