GP-100

Semi-automated Photometer (Analyzer)

Service Manual

Greiner Diagnostic GmbH – D-79353 Bahlingen a. K. – Unter Gereuth 10

Germany
Telephone: +49 76 63 / 91 4 90 – Telefax: +49 76 63 / 91 49 150
e-mail: [email protected]

GP-100 Service manual vers.1.4.3. p.1

 CONTENTS
SYMBOLS ON THE INSTRUMENT ....................................................................................................... 4

SAFETY PRECAUTIONS AND POTENTIAL HAZARDS .................................................................. 5

CHAPTER 1 GENERAL DESCRIPTION .............................................................................................. 9

1.1 FOREWORD ......................................................................................................................................... 9

1.2 TECHNICAL CHARACTERISTICS ......................................................................................................... 10

CHAPTER 2 INSTALLATION AND PRIMARY OPERATION .......................................................... 11

2.1 INSTRUMENT UNPACKING AND INSTALLATION ................................................................................... 11

2.1.1 Unpacking of the instrument ................................................................................................... 11
2.1.2 Select proper mounting location. ............................................................................................. 11
2.1.3 Power supply requirement........................................................................................................ 12
2.1.4 Connect the instrument to power ............................................................................................. 12
2.1.5 Connect to the external printer ................................................................................................ 12
2.1.6 Adjust the display to an appropriate position .......................................................................... 13
2.1.7 Place flow cell........................................................................................................................... 13
2.2 INSTRUMENT STRUCTURE .................................................................................................................. 14
2.2.1 Front view ................................................................................................................................. 14
2.2.2 Rear view .................................................................................................................................. 14
2.2.3 Keyboard ................................................................................................................................... 15
2.2.4 Flow cell ................................................................................................................................... 16
2.2.5 Flow-cell installation direction ................................................................................................ 16

CHAPTER 3 FUNCTION DESCRIPTION ........................................................................................... 18

3.1 PCB DIAGRAM ........................................................................................................................... 18

3.2 FRONT BOARD OUTLINE............................................................................................................. 18
3.2.1 Front Board Function .......................................................................................................... 18
3.2.2 Front Board Diagram ........................................................................................................... 19
3.2.3 Filter Choice Control ............................................................................................................ 19
3.2.4 Sipper Pump Aspirate Control.............................................................................................. 19
3.2.5 Temperature Test Control ..................................................................................................... 20
3.2.6 Light Energy Sampling and Conversion ............................................................................. 20
3.2.7 Halogen tungsten lamp control ............................................................................................ 20
3.3 HYDRAULICS SYSTEM DESCRIPTION........................................................................................... 20
3.3.1 Function ............................................................................................................................... 20
3.3.2 Structure................................................................................................................................ 21
3.4 PHOTOMETER SYSTEM DESCRIPTION .......................................................................................... 21
3.4.1 Function ............................................................................................................................... 21
3.4.2 Structure................................................................................................................................ 21

CHAPTER 4 SPARE PART REPLACEMENT .................................................................................... 23

GP-100 Service manual vers.1.4.3. p.2

 4.1 INSTRUMENT’S DISASSEMBLY ..................................................................................................... 23
4.2 POWER SWITCH REPLACEMENT .................................................................................................. 24
4.3 SIPPER PUMP PIPE REPLACEMENT .............................................................................................. 25
4.4 FLOW-CELL REPLACEMENT ........................................................................................................ 26
4.5 LAMP REPLACEMENT ................................................................................................................. 27
4.6 FILTER REPLACEMENT ................................................................................................................ 29
4.7 PHOTOMETER DETECTOR REPLACEMENT ................................................................................... 30
4.8 FRONT BOARD REPLACEMENT .................................................................................................... 32
4.9 MAIN BOARD REPLACEMENT ..................................................................................................... 32
4.10 POWER SUPPLY ASSEMBLY REPLACEMENT ................................................................................. 33
4.11 LCD REPLACEMENT ................................................................................................................... 33
4.12 TRANSITION BOARD REPLACEMENT ........................................................................................... 34
4.13 PELTIER REPLACEMENT .............................................................................................................. 35
4.14 TEMPERATURE SENSOR REPLACEMENT ...................................................................................... 36
4.15 PELTIER FAN REPLACEMENT....................................................................................................... 37
4.16 PRINTER DRIVER BOARD REPLACEMENT ................................................................................... 37
4.17 INTERNAL PRINTER REPLACEMENT ............................................................................................ 38

CHAPTER 5 DAILY MAINTENANCE .................................................................................................. 39

5.1 GENERAL INTRODUCTION.................................................................................................................. 39

5.2 CLEAN THE INSTRUMENT................................................................................................................... 39
5.2.1 Clean outer surface of instrument ........................................................................................... 39
5.2.2 Clean the flow-cell.................................................................................................................... 39

CHAPTER 6 TROUBLE SHOOTING LIST ......................................................................................... 40

GP-100 Service manual vers.1.4.3. p.3

Symbols on the instrument

This symbol means that the labeled item is hot while the
instrument is in use. Don’t touch the labeled item as you could be
scalded.
The symbol is labeled on the lamp support of optic system.

This means that the labeled item could lead to personal injury
and/or damage to the analyzer.
The symbol is labeled beside the power outlet and some external
interface.

Cautions should be followed carefully to ensure your instrument

work correctly and to avoid unnecessary personal injury

The symbols for “SERIAL NUMBER”, The serial number shall be

after or below the symbol, adjacent to it.

