C L A S S C e S T o I D e A: Envelope Are Called Coracidia
C L A S S C e S T o I D e A: Envelope Are Called Coracidia
- adults found in humans all have a flat and ribbonlike body Embryogenesis within the egg to result in a larva, the oncosphere
C
- living worms are white or yellowish
E
- body consists of an anterior attachment organ, or scolex, followed by a chain of segments or Hatching of the oncosphere after or before being eaten by the next host where it
S
proglottids, also known as strobila penetrates to a parenteral (extraintestinal) site
T
O - strobila grows throughout the life of the tapeworm by continuous proliferation of new segments
or proglottids in the region immediately posterior to the scolex Metamorphosis of the larva in the parenteral site into a juvenile (metacestode)
D
- new segments are referred to as immature because they do not yet contain fully developed usually with a scolex
E
S internal structures
- mature segments are larger and are found near the middle of the chain, and each may contain Development of an adult from the metacestode in the intestine (enteral site) of the
or
either one or two sets of both male and female reproductive organs same or another host
C - terminal portion of the strobila contains the ripe or gravid segments usually filled with eggs
l - eggs are enclosed in the uterus, a structure that varies in shape and size in different cestode
Oncospheres that have three pairs of hooks are also referred to as hexacanth
a species
s - terminal proglottids of some species may become detached in the intestine and pass out with the Free –swimming oncospheres hatching from an egg that have a ciliated inner
s stool; some types may be too small to be seen in gross examination envelope are called coracidia
- adults inhabit the small intestine, where they live attached to the mucosa Larvae with ten hooks (decacanths), are also ciliated and are called lycophoras
C - attachment is accomplished by means of the scolex (vary from species to species) Embryophore – name applied both to the full ciliated inner envelope of a coracidium,
e - all cestodes of humans have four muscular, cup-shaped suckers on the scolex and to a specialised intracellular proteinaceous lamina produced within the inner
s - in addition to suckers, scolex may have an elongate and protrusible structures , the rostellum, envelope of a cestode with a non-swimming oncosphere. (Note: some authorities
t situated in the center of the scolex prefer to distinguish the motile inner envelope of a coracidium by referring to it as a
o - in some species the rostellum bears hooks and is referred to as armed “ciliated embryophore”.)
i - while precise identification of the tapeworms of humans is usually made on the basis of the eggs Types of
d or proglottids, the scolex of each species is quite characteristic and is sufficient for identification Cestode
e - no digestive system; food is absorbed from the host’s intestine Metacestodes
a - human cestodes have complex life cycles that generally involve both a definitive and an
intermediate host
or - some utilize humans only as definitive hosts, growing to adulthood in the intestine after ingestion
of the infective larvae (eg., D. latum, Taenia saginata, Hymenolepis diminuta)
t - for some species, humans are equally acceptable as definitive or intermediate hosts (eg., Taenia
a solium, Hymenolepis nana)
p - others, such as Echinococcus, utilize humans as one of their possible intermediate hosts, but
e never as definitive host
w - extraintestinal infection with the larval forms is a much serious matter than infection with the
o adult worm
r - eggs vary considerably in appearance of the external shell as well as in the number and thickness
m of the embryonic membranes (membranes serve as protective coverings of the embryo, which is
s called an oncosphere and bears six elongate hooks)
Taeniasis
- Parasite: Taenia saginata (beef tapeworm) or Taenia solium (pork tapeworm) - Location of adults in humans : attached to small intestine
- Means of human infection : ingestion of larvae in beef or pork - Clinical features : vague digestive disturbances, anorexia; majority asymptomatic
- Location of larvae in humans : not present for T. saginata; subcutaneous tissues, muscle, eye, - Laboratory diagnosis : embryonated eggs or proglottids in stool
brain for T. solium
C. name dwarf tapeworm rat tapeworm double-pored dog tapeworm (not in pdf) fish tapeworm or broad tapeworm
- personal hygiene and environmental - personal hygiene and environmental - personal hygiene and environmental - thorough cooking of freshwater fish or
Preven
sanitation sanitation sanitation freezing for 24 to 48 hours at -18 ◦C;
tion
- rodent control - rodent control - periodic deworming of pet cats and dogs marinating will not
and
- proper storage of food - elimination of insect intermediate hosts - elimination of intermediate hosts (anti- - personal hygiene and environmental
Control
- thorough treatment of cases - protection of food flea treatment of pets) sanitation
Inf. Stg. Embryonated egg Cysticerci Cysticercoid Procercoid larvae
(see pic then read below)
FOR H. nana (see pic then read after) (no extra details in PDF for H. diminuta & D. caninum)
In addition, copepods may accidentally be
Intermediate Hosts
ingested by humans or other definitive
Arthropods, especially beetles, serve as intermediate hosts for Hymenolepis spp. The arthropod intermediate host is
hosts while drinking copepod-
required for H. diminuta, but not H. nana, and humans can become infected with the latter by direct ingestion of eggs. Within the
contaminated water. In those cases, the
Life arthropod host, the eggs develop into cysticercoids, which can infect the mammalian host upon ingestion and develop into adults in
plerocercoid may develop in the definitive
Cycle the small intestine.
