Syllabus ２０２２

Faculty of Pharmaceutical Sciences

Tohoku University
 INDEX
◆Basic Educational Subjects
◇Lecture
1st Semester
Introduction to Pharmaceutical Sciences 1 …………………………………… 1
Functional Morphology 1 …………………………………… 3
nd
2 Semester
Organic Chemistry 1 …………………………………… 5
Organic Chemistry 2 …………………………………… 7
Analytical Chemistry 1 …………………………………… 9
Physical Chemistry 1 …………………………………… 11
Functional Morphology 2 …………………………………… 13
Biochemistory 1 …………………………………… 15
rd
3 Semester
Introduction to Pharmaceutical Sciences 2 …………………………………… 17
Organic Chemistry 3 …………………………………… 19
Pharmacognosy 1 …………………………………… 21
Physical Chemistry 2 …………………………………… 23
Biochemistory 2 …………………………………… 25
Biochemistory 3 …………………………………… 27
Pharmacology 1 …………………………………… 29
Pharmacology 2 …………………………………… 31
Pharmaceutics 1 …………………………………… 33
4th Semester
Organic Chemistry 4 …………………………………… 35
Organic Chemistry 5 …………………………………… 37
Pharmacognosy 2 …………………………………… 39
Analytical Chemistry 2 …………………………………… 41
Radiochemistry …………………………………… 43
Structural Chemistry …………………………………… 45
Biochemistory 4 …………………………………… 47
Molecular Biology …………………………………… 49
Pharmacology 3 …………………………………… 51
Health Chemistry 1 …………………………………… 53
Pharmaceutics 2 …………………………………… 55
th
5 Semester
Medicinal Chemistry 1 …………………………………… 57
Organic Reaction …………………………………… 59
Analytical Chemistry 3 …………………………………… 61
Physical Chemistry 3 …………………………………… 63
 Pharmacology 4 …………………………………… 65
Environmental Health Science …………………………………… 67
◇Training
4th Semester
General Training in Analytical Chemistry …………………………………… 69
General Training in Physical Chemistry …………………………………… 71
General Training in Organic Chemistry 1 …………………………………… 73
5th Semester
General Training in Organic Chemistry 2 …………………………………… 75
General Training in Life Sciences …………………………………… 77
General Training in Biopharmacy and Pharmacy Practice …………………… 79

◆Department of Pharmaceutical Sciences

（Advanced Educational Subjects / Researcher Educational Subjects）
◇Lecture
6th Semester
Natural Products Chemistry …………………………………… 81
Organic Synthesis …………………………………… 83
Medicinal Chemistry 2 …………………………………… 85
Structure Analysis of Organic Compound …………………………………… 86
Principles of Clinical Medicine …………………………………… 88
Drug Design and Development …………………………………… 90
Imaging Diagnosis …………………………………… 92
Pharmaceutic Laws 1 (It is also taught for students of Department of Pharmacy.)
…………………………………… 94
◇Training
6th Semester Advance Training in Pharmaceutical Sciences ………………… 96
◇Research
7th/8th Semester Research Training …………………………………… 97

◆Department of Pharmacy（Advanced Educational Subjects / On-site Training subjects /

Researcher Educational Subjects ）
◇Lecture
6th Semester
General Introduction to Various Forms of Illness ………………………… 98
Pharmacostatistics …………………………………… 100
Immunology …………………………………… 101
Food Hygiene and Safety …………………………………… 103
 Infectious Diseases …………………………………… 105
Pathology …………………………………… 107
Human Genomics …………………………………… 110
Bioorganic Chemistry …………………………………… 111
th
7 Semester
Health Chemistry 2 …………………………………… 113
Fundamentals of Practical Pharmacy …………………………………… 115
Pharmacotherapeutics 1 …………………………………… 118
Medical Informatics …………………………………… 120
Kampo Medicine …………………………………… 122
Clinical Pharmacology …………………………………… 124
Clinical Pharmaceutics …………………………………… 126
Prescription Analysis …………………………………… 128
th
8 Semester
Pharmacotherapeutics 2 …………………………………… 130
Pharmacotherapeutics 3 …………………………………… 132
Clinical Laboratory Medicine …………………………………… 134
Pharmaceutic Laws 2 …………………………………… 136
Non-Prescription Medications and Care …………………………………… 138
Clinical Communication Skills …………………………………… 140
Pharmaceutical English …………………………………… 141
◇Training
6th Semester Advance Training in Pharmacy 1 ………………………………… 142
7th / 8th Semester Advance Training in Pharmacy 2 …………………………… 143
8th Semester Basic Training in Biopharmacy and Pharmacy Practice ……… 144
9th Semester Pharmacy Practice in hospital …………………………………… 146
8th / 9th Semester Pharmacy Practice in Community ………………………… 147
◇Practice
8th Semester General Training in Biopharmacy and Pharmacy Practice 1 … 148
8th Semester General Training in Biopharmacy and Pharmacy Practice 2 … 149
12th Semester Practice in Pharmaceutical sciences …………………………… 150
◇Research
10th / 11th / 12th Semester Research Training ………………………………… 151

◆Appendix
◇Subjects of General Education（Pharmaceutical Basics）
1st / 2nd Semester
Chemistry A …………………………………… 152
Chemistry B …………………………………… 154
Chemistry C …………………………………… 156
Biology A …………………………………… 158
 Subject Introduction to Pharmaceutical Sciences 1

Course Numbering YAL-PHA201J Categories Required

Preferable
1st Semester 1 Credits 2
Participants
Profs. Nakabayashi Takakazu, Tokuyama Hidetoshi, Yoshikai Naohiko, Doi
Takayuki, Konno Tomohiro, Asai Teigo, Saito Yoshiro, Matsuzawa Atsushi,
Instructor
Kurata Shoichiro, Sasaki Takuya, Oe Tomoyuki, Akita Hidetaka, Mano
Nariyasu, Takahashi Nobuyuki, and Tomioka Yoshihisa
Practical business
Learn that science of medicine is made up of research in a wide field. In addition,
the prospect of the research field of its own to learn pharmaceutical sciences and
Objectives and
pharmacy in the near future, to understand the importance of learning courses
summary of class
to learn at the university in the future. This class is to be learned as part of
introduction of pharmaceutical education.
Outlook a wide discipline in the future study at Faculty of Pharmaceutical
Goal of study Sciences, to understand the importance of learning a wide range of specialized
subjects.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

1 Nakabayashi Introduction(1) Class guidance, Drug and light

2 Tokuyama Introduction(3) Drug and molecular structure

3 Yoshikai Introduction(3) Drug and chemical synthesis

4 Doi Introduction(4) Drug design

5 Konno Introduction(5) Medicine and biomaterials

6 Asai Introduction(6) Drug produced by organisms

7 Saito Introduction(7) Medicine and metabolism

8 Matsuzawa Introduction(8) Medicine and mechanism of cellular stress

9 Kurata Introduction(9) Drug and biological function

10 Sasaki Introduction(10) Pharmacological effects

11 Oe Introduction(11) Measurement of drug

12 Akita Introduction(12) Safety and control of kinetics (DDS) of drug

Analysis in biomedical science at the pharmaceutical
13 Mano Introduction(13)
department in hospital
14 Takahashi Introduction(14) Journey of Medicines to get prescribed

15 Tomioka Introduction(15) Medicines and diseases

Record and evaluation
Evaluated by report (70%) and class performance (30%)
method
Textbook Not specified

Reference
 Preparation About the special field and research content of each professor in charge of the
and Review class, prepare at the laboratory homepage.
Language Used in
Japanese
Course
Office hours Make an advance appointment via e-mail or other means. (See student handbook)

In addition
 Subject Functional Morphology 1
Course
YAL-PHA231J Categories Elective
Numbering
Preferable
1st Semester 1 Credits 2
Participants
Instructor Professor Hirasawa Noriyasu

Practical business
Objectives and This course provides students with basic knowledge about human body. Functional
summary of class Morphology 1 covers cells and tissues, respiratory systems, and digestive systems.
Students can explain the structures and functions of organelle in cells, blood cells,
Goal of study
hematopoiesis, and organs in respiratory system and digestive system.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students understand the significance to study functional
Structure of human
1 Hirasawa morphology in Pharmaceutical sciences. In this course,
body
students learn the outline of organs and their locations.
Structure and Students learn the outline of cells and the structure and
2 Hirasawa
functions of Cells (I) function of cell membrane.
Structure and
3 Hirasawa Students learn structures and functions of organelle.
functions of Cells (II)
Structure and
4 Hirasawa Students learn cytoskeleton, cell cycle and cell adhesion.
functions of Cells (III)
Blood and Students learn types of blood cells and their functions, and
5 Hirasawa
hematopoiesis hematopoiesis and differentiation of blood cells.
Students learn structure and function of lymph node, spleen
6 Hirasawa Lymphatic system
and thymus.
7 Hirasawa Epithelial tissue Students learn the structure and function of epithelial cells.
Students learn the structure and function of connective
8 Hirasawa Connective tissue
tissues.
Students learn the structure and function of respiratory
9 Hirasawa Respiratory system
system.
Students learn outline of digestive system, and basic
10 Hirasawa Digestive system
structures of digestive tracts.
11 Hirasawa Stomach Students learn the structure and function of stomach.
Small intestine and Students learn the structure and function of small and large
12 Hirasawa
large intestine intestines.
13 Hirasawa Liver (I) Students learn outline of liver and its functions.
Students learn the micro-structures of liver and the relation
14 Hirasawa Liver (II)
to the functions.
15 Hirasawa Pancreas Students learn the structure and function of pancreas.
Record and
evaluation Students are evaluated on the final examination (100%).
method
Textbook Materials are provided via ISTU.

Reference
Preparation
and Review
Language Used in
Japanese
Course
Questions are accepted at any time. Make an advance appointment via e-mail or other
Office hours
means.
In addition
 Subject Organic Chemistry 1
Course
YAL-PHA221J Categories Elective
Numbering
Preferable
1st Semester 2 Credits 2
Participants
Instructor Associate Professor Masaatsu Adachi and Assistant Professor Kosuke Ohsawa
In this course, students will understand basic concepts of organic chemistry
following Chemistry C of the General Education in which atomic orbitals, molecular
orbitals, and the theory of chemical bonding are introduced. This course covers
Objectives and
stereochemistry for spatial understanding of molecular structure. Students will also
summary of class
learn about substitution reactions (S N 1 and S N 2 reactions) and elimination
reactions (E1 and E2 reactions) of alkyl halides based on the fundamental theory of
chemical reactions.
The aim of this course is to help student explain the meaning of basic terms for
stereochemistry with specific examples.
The aim of this course is to help student explain the organic reactions based on
thermodynamic and kinetic point of view.
The aim of this course is to help student explain characteristics, reaction
Goal of study mechanisms, stereochemical outcomes, and factors affecting reactions regarding
substitution reactions with alkyl halides (S N 1 and S N 2 reaction).
The aim of this course is to help student explain characteristics, reaction
mechanisms, stereochemical outcomes, competition with substitution reactions, and
factors affecting reaction regarding elimination reactions with alkyl halides (E1 and
E2 reaction).
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Stereochemis Students will learn about classification of isomers and concept of
1 Adachi
try (1) stereogenic center.
Stereochemis Students will learn about stereogenic center of cyclic compounds and
2 Adachi
try (2) rules to define absolute configuration (R and S).
Stereochemis
3 Adachi Students will learn about diastereomers and meso compounds.
try (3)
Stereochemis Students will learn about technical terms of optical activity, optical
4 Adachi
try (4) purity, and enantiomeric excess.
Understandi
Students will learn about category of organic reaction, writing style of
5 Adachi ng of organic
chemical equation, and bond-dissociation energy.
reactions (1)
Understandi
Students will learn about organic reactions from thermodynamic point
6 Adachi ng of organic
of view.
reactions (2)
Understandi
Students will learn about organic reactions from kinetic point of view,
7 Adachi ng of organic
and learn about catalysts and enzymes.
reactions (3)
Substitution
reaction with Students will learn about properties, structures, nomenclature of
8 Adachi
alkyl halides alkyl halide and concept of nucleophilic substitution reaction.
(1)
Substitution
Students will learn about category of nucleophilic substitution
reaction with
9 Adachi reactions (S N 1 and S N 2 reaction) and reaction mechanisms of S N 2
alkyl halides
reaction.
(2)
 Substitution
reaction with
10 Adachi Students will learn about reaction mechanisms of S N 1 reaction.
alkyl halides
(3)
Substitution
reaction with
11 Adachi Students will learn about factors affecting S N 1 and S N 2 reactions.
alkyl halides
(4)
Elimination
reaction with Students will learn about concept of elimination reactions, and
12 Ohsawa
alkyl halides structure and physical property of elimination products, alkenes.
(1)
Elimination
reaction with Students will learn about reaction mechanism of E2 reaction and
13 Ohsawa
alkyl halides factors affecting mechanisms of E2 reaction.
(2)
Elimination
reaction with Students will learn about reaction mechanisms of E1 reaction and
14 Ohsawa
alkyl halides factors affecting mechanisms of E1 reaction.
(3)
Elimination
Students will learn about relationships between E2 reaction and
reaction with
15 Ohsawa stereochemistry, and factors determining course of reactions (S N 1,
alkyl halides
S N 2, E1, or E2 reaction).
(4)
Record and
evaluation Evaluated mainly by examination (80%) and class performance (20%)
method
Textbook ‘Organic Chemistry — 5th edition’ J. G. Smith