The symbol means the product is in vitro diagnostic medical

device.
The symbol indicates the manufacturer and its address, after
which are shown its name and address.
The symbol indicates EU representatives of the manufacturer
and their addresses, after which are shown their names and
addresses.
The symbol indicates biological pollution, marked in the part
where the instrument contacts the clinical reagent. The symbol
appears in black side and yellow background.

Symbols on the sales packaging

The symbol means that the environment of instruments must be

dampproof in the course of transport, and instrument must be
kept in a dry environment.
This means that instrument should handle with care in the course
of transportation, so as not to damage it.
The symbol means the instrument packaged should not be
upended at any time
The symbol means that the level piled up can't exceed 8 layers,
as not to damage instrument.
The symbol indicates temperature range of the analyzers during
storage and transportation.

GP-100 Service manual vers.1.4.3. p.4

Safety Precautions and Potential Hazards

General

Before you start installing and working with the analyzer, you should read the safety
precautions and regulations shown in this chapter.

Operator Qualification

Please note that the operation with Chemistry analyser should be carried out only by the
doctor or clinical inspector who has undergone necessary training provided by the sales
agent.

Service Technician Qualification

To install, maintain and repair the instrument, a service technician has to be trained on the
instrument by the manufacturer or their representative. A service technician is also expected
to be familiar with the normal operation of the instrument as described in the User’s manual
and the special operations as described in the service manual.

Electrical

To use analyser safely, pay attention to the following items:

To prevent the risk of electrical shock and/or damage to the instrument Operator should not
open the white cover of the instrument. Only authorized personnel, for example, service
technicians, may open the instrument to perform maintenance or repair.

Touching the main board when the power is on may cause severe injury or death. Any
problem, please ask for helps from your supplier.

Mechanical

There is no risk presented by the mechanical parts of the instrument when the instrument is
closed. If the covers of the instruments are removed, mechanical parts could cause personal
injury or the instrument may be damaged if the following advice is not being considered: DO
NOT wear loose garments or jewellery that could catch in mechanisms. DO NOT put your
fingers/hands into the pathway or any part while the analyzer is in operation. DO NOT attempt
mechanical repair unless the instrument is not in operation or OFF.

Lamp

The source lamp becomes extremely hot during operation; never touch the lamp when it is on!
Look directly into the light path of the lamp may cause eyes damage, too.

GP-100 Service manual vers.1.4.3. p.5

If the lamp needs to be changed, always switch off the lamp by switching off the instrument
and then wait until the lamp has cooled down.

Chemical

The operator is responsible for taking all necessary precautions against hazards associated
with the use of clinical laboratory chemicals. Specific recommendations for each reagent
used with the analyzer are normally found on the manufacturer’s package inserts or the on
the product information sheets for each chemical. Wipe up any reagent spillage on the
instrument immediately.

Biohazardous Materials

As with all vitro diagnostic equipment, patient samples and serum-based quality control (QC)
products that are assayed on this system, as well as all waste from the waste container,
should be treated as the potentially biohasardous. All materials and mechanical components
associated with the sampling and waste system should be handled according to your facility’s
biohazard procedure. Use the personal protective equipment recommended by your facility
when handling any of these components. Detailed recommendations:

- Samples

Treat all samples as potentially biological pollution and infectious. If any sample is spit on the
instrument, utilize the correct personal protective equipment (PPE- gloves, lab coat, etc...),
wipe it up immediately and clean the contaminated with a disinfectant.

- Waste solutions and solid wastes

Avoid direct contact with waste solution and/or solid waste. Both should be handled as
potentially biohazardous.

Dispose of waste solution and/or solid waste according to the relevant governmental
regulations.

Consult the reagent manufacturer for information on the concentrations of heavy metals and
other toxic constituents in each reagent.

- Biohazardous parts

Avoid direct contact with the sipper tubing and all parts of the sample flow path. Treat these
areas as potentially biohazardous and /or infectious

GP-100 Service manual vers.1.4.3. p.6

- Reagents

Avoid direct body-contact with reagents. Direct body-contact may result in irritation or
damage to your skin. Refer to the manufacturer’s reagent kit box and package inserts, or
product information sheets for specific instructions.

Avoid direct body-contact with cleaning solution. Direct body-contact amy result in skin
irritation or damage. Refer to the manufacturer’s kit box and package inserts, or product
information sheets for specific instructions.

ATTENTION! Cautions

Require for Samples and Reagents, calibrators and controls.

Greiner’s Semi-automated Photometer (Analyzer) is a Reagent open system. But before
the testing, the following items should be noted first.
Generally, all the reagent and samples have to be stored and prepared as per the
manufactures’ instructions. Greiner do recommend that these reagents should from the
manufactures with valid product quality certificate and production permission legalized
by local government or from the valid distributors appointed by Greiner Electronics Inc.
in your country.
Before your test, please check the following.
Check the expiration date of the material
Check if the reagent is stored properly as the requirement. (E.g. cooled or frozen storage
before using)
Check for proper programming in parameter setting menu according to the specified reagent
instructions.
Check for volume required for each material.
Check for proper and calibrated pipette to prepare the solution.

Additional Precautions

- Flammables

Avoid using dangerous flammable material around the instrument.

- Accuracy/Precision of the Measured Results

For proper use of the instrument, measure control samples and monitor the instrument during
the operation.

GP-100 Service manual vers.1.4.3. p.7

An incorrectly measured result may lead to an error in diagnosis, thereby posing a danger to
the patient.

Treat all reagents according to the manufacturer’s recommendations. Refer to the reagent kit
box and package inserts, or product information sheets for specific instructions.

Make sure that the sample/reagent mixture does not contain any blood clots, dust or other
insoluble contaminants. If insoluble contaminants are contained in the sample, correct
measuring values may not be obtained.