or final host as a sparganum. The
Tribolium confusum, a common intermediate host for Hymenolepis spp. Tribolium and related genera breed in cereals,
condition in which plerocercoids or
grains, and grain-based snack foods and are easily ingested by humans and rodents. Since these food products are usually not
spargana develop in the definitive host is
heated prior to consumption, cysticercoids within the beetles remain viable and infective.
known as sparganosis. (referring to other
Diphyllobothrium spp.)
Echinococcosis
Causal Agent
Human echinococcosis (hydatidosis, or hydatid disease) is caused by the larval stages of cestodes (tapeworms) of the genus Echinococcus.
Echinococcus granulosus causes cystic echinococcosis, the form most frequently encountered E. vogeli causes polycystic echinococcosis
E. multilocularis causes alveolar echinococcosis E. oligarthrus is an extremely rare cause of human echinococcosis
S.name Echinococcus granulosus (9)
C.name hydatid tapeworm
General Characteristics Diagnosis
- larval form in human tissue causes pathology - X-ray, ultrasound, CT
- human accidentally ingests eggs by close contact with infected dog; usual intermediate host - aspirate of “hydatid sand”
is sheep - serologic tests
Adult
- inhabits small intestines of canines Treatment
- 3 to 6 mm in length - Surgical resection (treatment of choice)
- pyriform scolex, short neck, and three proglottids (immature, mature, gravid) - Albendazole for inoperable cysts
- scolex is taeniid in that it has four acetabula
- armed with 30 to 36 hooks
Gravid Proglottid
Prevention and Control
- widest and longest proglottid
- Reduction of infected population
- uterus is midline with lateral evaginations and is filled with eggs which resemble those of
- Minimize opportunities for transmission
other taeniid worms
S.name Echinococcus granulosus (9)
C.name hydatid tapeworm
Egg Clinical Manifestation
- may be released inside or outside the host - pathology caused by developing larval cyst (liver is the most important site)
- contains a hexacanth embryo - local immunosuppression (able to escape host cell-mediated response)
- when swallowed by intermediate host, embryo released by the action of digestive juices, - enlarging cyst results in organ impairment as the neighboring tissues undergo atrophy and
bore actively into the intestinal wall and enter blood vessel tissue necrosis
-As dogs and other canids are the definitive hosts for Echinococcus spp., eggs are not - rupture of cyst : protoscolices, brood capsules, and daughter cysts may metastasize and
expected to be found in human stool and are not considered diagnostic in human infections. reach other tissues to develop into secondary cysts after 2 to 8 years (multiple organ
Eggs are however indistinguishable from the eggs of Taenia spp. and other members of the involvement)
Taeniidae. The eggs measure 30-35 µm in diameter and are radiallystriated. The internal - serious anaphylaxis may result from large amount of hydatid material entering the
oncosphere contains 6 refractile hooks. bloodstream when primary cyst ruptures
Hydatid Cyst
Life Cycle
- larval stage in the intermediate host (goat, horse, camel, sheep, human)
- Intermediate Host : sheep, goat, swine, cattle, horses, camel
- formed through central vesiculation
- unilocular hydatid cyst
- contains numerous protoscolices
- usually measure 1 to 7 cm in diameter
- has an outer laminated hyaline layer and an inner nucleated germinal layer
- vesicular structure formed by E. granulosus larvae in the intermediate host
- contains fluid, brood capsules, and also daughter cysts in which the scolices of potential
tapeworms are formed
Cross section of a hydatid cyst. Host tissue can be seen in the upper left corner, then the wall
of the cyst, the germinal layer and finally a daughter cyst, containing protoscoleces, floating
free in the fluid-filled interior.
