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The Humble "Salt" For Pots: High Dietary Salt Intake in Patients With Postural Orthostatic Tachycardia Syndrome

A study examined the effects of high versus low sodium diets on patients with postural orthostatic tachycardia syndrome (POTS). The study found that compared to a low sodium (10 mEq/day) diet, a high sodium (300 mEq/day) diet for one week in POTS patients led to an increase in plasma volume and a decrease in standing norepinephrine levels and heart rate increase upon standing.

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Maung Oo
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68 views2 pages

The Humble "Salt" For Pots: High Dietary Salt Intake in Patients With Postural Orthostatic Tachycardia Syndrome

A study examined the effects of high versus low sodium diets on patients with postural orthostatic tachycardia syndrome (POTS). The study found that compared to a low sodium (10 mEq/day) diet, a high sodium (300 mEq/day) diet for one week in POTS patients led to an increase in plasma volume and a decrease in standing norepinephrine levels and heart rate increase upon standing.

Uploaded by

Maung Oo
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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THE HUMBLE

“SALT” FOR POTS


HIGH DIETARY SALT INTAKE
IN PATIENTS WITH POSTURAL
ORTHOSTATIC TACHYCARDIA
SYNDROME

Reference: Garland et al. (2021). Effect of High Dietary Sodium Intake in Patients With
Postural Tachycardia Syndrome. J Am Coll Cardiol 77(17): 2174–2184

https://www.jacc.org/doi/10.1016/j.jacc.2021.03.005

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Salt intake PATIENTS WITH POTS COMMON CAUSES OF POTS1
Low sodium intake for High sodium intake
one week (10 mEq for one week (300 Dehydration, infections, hyperthyroidism, cardiac disease,
sodium/ day) mEq sodium/ day)
anxiety, anemia, metabolic disorders, chronic fatigue syndrome,
or deconditioning
plasma volume

Recently, a group of Swedish researchers implicated POTS


Change in

occurring as part of long-COVID syndrome, about 3-months


Decreased volume Increase in volume
after the active infection (postulated due to post-viral
autoimmune activation)
standing NE

Increase in Decrease in
In POTS patients, high dietary sodium intake compared with low
Change in

norepinephrine levels norepinephrine levels


(Median: 753 pg/ml) (Median: 387 pg/ml) dietary sodium intake2:

Median: 46 beats/min Median: 19 beats/min increases plasma lowers standing plasma decreases Δ
Δ Heart Rate

volume norepinephrine heart rate


1. Johansson et al (2021). J Am Coll Cardiol Case Rep 3(4): 573–80
2. Garland et al (2021). J Am Coll Cardiol 77(17): 2174–2184 1 mEq sodium = 23 mg sodium OR
~58 mg salt | POTS, Postural Orthostatic Tachycardia syndrome

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