- Application

The instrument is designed for clinical chemistry test analysis using water-soluble samples
and reagents.

Please note that other types of analysis may not be applicable to the instrument.

- Operation and Maintenance

During operation and maintenance of the instrument, proceed according to the instructors
and do not touch any parts of the instrument other than those specified.

Never leave a Reagents/sample mixture in the flow-cell for longer than necessary. Always
clean the flow-cell after a batch of measurement and keep the flow-cell filled with distilled
water when not in use.

Verify the front covers closed while the instrument in operation.

Avoid touching the mechanism, such as the sipper mechanism inside the instrument, while
the instrument is operating. This may cause operation stop or damage the instrument.

GP-100 Service manual vers.1.4.3. p.8

Chapter 1 General Description

1.1 Foreword

GP-100 is a universal photometric Semi-automated Photometer (Analyzer). The

advanced software based on Windows CE gives the instrument friendly interfaces which
meet the individual requirements of clinical chemistry laboratory.

⚫ 47 of the most commonly assays are stored in the flashing RAM of the GP-100,
which enables user can start working right away with the instrument. 130 of
assays can be programmed.
⚫ All original programs setting of tested items can be revised by user.
⚫ It has double coloring system: One is flow-cell system and the other is cuvette
system.
⚫ 6 Analytical Modes:
Endpoint
Two-point
Kinetics
Dichromatic
Absorbency
Multi-Calibration
⚫ It can analyze samples of blood serum, blood plasma, whole blood and urine
etc.
⚫ It has no restriction of reagent.
⚫ The user could connect the unit to the PC of clinic lab by RS232 interface.
⚫ Either built-in printer or external printer can be selected.
⚫ The external standard (XT/AT) keyboard, mouse.
⚫ Power-off protection, real-time data saving.

GP-100 Service manual vers.1.4.3. p.9

1.2 Technical Characteristics

Resolution 0.001Abs(display),0.0001 Abs(inner calculation)

Light source halogen tungsten lamp,6V/10W,service life about 1000 hours

Wavelength 340,405,500,546,578,620,670nm ,One blank for optional filter

Temperature control Ambient temperature,25,30,37℃ (Peltier component),

Precision≤±0.5℃，amplitude of fluctuation≤±0.4℃

Flow-cell 30μl quartz flow-cell (metal-base)

Cuvette 12.5mm×12.5mm square test tube

Port Mouse, RS232, Keyboard, Printer

Display 7″color LCD display(640×240line),256color

Print Built in or external universal printer

Working environment 0℃～40℃;Maximum humidity 85%R.H.

Storage environment -10℃～40℃; Maximum humidity 85%R.H.

Net weight 8kg

Dimension 460mm(L)×330mm(W)×190mm(H)

Power 80VA

Fuse T3.15AL250V，Φ5×20

Power supply a.c.220V±22V，50Hz±1Hz

GP-100 Service manual vers.1.4.3. p.10

Chapter 2 Installation and primary operation

2.1 Instrument unpacking and installation

2.1.1 Unpacking of the instrument

Unpack the instrument and remove the materials used for delivery. Keep the packing
boxes and materials for repacking the instrument in the future.
1） Take the instrument out from the boxes.
2） Take away the packing materials; take out the instrument from the plastic
packing bags.
3） Check the articles in the packing box and confirm that the following articles are
contained:：
⚫ GP-100 mainframe
⚫ User’s manual
⚫ Packing list
⚫ Repair guarantee certificate of the agent
⚫ Power cable
⚫ Product approved certificate

Note: If any part is found missing or damaged or not conform to the

encasement checklist, please contact the dealer.

2.1.2 Select proper mounting location.

The instrument should not be directly exposed to the sun.. The working table selected shall
be smooth in surface and has enough space to mount GP-100. The front edge of instrument
shall be close to the edge of working table. The working table is prevented to have great
vibration (e.g. centrifuge is placed on the table).

Note: The working environment of the instrument:

The temperature shall be 0℃-40℃

The related humidity shall be less than85%.

To ensure the normal operation of the instrument, it is forbidden to mount the instrument
in the following places：

GP-100 Service manual vers.1.4.3. p.11

 ⚫ A place with extreme change of temperatures.
⚫ A place too hot or too cold
⚫ A place with many dust
⚫ Close to electromagnetic equipment that can produce magnetic field.
⚫ Avoid direct sunshine

2.1.3 Power supply requirement

⚫ a.c.220V±22 V
⚫ 50Hz±1Hz
⚫ 80VA

2.1.4 Connect the instrument to power

1） Insert one end of power source line to the power source socket of the
instrument.
2） Insert the other end of power source line to the alternating current power source
socket.

⚫ The alternating current shall have fine grounding（zero voltage<5V）.

Warning ⚫ The alternating current shall be stable. It is forbidden to use power
source together with appliance with great voltage. It is better to
equip stable-voltage power source.
⚫ In the unstable voltage area, please use UPS to make sure the
instrument can work normally.
⚫ When pulling out power source line, hold the connector plugs; do
not hold power source line.
⚫ If smoke, peculiar smell or strange sound is found in the instrument,
turn off the power immediately and contact with repair service
center.

2.1.5 Connect to the external printer

1) The printer and instrument must be turned off.

2) Insert the USB connected printing cable to the USB output port at back of the
printer.
3) Fix the plug with fixed wire button.
4) Insert the other end of the USB printing cable into the USB port of the instrument.
5) Connect the printer to alternating current power source with power source line
equipped in printer.

Note: GP-100 can also use special built-in thermo printer.