Reference
Prepare for the textbook before attending the lecture. In addition, after the lecture,
Preparation
review the content of the lecture and solve the end-of-chapter problems to deepen
and Review
your understanding.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means before students will visit
Office hours office.
E-MAIL: TEL: [email protected], [email protected]
In addition Conducted exercises and SGD every time
 Subject Organic Chemistry 2
Course
YAL-PHA222J Categories Elective
Numbering
Preferable
1st Semester 2 Credits 2
Participants
Instructor Professor Hidetoshi Tokuyama and Assistant Professor Juri Sakata
In the organic chemistry 2, studied are 1) the structure, property and reaction of
alcohols, ethers, and epoxides; 2) the structure, property and reaction of alkenes and
Objectives and
alkynes; 3) basis of multistep synthesis. Reactions include hydrogenation and
summary of class
oxidation of alkenes and alkynes along with radical reactions, which are
fundamental expertises of medicinal chemistry.
To be able to explain structure, nomenclature, chemical property, and reaction of
alcohols, ethers, and epoxides
To be able to explain structure, nomenclature, and property of alkenes and alkynes
To be able to explain mechanism, selectivity, and stereochemistry of alkene and
Goal of study
alkyne addition reactions
To be able to explain C-C bond forming reaction using acetylide
To be able to explain reduction and oxidation reactions
To be able to explain radical halogenation reaction
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Alcohol,
Tokuyama Structure, property, and nomenclature of alcohols, ethers, and
1 ether, and
Sakata epoxides
epoxide 1
Alcohol,
Tokuyama
2 ether, and Synthesis of alcohols, ethers, and epoxides
Sakata
epoxide 2
Alcohol,
Tokuyama
3 ether, and Reaction of alcohols
Sakata
epoxide 3
Alcohol,
Tokuyama
4 ether, and Reaction of ethers and epoxides
Sakata
epoxide 4
Tokuyama
5 Alkene 1 Structure, property, and nomenclature of alkenes
Sakata
Tokuyama
6 Alkene 2 Addition reaction of hydrogen halide, water, and halogen to alkenes
Sakata
Tokuyama
7 Alkene 3 Alkene hydroboration and oxidation
Sakata
Tokuyama
8 Alkyne 1 Structure, property, and nomenclature of alkynes
Sakata
Tokuyama
9 Alkyne 2 Addition to alkynes
Sakata
Tokuyama
10 Alkyne 3 C-C bond formation using acetylides and multiple step synthesis
Sakata
Oxidation
Tokuyama
11 and Hydrogenation of alkenes and alkynes
Sakata
reduction 1
Oxidation
Tokuyama
12 and Oxidation of alkenes, alkynes, and alcohols
Sakata
reduction 2
Tokuyama Radical
13 Structure of radical and alkane radical halogenation
Sakata reaction 1
 Tokuyama Radical
14 Stereochemistry of radical reaction
Sakata reaction 2
Radical
15 Yoshikai Halogenation at the allylic position
reaction 3
Record and
evaluation Evaluated mainly by examination (80%) and class performance (20%)
method
Textbook ‘Organic Chemistry — 5th edition’ J. G. Smith

Reference
Preparation
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected], [email protected]
In addition
 Subject Analytical Chemistry 1
Course
YAL-PHA211J Categories Elective
Numbering
Preferable
1st Semester 2 Credits 2
Participants
Instructor Professor Oe Tomoyuki

Practical business
Medicinal drugs are used to cure, treat, or prevent diseases. The qualities should be
assured to avoid adverse reactions and are strictly controlled by low. Therefore, reliable
Objectives and analytical methods are required to monitor the impurities, contents of the ingredients,
summary of class etc. This course covers quantitative drug analyses in Japanese Pharmacopoeia, 16th
Ed (JP16) and aims to help students understand the concept of quantitative
analysis.
Better understanding of chemical equilibrium to explain/calculate pH values of
Goal of study solutions and buffer solutions. Better understanding of gravimetric and volumetric
analyses to quantitate chemicals.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction: Overviewing analytical chemistry: How to contribute in
1 Oe
analytical chemistry pharmaceutical sciences
Overview: Overviewing quantitative drug analysis in JP16, in terms of
2 Oe quantitative analysis the technical terms, reagents, apparatus, and handling of
of drugs analytical data
Weighing scale and Learning about the principle of weighing scales to understand
3 Oe
gravimetric analysis the basis of gravimetric analysis
Overview: volumetric Overviewing volumetric analysis: categorization, operation,
4 Oe
analysis and preparation/standardization of standard solutions
Learning about the definition of “acid and base”, and chemical
5 Oe Acid-base titration I
equilibrium to understand acid-base titration
Learning how to calculate pH value of acid, base, and salt
6 Oe Acid-base titration II
solutions
Learning about Henderson–Hasselbalch equation to
7 Oe Acid-base titration III
understand how buffer solution can work
8 Oe Acid-base titration IV Learning about acid-base titrations appeared in JP17
Learning about typical acid-base titrations and redox titration
9 Oe Non-aqueous titration
(Karl Fisher method) performed in non-aqueous solution
Chelatometric Learning about coordination complex to understand
10 Oe
titration I Chelatometric titrations
Chelatometric
11 Oe Learning about chelatometric titrations appeared in JP16
titration II
Learning about Fajans–Paneth–Hahn Law and examples in
12 Oe Precipitation titration
JP17
Learning about the definition of “oxidation and reduction”, and
13 Oe Redox titration I
Nernst equation to understand redox titration
Learning about typical redox titrations (iodometry, iodimetry,
14 Oe Redox titration II
and permanganometry) appeared in JP16
15 Oe Practice
Record and
evaluation Based on the written exam
method
Analytical Chemistry I (パートナー分析化学 I), 4th Ed., Ed. J. Haginaka, K. Kato,
Textbook
Nankodo Co., Ltd., 2021 (ISBN 978-4-524-40384-4)
 Quantitative analysis (図解とフローチャートによる定量分析), Ed. S. Asada, S. Uchide,
M. Kobayashi, Gihodo Shuppan Co., Ltd., 1987 (ISBN 4-7655-0342-9)
Basic reactions in analytical chemistry (分析化学反応の基礎), Ed. The Japan Society for
Analytical Chemistry, Hokkaido Branch and Tohoku Branch, Baifukan Co., Ltd., 1994
(ISBN 4-5630-4535-7)
Quantitative drug analysis (定量薬品分析), Ed. T. Momose, Hirokawa Publishing Co.,
Reference
Ltd., 1989 (ISBN4-567-25204-7)
Experimental analytical chemistry ( 新 分 析 化 学 実 験 ), Ed. The Japan Society for
Analytical Chemistry, Hokkaido Branch and Tohoku Branch, Kagaku-Dojin Publishing
Co., Inc., 1989 (ISBN 4-7598-0199-5)
Quantitative analytical chemistry (定量分析化学), Ed. S. Kawai, T. Kinoshita, A. Tsuji,
and M. Watanabe, Maruzen Co., Ltd., 1993 (ISBN 4-6210-3111-2)
Preparation
and Review
Language Used in
Japanese
Course
An appointment required by E-mail ([email protected]) or phone
Office hours
(795-6817).
In addition
 Subject Physical Chemistry 1

Course Numbering YAL-PHA214J Categories Elective

Preferable
1st Semester 2 Credits 2
Participants
Instructor Associate Professor Kajimoto Shinji

Practical business
In this course, students will understand the nature and structure of molecules on
the basis of quantum theory. Molecular science is increasingly becoming
Objectives and important in the fields of analysis and development of drugs. This course covers
summary of class from the introduction to molecular orbital theory to the structural analysis of
molecules by using electronic spectra. Completion of “Physical Chemistry 1” is
important for understanding “Structural Chemistry” that is held at Semester 4.
(1) This course helps students understand molecular orbital method and obtain
wave functions and their energy levels of σ orbitals of hydrogen molecule and π
orbitals of ethene and butadiene by calculation.
(2) Students will understand the difference between bonding and antibonding
molecular orbitals based on the wave functions.
Goal of study (3) Students will be able to determine whether an electronic transition is allowed
or forbidden based on the symmetry of molecular orbitals.
(4) Students will be able to explain electronic transitions such as π−π*, n-π* and
d-d transition.
(5) Students will learn about the principles, measurements and applications of
ultraviolet (UV)-visible absorption, fluorescence and circular dichroism.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students will obtain molecular orbitals (MOs) of
Molecular orbital
1 Kajimoto hydrogen molecule using one electron approximation,
method (1)
LCAO MO approximation and variational calculus.
Students will obtain wave functions and energy levels of
Molecular orbital π orbitals of ethene and butadiene by the simple Hückel
2 Kajimoto
method (2) method, and understand the electronic ground and
excited states of these molecules.
Students will understand the effects of the π bond
formation and the conjugation of double bonds on the
Molecular orbital stabilization of the ground state of molecules with double
3 Kajimoto
method (3) bonds. Extension of the conjugated system lowers the
energy of the HOMO-LUMO gap to give a UV-visible
absorption at longer wavelength.
Students will be able to find symmetry operations of
Molecular symmetry molecules. Students will understand that a complete set
and group theory (1) of symmetry operations of a molecule forms a point group.
4 Kajimoto
Symmetry operation Students will study the relationship between molecular
and Point group symmetry and properties of some organic and inorganic
molecules.
Molecular symmetry A symmetry operation can be mathematically expressed
and group theory (2) by a matrix called representation. Students will
5 Kajimoto
Representation and understand properties of the character which is the sum
character of the diagonal elements of representation matrix.
Molecular symmetry Students will be able to block-out a reducible
6 Kajimoto and group theory (3) representation to irreducible representations by using a
Character table character table.
Symmetry of Students will be able to estimate the symmetry of MOs
7 Kajimoto
electronic states and electronic states of ethene and butadiene.
 Allowed and Students will learn a method to judge an electronic
8 Kajimoto forbidden electronic transition is allowed or not based on the symmetry of MOs
transitions and the electronic states.
Students will understand (1) various electronic
Various electronic transitions such as π-π* and n-π* transition and (2)
9 Kajimoto
transitions solvent effects on the energy levels of electronic states and
absorption spectrum of molecules.
Students will be able to judge electronic transitions of
Electronic states and
various molecules such as benzene and formaldehyde are
10 Kajimoto absorption spectrum
allowed or not. The obtained results are compared to
of various molecules
absorption spectra of the molecules.
Students will understand that the colour in transition
Absorption spectra of metals is due to the splitting of the d orbitals into different
11 Kajimoto
metal complexes energy levels by the ligand field and electronic transitions
between the d orbitals (d-d transition).
An electronic transition involves the simultaneous
changes in electronic and vibrational energy levels of a
Franck–Condon molecule (vibronic transition). Students will be able to
12 Kajimoto
principle explain the intensities of the vibronic transitions and the
shape of an absorption band based on the Franck–Condon
principle.
Students will understand the relaxation process for
Fluorescence and
13 Kajimoto fluorescence or phosphorescence emission after the
phosphorescence
excitation of a molecule.
Application of Electronic spectra can provide information on the
electronic spectra (1) molecular structure. Students will learn about the
14 Kajimoto
absorption and principles, measurements and applications of UV-visible
emission absorption and fluorescence spectra.
Application of
Students will understand why optically active chiral
15 Kajimoto electronic spectra (2)
molecules show optical rotation and circular dichroism.
circular dichroism
Record and Students are evaluated on the final examination (about 70%) and all the small
evaluation method tests (about 30%).
Textbook
Atkins' Physical Chemistry (10th edition), Peter Atkins and Julio de Paula,
Reference
Oxford University Press, ISBN: 978-0199697403.
Preparation The session time is limited and therefore self-directed learning is important.
and Review Students are required to prepare and review for each class.
Language Used in
Japanese
Course
Students are welcome to visit the office (taking an appointment by e-mail is
Office hours
recommended). E-MAIL: [email protected]
In addition
 Subject Functional Morphology 2

