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MMC 1

This supplementary appendix provides additional data to support the findings of the main document. It includes 4 figures (A-D) comparing the immunogenicity of the mRNA BNT162b2 vaccine and the inactivated CoronaVac vaccine. Figures A and B show RBD ELISA and sVNT responses before and after the first and second doses of each vaccine. Figures C and D show PRNT50 and PRNT90 titers at the same timepoints.

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Sigit Adi
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40 views

MMC 1

This supplementary appendix provides additional data to support the findings of the main document. It includes 4 figures (A-D) comparing the immunogenicity of the mRNA BNT162b2 vaccine and the inactivated CoronaVac vaccine. Figures A and B show RBD ELISA and sVNT responses before and after the first and second doses of each vaccine. Figures C and D show PRNT50 and PRNT90 titers at the same timepoints.

Uploaded by

Sigit Adi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Supplementary appendix

This appendix formed part of the original submission. We post it as supplied by the
authors.

Supplement to: Lim W, Mak L, Leung GM, Cowling BJ, Peiris M. Comparative
immunogenicity of mRNA and inactivated vaccines against COVID-19. Lancet Microbe
2021; published online July 15. https://doi.org/10.1016/S2666-5247(21)00177-4.
A RBD ELISA
B sVNT
5 100%
RBD ELISA (OD450 value)

4 80%

sVNT inhibition (%)


3 60%

2 40%

1 20%

0 0%
BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac

Pre-vaccination After After Pre-vaccination After After


first dose second dose first dose second dose

C PRNT50 D PRNT90

≥320 ≥320
160 160
PRNT50 titer

PRNT90 titer

80 80
40 40
20 20
10 10
<10 <10
BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac BNT162b2 CoronaVac

Pre-vaccination After After Pre-vaccination After After


first dose second dose first dose second dose

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