GP-100 Service manual vers.1.4.3. p.12

2.1.6 Adjust the display to an appropriate position

As indicated in the following drawing, move the LCD display screen to an appropriate
position deemed by you.（beware to impose proper strength）.

Figure 2.1.1

2.1.7 Place flow cell

As indicated in the following drawing, take away the cover of flow-cell (beware proper
strength is used)

Figure 2.1.2

1) Tear the adhesive tape use in fixing flow-cell.

2) Remove packing materials
3) Place the flow-cell into incubation carefully and make the aspirate tube in front。

GP-100 Service manual vers.1.4.3. p.13

2.2 Instrument structure

2.2.1 Front view

Figure 2.2.1

1) Pump cover 6) Hot-key

2) Flow cell cover 7) Power-on indicator
3) Sample tube 8) Printer cover
4) Sample button
5) LCD Screen
2.2.2 Rear view

Figure 2.2.2
1. Power Switch
2. Fuse
3. AC power connector
4. Fan
5. Pump
6. Brightness

GP-100 Service manual vers.1.4.3. p.14

7. Lan
8. USB
9. SD Card
10. RS-232 interface
11. Drain Port

2.2.3 Keyboard

Figure 2.2.3

1) Soft keyboard: Open or close soft keyboard.

2) Rinse On, Off: Pressing this control will switch on the sipper pump
in a continuous mode, press the key again will stop
the pumping action at the end of a complete cycle.

3) Feed Paper: Control the printer paper for the embedded printer.

4) Print: Set the printer enable or disable.

5) Lamp On, Off: Turn off or turn on the Lamp.

6) Left: This key is used to go backwards in a procedure.

7) Right: This key will advance the cursor to the next position.

8) Enter: This key is used to confirm an entry via the

keyboard.

GP-100 Service manual vers.1.4.3. p.15

2.2.4 Flow cell

Open the cover of flow-cell as indicated in the following drawing.

Note: When opening the cover of flow-cell or inner cover of light lamp,
press the two sides of cover so that it deform innerward, and then
open it according to the direction of the following drawing.

Figure 2.2.4

Inside the colorimetric system there are：

⚫ Incubation
⚫ Inner cover of light source
⚫ Flow-cell

Inner cover of light source

Incubation

Colorimetric system

Figure 2.2.5

2.2.5 Flow-cell installation direction

When installing the flow-cell:

The front view should be on the low level facing to the operator;
The rear view should be on the high level, which insures the bubbles go out easily.

GP-100 Service manual vers.1.4.3. p.16

 Solution
out
Solution
in

Front view figure Rear view figure

Figure 2.2.6

GP-100 Service manual vers.1.4.3. p.17

Chapter 3 Function Description

3.1 PCB Diagram

Figure 3.1.1

3.2 Front Board Outline

3.2.1 Front Board Function

The front board is under the control of main board of computer. The front board
executes and completes all the unique functions of the semi-automatic biochemical
analyzer; it is the control execution center of the semi-automatic biochemical analyzer.
In semi-automatic biochemical analyzer GP-100, the front board mainly completes the
following functions:
⚫ Filter selection
⚫ pump rotate to aspirate liquid
⚫ Tungsten halogen lamp control
⚫ Transfer, amplify and sampling of light and electric signals
⚫ Temperature test and control

GP-100 Service manual vers.1.4.3. p.18

3.2.2 Front Board Diagram

Figure 3.2.1

3.2.3 Filter Choice Control

In Semi-automated Photometer (Analyzer) GP-100, there are 7 filters: 340nm﹑405nm
﹑500nm﹑546nm、578nm、620nm and 670nm. Different filter is needed for different
test method. Place the filters evenly on circumference of 8 holes round disk. The
angle of neighboring two hole is 360/8=45°. The remaining hole is preserved for
adding unique filter in the future. The round disk is rotated by step motor. When step
motor rotates on different angles, different wavelength is selected by the system. The
model of step motor is UBD6N07D04AKNC. The reduction gear is equipped in the
motor to increase the rotation moment. The reduction gear is equipped together with
step motor 8254 OUT. After filter output pulse, related filter is selected.

3.2.4 Sipper Pump Aspirate Control

In Semi-automated Photometer (Analyzer) GP-100, the instrument automatically
absorbs related amount of reagent according to the amount of liquid set by the test
item. Similar with the filter wheel motor, the step motor is adopted to control precise
amount of liquid absorbing. The control method is similar to that of the filter wheel step
motor. When the step motor rotates different angel, the instrument absorbs different
amount of reagent. Since the movement is large when pump is absorbing and rotating,
the double stages step motor is selected. The model is 17HS1022. The double stage
drive of L297 and L298 control/drive chip are adopted in related circuit drive.

Since the test sample is different and have different density, it can offer different

GP-100 Service manual vers.1.4.3. p.19

 absorbing rate to users. 1～8 rates are set on the pump. Different frequency division is
written on Timer/Count of 82C54. OUT0 exports different frequency, the pump rotates
in different speed.

3.2.5 Temperature Test Control

Temperature control can be divided into temperature test and temperature rise/fall.
The digital temperature sensors DS1820 produced by DALLAS that can decrease
peripheral conversion circuit is adopted in temperature test.