Course Numbering YAL-PHA232J Categories Elective

Preferable
1st Semester 2 Credits 2
Participants
Instructor Takahashi Nobuyuki, Sato Emiko, Takuya Sasaki, Nariko Arimura

Practical business 〇
In this course, students will understand the functional morphology of
cardiovascular system, kidney and urinary tract system, endocrine system, central
and peripheral nerve system, sensory organs, and musculoskeletal system.
Objectives and
Students will also understand the mechanisms of homeostatic maintenance
summary of class
through interactions of organ systems. Together with Functional Morphology 1,
this course provides basic knowledge for students to study pathophysiology and
pharmacotherapeutics in advanced courses.
This course is designed to help students understand the structure and functional
Goal of study role of cardiovascular system, kidney and urinary tract system, endocrine system,
central and peripheral nerve system, sensory organs, and musculoskeletal system.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Blood circulation is essential for life. Students will learn the roles
1 Takahashi Cardiovascular 1 heart, arteries and veins together with the mechanisms of their
maintenance in relation to common diseases.
The purpose of this class is to help students understand the
anatomy of heart and its supplying vessels (coronary arteries),
2 Takahashi Cardiovascular 2
conduction system, electrocardiography, ischemic heart disease,
arrhythmia, and blood pressure regulation.
The kidney filtrates blood and produces urine to control the
amount of body water, electrolytes, and acid-base balance.
3 Takahashi Kidney 1
Students will learn structure and function of nephron, a unit of
kidney function.
The purpose of this class is to help students understand
4 Takahashi Kidney 2
physiology and function of renal tubules and its regulation.
Endocrine system is important for the regulation and
5 Sato Endocrine 1 maintenance of whole body function. In this class, students
learn about the hypothalamo-pituitary-adrenal axis.
Students learn about biological functions and regulatory
6 Sato Endocrine 2
mechanisms of thyroid hormone and parathyroid hormone.
Students learn about the hormones secreted by the pancreas,
7 Sato Endocrine 3
adrenal gland, and sexual glands.
Endocrine 4 and Students learn about the kidney as an endocrine gland.
8 Sato
Midterm Exam A midterm test is given.
Understanding the spinal and central control of movement and
9 Arimura Central Nerve 1
sensory organization through the spinal cord.
Understanding the anatomy of central nervous system and the
10 Arimura Central Nerve 2
methods to define the functional analyses of nervous system.
Understanding the specific brain regions accounting for
11 Arimura Central Nerve 3 disorders in sleep, memory, epilepsy and pervasive
development.
Understanding the regulation of peripheral homeostasis
12 Arimura Peripheral Nerve
through autonomic nervous system and somatic sensation.
Understanding the functional morphology of somatic and
13 Sasaki Sensory Organ 1
visceral sensation, and visual system.
 Understanding the functional morphology of auditory and
14 Sasaki Sensory Organ 2 balance senses, and the chemical senses such as taste and
smell.
Understanding the functional morphology and contraction of
15 Sasaki Muscle
skeletal, cardiac and smooth muscles.
Record and Students are evaluated based on the midterm examination (45%), term-end
evaluation method examination (45%), and class performance (10%).
Textbook The textbook will be designated at the beginning of the course.

Reference References are handed out at every class.

Preparation Students are required to prepare knowledge of pathology related to content of the
and Review class using internet and books.
Language Used in
Japanese
Course
The office hours are from 14:00 to 16:00 on Tuesdays. Make an appointment in
Office hours advance via e-mail: [email protected] (Takahashi Nobuyuki),
e-mail: [email protected] (Sasaki Takuya)
In addition
 Subject Biochemistry 1
Course
YAL-PHA233J Categories Elective
Numbering
Preferable
1st Semester 2 Credits 2
Participants
Instructor Kurata Shoichiro

Practical business
To understand diseases based on the functions of body as targets of drugs, it is
necessary to know biochemical functions and structures of biological substances.
Objectives and
In this course, students will understand the structures and functions of
summary of class
carbohydrates, amino acids, proteins, lipids, nucleic acids, and their related
substances.
The purpose of this course is to help students explain the basic structures,
Goal of study
characteristics, and functions of biological substances.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Structure of
1 Kurata To understand the structure of typical monosaccharides.
carbohydrates (1)
Structure of To understand the structure of polysaccharides and glycosidic
2 Kurata
carbohydrates (2) bonds.
Functions of To understand the structure, functions, and characteristics of
3 Kurata
carbohydrates (1) typical monosaccharides and disaccharides.
Functions of To understand the structure, functions, and characteristics of
4 Kurata
carbohydrates (2) typical polysaccharides.
Cell surface To understand the structure and functions of polysaccharides
5 Kurata
carbohydrates conjugated to proteins and lipids.
Structure of amino
6 Kurata To understand the structure of amino acids.
acids
Characteristics of
7 Kurata To understand the characteristics of amino acids.
amino acids
Structure of peptides To understand the structures of peptides and primary,
8 Kurata
and proteins secondary, tertiary, and quaternary structures of proteins.
Functions of proteins
9 Kurata To understand the functions and properties of enzymes.
(1)
Functions of proteins
10 Kurata To understand the basic functions of proteins.
(2)
Stractures and To understand the structures and properties of lipids found in
11 Kurata
functions of lipids membranes.
Basic structure of
12 Kurata To understand the structures and properties of membranes.
membranes
Structure of nucleic To understand the structures of nucleic acids and similarities
13 Kurata
acids and differences between DNA and RNA.
Structure of DNA and
14 Kurata To understand the structures of DNA and replication process.
replication
Transcription and
15 Kurata To understand transcription and translation.
translation
Record and
Evaluation is performed based on class performance including the small tests (20%)
evaluation
and the final examinations (80%).
method
Basic Pharmaceutical Sciences Textbook Series: Biochemistry, Editor: Yoshinobu
Textbook
Nakanishi,
Biochemistry: The Molecular Basis of Life, Fourth Edition, Trudy McKee and James
Reference
R. McKee, Oxford University Press, Inc.
 Preparation
Understanding of each themes by textbook and reference book.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-5916
In addition It is not necessary to bring your own device.
 Subject Introduction to Pharmaceutical Sciences 2

Course Numbering YAL-PHA202J Categories Required

Preferable
2nd Semester 3 Credits 1
Participants
Prof. Nakabayashi Takakazu, Assoc. Prof. Kikuchi Masafumi, Tominaga Atsuko,
Instructor Sato Yoshiaki, Ikeda Koji, Chiba Kenji, Uneyama Chikako, Taniguchi Takahiko,
Takamachi Koji, and Oota Miki
Practical business 〇
To clarify the future goals as a pharmaceutical student, it is important to actually
see and hear the state of the scene where pharmaceutical graduates are active, such
Objectives and
as hospitals, pharmacies, pharmaceutical companies, research institutes, and
summary of class
administrative organizations. In this class, we listen to the experts who are active
at each site as early experience learning.
To raise a will to actively learn pharmaceutical sciences and pharmacy and to find
future goals, understand the work of the field at hospitals, pharmacies,
Goal of study
pharmaceutical companies, research institutes, etc. where the graduates of faculty
of pharmaceutical sciences have fruitful works.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Guidance/
The work and mission of a hospital pharmacist as a medical
1 Kikuchi Introduction
person
(1)
Introduction
2 Tominaga The role of pharmacists in regional medicine
(2)
Introduction
3 Sato The role of analytical chemistry in pharmaceutical research
(3)
Introduction
4 Ikeda Current status and issues of drug and medical device development
(4)
Introduction
5 Chiba Drug development in pharmaceutical company
(5)
Introduction
6 Uneyama Food safety and pharmacy
(6)
Introduction Challenge to new drugs: drug discovery research in
7 Taniguchi
(7) pharmaceutical company
Introduction
8 Takamachi Lecture related to a drug-induced disease
(8)
Introduction
9 Oota Health administration and pharmacy: roles of medicine officials
(9)
To be Introduction
10 Current status and issues of drugs abuse
Assigned (9)
Visiting
Visit the drug discovery research institute, pharmaceutical
11 Nakabayashi laboratory and
factory, pharmaceutical wholesale center, and University hospital
institution
Record and
Evaluated by class performance (50%) and report (50%)
evaluation method
Textbook Not specified

Reference
Preparation
and Review
Language Used in
Japanese
Course
 Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 022-795-6855
In addition Lecture schedule will be notified in Classroom and on a message board.
 Subject Organic Chemistry 3
Course
YAL-PHA223J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Yoshikai Naohiko
In the organic chemistry 3, students will learn about modern analytical methods 1)
to determine the molecular mass and molecular formula of an organic compound, 2)
Objectives and to identify functional groups contained in an organic compound, 3) to identify the
summary of class carbon-hydrogen framework of an organic compound. The students will also learn
about a) conjugation and resonance of a conjugated compound, b) aromaticity of
benzene and related aromatic compounds, and c) reactions of aromatic compounds.
After successfully completing this course, the students will be able to:
• Identify structures of simple organic compounds using mass spectrometry (MS),
infrared spectroscopy (IR), and nuclear magnetic resonance spectroscopy (NMR)
• Explain the concept of resonance and draw resonance structures
• Explain reactions under kinetic versus thermodynamic control
• Explain the Diels-Alder reaction and its relevance to organic synthesis
• Define aromaticity and explain the reactivity of aromatic compounds
Goal of study
• Explain the mechanism and the variation of electrophilic aromatic substitution of
benzene derivatives
• Rationalize substituent effects in electrophilic aromatic substitution and design
multistep synthesis of substituted benzenes
• Explain the mechanism of nucleophilic aromatic substitution of substituted
benzenes
• Explain the chemistry of benzyne and transformations on substituents on benzene
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
The principle of mass spectrometry and its application in structure
1 Yoshikai MS and IR (1)
determination of organic compounds
The principle of infrared spectroscopy and its application in
2 Yoshikai MS and IR (2)
identification of functional groups in organic compounds
The basic principle of nuclear magnetic resonance spectroscopy and the
3 Yoshikai NMR (1)
concept of chemical shift and shielding/deshielding effects
Spin-spin couplings in 1H NMR and their relevance to structure
4 Yoshikai NMR (2)
determination of organic compounds
13C NMR and its application in structure determination of organic
5 Yoshikai NMR (3)
compounds as well as the basics of two-dimensional NMR
Conjugation,
Conjugation, resonance, resonance hybrid, and electron delocalization
6 Yoshikai Resonance, and
Dienes (1) in common conjugated systems
Conjugation,
Kinetic versus thermodynamic control in electrophilic addition to
7 Yoshikai Resonance, and
Dienes (2) conjugated dienes
Conjugation,
8 Yoshikai Resonance, and Diels-Alder reaction: Mechanism and synthetic applications
Dienes (3)
Benzene and
The definition of aromaticity, and the types and properties of aromatic
9 Yoshikai Aromatic
Compounds (1) and heteroaromatic compounds
Benzene and
Molecular orbital analysis of aromatic systems and the theoretical
10 Yoshikai Aromatic
Compounds (2) basis of aromaticity (Hückel’s rule)
Reactions of
The general mechanism of electrophilic aromatic substitution reaction
11 Yoshikai Aromatic
Compounds (1) and halogenation, nitration, and sulfonation of benzene
 Reactions of
12 Yoshikai Aromatic The Friedel-Crafts alkylation and acylation reactions
Compounds (2)
Reactions of
Effects of different substituents on the reactivity and the
13 Yoshikai Aromatic
Compounds (3)
regioselectivity of electrophilic aromatic substitution
Reactions of
Strategies for the synthesis of multisubstituted benzenes through
14 Yoshikai Aromatic
Compounds (4) electrophilic aromatic substitution
Reactions of Nucleophilic aromatic substitution by addition-elimination and by
15 Yoshikai Aromatic elimination-addition (benzyne), and transformations on substituents
Compounds (5) on a benzene ring
Record and
Evaluation will be performed based on a written examination (80%) and submitted
evaluation
reports (20%).
method
「スミス 基礎有機化学(上・下)第５版」J. G. Smith 著、山本尚・大嶌幸一郎 監訳 化
Textbook 学同人（2017）
「Organic Chemistry」Author: J. G. Smith，McGraw Hill Higher Education
Reference
Preparation
and Review
Language Used in
Japanese
Course
Make an appointment via e-mail or other means before visiting.
Office hours
E-MAIL: [email protected] TEL: 022-795-6812
In addition
 Subject Pharmacognosy 1
Course
YAL-PHA226J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Professor Asai Teigo, Associate professor Taro Ozaki