Hydatid Sand
- granular material consisting of free scolices, hooklets, daughter cysts, and amorphous
material
- found in the fluid of older cysts of E. granulosus
S.name Echinococcus multilocularis (10) Echinococcus vogeli (11) Echinococcus oligarthus (12)
Gen - same life cycle as with E. granulosus except the hosts - same life cycle as with E. granulosus except the hosts - same life cycle as with E. granulosus except the hosts
Charac - foxes are the natural definitive host, and to a lesser
extent dogs, cats, coyotes and wolves; the intermediate - definitive hosts are bush dogs and dogs; the - up to 2.9 mm long
host are small rodents
- 1.2 to 3.7 mm long Echinococcosis
- human infection through eating raw plants intermediate hosts are rodents; and the larval stage (in
contaminated with feces of infected canines or cats the liver, lungs and other organs) develops both
- most common site of alveolar hydatid cyst is the liver externally and internally, resulting in multiple vesicles - has a life cycle that involves wild felids as definitive
(hepatic lesions consisting of many alveoles that hosts and rodents as intermediate hosts
contained a gelatinous mass) - up to 5.6 mm long
- treatment : surgery or albendazole in inoperable cases
SEE PIC ABOVE FOR LIFE CYCLE BESIDE ECHINOCOCCOSIS
----------Sparganosis----------
Sparganosis is an infection by the plerocercoid larvae of various diphyllobothroid Sparganum infection occurs by three major routes:
tapeworms belonging to the genus Spirometra. It is similar in morphology and life cycle to the 1. drinking water contaminated with copepods infected with the procercoid larval stage of the
fish tapeworm, Diphyllobothrium latum. Sparganosis is reported sporadically around the world; parasite
a higher prevalence of the disease occurs in several Asian countries. 2. ingestion of undercooked meat, such as pork, that is infected with the plerocercoids
Sparganosis is infection by the third-stage plerocercoid larva (sparganum) of 3. placing poultices of frog or snake flesh on open wounds or other lesions, or the eyes
pseudophyllidean cestodes of the genera Spirometra. There are several species of Spirometra, Hosts & Vectors:
including S. mansoni, S. mansonoides, S. erinacei, S. ranarum, S. decipiens, S. houghtoni, S. Dogs and cats are the primary hosts of the adult worm. The first intermediate hosts are
proliferum. copepods, or freshwater crustaceans. The second intermediate hosts are amphibians, reptiles,
The larvae are often referred to by the generic name Sparganum, because this stage birds, and mammals.
was previously thought to represent a separate genus. Humans cannot serve as definitive hosts for Spirometra spp., but serve as paratenic or
Spargana can be found in many organs in the human host, including the pleural cavity, second intermediate hosts and develop sparganosis. Snakes and tadpoles/frogs are the vectors
eyes, pericardium, abdominal cavity and viscera, and the central nervous system. for sparganum.
The clinical manifestations of sparganosis depend on which organs or tissues are Prevention:
Diagnostic Tests:
involved. Subcutaneous tissues are most likely to be infected by the parasite, but visceral 1. drinking boiled or filtered water
1. Computed tomography (CT)
organs and the orbit of the eye, and rarely, the brain. 2. cooking possible intermediate and
2. Magnetic resonance imaging (MRI)
Ocular sparganosis - may result in blindness paratenic hosts thoroughly
3. Enzyme-linked immunosorbent assay
Cerebral sparganosis - characterized by seizures, fatigue, fever, confusion, headaches, 3. avoiding the practice of applying flesh of
(ELISA)
memory loss, and other CNS symptoms frogs to inflamed areas
Proliferative sparganosis - caused by S. proliferum, begins with a subcutaneous tumor Management and Therapy:
in the thigh, shoulder, or neck, and eventually spreads to other parts of the body 1. Surgical removal of sparganum larvae is usually curative
The early migratory stages in the development of the sparganum are asymptomatic, 2. Praziquantel (no effect on adult worms in the CNS)
but when it has reached its final site and begins to grow, its presence elicits a painful There is no available treatment for proliferative sparganosis. Attempts at surgical
inflammatory reaction in the surrounding tissues. removal of S. proliferum have been unsuccessful because of the widespread dissemination of
the larva.
----------Sparganosis----------
Sparganum proliferum. Gross pictures of male patient showing multiple skin lesions The white plerocercoid seen in the subcutaneous tissue along the excision line (gross
which are mostly popular and nodular. Linear elevations suggest shape of the worm beneath findings). Moving speed of the larva, Sparganum mansoni, is slow, so that the larva can easily
the skin. Note gynecomastia. be found during biopsy procedure. (after eating meat of wild chicken)
Life Cycle