3.2.6 Light Energy Sampling and Conversion

The sampling test of light energy is the core of Semi-automated Photometer
(Analyzer). All the test and calculation are performed through test on light intensity.
Therefore the light energy sampling shall be precise and stable to satisfy the
requirement of instruments on sampling test speed. The photoelectric sensor
OPT301M of B-B Company is adopted. The component integrates the silicon
photovoltaic cell and embedded calculation amplifier. The silicon photovoltaic cell
transfers the photocurrent signal into low voltage signal. The embedded calculation
amplifier amplifies the low voltage so as to satisfy the measurement requirement of
voltage. OPT301M has the strong point of high integration and fine performance. At
the same time, only by transferring the voltage signal into digital amount to CPU can it
start processing. So A/D transfer circuit shall be added. ADS774 of B-B Company is
adopted as A/D converter, its main indexes are: 12Bit. All can satisfy requirements of
instrument on measuring range, precision and speed. The voltage range of input A/D
is 0-10V.

3.2.7 Halogen tungsten lamp control

To extend the working life of the lamp, the instrument can automatically shut the lamp
if instrument does not measure after being on for a long time. The lamp used by the
instrument is halogen tungsten lamp. Its specification is 6V/10W. Both the current
passes and voltage are high .If voltage MOS tube is adopted to control on/off of
halogen tungsten lamp, voltage drop pressure and consumption of the voltage MOS is
high, many disadvantages such as heat emission will be brought along. So the small
relay is adopted to control the lamp. The voltage drop of relay contact is almost zero.
And the voltage of relay line package is small. Control signal is put out by PB.6 of 8255.
Audion is used to drive the control relay on/off of line package.

3.3 Hydraulics system Description

3.3.1 Function
When you press aspirate button in the test, system drives the sipper pump to rotate
and enable the tested liquid in pipeline extrude to liquid drainage port. So the tested
liquid is absorbed into the flow-cell. When sample volume set by measuring item is
absorbed, the system stops the sipper pump motor. Liquid to be tested is in the

GP-100 Service manual vers.1.4.3. p.20

 flow-cell. After measurement, the system drives the rotation of sipper pump to empty
the tested liquid in flow-cell to decrease cross pollution and ready for the next
measurement.

3.3.2 Structure

Figure 3.3.1

3.4 Photometer system Description

3.4.1 Function
The optical structure of GP-100 is, as the below diagram, spectrums structure after
going through filter. After lightening tungsten halogen lamp, radiate light with filament
as center is given out. The radiate light is converted to parallel ray after going through
convex lens. The protection glass plays the role of protecting convex lens. After the
parallel ray pass through the flow-cell with sample liquid to be tested, a part of light
energy is absorbed by liquid. Light that shoot up is called shoot-up light. The shoot-up
light is changed to single color light after going through single color filter. The single
color ray shoots on the photoelectric receiver. The photoelectric receiver transfer the
light signal into electric signal and input it to front board for processing. The color of
filter and color of tested liquid shall be additive complementary colors.

3.4.2 Structure

①．Lamp 6V/10W
②．Protection glass
③．Convex lens
④．Flow cell
⑤．Filter
⑥．Photometer Detector

GP-100 Service manual vers.1.4.3. p.21

 Figure 3.4.1

GP-100 Service manual vers.1.4.3. p.22

Chapter 4 Spare Part Replacement

4.1 Instrument’s disassembly

If the user meets some problems and needs to open the instrument, you can do as
follow:
1) Turn over the instrument.
2) From bottom of the instrument you can see seven plastic pillars with screw hole.
Uses a screwdriver unscrew these seven screws. (Figure 8.1)
3) Turn the instrument back to normal position.
4) Set the LCD screen to vertical position. (Figure 8.2)
5) Lift the top cover of instrument gradually, and open the front side about 3 inches
first. Do not use too much force, because there are cables between top and foot
cover.
6) After open the machine, you can see the inside distribute of top and foot cover like
figuer8.3
7) Find the LCD connector on the main board, and open it carefully.
8) Then turn over the top cover, disconnect 5 other cables

Set up the machine in reverse order.

Figure 4.1.1

Top cover

Foot cover
Front side

GP-100 Service manual vers.1.4.3. p.23

 Figure 4.1.2

Figure 4.1.3

4.2 Power Switch Replacement

1. Turn off the machine, unscrew the bolts on base of instrument; take out the upper
cover of instrument.
2. Pull out plugs①、②、③.
3. Press firmly the flip plate④ on both end of switch, push outwards the entire switch
seat and remove the switch seat.
4. Pull out tie-in of power source line⑤、⑥ with switch. Press firmly the flip plate and
push outwards the switch.
5. Take a fine quality switch.
6. Connect the tie-in of power source line⑤、⑥and switch.
7. Press the switch socket outwards into the base of instrument, the power source
line socket shall face the fan.
8. Connected power source line①、②、③.
9. Place the upper cover, firmly screw bolts.
Note:
Don’t connect line wrong. Various connection lines do not press on the bolt port to
prevent damage of connection line.

GP-100 Service manual vers.1.4.3. p.24

 Figure 4.2.1

4.3 Sipper Pump Pipe Replacement

The whole view of sipper pump:

Adjust Screw
Clip Button

Pump Clip Bar

Pump Tube
Motor

Figure 4.3.1

1. Unscrew the adjust screw off the clip bar.

Clip Bar

Figure 4.3.2

GP-100 Service manual vers.1.4.3. p.25

 2. Open clip button, pump tube can be seen.

Clip Button

Pump Tube

Figure 4.3.3

3. Take out the pump tube, tear the belt, then the pump tube can be removed
from the white cuff.

Cable Tie
White Connector

Figure 4.3.4

4. Replace a new pump tube, tie the belt, and operate reservedly so that the
replacement can be completed.

4.4 Flow-cell Replacement

1. Open the cover of the flow-cell and lamp cover; you will see the flow-cell located in the
incubator.

Flow-cell

Figure 4.4.1

GP-100 Service manual vers.1.4.3. p.26

2. Pull out the sampling tube from the tube hole and then take out the flow-cell, put on the
clove and push out the sampling tube and transition tube from the bottom of steel tube.