Practical business
This course covers definition, history, scope and development of Pharmacognosy.
Objectives and Students learn the sources, constituents, pharmacological properties and
summary of class therapeutic uses of crude drugs, together with biosynthetic pathways of
constituents.
The purpose of this course is to help students explain the basic knowledge of crude
Goal of study drugs on their sources, constituents, pharmacological properties and therapeutic
uses.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Asai
1 Introduction Definition and history of Pharmacognosy
Ozaki
Asai Classification of Classification of natural products based on structure, origin,
2
Ozaki natural products biosynthesis and biological activities.
Asai Structure, origin, biological activities and biosynthesis of
3 Terpenoids 1
Ozaki terpenoids.
Asai Structure, origin, biological activities and biosynthesis of
4 Terpenoids 2
Ozaki terpenoids.
Asai Structure, origin, biological activities and biosynthesis of
5 Polyketides
Ozaki polyketides.
Asai Structure, origin, biological activities and biosynthesis of
6 Shikimic pathway
Ozaki natural products from shikimic pathway.
Asai Peptide natural Structure, origin, biological activities and biosynthesis of
7
Ozaki products peptide natural products.
Asai Structure, origin, biological activities and biosynthesis of
8 Alkaloids 1
Ozaki alkaloids.
Asai
9 Alkaloids 2 The same as above.
Ozaki
Asai Biologically active Structure, origin, biological activities, chemical biology and
10
Ozaki natural products biosynthesis of biologically active natural products.
Asai Isolation and Methods of purification and structure elucidation of natural
11
Ozaki Structure elucidation products.
Asai Discovery of natural
12 Strategy to discover novel natural products.
Ozaki products
Asai Biosynthetic study of
13 History of biosynthetic study on natural products.
Ozaki natural products
Total biosynthesis
Asai Powerful methods to produce natural products and its
14 and combinatorial
Ozaki analogs, total biosynthesis and combinatorial biosynthesis.
biosynthesis
Natural
Asai
15 product-based drug Future of natural product-based drug development.
Ozaki
development
Record and
evaluation Evaluated by examination (60%) and submitting report (40%).
method
Textbook
 「パートナー天然物化学改訂第 4 版」 森田博史、阿部郁朗 編集、南江堂 (2021)
「ベーシック薬学教科書シリーズ７ 生薬学・天然物化学」吉川雅之編、化学同人（2013）
Reference 「医薬品天然物化学」 海老塚豊 監訳、南江堂（2004）
「天然物化学」菅原二三男、浅見忠男、葛山智久、倉持幸司、新家一男、永田晋治、コロナ
社（2019）
Preparation
Review frequently using textbooks and handouts distributed during lectures.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means before students will visit
Office hours office.
E-mail: [email protected] Tel: +81-22-795-6822
In addition
 Subject Physical Chemistry 2
Course
YAL-PHA215J Categories Elective
Numbering
Preferable Semest
2nd 4 Credits 2
Participants er
Instructor Professor Konno Tomohiro

Practical business
Objectives and The purpose of this course is to learn phase equilibrium, interfaces, electrolyte
summary of class solutions, and electrochemistry.
This course is designated to help students understand the basics and applications
Goal of study
of phase equilibrium, interfaces, electrolyte solutions, and electrochemistry.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

1 Konno Solution 1 Properties of non-electrolyte solutions

2 Konno Solution 2 Chemical potential

3 Konno Solution 3 Raoult's law, Henry's law

4 Konno Solution 4 Colligative properties

5 Konno Interface 1 Surface and surface tension

6 Konno Interface 2 Surface adsorption

7 Konno Interface 3 Physical adsorption, chemical adsorption

8 Konno Interface 4 Adsorption isotherms

Electrolyte solution
9 Konno Strong electrolytes, weak electrolytes
1
Electrolyte solution
10 Konno Ion conductivity, transference number, ion mobility
2
Electrolyte solution
11 Konno Ionic strength, Debye-Hückel theory
3
12 Konno Electrochemistry 1 Faraday’s law

13 Konno Electrochemistry 2 Principle of chemical cells

14 Konno Electrochemistry 3 Electro-motive force

15 Konno Electrochemistry 4 Nernst equation, electro-analysis

Record and
evaluation Students are evaluated on the small quizzes (20%) and final test (80%).
method
Textbook
“Physical Chemistry 2nd Edition.”, Publisher: Kagaku-Dojin Publishing Company,
(2018) (ISBN: 978-4-7598-1628-0)
Reference
“Atkins' Physical Chemistry, 10th Edition.”, Publisher: Tokyo-Kagaku-Dojin
Publishing Company, (2017) (ISBN: 978-4-8079-0908-7)
Preparation
Students are required to prepare and review using handouts and textbook.
and Review
Language Used in
Japanese
Course
 Make an advance appointment via e-mail or other means.
Office hours
E-mail: [email protected] Phone: 795-6841
In addition
 Subject Biochemistry 2
Course
YAL-PHA235J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Inoue Asuka

Practical business
Biochemistry is a molecular understanding of chemical processes in cells. In this
Objectives and class, students will learn synthesis, folding and function of proteins. By focusing on
summary of class enzymes, students learn kinetics and regulation of enzymes as well as their
underlying molecular mechanisms.
The purpose of this course is to help students learn how proteins are made in cells
and exert their functions such as signal transduction, immune response and
Goal of study
metabolism. Students will also learn methods of protein analysis and genetic
engineering.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
To review the basic knowledge of biochemistry and understand the
1 Inoue Introduction
significance of biochemistry in the pharmaceutical sciences.
Protein
2 Inoue To understand the structures of amino acids and proteins.
diversity
Protein To understand the folding of proteins and protein misfolding disease
3 Inoue
structure (proteopathy).
Protein
4 Inoue To understand the synthesis of proteins in cellular machinery.
synthesis
5 Inoue Receptor (I) To understand the diversity of receptors.

6 Inoue Receptor (II) To understand the functions of receptors.

To understand the structures and the functions of antibodies as well
7 Inoue Antibody
as generation and applications of antibodies.
Cytoskeleton To understand the structure and the function of cytoskeleton
8 Inoue
protein proteins.
9 Inoue Enzyme (I) To understand the properties of enzymes.

10 Inoue Enzyme (II) To understand the kinetics of enzymes.

11 Inoue Enzyme (III) To understand the regulations of enzymes.

Protein To understand the methods to analyze expression and the function of
12 Inoue
analysis (I) proteins.
Protein To understand the central dogma and to review the structure and the
13 Inoue
analysis (II) function of nucleotides (DNA/RNA).
Protein To understand the central dogma and to review the structure and the
14 Inoue
analysis (III) function of nucleotides (DNA/RNA).
Summary of
15 Inoue To review the course and understand the biochemistry of proteins.
the course
Record and
Evaluation is performed based on class performance including the final (90%)
evaluation
examination and the class performance (10%).
method
Basic Pharmaceutical Sciences Textbook Series: Biochemistry, Editor: Yoshinobu
Textbook Nakanishi.
Essential Cell Biology, Fifth Edition, Editor: Bruce Alberts et al.
Reference Molecular Biology of the Cell, Sixth Edition, Bruce Alberts et al.
 Preparation
Understanding of each theme by textbook and reference book.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-6861
In addition
 Subject Biochemistry 3
Course
YAL-PHA235J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Kurata Shoichiro, Yano Tamaki and Inoue Asuka

Practical business
In this course, students will understand the structures and functions of proteins
Objectives and
involved in biological reactions and intra-and extra-cellular signal transductions and
summary of class
learn the structures, the function and the metabolism of lipids and membrane.
The purpose of this course is to help students explain the structures and functions
Goal of study of proteins involved in biological reactions and signal transductions and the function
of lipid membrane and lipid mediators.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
To understand the biochemical significance in the
1 Kurata Introduction pharmaceutical sciences related to biological reactions and
signal transduction.
Post-translational To understand the mechanisms and functions of post-
2 Kurata
protein modifications translational protein modifications.
Intracellular signal
To understand the mechanisms of intracellular signal
3 Kurata transduction and
transduction and cancer.
cancer
Hormone and signal To understand the communication between cells and tissues
4 Yano
transduction via hormones, the extracellular signaling molecules.
To understand the molecular mechanisms of membrane
transport, which contribute to receptor clearance
5 Yano Membrane transport
(Endocytosis), hormone secretion (Exocytosis), and protein
degradation.
Cell-cell contact and To learn the molecules essential for cytoskeleton, cell-cell
6 Yano
cell matrix junctions, and extracellular matrix.
Kurata, Summary of the first To confirm the contents that was handled in the first part of
7
Yano half of this course this course.
To understand the structures of various lipid molecules and
8 Inoue Lipid and membrane (I)
property of lipid membrane
Lipid and membrane To understand the function of glycoproteins, glycolipids and
9 Inoue
(II) lipid proteins
Lipid and membrane
10 Inoue To understand the fluidity of lipid membrane and lipid raft
(III)
11 Inoue Lipid and metabolism To understand the metabolism of fatty acids and cholesterols
To understand the structures and functions of membrane
12 Inoue Membrane protein
proteins
13 Inoue Functional lipid (I) To understand the function of lipid mediators
To understand the function of PI turnover and
14 Inoue Functional lipid (II)
lysophospholipid mediators
Summary of the last To confirm the contents that was handled in the second part
15 Inoue
half of this course of this course.
Record and
Evaluation is performed based on class performance including the small tests (20%),
evaluation
the midterm (40%) and the final (40%) examinations.
method
Basic Pharmaceutical Sciences Textbook Series: Biochemistry, Editor: Yoshinobu
Textbook
Nakanishi,
 Essential Cell Biology, Fifth Edition, Editor: Bruce Alberts et al.

