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B Globin Student Handout

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Dr-Qussai Zuriegat
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93 views

B Globin Student Handout

Uploaded by

Dr-Qussai Zuriegat
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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where molecules become realTM

A 3DMD Paper BioInformatics Activity©

The β -Globin Gene Exercise


Student Handout
The human β-globin protein functions in transporting oxygen throughout our
bodies. The sequence of the 147 amino acids that comprise the precursor protein is
encoded in a sequence of nucleotides that make up the β-Globin Gene. The first
amino acid (Met) is later removed to produce a 146 amino acid protein.

In this exercise, you are given a model of DNA. This model is a Map which
contains the nucleotide sequence of the region of the human genome that contains
the β-globin gene. In addition to the nucleotide sequence of both strands of DNA,
you will find three possible amino acid sequences encoded in this DNA sequence.
These are printed below the nucleotide sequence.

Using the map, find the nucleotide sequence in the DNA that encodes the amino
acid sequence (given below) of the β-globin protein. Highlight (with a highlighter
or white board marker) both the nucleotide sequence and the corresponding amino
acid sequence on your map. You may wish to consult the Table of Codons and the
one-letter abbreviation of each amino acid as you work on this exercise.

The amino acid sequence of the β-globin protein is shown below this paragraph.
Please note that the one-letter abbreviation of each amino acid is used.

MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDL
STPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLH
VDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH

www.3dmoleculardesigns.com • 3D Molecular Designs Copyright 2005 Student 1


A 3DMD Paper BioInformatics Activity©

Standard Genetic Code

AUG is part of the initiation signal, as well as being the codon for internal methionine.

Amino Acids
Name Abbreviations Name Abbreviations

Alanine Ala A Leucine Leu L


Arginine Arg R Lysine Lys K
Asparagine Asn N Methionine Met M
Aspartic Acid Asp D Phenylalanine Phe F
Cysteine Cys C Proline Pro P
Glutamine Gln Q Serine Ser S
Glutamic Acid Glu E Threonine Thr T
Glycine Gly G Tryptophan Trp W
Histidine His H Tyrosine Tyr Y
Isoleucine Ile I Valine Val V

Student 2 www.3dmoleculardesigns.com • 3D Molecular Designs Copyright 2005

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