Figure 4.4.2

3. Replace with a new flow-cell, following the reverse procedure. Be careful not to fold the
sampling tube.

NOTE:
The flow-cell should be installed in right direction. The side in the following left
picture should be facing the sampling tube; the other side should be facing the drain
tube.

Figure 4.4.3

4.5 Lamp Replacement

Turn off the instrument, open the cover of lamp, pull out power supply wire of lamp,
unscrew the screw ③ and ② then unscrews ①，take out the lamp from the holder.
The structure of lamp is showing in the following figure：

GP-100 Service manual vers.1.4.3. p.27

 ④

②
A
①
B
③
S

Figure 4.5.1

①． Fixing screw. Its function is to fix the lamp to holder of lamp

②． ③．Adjusting screw. Its function is to micro-adjust the location of lamp and intensity of
light (lamp)
④．Lamp wire

1. Replace a new lamp and install it to the holder, screw the screw①，but do not screw it
too firm, connect the lamp wire to power supply wire.
2. Screw the screws ②、③ ，but do not screw it too firm
3. Turn on the instrument and enter the main menu, select“ABS”; enter setting window,
set Wavelength as 340nm and Reading as 200 second，interval time 1 second. Then
aspirate distilled water to test.

Figure 4.5.2
4. Move the lamp forwards and backwards to maximize the tested AD value. The value is
in the small bracket (show as 2500…), which is displayed on the screen.
5. Use a screwdriver to screw the screws ① (not too firm).
6. Adjust screws ②、③，which enable the tested AD value is about 3500（2500—3900
is also permissible）, then to fasten screw ①.

GP-100 Service manual vers.1.4.3. p.28

 ABS
AD
D值

Figure 4.5.3

7. The adjustment of lamp finished. Turn off the instrument normally.

8. 2 minutes later, turn on the instrument, when the initialization finished. Press the
RINSE to rinse the flow cell with distilled water.
9. Now the instrument is ready for test.

4.6 Filter Replacement

1. Open the upper cover of GP-100，beware of the connection lines between upper cover
and main board.

Cassette

Fix Screw

Figure 4.6.1

2. Unscrew 2 fixed screws of filter cassette, and then take out the cassette (Figure 4.6.2).
At the same time, unfasten the 3 screws in the filter wheel (Figure 4.6.3).

Figure 4.6.2

GP-100 Service manual vers.1.4.3. p.29

 Figure 4.6.3 Figure 4.6.4

3. Screw out 2 screws and dismantle filter wheel motor (Figure 4.6.4).
4. Take out the filter wheel as showed in Figure 4.6.5. Filter is installed in the filter wheel
follow certain sequence (Figure 4.6.6).

Filter Wheel 670nm

340nm
546nm (A gap beside)

Figure 4.6.5 Figure 4.6.6

5. Select replacement needed filter, take out the fixed ring and filter carefully (Figure

4.6.7).

Filter

Fix Ring

Figure 4.6.7

6. Replace a new filter with same wavelength, fix it with cooper ring.
7. Reverse the above dismantling procedure, and the filter replacement is completed.

4.7 Photometer Detector Replacement

The function of photometer detector is to change the variable light signal into the
electric signal, and then calculated and process. It is the most important component in
the light path system.

GP-100 Service manual vers.1.4.3. p.30

 The replacement method is as follows.
1. Open upper cover of GP-100, and take out the filter cassette. The photometer
detector can be seen.
Screws with red gasket

Photometer Detector

Figure 4.7.1

2. Unscrew 3 screws with red gasket and draw outwards the photometer detector
board (Figure 4.7.2).

Figure 4.7.2

3. Replace a new photometer detector, connect power source line, screw the screws,
add cassette and equip with cassette.

Figure 4.7.3

4. Connect the other end of power source line in J5 of front board. The replacement
is finished. The signal receiver can work normally.

GP-100 Service manual vers.1.4.3. p.31

4.8 Front board Replacement

1. Open the upper cover of the instrument; you can see two boards (big and small) at
the bottom. The small board is the front board (Figure 4.8.1).

Figure 4.8.1

2. Unscrew four screws in the front board, pull out all plugs on the board carefully and
connect them to new board, operate reversely to finish the replacement.
Note:
There is a layer of glue in the plug, scrape the glue first when pull out
the plug; if you are not familiar with positions of plug, write down the
position first, in case of plug wrong.

4.9 Main Board Replacement

1. Open the upper cover of the instrument; you can see two boards (big and small) at
the bottom. The big board is the main board (Figure 4.9.1).

Figure 4.9.1

2. Unscrew four screws in the front board, pull out all plugs on the board carefully and
connect them to new board, operate reversely to finish the replacement.

GP-100 Service manual vers.1.4.3. p.32

 Note:
There is a layer of glue in the plug, scrape the glue first when pull out
the plug; if you are not familiar with positions of plug, write down the
position first, in case of plug wrong.

4.10 Power Supply Assembly Replacement

1. Open the upper cover of the instrument; you can see the power supply assembly
as follow.

Screw

Screw

Figure 4.10.1

2. Pull out all lines connected in the front board and main board; unscrew two fixed
screws in figure 4.10.1, and replace with a new board and operate reversely to
finish the replacement.

4.11 LCD Replacement

1. Open upper cover and turn it over (Figure 4.11.1).

Figure 4.11.1

GP-100 Service manual vers.1.4.3. p.33

 2. Pull out the plug of data cable and power line from transition board to LCD. Buckle
in the plug of LCD data cable can be broken easily, so you have to operate
carefully.
3. Take out fixture block as it shows in Figure 4.11.2 and take out the LCD.