Biochemistry: The Molecular Basis of Life, Fourth Edition, Trudy McKee and James
Reference R. McKee, Oxford University Press, Inc.
Molucular Cell Biology, Fifth Edition, Lodish et al., W. H. Freeman and Campany
Preparation
Understanding of each themes by textbook and reference book.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
E-MAIL: [email protected] TEL: 795-5916
Office hours
E-MAIL: [email protected] TEL: 795-4555
E-MAIL: [email protected] TEL: 795-6861
In addition
 Subject Pharmacology 1
Course
YAL-PHA251J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Takuya Sasaki, Nariko Arimura

Practical business
Pharmacology is a discipline which explores an interaction between drugs and a
human body. To better understand the action of clinically available drugs, students
need to acquire abundant knowledge about not only the machinery of human body
but also the mechanism of disease development. In human body, many chemical
Objectives and
transmitter and intracellular signaling molecules work to keep the body healthy. In
summary of class
this course, students first acquire the elementary knowledge to understand the action
of drugs. Students also understand the clinical application and effectiveness of drugs
and identify a clinical issue through the understanding the extracellular chemical
transmitter and intracellular signal transduction.
The purpose of this course is to help students learn the basic knowledge and the point
of view of the pharmacotherapy. Also, students understand the elementary chemical
Goal of study
transmitter and intracellular signal transduction and develop the ability to consider
the mechanism of drug action.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
In this course, students will learn about basic matters to
understand the action of drugs such as the history of the
pharmacology, a mode of drug action and dose-
1 Sasaki Introduction (1)
responsibility. Students will also understand the
regulation system of biological functions such as neural
system and endocrine system.
In this course, students will understand the factors that
influence the effectiveness of drugs. Also, this course will
offer the opportunity to learn the change of drug
2 Sasaki Introduction (2)
effectiveness or appearance of side effect by
coadministration of several drugs and repeated
administration.
Cellular signal In this course, students will understand the intracellular
transduction:seven- signal transduction via seven-pass transmembrane
3 Sasaki
pass transmembrane receptors, many of which are molecular targets of clinically
receptor available drugs.
Cellular signal In this course, students will learn about a class, functions
transduction: and activation/inactivation mechanisms of heterotrimeric
4 Sasaki
heterotrimeric G G protein which is coupled to seven-pass transmembrane
protein receptors.
Cellular signal
transduction: small G In this course, students will learn about a class, functions
5 Sasaki protein/growth factor and activation/inactivation mechanisms of small G
receptor/intracellular protein, growth factor receptor and intracellular receptor.
receptor
This course offers an opportunity to learn about the dose-
responsibility of drugs and to understand a concept of
Quantitative analysis agonist and antagonist and its quantitative analysis. The
6 Sasaki
of receptors students will also understand the principle and methods of
the receptor binding assay and will be able to do the
quantitative analysis.
 Cellular signal
In this course, students will learn about several ion
transduction: ion
7 Sasaki channels and transporters as molecular targets of clinically
channels and
available drugs.
transporter
This course offers an opportunity to learn about a molecular
mechanism of the circadian clock which govern the
Chronopharmacology
8 Sasaki biological rhythm with 24 hr periodicity and to understand
and Midterm Exam
the mechanisms underlying the daily variation of
action/side effect of drugs and chronopharmacology.
In this course, students will learn about a class and
Bioactive substance:
9 Arimura physiological roles of vitamin and their significance in the
vitamin
regulation of biological functions.
This course offers an opportunity to learn about a
Bioactive substance: biosynthesis/metabolism, receptors and related-drugs of
10 Arimura
acetylcholine acetylcholine, which acts as an important neurotransmitter
in the central nervous system and peripheral tissue.
This course offers an opportunity to learn about a
biosynthesis/metabolism, receptors and related-drugs of
Bioactive substance:
11 Arimura catecholamine, which acts as an important
catecholamine
neurotransmitter in the central nervous system and
peripheral tissue.
This course offers an opportunity to learn about an outline
Bioactive substance: of bioactive peptides and to understand their functions and
12 Arimura
bioactive peptides clinical application of typical bioactive peptides such as
angiotensin and orexin.
This course offers an opportunity to learn about a
Bioactive substance: biosynthesis/metabolism, receptors and related-drugs of
13 Arimura
serotonin serotonin, which acts as an important bioactive substance
in the central nervous system and peripheral tissue.
This course offers an opportunity to learn about a
biosynthesis/metabolism, receptors and related-drugs of
Bioactive substance:
14 Arimura histamine and amino acids such as glutamate and GABA,
histamine/amino acid
which act as an important bioactive substance in the
central nervous system and peripheral tissue.
This course offers an opportunity to learn about a
Bioactive substance: biosynthesis and physiological/patho-physiological roles of
15 Arimura
eicosanoid eicosanoids such as prostaglandin and leukotrien and to
understand the action of related-drugs.
Record and Students are evaluated based on the midterm examination (45%), term-end
evaluation method examination (45%), and class performance (10%).
Textbook
Tanaka, Chikako and Kato, Ryuichi eds., New Pharmacology (6th Edition). Nankodo
Nabeshima, Toshitaka and Inoue, Kazuhide eds., Mitewakaru Yakugaku Zukai
Yakurigaku (1st Edition). Nanzando
Sato, Susumu ed., Shin-yakurigaku text (3rd Edition). Hirokawa Publishing Co.
Reference Yanagisawa, Teruyuki ed., Shin-yakurigaku nyuumon (3rd Edition). Nanzando,
Laurence Brunton, Bruce Chabner and Brorn Knollman eds., Goodman & Gilman's
The Pharmacological basis of Therapeutics (Translation supervised by Takaori,
Syuzo, Keitaro Hashimoto, Akaike, Akinori and Ishii, Kunio). Hirokawa Publishing
Co.
Preparation Students can previously download the slide files and prepare the contents with the
and Review above textbook.
Language Japanese
Make an advance appointment via e-mail or other means.
Office hours
（Sasaki）E-MAIL：[email protected] TEL：022-795-5503
In addition Materials are provided via Google Classroom.
 Subject Pharmacology 2
Course
YAL-PHA252J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Associate Professor Moriguchi Shigeki

Practical business
Pharmacology is summarized in the interactions between medicines and biological
functions. Students lean the clinical application, therapeutic and side effects of
Objectives and
medicines through those biological actions. Pharmacology 2 focuses on medicines
summary of class
acting on peripheral and central nervous systems, and respiratory and digestive
organs.
Students understand the molecular basis in drug actions of therapeutics. In
Goal of study addition, students deepen their understanding of the pharmacological mechanisms
underlying the main and side effects of medicine.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Pharmacology Students learn the role of autonomic or somatic nervous system,
1 Moriguchi of peripheral neurotransmitter receptor, agonists and antagonists acting on these
nervous system nervous systems.
Autonomic Students learn the regulation of organ function through the
2 Moriguchi nervous system sympathetic nervous system and clinical application of agents acting
therapeutics (1) on the sympathetic nervous system.
Students learn the regulation of organ function through the
Autonomic
parasympathetic nervous system, and clinical application of agents
3 Moriguchi nervous system
acting on the parasympathetic nervous system the autonomic
therapeutics (2)
ganglion.
Somatic Students learn the therapeutics acting on the sensory and motor
4 Moriguchi nervous system neurons. Students also learn the local anesthetic agents and muscle
therapeutics relaxants.
Pharmacology The biological homeostasis is regulated by interaction of nervous,
5 Moriguchi of central endocrine and immune systems. Students learn the pharmacological
nervous system interaction nervous, endocrine and immune systems.
Mid-term
examination
and drug Students learn the principle methods to evaluate the pharmacological
6 Moriguchi
evaluation in actions of central nervous system agents.
central nervous
system
Central nervous Students learn the interactions of synaptic transmission, receptor
7 Moriguchi system and ion channel. Especially, students understand the basic
therapeutics (1) mechanism of agents acting on the central nervous system.
Central nervous
Students learn the pharmacology of general anesthetic, hypnotic,
8 Moriguchi system
antianxiety agents and antidepressants.
therapeutics (2)
Central nervous Students learn the pharmacology of muscle relaxants, antiepileptics,
9 Moriguchi system narcotic or non-narcotic analgesics. Students also learn therapeutics
therapeutics (3) for migraine and for drug and alcoholic dependence.
Central nervous
Students learn the pharmacology of therapeutics for psychosis,
10 Moriguchi system
schizophrenia, Parkinson’s disease and narcolepsy.
therapeutics (4)
Neurodegenerat
Students learn the therapeutics for stroke, Alzheimer’s disease,
11 Moriguchi ive disorder
Huntington’s disease and amyotrophic lateral sclerosis.
therapeutics
 Students learn the pharmacology of antitussive, expectorants,
Respiratory antiasthmatic agents and respiratory stimulants. Students also learn
12 Moriguchi
therapeutics therapeutics for chronic obstructive pulmonary disease, smoking
disease and pneumonitis.
Students learn the regulation of gastric acid secretion by nervous
Gastrointestina
system and gastrointestinal hormone. Students also learn the agents
13 Moriguchi l therapeutics
of gastritis, gastroesophageal reflux disease, gastroduodenal ulcer
(1)
and bowel disease.
Gastrointestina Students learn the regulation of gastrointestinal function by
14 Moriguchi l therapeutics gastrointestinal hormone. Students also learn the therapeutics for
(2) liver, bile duct and pancreatic diseases.
Gastrointestina
Students learn the therapeutics acting on the intestinal immunity
15 Moriguchi l therapeutics
and intestinal flora.
(3)
Record and
Mid-term examination (45%), examination (45%), class performance (10%) and so
evaluation
on.
method
Textbook 「Zukai Yakurigaku」Ed. T Nabeshima and K Inoue, Nanzando

Reference References will be provided as necessary.

Students are required to prepare knowledge of target organs for drugs and
Preparation
pathology related to content of the class using internet and books.
and Review
Language Used in
Japanese
Course
Make an appointment via e-mail before visiting the office. The contact information
Office hours for the lecturers will be announced in the lecture.
E-MAIL: [email protected] TEL: 022-795-4562
In addition
 Subject Pharmaceutics 1
Course
YAL-PHA261J Categories Elective
Numbering
Preferable
2nd Semester 3 Credits 2
Participants
Instructor Professor Akita Hidetaka, Lecturer Uchida Yasuo, Lecturer Sakurai Yu

Practical business
The purpose of this class is to understand the basis of pharmaceutics including
physical pharmaceutics and pharmacokinetics in a comprehensive manner. This
Objectives and course will also explore the relationship between the drug formulations and the
summary of class biological properties of absorption, distribution, metabolism and elimination
(ADME). Small test will be given in each lecture to evaluate the achievement of
understandings.
Upon completion of this course, a student should be able to:
·Explain characteristics, production methods, and quality test of drug formulations
Goal of study ·Explain drug delivery system
·Explain the fate of drugs and various factors affecting absorption, distribution,
metabolism, and excretion in the body
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Overview of pharmaceutics including the development of drug
formulations, their administration pathways, and the
Introduction to
1 Akita absorption processes of various drug preparations
Pharmaceutics
Process of drug development from the viewpoints of
pharmaceutics
Biomembrane Mechanisms of biomebrane transport as a rate-limiting
2 Akita
transport process of the fate of drugs in the body
3 Akita Drug absorption Mechanisms of drug absorption in the small intestine
Classification of drug-protein bindings and the analyzing
4 Uchida Protein binding
methods
Tissue Factors affecting the drug distribution in the targeted
5 Uchida
distribution organs/tissues
Drug metabolism Factors affecting the drug metabolizing rate, e.g., membrane
6 Akita and First pass permeability, protein binding, blood flow rate, and
effect administration pathway
Renal and biliary Mechanisms of renal and biliary excretion as the main routs of
7 Akita
excretion drug elimination from the body
Characteristics, production methods, and advantages of solid
8 Sakurai Solid formulation
formulation
Semi-solid Characteristics and production methods of semi-solid
9 Sakurai
formulation formulation
Liquid
10 Sakurai Characteristics and production methods of liquid formulation
formulation
Characteristics, production methods, and administration
Sterile
11 Sakurai pathway of the formulation for injection, ophthalmic solution,
formulation
and ophthalmic ointments
Quality control, Quality tests of drug formulations for quality control in
12 Uchida pharmaceutical Japanese Pharmacopoeia (JP) and the stability of drug
test, stability formulations
Factors affecting the solubility and pharmacokinetics of drug
Solubility and
13 Sakurai formulations
kinetics
 Drug delivery
14 Sakurai Basics of drug design and formulation of drug delivery system
system 1
Drug delivery Application of drug design and formulation of drug delivery
15 Sakurai
system 2 system
Record and
Students are evaluated on their points from all the small tests (40%), and the
evaluation
midterm and regular examinations (60%).
method
(Japanese) Partner Pharmaceutics, Fourth edition (2022)
Textbook (ISBN:9784524403875)
パートナー薬剤学 改訂第 4 版 原島秀吉ら編集、南江堂（2022）
1. (English) Clinical Pharmacokinetics and Pharmacodynamics: concepts and
applications Fourth Edition Malcolm Rowland and Thomas N. Tozer, Lippincott
Williams and Wilkins (2009) (ISBN:9780781750097)
2. (Japanese) Biopharmaceutics (ISBN:9784567482349)
わかりやすい生物薬剤学 第 5 版 荻原琢男執筆者代表、廣川書店（2014）
3. (Japanese) Physical Pharmaceutics (ISBN:9784567482653)
わかりやすい物理薬剤学 第 5 版 辻 彰・河島 進 編、廣川書店（2015）
Reference
4. (Japanese) Clinical pharmacokinetics (ISBN: 9784524250554)
臨床薬物動態学 第４版 加藤隆一著、南江堂 (2009)
5. (Japanese) Tsuji's pharmacokinetics Episode Pharmacokinetics
(ISBN:9784901789998)
エピソード薬物動態学―薬物動態学の解明、京都廣川書店（2012）
6. (Japanese) Basic science of drug formulation (ISBN:9784860342890)
基礎から学ぶ製剤化のサイエンス第 3 版山本恵司監修、エルゼビア・ジャパン（2016）
Preparation Getting basic knowledge on each topic using the text books and references above as
and Review a pre-study and Trying several practice problems as a review
Language Used in
Japanese
Course
Please make an advance appointment via e-mail or other means. The contact
Office hours
information for the lecturers will be given in the class.
In addition
 Subject Organic Chemistry 4

