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Hexose Monophosphate Shunt

The document describes the hexose monophosphate pathway (HMP pathway), a metabolic pathway present in many organisms that involves the oxidative decarboxylation of glucose-6-phosphate via 6-phosphogluconate to ribulose-5-phosphate. The pathway provides NADPH for biosynthesis and precursors for various biosynthetic pathways, and can generate energy even without a complete TCA cycle by transferring reducing equivalents to an electron acceptor via respiration. Intermediates can re-enter glycolysis or be converted to other products like pyruvate or acetyl-CoA.

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Dr. SHIVA AITHAL
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4K views2 pages

Hexose Monophosphate Shunt

The document describes the hexose monophosphate pathway (HMP pathway), a metabolic pathway present in many organisms that involves the oxidative decarboxylation of glucose-6-phosphate via 6-phosphogluconate to ribulose-5-phosphate. The pathway provides NADPH for biosynthesis and precursors for various biosynthetic pathways, and can generate energy even without a complete TCA cycle by transferring reducing equivalents to an electron acceptor via respiration. Intermediates can re-enter glycolysis or be converted to other products like pyruvate or acetyl-CoA.

Uploaded by

Dr. SHIVA AITHAL
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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PTS = Phosphoenolpyruvate-dependent phosphotransferase system.

TPP = thiamine pyrophosphate.

Dr. Shiva C. Aithal, Dept. of Microbiology, Dnyanopasak College, PARBHANI [email protected]


HEXOSE MONOPHOSPHATE PATHWAY

(HMP pathway or HMP shunt or Oxidative pentose phosphate pathway or Pentose phosphate
pathway/cycle or Phosphogluconate pathway or Warburg–Dickens pathway)

A metabolic pathway present in a wide range of prokaryotic and eukaryotic microorganisms as


well as in plants and animals; it involves the oxidative decarboxylation of glucose 6-phosphate,
via 6-phosphogluconate, to ribulose 5-phosphate, followed by a series of reversible, non-
oxidative interconversions whereby hexose and triose phosphates are formed from pentose
phosphates. The generally accepted scheme for the HMP pathway is shown in figure above. The
HMP pathway can serve various functions, the major ones probably being to provide NADPH. (2
molecules per molecule of glucose converted to ribulose 5-phosphate) necessary for biosyntheses
(e.g. of fatty acids), and to provide precursors for various biosynthetic pathways (e.g. pentoses
for histidine and nucleotide biosynthesis, erythrose 4-phosphate for aromatic amino acid
biosynthesis. Fructose 6-phosphate may be converted to glucose 6-phosphate and re-enter the
pathway, or may be converted to pyruvate via high-dry objective reactions of the EMBDEN–
MEYERHOF–PARNAS PATHWAY; similarly, glyceraldehyde 3-phosphate may be converted
to pyruvate via the latter part of the EMP pathway. In organisms with a functional TCA CYCLE,
pyruvate can be oxidized to yield energy via the TCA cycle and a respiratory chain. In organisms
which lack a complete TCA cycle, pyruvate may be converted to acetyl-CoA and thence to acetic
acid (as in some acetic acid bacteria). Alternatively, under certain conditions, glyceraldehyde 3-
phosphate can be converted to glucose 6-phosphate (by reactions of GLUCONEOGENESIS)
which can then re-enter the HMP pathway; in this case, for every six molecules of glucose
entering the pathway, one molecule is effectively completely oxidized. If reducing equivalents
from NADPH can be transferred to NAD+ (see TRANSHYDROGENASE) and thence to an
electron acceptor via a respiratory chain, the pathway can be used to generate energy even in the
absence of a TCA cycle. Other functions of the HMP pathway include the metabolism of those
pentoses which can be converted to intermediates of the pathway.

Dr. Shiva C. Aithal, Dept. of Microbiology, Dnyanopasak College, PARBHANI [email protected]

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