Figure 4.11.2

4. Unscrew 4 screws to open the LCD display assembly.

Data Cable

Power Lines

Figure 4.11.3

5. Cut the 2 power lines showed in Figure 4.11.3, pull out data cable and unscrew 4
fixed screws. The LCD can be taken out.
6. Replace with a same model LCD; operate reversely to finish the replacement.

4.12 Transition Board Replacement

1. Open the upper cover and turn it over (Figure 4.12.1).

Figure 4.12.1

GP-100 Service manual vers.1.4.3. p.34

 2. Pull the lines and plugs out carefully and unscrew screws to replace the transition
board with a new one. Operate reversely to finish the replacement.

4.13 Peltier Replacement

1. Open the upper cover and the optical assembly can be seen as follow (Figure
4.13.1).

Incubator

Peltier

Thermal discharge
Slices and Fan

Figure 4.13.1

2. Changing the peltier, you need to dismantle the whole optical assembly. Turn over
the instrument and unscrew 4 screws as showed in Figure 4.13.2 to dismantle
optical assembly.

Figure 4.13.2

3. After you take out the optical assembly, unscrew 2 screws showed in Figure 4.13.3,
you will find the peltier (Figure 4.13.4).

GP-100 Service manual vers.1.4.3. p.35

 Peltier

Figure 4.13.3 Figure 4.13.4

4. Replace a new peltier with same model and operate reversely to finish the
replacement.

NOTE:
While changing the peltier, pay attention to the direction of two lines
(black and red) and do not connect wrong. The peltier should be lain
on a layer of silicone evenly.

4.14 Temperature Sensor Replacement

1. Open upper cover of GP-100 and unscrew 4 screws of optical assembly at the
bottom of instrument and take out the optical assembly.
2. Unscrew 1 screw showed in Figure 4.14.1 to take out the incubator. The
temperature sensor is fixed on it.

Figure 4.14.1

3. Cut the cable tie of temperature sensor and pull it out (Figure 4.14.2).

GP-100 Service manual vers.1.4.3. p.36

 Incubator

Temperature
Sensor

Figure 4.14.2

4. Replace a new temperature sensor with same model and operate reversely to
finish the replacement.

NOTE:
Before replace the temperature sensor back, make sure there is
silicone in the hole for good heat conduction.

4.15 Peltier Fan Replacement

1. Open upper cover of GP-100 and unscrew 4 screws of optical assembly at the
bottom of instrument and take it out.
2. Unscrew 2 screws at the bottom of optical assembly (Figure 4.15.1).

Figure 4.15.1

3. Replace a new peltier fan with same model and operate reversely to finish the
replacement.

4.16 Printer Driver Board Replacement

1. Open upper cover and turn it over, you can see the printer driver board (Figure
4.16.1).

GP-100 Service manual vers.1.4.3. p.37

 Figure 4.16.1

2. Pull the connected lines out carefully and unscrew the fixed screws to take out the
board.
3. Replace a new printer driver board with same model and operate reversely to
finish the replacement.

4.17 Internal Printer Replacement

1. Open upper cover, you can see the internal printer (Figure 4.17.1).

Internal Printer

Printer Driver Board

Figure 4.17.1 Figure 4.17.2

2. Pull the connected lines out carefully and unscrew the fixed screws to take out the
internal printer.
3. Replace a new printer with same model and operate reversely to finish the
replacement.

NOTE:
There are two kinds of internal printer. Pinter in Figure 4.17.1 has two
fixed screws, the other only has 1 fixed screw.

GP-100 Service manual vers.1.4.3. p.38

Chapter 5 Daily Maintenance

5.1 General Introduction

GP-100 is a precise clinical analyzer. To keep the instrument in a good condition, daily
maintenance shall be performed. The maintenance of GP-100 is simple, but it shall be
done earnestly and carefully.

5.2 Clean the instrument

5.2.1 Clean outer surface of instrument

⚫ Keep the working environment of instrument clean.

⚫ Use neutral detergent and wet cloth to clean the surface of the instrument
⚫ Please clean the LCD with soft cloth

Warning：Please keep this instrument away from any organic solvent,

grease or corrosive substance.

5.2.2 Clean the flow-cell

The cleanness of flow-cell must be kept to ensure the accuracy and reliability of test
results.
1. Outer cleaning
a、Place flow-cell according to requirements.
b、If the outer flow-cell is polluted, use soft cloth with alcohol to clean it softly.
2. Inside cleaning
a) Put distilled water under the aspirate tube, press RINSE key to start continuous
cleaning function. Press RINSE key again to stop cleaning. Generally, the cleaning
takes half a minute.
b) Detergent, dilute HCL (0.1N), dilute Tween 20 liquid (2-3drop/L) can be used to
clean flow-cell. Push RINSE key to aspirate detergent, press RINSE key again to
stop. Keep the detergent stay in flow-cell for 5 minutes, and then clean the
flow-cell with distilled water for 1 minute. If it cannot clean well once, detergent
should be used to clean twice.
The flow-cell shall be cleaned in the following situation:
⚫ The water blank value’s deviation is too large when power on the
instrument.
⚫ Change test item.
⚫ Power off the instrument.

Warning：Do not let reagent and other pollutant in the flow-cell for a long time.

GP-100 Service manual vers.1.4.3. p.39

Chapter 6 Trouble Shooting List

Malfunction Solution
Time pop up randomly, date can not 1. Battery power is used out, replace another battery.
be saved after change.