Course Numbering YAL-PHA224J Categories Elective

Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Yoshiharu Iwabuchi and Lecturer Yusuke Sasano

Practical business
Carbonyl groups are regarded as one of the most important functional groups to
Objectives and understand organic chemistry from the viewpoints of the general existence and
summary of class diverse reactivities. The principle of the reactions can be understood by basic
reaction patterns. Organic chemistry 4 focuses on carbonyl group chemistry.
To understand the basic character, reactivity and synthetic methods and to become
Goal of study
to explain basic reaction mechanisms.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Iwabuchi Carboxylic acid Nomenclature, structure, physical property, hydrogen bonding,
1
Sasano 1 synthetic method and reactions of carboxylic acid
Iwabuchi Carboxylic acid Acidity and pKa value of carboxylic acid, separation using
2
Sasano 2 extraction, amino acid.
Iwabuchi Carbonyl General reactions of carbonyl compounds. Reduction of
3
Sasano compound 1 aldehyde and ketone.
Stereochemistry in the reduction of carbonyl groups.
Iwabuchi Carbonyl
4 Reduction of carboxylic acid and derivatives. Oxidation of
Sasano compound 2
aldehyde.
Iwabuchi Carbonyl Basic concept of organometallic reagents and reaction with
5
Sasano compound 3 aldehyde and ketone.
Reaction of organometallic reagents with carboxylic acid
Iwabuchi Carbonyl
6 derivatives. a,b-Unsaturated carbonyl compounds and protecting
Sasano compound 4
groups.
Iwabuchi Aldehyde & Nomenclature, structure, physical property, synthetic method of
7
Sasano ketone 1 aldehyde and ketone.
Iwabuchi Aldehyde & General reactions of aldehyde and ketones with hydride, carbon
8
Sasano ketone 2 nucleophiles, cyanide.
Conversion of carbonyl groups to alkenes using Wittig reaction.
Iwabuchi Aldehyde &
9 Imine, enamine formation by the reaction with nitrogen
Sasano ketone 3
nuclephiles.
Acetal formation by the reaction with oxygen nucleophiles and
Iwabuchi Aldehyde &
10 the use as protecting groups. Cyclic acetal formation and
Sasano ketone 4
introductory sugar chemistry.
Iwabuchi Carboxylic acid Nomenclature, structure, physical property of ester, amide,
11
Sasano derivative 1 carboxylic acide anhydride.
Iwabuchi Carboxylic acid
12 Reaction of carboxylic acid halide and anhydride.
Sasano derivative 2
Iwabuchi Carboxylic acid Conversion of carboxylic acid to ester, amide, anhydride.
13
Sasano derivative 3 Reaction of ester and hydrolysis of lipid.
Iwabuchi Carboxylic acid Reaction of amides and biological activity of b-lactam. Natural
14
Sasano derivative 4 and synthetic fibers with amide and ester linkages.
Iwabuchi Carboxylic acid
15 Acylation in metabolism. Basic reactions of nitrile.
Sasano derivative 5
Record and Evaluated by final examination (80%) and class performance including exercise
evaluation method (20%).
Textbook ‘Organic Chemistry — 5th edition’ J. G. Smith
 Reference
Preparation Students should read above contents in the textbook before lecture and solve
and Review problems in the textbook to deepen their understanding after the lecture.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-6846
In addition
 Subject Organic Chemistry 5
Course
YAL-PHA225J Categories Elective
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Professor Yoshinori Kondo, Associate Professor Masanori Shigeno, and Assistant
Instructor
Professor Kanako Kumada
Objectives and In this course, students will learn chemistry of carbonyl compounds, amines, pericyclic
summary of class reactions, and heterocycles.
· Students will understand chemical property and reactivity of carbonyl compounds, amines, and
Goal of study heterocycles, and synthetic methods for them.
· Students will understand pericyclic reactions to illustrate the basic mechanism of them.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Kondo
Basics of
1 Shigeno Students will understand the acidity of the α-proton of carbonyl compounds.
Enolates
Kumada
Kondo
Enolate Students will understand the enolate formation and the α-alkylation of carbonyl
2 Shigeno
Chemistry (1) compounds.
Kumada
Kondo
Enolate Students will understand the alkylation of activated esters, β-keto esters and
3 Shigeno
Chemistry (2) malonates
Kumada
Condensation
Kondo
of Carbonyl
4 Shigeno Students will understand aldol reactions
Compounds
Kumada (1)
Condensation
Kondo
of Carbonyl Students will understand the Claisen condensation, cross condensation, and
5 Shigeno
Compounds intramolecular condensation.
Kumada
(2)
Kondo
6 Shigeno Amines (1) Students will understand the chemistry of amines and formation of amines.
Kumada
Kondo
7 Shigeno Amines (2) Students will understand the reactions of amines.
Kumada
Kondo Carbon−
8 Shigeno Carbon Bond Students will understand carbon−carbon bond forming reactions.
Kumada Formation (1)
Kondo Carbon−
Students will understand the synthetic methods for cyclopropane formation and
9 Shigeno Carbon Bond
metathesis.
Kumada Formation (2)
Kondo
Pericyclic Students will understand the molecular orbital theory and conservation of
10 Shigeno
Reactions (1) orbital symmetric theory
Kumada
Kondo
Pericyclic
11 Shigeno Students will understand cycloaddition reactions.
Reactions (2)
Kumada
Kondo
Pericyclic
12 Shigeno Students will understand electrocyclic reactions.
Reactions (3)
Kumada
Kondo
Heterocycles
13 Shigeno Students will understand the chemistry of five-membered heterocycles.
(1)
Kumada
 Kondo
Heterocycles
14 Shigeno Students will understand the chemistry of six-membered heterocycles.
(2)
Kumada
Kondo
Amino Acids
15 Shigeno Students will understand the chemistry of amino acids, peptides, and proteins.
and Proteins
Kumada
Record and
evaluation Students are evaluated on examination (ca.80%) and class performance (ca.20%).
method
Textbook ‘Organic Chemistry — 5th ed.’ J. G. Smith
The chemistry of heterocycles: structure, reactions, synthesis, and applications, 3rd
Reference edition/ T. Eicher, S. Hauptmann, A. Speicher, Wiley-VCH (2012).
Pericyclic reactions/ Ian Fleming, Oxford University Press (1999)
Students are required to read the relevant part of the textbook. After the lecture,
Preparation
students should review the contents of the lecture and solve problems of the
and Review
textbook to deepen their understanding.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-6804
In addition Practice every time
 Subject Pharmacognosy 2

Course Numbering YAL-PHA227J Categories Elective

Preferable
2nd Semester 4 Credits 2
Participants
Instructor Kawahata Ichiro

Practical business
In this course, students understand basic important points of pharmacognosy,
including the origin, bioactive constituents, efficacy and application of the crude
drugs listed in Japanese Pharmacopoeia, and learn about the actions of these
Objectives and natural drugs on gene expression in mammalian cells, the basic concepts necessary
summary of class for understanding the diagnosis and treatment in Kampo medicine, and the
importance of plant biotechnology in securement of medicinal plant resources. This
course also offers the opportunity to deepen the understanding of therapeutic
natural medicines for neurodegenerative disorders.
The purpose of this course is to help students explain the importance of natural
Goal of study
drugs in modern medicine and drug discovery research.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( Papers )
Term Lecturer Theme Contents
Overview of the history and the importance of
pharmacognosy, and learn about the origins,
1 Kawahata Introduction properties, and clinical applications of
representative crude drugs as well as crude drug
classification.
Learn about plant morphology and organs.
Plant morphology
Additionally, learn about the basics of typical
2 Kawahata Medicinal plants, animals,
medicinal plants, active ingredients, structural
and minerals 1
formulas, pharmacological actions, and uses.
Learn about the basics of typical medicinal plants,
Medicinal plants, animals, active ingredients. Also, learn about their
3 Kawahata
and minerals 2 structural formulas, pharmacological actions, and
uses.
Learn about the basics of typical medicinal plants,
Medicinal plants, animals, animals, minerals, active ingredients, and
4 Kawahata
and minerals 3 structural formulas, as well as pharmacological
actions and uses.
Learn about the methods for identification of crude
5 Kawahata Crude drug identification
drugs and understand the importance.
Understand the applications of plant
6 Kawahata Plant biotechnology 1 biotechnology for the production of useful
bioactive constituents of crude drugs.
Understand the applications of plant
7 Kawahata Plant biotechnology 2 biotechnology for the production of useful
bioactive constituents of crude drugs.
Summary of the first half of Review the contents in the first half part of this
8 Kawahata
this course course.
Learn about the differences between Kampo
medicine and western medicine, and understand
9 Kawahata Kampo medicine
an important position of Kampo medicine in
modern medicine in Japan.
Evaluation of the efficacy of Understand how to evaluate the efficacy of crude
10 Kawahata
natural drugs drugs, Kampo medicines, and their constituents.
 Understand mechanisms underlying actions of
Natural drugs for treatment
11 Kawahata natural drugs in the nervous system, and learn
of neural disorders
about the clinical potential and benefits.
Understand the mechanisms of anti-inflammatory
Natural drugs for treatment and anti-allergic actions of crude drugs and
12 Kawahata
of inflammation and allergy natural compounds, and learn about the clinical
potential and benefits.
Learn about the history of discovery and isolation
Natural drugs acting on
of natural drugs that act on the aspiratory and
13 Kawahata aspiratory and cardiovascular
cardiovascular system, and understand their
system
action mechanisms and clinical applications.
Understand the importance of natural drugs
Natural drugs acting on employed as digestants, stomachics, peptic ulcer
14 Kawahata
digestive system agents, antidiarrheal drugs, cathartic drugs,
emetics, and antiemetics.
Confirm the contents in the last half part of this
15 Kawahata Summary of this course
course.
Record and Students are evaluated on the final examination (90%) as well as class performance
evaluation method (10%).
Textbook Basic Pharmaceutical Sciences Textbook Series: Pharmacognosy & Natural
Products Chemistry (2nd ed.), edited by Masayuki Yoshikawa (KAGAKUDOJIN)
Medicinal Resources (2nd ed.), edited by Mikio Yamazaki & Kazuki Saito
Reference (MARUZEN); Pharmacognosy (7th ed.), edited by Isao Kitagawa (Hirokawa-Shoten);
Signal Transduction, edited by Tetsu Akiyama (YODOSHA)
Preparation and submission of papers on the original plant (or animal) source,
Preparation
medicinal part, bioactive constituents, efficacy and application of the crude drugs
and Review
listed in Japanese Pharmacopoeia four times.
Language Used in
Japanese
Course
Make an advance appointment via e-mail.
Office hours
（Kawahata）E-MAIL：[email protected] TEL：022-795-6838
In addition
 Subject Analytical Chemistry 2
Course
YAL-PHA212J Categories Elective
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Oe Tomoyuki, Associate professor Lee Seon Hwa

