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BD TD Formula Tion Code Carr, S Index Hausner 'S Ratio Angle of Repose Pure Drug Physical Mixture

The document presents results from experiments testing different formulations of a drug. It includes data on the bulk density, tapped density, Carr's index, Hausner ratio, and angle of repose for various formulations. Additional data shows the aqueous solubility, average particle size, and drug content of different Quasi Aqueous Ternary Systems (QATS) formulations compared to the pure drug and physical mixture. Dissolution profiles over 8 hours are also displayed for the formulations.

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0% found this document useful (0 votes)
109 views7 pages

BD TD Formula Tion Code Carr, S Index Hausner 'S Ratio Angle of Repose Pure Drug Physical Mixture

The document presents results from experiments testing different formulations of a drug. It includes data on the bulk density, tapped density, Carr's index, Hausner ratio, and angle of repose for various formulations. Additional data shows the aqueous solubility, average particle size, and drug content of different Quasi Aqueous Ternary Systems (QATS) formulations compared to the pure drug and physical mixture. Dissolution profiles over 8 hours are also displayed for the formulations.

Uploaded by

SAI ASSOCIATE
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as XLSX, PDF, TXT or read online on Scribd
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30

BD TD
Formula BD TD Carr,s Hausner Angle of
tion Index ’s Ratio Repose
25
Code
Pure 0.8 1.39 9.21 2.1 23.21
20
Drug
Physical 1.26 1.85 10.03 1.8 24.43

Values
15
Mixture
QATS-1 1.35 2.06 10.2 1.9 25.82
10
QATS-2 1.41 2.17 10.15 1.8 24.36
QATS-3 1.48 2.21 10.12 1.6 22.32
QATS-4 1.53 2.28 10.1 1.5 5
21.45
QATS-5 1.59 2.34 10.06 1.4 20.2
0
Pure Drug Physical Mixtur
BD TD Carr,s Index Hausner’s Ratio Angle of Repose

Pure Drug Physical Mixture QATS-1 QATS-2 QATS-3 QATS-4 QATS-5

Formulation Code
Aqueous Average
Solubilit Particle
6
y Size % Drug
F. Code (µg/ml) (µm) Content Aqueous Solubility (µg/ml)
Ritonavir 5

Aqueous Solubility (µg/ml)


Physical
250 3
Mixture 0.06 96 .62
Average Particle Size (µm)
QATS-1 2.3 167.34 85.28
200
Average Particle Size (µm)

2
QATS-2 3.8 182.58 89.36
150 QATS-3 5.2 205.23 92.54
1
QATS-4 5.3 206.15 94.61
100
0

50
100 Formulation Code
0
QATS-1 QATS-2 QATS-3 QATS-4
95
Formulation Code
% Drug Content

90

85

80

75
Physical Mixture QATS-1 Q
Formulati
ueous Solubility (µg/ml)

Average
Particle
Size Physical
F. Code (µm) Mixture 98.62
QATS-1 85.28
QATS-2 89.36
QATS-1 167.34 QATS-3 92.54
QATS-2 182.58 QATS-4 94.61
QATS-3 205.23
QATS-4 206.15

Formulation Code

ture QATS-1 QATS-2 QATS-3 QATS-4


Formulation Code
Time Pure Drug Physical MiQATS-1 QATS-2 QATS-3 QATS-4
0 0 0 0 0 0 0
15 0 0 0.8 0.9 1.1 1.3
30 0 0 1.9 2.3 2.5 2.7
60 0 0.5 4.6 4.9 5.1 5.3
120 0 7.5 7.8 8 8.2
240 0 11.1 11.3 11.4 11.7
360 0 13.7 13.9 14.2 14.3
480 0 15.6 15.9 16.1 16.3
18

16

14

12

Pure Drug Physical Mixture QATS-1


10
QATS-2 QATS-3 QATS-4

0
0 100 200 300 400 500 600
ysical Mixture QATS-1
TS-3 QATS-4

500 600

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