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Classification of Drugs Are: Hepatoprotective Drugs E.g.: Silymarin Antibiotics E.G.

The document discusses the pharmacotherapy of alcoholic liver disease (ALD) with ascites. It begins with introducing ALD and its stages, from fatty liver to cirrhosis. Ascites, an accumulation of fluid in the abdomen, is described as a common complication of liver cirrhosis caused by portal hypertension. Several drug classes used to treat ALD with ascites are listed, including hepatoprotectives, antibiotics, vitamins, diuretics, and drugs for alcohol withdrawal, hepatic encephalopathy, and variceal bleeding. The document then describes a case study of a 47-year old male patient admitted with ALD and ascites who was treated and his pharmacotherapy analyzed to ensure rational drug use.

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Navya Sara Santhosh
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50 views2 pages

Classification of Drugs Are: Hepatoprotective Drugs E.g.: Silymarin Antibiotics E.G.

The document discusses the pharmacotherapy of alcoholic liver disease (ALD) with ascites. It begins with introducing ALD and its stages, from fatty liver to cirrhosis. Ascites, an accumulation of fluid in the abdomen, is described as a common complication of liver cirrhosis caused by portal hypertension. Several drug classes used to treat ALD with ascites are listed, including hepatoprotectives, antibiotics, vitamins, diuretics, and drugs for alcohol withdrawal, hepatic encephalopathy, and variceal bleeding. The document then describes a case study of a 47-year old male patient admitted with ALD and ascites who was treated and his pharmacotherapy analyzed to ensure rational drug use.

Uploaded by

Navya Sara Santhosh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Aim and Objectives: To study the Pharmacotherapy of Alcoholic liver disease with ascites.

Introduction: Alcoholic liver disease (ALD) is damage to the liver and its function due to
alcohol abuse. There are three stages:1) Alcoholic fatty liver disease: the first stage of ALD,
where fat starts to accumulate around the liver. It can be cured by not drinking alcohol
anymore. 2) Acute alcoholic hepatitis: Alcohol abuse causes inflammation (swelling) of the
liver in this stage. The outcome depends on the severity of damage. In some cases, treatment
can reverse the damage, while more severe cases of alcoholic hepatitis can lead to liver
failure. 3) Alcoholic cirrhosis: This is the most severe form of ARLD. At this point, the liver
is scarred from alcohol abuse, and the damage cannot be undone. Cirrhosis can lead to liver
failure.
Ascites is an abnormal accumulation of fluid within the (peritoneal) cavity. Ascites is one of
the most common liver diseases that is caused by cirrhosis of the liver. Signs and symptoms
of ascites include abdominal pain and bloating, shortness of breath, and liver failure.
Although the exact mechanism of ascites development is not completely understood, most
theories suggest portal hypertension (increased pressure in the liver blood flow to the liver) as
the main contributor.
Classification of drugs are: Hepatoprotective drugs e.g.: silymarin; Antibiotics e.g.:
ciprofloxacin; Vitamins and minerals- e.g.: B complex; Diuretics-e.g.: furosemide; Drugs for
alcohol withdrawal-e.g.: baclofen; Drugs for hepatic encephalopathy-e.g.: rifaximin; Drugs
for variceal bleeding-e.g.: octreotide; Corticosteroids-e.g.: prednisolone; Miscellaneous
drugs- e.g.: propranolol, etc.

Procedure: A 47 years old male patient bearing the IP.NO 0201900012750 was admitted to
the Male Medical Ward on 24/03/2021 with the chief complaints of generalized weakness,
cough, distended abdomen, yellow colored eye and swelling on the left limb. It was a known
case of Alcoholic liver disease with ascites with a personal history of reduced appetite,
disturbed sleep and habits of smoking and alcohol consumption (20 years). On physical
examination, he had icterus and edema while abdominal examination showed fluid thrill and
hepatomegaly. All these information is documented in Specially designed patient profile form
from the case sheets present in the allotted wards of respective department.
 Collected data was reviewed and the medication related issues (right drug,
right diagnosis, right dose, right duration, right dosage form for right patients)
deviating from the rational drug therapy was identified with help of drug
database, Lexicomp.
 Patient was also interviewed to report ADR if any, to physicians after taking
prescribed medications.
 Modified medication therapy was planned to recommend the use of rational
drug therapy including report of adverse drug reactions and patient education
and counseling using standard drug databases and reference textbooks such
Pathophysiological basis of Pharmacotherapy by Dipiro, to physicians.
Response of physicians to intervention was documented.
Observation: Further, the assessed case details using patient profile forms was presented in
SOAP (Subjective, Objective, Assessment and Plan) format and presentation was done
through the power point slides.
Report/conclusion: Case on alcoholic liver disease with ascites was analysed for the rational
pharmacotherapy of disease.

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