Practical business
Analytical chemistry in pharmaceutical sciences is an essential basic science in drug
discovery and ADME researches (pharmacokinetics and pharmacology for "absorption,
distribution, metabolism, and excretion). This course covers the basic knowledge and
Objectives and
applications of spectroscopy, chromatography, and mass spectrometry. The aim is to help
summary of class
students understand basic instrumental analyses. Qualitative analyses and purity tests
for organic/inorganic compounds in Japanese Pharmacopoeia, 17th Ed. (JP17) are also
introduced.
Better understanding of ultraviolet–visible spectroscopy, fluorescence spectroscopy,
chromatography, and mass spectrometry to make it possible to explain each theory, to
Goal of study interpret the spectra/data, and to apply to use practically. Better understanding of each
confirmatory test and purity test in Japanese Pharmacopoeia (JP) to make it possible to
explain.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction: qualitative
1 Oe analysis of drugs
Overviewing qualitative analysis of drugs
Ultraviolet–visible Learning about the principle, instrumentation, Beer-Lambert
2 Oe spectroscopy law, and applications for biomolecules
Fluorescence Learning about the principle of fluorescence, instrumentation,
3 Oe spectroscopy and the applications (including chemiluminescence)
Basics of chromatography Watching two Videos to image chromatography, followed by
4 Oe I overviewing chromatographic methods
Learning about two typical chromatographic modes, absorption
Basics of chromatography chromatography and partition chromatography, in terms of the
5 Oe II separation behavior, the role of stationary phase and mobile
phase
Learning about other chromatography: Ion exchange
Basics of chromatography
6 Oe III
chromatography, size exclusion chromatography, affinity
chromatography
Basics of chromatography Learning about the instrumentation and structures of LC system
7 Oe IV (pump, detector)
Basics of chromatography Learning about gas chromatography and thin layer
8 Oe V chromatography
Validation test for organic Learning about technical terms of chromatography and,
9 Oe compounds I quantitative applications using calibration curve
Validation test for organic
10 Oe compounds II
Learning about derivatization methods for HPLC and GC
Learning about confirmatory tests for specific functional groups
Validation test for organic
11 Oe compounds III found in JP17
Learning about systematic separation and identifications of
Qualitative inorganic
12 Oe analysis
metal cations (Separation scheme by precipitation and each
confirmatory test)
Watching a Video to image mass spectrometry followed by
Basics of mass learning about the difference between mass and weight,
13 Lee spectrometry I definition of relative molecular mass, monoisotopic mass, and
most abundant mass
Basics of mass Overviewing MS and learning about typical ionization methods
14 Lee spectrometry II and mass analyzers
 Basics of mass Learning about typical mass analyzers, each significance, and
15 Lee spectrometry III the applications
Record and
evaluation Based on the written exam
method
Analytical Chemistry I (パートナー分析化学 I), 3rd Ed., Ed. J. Haginaka, H. Nohta, M.
Yamaguchi, Nankodo Co., Ltd., 2017 (ISBN 978-4-524-40343-1)
Textbook
Analytical Chemistry II (パートナー分析化学 II), 3rd Ed., Ed. H. Nohta, J. Haginaka, M.
Yamaguchi, Nankodo Co., Ltd., 2017 (ISBN 978-4-524-40344-8)
「イメージから学ぶ分光分析法とクロマトグラフィー～基礎原理から定量計算まで」Y.
Sadakane, Kyoto Hirokawa Publishing Inc., 2009 (ISBN 978-4-901789-19-6)
Separation science supports high-technology (分離の科学 ハイテクを支えるセパレーシ
ョ ン ・ サ イ エ ン ス ), Blue Backs B723, K. Ueno, Kohdansha Inc., 1988 (ISBN
4-06-132723-1)
What can we know using mass spectrometry (物質の質量から何がわかるか), S. Tajima, S.
Tobita, Shokabo, 1991 (ISBN 4-7853-8547-2)
Reference Diagnostic using Novel prize awarded-mass spectrometry (ノーベル賞の質量分析法で病
気を診る), Iwanami Science Library 94, A. Shimizu, Iwanami Shoten, Publishers, 2003
(ISBN 4-00-006594-7）
Standard Pharmaceutical Sciences, Series II 2, Physical Pharmaceutical Sciences III,
Instrumental analysis & determination of chemical structure (スタンダード薬学シリー
ズ II 2 物理系薬学 III. 機器分析・構造決定), Ed. The Pharmaceutical Society of Japan,
Tokyo Kagaku（2016）(ISBN 978-4-8079-1704-4）
Preparation
and Review
Language Used in
Japanese
Course
An appointment required by E-mail ([email protected]) or phone
Office hours
(795-6817).
In addition
 Subject Radiochemistry

Course Numbering YAL-PHA217J Categories Elective

Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Furumoto Shozo, Senior Lecturer Funaki Yoshihito

Practical business
Radioisotopes are used as an essential tool for life science research and clinical
diagnosis. In this course, students will understand the basic knowledge of radiation
Objectives and and radioisotope correctly and learn a method for dealing with them properly.
summary of class Additionally, students will learn about radiopharmaceuticals for nuclear medicine
with respect to their properties and methods for preparation, management, and
usage.
Student will understand nature of radiation and deepen their knowledge about
usage of radioisotopes beneficial for life-science studies to have an ability to use
Goal of study
radio tracer for a research. Then, Students will learn actual clinical application of
radiopharmaceuticals.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students learn the importance of studying the utility of
radioisotope. This class will provide basic knowledges of radiation
Atomic nucleus
1 Furumoto chemistry such as concept of radiation, nuclear structure, types and
and radioactivity
properties of radiation, nuclear disintegration, radioactive decay
and half-life, and so on.
Interaction
This class is designed to help students understand interactions
between
2 Furumoto of radiation with materials with respect to a relationship
radiation and
between radiation types and their energy.
materials (I)
Interaction
This class is designed to help students understand interactions
between
3 Furumoto of radiation with materials with respect to the physiological
radiation and
changes and the process of energy absorption of radiation.
materials (II)
Students learn the principle of all kinds of measuring
Measurement of instruments and measuring methods according to nuclides, and
4 Furumoto
radiation (I) then understand how the radiation interaction with material is
applied to the measuring technology.
Students learn the usage of a liquid scintillation counter and an
Measurement of
5 Furumoto imaging plate technique that are necessary to life science
radiation (II)
researches.
Production of This class helps students understand the principles of nuclear
radionuclides and reactors and accelerators and their use for producing radionuclides.
6 Furumoto
radiolabeled Then, students learn the principle and properties of chemical
compounds synthesis of radiolabeled compounds used as a tracer.
Students learn the properties, measuring principle, and
measuring instruments with respect to diagnostic imaging with
Radiopharmaceu
7 Furumoto radiopharmaceuticals. Additionally, understanding
ticals (I)
characteristics of radioisotopes, students learn radiosynthesis
methods of radiopharmaceuticals used for PET and SPECT.
Radiopharmaceu Students learn about a principle of radiopharmaceuticals for
8 Funaki
ticals (II) diagnosis.
Radiopharmaceu Students learn about a principle of radiopharmaceuticals for
9 Funaki
ticals (III) therapy.
Radiopharmaceu Students learn about quality control of radiopharmaceuticals for
10 Funaki
ticals (IV) PET used as hospital preparation.
 The applicability
to the
pharmaceutical Students learn about an isotope dilution method and an
11 Funaki
territory of the activation analysis as examples using radioactive tracers.
radioactive
materials (I)
The applicability
to the
pharmaceutical Students learn about a radio receptor assay and an
12 Funaki
territory of the autoradiography as examples using radioactive tracers.
radioactive
materials (II)
The effect of the
This class is designed to help students understand biological
13 Furumoto radiation on
effects of radiation, acute effects, and late effects.
human body (I)
The effect of the This class is designed to help students understand effects from
14 Furumoto radiation on external and internal exposure and biological effects depending
human body (II) on the dose received
Students learn basic rules and practical methods of safety
Radiation handling when conducting tracer experiments using unsealed
15 Furumoto protection and radioisotopes, safety control in accordance with the Radiation
safety control Hazard Prevention Act, and reagents used to prevent radiation
hazard.
Record and
evaluation Students are evaluated on a written examination (100%).
method
“Radiochemistry and Radiopharmaceuticals, the 5th edition” Publisher: Nankodo
Textbook
Co., Ltd. This textbook is available for purchase at the University Co-op.
Reference No reference will be used.
Preparation
Preparation and review using textbooks and handouts.
and Review
Language Used in
Japanese
Course
Students can contact Prof Furumoto by email or telephone.
Office hours
Email: [email protected] TEL: 022-795-7801
In addition
 Subject Structural Chemstry

Course Numbering YAL-PHA218J Categories Elective

Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Nakabayashi Takakazu and Assistant Professor Tahara Shinya

Practical business
This course provides students with basic knowledge of intermolecular interactions
forming structures of biomolecules and the principles and concepts of a variety of
Objectives and spectroscopic methods for measuring biomolecular structures. The spectroscopic
summary of class methods treated are X-ray diffraction, UV-Vis absorption, fluorescence, circular
dichroism, IR, Raman, NMR, and ESR. Students are recommended to have finished
"Physical Chemistry 1" and "Chemistry-A" before taking this course.
This course is designed to help students explain (i) the basic properties of
intermolecular interactions and their relationships with the formation of biomolecular
structures, (ii) the principles of a variety of spectroscopic methods from the point of
Goal of study
view of light-matter interactions, (iii) the structural information obtained from each
spectroscopic method, and (iv) the application of spectroscopic methods to analyze
structures of biological and functional molecules.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Properties of Light, Concepts of Structural Analysis Using
UV-Vis Absorption
1 Nakabayashi
Spectroscopy I
Interactions of Molecules with Light (Electromagnetic Wave),
Lambert-Beer Law, Boltzmann Distribution
UV-Vis Absorption
2 Nakabayashi
Spectroscopy II
Transition Dipole Moment, Franck-Condon Factor, Selection Rules
UV-Vis Absorption
Spectroscopy III. Structural Analysis of Proteins and Nucleic Acids Using UV-Vis
3 Nakabayashi
Fluorescence Absorption, Jablonski diagram
Spectroscopy I
Fluorescence Fluorescence Lifetime, Fluorescence Quantum Yield, Radiative
4 Nakabayashi
Spectroscopy II and Non-Radiative Rate Constants
Fluorescence Application of Fluorescent Molecules and Proteins to Biological
5 Nakabayashi
Spectroscopy III Science
Vibrational Basic Concepts of Energy Levels and Wave Functions of
6 Tahara
Spectroscopy I Molecular Vibrations
Vibrational
7 Tahara
Spectroscopy II
Principles and Applications of IR and Raman Spectroscopy
Midterm
Optical Rotatory Dispersion, Structural Analysis of
8 Tahara Examination,
Circular Dichroism Biomolecules Using Circular Dichroism
Classification of Crystal Structures, Miller Indices, Bragg's
X-Ray
9 Tahara
Crystallography I
Law, Fundamentals of Crystal Structure Analysis Using X-Ray
Diffraction Pattern
X-Ray Application of Powder and Single Crystal X-Ray Diffraction,
10 Tahara
Crystallography II Structure and Properties of Inorganic Compounds
Intermolecular Permanent Dipole Moment, Ionic Bond, Molecular
11 Nakabayashi
Interactions I Polarizability, Induced Dipole Moment
Intermolecular Hydrogen Bond, Van der Waals Interaction, Lennard-Jones
12 Nakabayashi
Interactions II Potential, Hydrophobic Interaction
Magnetic Moments Arising from Electron Orbital Motion,
13 Nakabayashi NMR I Electron Spin, and Nuclear Spin, Shielding Constant, Chemical
Shift.
Splitting of NMR Peaks Arising from Spin-Spin Coupling,
14 Nakabayashi NMR II
Mechanism of Nuclear Overhauser Effect
 Investigation of Biomolecular Structures Using NMR, Basic
15 Nakabayashi NMR III, ESR
Concepts of ESR
Record and Students are evaluated on their points from the midterm examination (~30%), the
evaluation method term examination (~60%), and mini tests (~10%).
Textbook
"Physical Chemistry for the Chemical and Biological Sciences" R．Chang,
University Science Books（2000）
Reference
"Physical Chemistry: A Molecular Approach" D. A. McQuarrie、J. D. Simon,
University Science Books（1997）
Preparation Students are required to prepare and review for each class using handouts and
and Review references.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
MAIL: [email protected] TEL: 795-6855
In addition
 Subject Biochemistry 4
Course
YAL-PHA236J Categories Elective
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Instructor Inoue Asuka