ABS value is negative 1. Flow-cell is dirty or has bubble inside, clean it.
2. Air is aspirated when first turned on, turn it off and
power on again to aspirate.
1. The flow-cell has not been inserted to bottom.
“Absorbency deviation is too big, 2. Liquid has been aspirated or air is aspirated,
retry?” pop up after power on the aspirate distilled water again.
instrument. 3. Light intensity of lamp is low, change the lamp.
4. Flow-cell is dirty and easy to get bubble or flow-cell
is damaged, clean or replaces flow-cell.
5. Photometer detector is damaged, replace it.

1. The factor is 0 or no factor, such as factor does not

No test results been input in the kinetic method, standard has not
been set in End-point method and Two-point
method, or the standard was set but haven’t get the
factor in the calibration.
2. Reagent blank value is too high, retest reagent
blank.
1. The parameter is not right, re-input as needed.
2. The aspirate volume is too low and air is aspirate,
increase the volume.
The test result is not repeatable and 3. Volume of adding sample is not accurate.
there is great deviation in results. 4. Reagent is polluted or overdue.
5. Flow-cell is dirty and easy to get bubble or flow-cell
is damaged, clean or replaces it.
6. Lamp is aged, replace it.
7. Filter is aged, replace the filter.
8. Photometer detector is damaged, replace it.
9. Front board is damaged, replace it.

1. There is dust in light path, clean it.

2. Lamp is in the wrong position, readjust it.
Low AD value 3. Check whether the lamp or filter is aged, change if
necessary.
4. Photometer detector is damaged, replace it.
1. Lamp is not stable or damaged, replace it.

GP-100 Service manual vers.1.4.3. p.40

 2. Flow-cell is dirty and easy to get bubble or flow-cell
is damaged, clean or replaces it.
AD value not stable 3. Filter is aged or damaged, replace the filter.
4. Photometer detector is damaged, replace it.
5. Check J5 on front board, if its voltage is not +15V or
-15V, replace it.
Indicator is off, fan doesn’t work and 1. Power switch is damaged, replace it.
black screen 2. Fuse is damaged, replace it.
3. Power supply is damaged, replace it.
Indicator is on, but black screen and 1. Power supply is damaged, replace it (voltage of J3
no enable system sound. is 5V, J10 is 5V, 6V, 0V, and J11 12V, 5V, 0V).
2. Software is defective, reinstall software.
3. Main board is damaged, replace it.
Indicator is on and enable system 1. LCD cable is not connected well or damaged,
sound is heard, but black screen reconnect or replace it.
2. Dc-to-ac inverter is damaged, replace it.
3. LCD is damaged, replace it.
4. Main board is damaged, replace it.
1. LCD cable is not connected well or damaged,
Disorder screen reconnect or replace it.
2. Main board is damaged, replace it.
1. J11, J8 in front board plug has poor connection,
reconnect it.
Temperature control fails 2. U10 is invalid welding or damaged, re-welding or
replace it.
3. The peltier is damaged（it shall be 4 ohm in empty
load）, change it.
4. Temperature sensor is damaged, replace it.

1. Sampling tube is fold or blocked, change it.

2. Flow-cell is blocked or damaged, clean or replace it.
The pump does not aspirate liquid. 3. Sipper pump tube is broken, replace it.
4. Sipper pump motor is damaged, replace it.
5. Front board is damaged, replace it.

1. The sleeve of light sensor of receiver is too long,

use scissors to shear it.
It is reported that “please check 2. Check if the positioning light coupling is damaged,
whether the filter wheel is in normal replace the positioning light coupling.
operation.” When power on. 3. Check whether the L297, L298, 5804LB on the front
board is damaged or not，change it if there is any.
4. Filter wheel motor is damaged, replace it.

1. Add attenuation plate or adjust position of lamp.

GP-100 Service manual vers.1.4.3. p.41

AD value is 4095 2. The filter wheel does not rotate in right place, fix the
filter wheel, check the light coupling, adjust position
of light coupling or replace it
1. Check in system setting, whether the internal printer
is selected.
Internal printer can not print. 2. Data cable between printer driver board and printer
is loosen or damaged, reconnect or replace it.
3. Printer driver board is damaged, replace it.
4. Internal printer is damaged, replace it.
5. IC ST16C552 of main board is damaged.
1. Check in system setting, whether the external
printer is selected.
External printer can not print. 2. Open the instrument first, and then the printer.
3. Pinter cable is damaged, change it.
4. External printer is damaged, replace it.
5. IC ST16C552 of main board is damaged.
1. Adjust factor of pump in back door.
Aspirate volume of sipper pump is not 2. Check whether sampling tube and pump tube is
correct. damage.
3. Adjust screw is screwed too tight or too loose.
1. Check whether the pump is in normal operation.
2. Check the connections of aspirate tube and flow-cell
There is no liquid in flow-cell. port etc.
3. The aspirate tube is too long or too short.
4. The aspirate tube may be blocked, clean it.
5. Flow-cell is dirty, clean it.
The absorbing volume of flow-cell is 1. Check whether the aspirate tube is blocked or not.
not constant. 2. Pump tube is damaged, replace it.
When break line and set standard in 1. Check whether standard reagent is aspirate
end-point method，it is reported that correctly. Please exit the standard setting procedure
“standard set error” and then enter again to reset the standard.
______________________________________________________________

Note：
This manual may contain other ownership declaration and copyright
information. Its articles shall be observed and abided by. The
information in the manual may have inaccurate parts in technology
and printing error.
The manual can be revised or upgraded without additional notice
Greiner also can improve/revise the product/program described in the
material at any time without additional notice.
_______________________________________________________________________________

GP-100 Service manual vers.1.4.3. p.42