Scribd
Upload
4K views3 pages

Promethazine

Promethazine hydrochloride is an antihistamine used as an antiemetic, antivertigo, and sedative-hypnotic drug. It works by competing with histamine for H1 receptor sites, thereby reducing allergy symptoms. It is also used to prevent and treat nausea, vomiting, motion sickness, and vertigo. Common side effects include sedation, dizziness, and extrapyramidal symptoms. As a nurse, responsibilities include monitoring for bone marrow depression, injecting the intramuscular form deeply into large muscle mass while rotating sites, and supervising ambulation due to potential marked sedation.

Uploaded by

Gwyn Rosales
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
4K views3 pages

Promethazine

Promethazine hydrochloride is an antihistamine used as an antiemetic, antivertigo, and sedative-hypnotic drug. It works by competing with histamine for H1 receptor sites, thereby reducing allergy symptoms. It is also used to prevent and treat nausea, vomiting, motion sickness, and vertigo. Common side effects include sedation, dizziness, and extrapyramidal symptoms. As a nurse, responsibilities include monitoring for bone marrow depression, injecting the intramuscular form deeply into large muscle mass while rotating sites, and supervising ambulation due to potential marked sedation.

Uploaded by

Gwyn Rosales
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 3

Nursing

Name of Drug Classification Mechanism of Action Indication Contraindication Side Effects


Responsibilities
Generic Name: Pharmacologic Class: Pharmacodynamics General Indication: - Angle-closure CNS: Akathisia, CNS Before Drug
Promethazine Phenothiazine or Mechanism of  To prevent or glaucoma stimulation, confusion, Administration
Hydrochloride derivative Action: treat - bladder neck
motion dizziness, drowsiness, -Monitor patient’s
Competes with sickness obstruction dystonia, euphoria, hematologic status as
Trade/Brand Name: Therapeutic Class: histamine for H1-  To treat vertigo bone marrow excitation, fatigue, ordered because
Histantil, Phenergan, Antiemetic, receptor sites, thereby  To prevent or depression hallucinations, promethazine may
Phenadoz antihistamine, antagonizing many treat nausea and - hypersensitivity or hysteria, cause bone marrow
antivertigo, histamine effects and vomiting history of incoordination, depression.
Minimum dose: sedative-hypnotic reducing allergy signs  To treat signs andidiosyncratic insomnia, irritability,
12.5 mg q4-6h PRN and symptoms. symptoms reaction to
of nervousness, During Drug
Pregnancy Category: Promethazine also allergic responsepromethazine, other neuroleptic malignant Administration
Maximum dose: C prevents motion  Induction phenothiazines, or
of syndrome, paradoxical -Inject I.M. form deep
25 mg q4-6h PRN sickness, nausea, and sedation their components stimulation, into large muscle mass,
vertigo by acting -use of large restlessness, sedation, and rotate sites.
Patient’s Dose: centrally on medullary Patient’s Indication: quantities of CNS seizures, syncope, -Give IM injection
25 mg IM STAT then chemoreceptive trigger For relief of vertigo, depressants tardive dyskinesia, deep into large muscle
q4 hours PRN for zone and by decreasing nausea, and vomiting tremor mass. Aspirate
vomiting vestibular stimulation carefully before
and labyrinthine CV: Bradycardia, injecting drug.
Route: function in the inner hypertension,
Intramuscular ear. It also promotes hypotension, After Drug
sedation and relieves tachycardia Administration
Frequency: anxiety by blocking -Supervise ambulation.
STAT then q4h PRN receptor sites in CNS, EENT: Blurred vision; Promethazine
for vomiting directly reducing diplopia; dry mouth, sometimes produces
stimuli to the brain. nose, and throat; nasal marked sedation and
Availability: congestion; tinnitus; dizziness.
Pharmacokinetics: vision changes - Be aware that patient
Absorption: Readily shouldn’t have
from GI tract. ENDO: intradermal allergen
Hyperglycemia tests within 72 hours of
Onset: 20 min receiving promethazine
GI: Anorexia, because drug may
Duration: 2–8 h. cholestatic jaundice, significantly alter flare
ileus, nausea, vomiting response.
Tablet
Distribution: Crosses -Instruct patient to
oral solution
placenta. GU: Dysuria notify prescriber
rectal suppository
immediately if she has
injection
Metabolism: In liver HEME: involuntary
(CYP2D6, 2B6). Agranulocytosis, movements and
Content:
leukopenia, restlessness.
promethazine
Elimination: Slowly in thrombocytopenia,
hydrochloride, dibasic
urine and feces. thrombocytopenic
calcium phosphate,
purpura RESP: Apnea,
magnesium stearate,
respiratory depression,
microcrystalline
tenacious bronchial
cellulose, sodium
secretions S
starch glycolate and
stearic acid
KIN: Dermatitis,
diaphoresis, jaundice,
photosensitivity, rash,
urticaria

Other: Angioedema,
paradoxical reactions

References:
Vallerand, A., Sanoski, C., & Deglin, J. (2017). Drug Guide for Nurses. 15th Ed. FA Davis Company: Philadelphia

Schull, P. D. (2013). McGraw-Hill nurses drug handbook. New York: McGraw-Hill Medical.

JONES & BARTLETT LEARNING. (2018). Nurses Drug Handbook. SUDBURY.

You might also like