Practical business
Biochemistry is a molecular understanding of chemical processes in cells. In this
class, students will learn how cells degrade nutrients such as glucose and fatty
Objectives and
acids and produce ATP, an energy currency in cells. Students will also learn
summary of class
importance of these energetic pathway from genetic diseases and compounds to
inhibit the pathway.
The purpose of this course is to help students learn how energy is obtained from
foods (sugar, lipid and proteins) in cells. Students will understand synthesis,
Goal of study conversion and degradation of key metabolic pathways including glycolysis, citrate
cycle and ATP synthesis in mitochondria. Student will also learn genetics and
diseases related to dysregulation of metabolism.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Basics of To understand basic knowledge of energy metabolisms through food
1 Inoue
metabolism digestion and catabolism as well as a concept of metabolic map.
To understand glycolysis and its enzymatic reactions as well as
2 Inoue Glycolysis
aerobic and anaerobic glycolysis.
To understand citrate cycle and its roles in ATP synthesis, supply to
3 Inoue Citrate cycle
amino acids and anaplerosis.
Electron and
4 Inoue ATP To understand electron transport chain and oxidized phosphorylation.
synthesis (I)
Electron and
To understand ATP generation in mitochondria. To learn molecules to
5 Inoue ATP
inhibit ATP synthesis and their mechanism of action.
synthesis (II)
Glycogen To understand the structure and the function of glycogen and the
6 Inoue
metabolism regulation by hormone. To learn pentose phosphate cycle.
Fatty acid To understand the synthesis and the degradation (via β oxidation) of
7 Inoue
metabolism fatty acids.
Lipid To understand the synthesis and the degradation of cholesterol,
8 Inoue
metabolism phospholipids and triacylglycerol.
Amino acid
9 Inoue To understand the metabolisms of amino acids and urea cycle.
metabolism
Nucleotide
10 Inoue To understand the metabolisms of nucleotides.
metabolism
Basics of
11 Inoue To learn the basics of genetics.
genetics
Methods of To understand model animals and mutants. To understand forward
12 Inoue
genetics and reverse genetics.
Human To understand human genetics and genetic disease. To learn how to
13 Inoue
genetics identify a gene responsible for a genetic disorder.
Bioinformati To understand the concept of bioinformatics and methods to obtain
14 Inoue
cs information from online database.
Summary of To review the course and understand the biochemistry of metabolism
15 Inoue
the course and genetics.
Record and
Evaluation is performed based on class performance including the final (90%)
evaluation
examination and the class performance (10%).
method
 Basic Pharmaceutical Sciences Textbook Series: Biochemistry, Editor: Yoshinobu
Textbook Nakanishi.
Essential Cell Biology, Fifth Edition, Editor: Bruce Alberts et al.
Reference Molecular Biology of the Cell, Sixth Edition, Bruce Alberts et al.
Preparation
Understanding of each theme by textbook and reference book.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-6861
In addition
 Subject Molecular biology
Course
YAL-PHA237J Categories Elective
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Inada Toshifumi

Practical business
Objectives and The purpose of this course is to learn the functions and structure of the cell, the
summary of class principle of gene expression.
Students will understand the molecular basis of DNA replication, repair,
Goal of study
transcription, RNA processing, translation.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Sex and
1 Inada Principal of Mendelian inheritance
genetics I
Sex and
2 Inada Mechanism of meiosis and recombination
genetics II
DNA and
3 Inada Structure of DNA and chromosome
chromosome
DNA Mechanism of DNA replication, a process of producing two
.4 Inada
replication identical replicas from one original DNA molecule
DNA damage DNA is damaged by metabolic activities and environmental
5 Inada
and repair factors and corrected by the specific mechanisms.
Gene A process by which genetic information in DNA is converted into a
6 Inada
expression functional gene product
In transcription, a particular segment of DNA is copied into RNA
7 Inada Transcription
by RNA polymerase.
Chromatin
8 Inada Chromatin structure and histone proteins
structure
Transcriptiona Transcription is regulated by protein binding to regulatory DNA
9 Inada
l regulation sequences.
RNA An important process to provide mature mRNA, a template for
10 Inada
processing protein synthesis
Translation
11 Inada Mechanism of initiation step of protein synthesis
initiation
Translation
12 Inada Mechanism of translation elongation
elongation
Analyzing
Methods to analyze gene products (Western blotting and Northern
13 Inada gene and
blotting)
genome I
Analyzing
14 Inada gene and Methods to analyze gene and genome (PCR, DNA sequence)
genome II
Quality control
Quality controls that recognize and eliminate aberrant mRNA and
15 Inada for gene
proteins to ensure the fidelity of gene expression.
expression
Record and
Valuation is performed based on short tests (about 10%) and the final examination
evaluation
(about 90%).
method
Textbook Essential Biology IV

Reference
 Preparation Preparation: Reading the textbook for the next lecture
and Review Review: Answer of the small test and commentary by the lecture
Language Used in
Japanese
Course
Office hours E-MAIL: [email protected] TEL: 795-6874

In addition
 Subject Pharmacology 3
Course
YAL-PHA253J Categories Elective
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Instructor Takuya Sasaki

Practical business
Pharmacology is summarized in the interactions between medicines and biological
functions. Students lean the clinical application, therapeutic and side effects of
Objectives and medicines through those biological actions. Pharmacology 3 focuses on medicines
summary of class and its clinical application acting on cardiovascular system, kidney, urinary, genital
organs. Pharmacology 3 also focused on therapeutics for metabolic diseases and
cancer.
Students understand the molecular basis in drug actions of therapeutics. In
Goal of study addition, students deepen their understanding of the pharmacological mechanisms
underlying the main and side effects of medicines.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction of
Students learn the pathology of cardiovascular and kidney diseases
1 Sasaki cardiovascular
and pharmacology of therapeutics acting on circulatory organs.
pharmacology
Students learn the heart failure and its therapeutics including
Cardiovascular
2 Sasaki cardiac glycoside, beta adrenergic agents and angiotensin-converting
therapeutics (1)
enzyme inhibitors.
Cardiovascular Students learn the therapeutics for angina including nitrate, calcium
3 Sasaki
therapeutics (2) channel blockers, vasodilators and beta receptor inhibitors.
Cardiovascular Students learn the antiarrhythmia agents such as sodium channel
4 Sasaki
therapeutics (3) inhibitors.
Cardiovascular Students learn the agents of hypertension such as sympathetic
5 Sasaki system nervous system modulator, renin-angiotensin inhibitors, calcium
therapeutics (4) channel inhibitors and diuretic.
Coronary and
Coronary and cerebral thrombosis causes myocardial infarction and
cerebral
6 Sasaki stroke. Students learn the thrombolytic agents and protectants for
thrombosis
acute and subacute heart or brain infarction.
therapeutics
Mid-term
examination, Students learn the regulation of urine formation and the effects of
7 Sasaki
and renal diuretic agents on hypertension and heart failure.
therapeutics
Urinary organ Students learn the therapeutics for dysuria and prostatic
8 Sasaki
therapeutics hyperplasia.
Genital organ Students learn the agents of uterine construction, uterine relaxant
9 Sasaki
therapeutics and improving drugs for sexual cycle and functions.
Metabolic
Students learn the lipid and purine metabolism and the therapeutics
10 Sasaki disease
for hyperlipidemia and gout.
therapeutics (1)
Students learn the mechanism underlying autoimmune disease, and
Metabolic
bone and calcium metabolism. Students also learn the therapeutics
11 Sasaki disease
for rheumatoid arthritis, collagen disease, osteoporosis and
therapeutics (2)
osteoarthrosis.
Eye and skin
Students learn the therapeutics for eye and skin diseases including
12 Sasaki disease
glaucoma, atopic dermatitis and decubitus
therapeutics
 Students learn the mechanism of anticancer regents and the
Anticancer
13 Sasaki application for typical cancers.
therapeutics (1)
Students learn the mechanism for the resistance acquisition and the
Anticancer
14 Sasaki therapeutics for prevention of side effects of anticancer regents.
therapeutics (2)
Drug-induced Students learn the cause of harmful side effects and skill for
15 Sasaki
suffering prevention of the drug-induced suffering.
Record and
Mid-term examination (45%), examination (45%), class performance (10%) and so
evaluation
on.
method
Textbook 「Zukai Yakurigaku」Ed. T Nabeshima and K Inoue, Nanzando

Reference References will be provided as necessary.

Preparation Students are required to prepare knowledge of target organs for drugs and
and Review pathology related to content of the class using internet and books.
Language Used in
Japanese
Course
Make an appointment via e-mail before visiting the office. The contact information
Office hours for the lecturers will be on the textbook.
E-MAIL: [email protected] TEL: 022-795-5503
In addition
 Subject Health Chemistry 1

Course Numbering YAL-PHA241J Categories Elective

Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Matsuzawa Atsushi, Associate Professor Noguchi Takuya

Practical business
Health Chemistry is the research field to understand the essential nutrients for
human and to find the method by which protect human from various types of
stress including environmental stress, chemicals, and drugs, leading to
maintenance and increase of human health and prevention of human diseases.
Objectives and
Therefore, the important theme is changed by the needs of the times. In this
summary of class
course, students can especially deepen their understanding of digestion and
absorption of nutrients, energy metabolism, relationship between essential
nutrients and human health, dynamics of nutrients and chemicals in internal
body, toxicity of chemicals, safety evaluation method of chemicals.
1. Understanding of various types of stress caused by environment, chemicals,
drugs, and so on.
2. Understanding of digestion and absorption of nutrients, energy metabolism,
Goal of study
relationship between essential nutrients and human health.
3. Understanding of dynamics of nutrients and chemicals in internal body,
toxicity and safety evaluation method of chemicals.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Digestion and absorption of Students learn the three major nutrients such as
1 Matsuzawa
nutrients (1) carbohydrates, lipids, and proteins.
Digestion and absorption of Students understand the mechanisms of digestion
2 Matsuzawa
nutrients (2) and absorption of nutrients.
Delivery systems of Understanding of delivery systems of the three
3 Matsuzawa
nutrients major nutrients.
Understanding of storage, utilization, and
Storage, utilization, and
4 Matsuzawa interconversion of the three major nutrients, and
interconversion of nutrients
energy metabolism.
Students learn water-soluble vitamins as
5 Matsuzawa Vitamins (1) important nutrients except for the three major
nutrients.
Students learn fat-soluble vitamins as important
6 Matsuzawa Vitamins (2)
nutrients except for the three major nutrients.
Students learn minerals required in trace or large
7 Matsuzawa Minerals
amounts.
Dietary fibers and
8 Matsuzawa Students learn dietary fibers and non-nutrients.
non-nutrients
Students understand the relationship of human
Effect of nutrients on
diseases with deficiency and excess of nutrients or
9 Matsuzawa human health and diseases
energy metabolism, and the change of dietary
(1)
reference intakes, dietary life, and dietary habits.
Students understand the relationship of food
Effect of nutrients on ingredient and nutrients with increase of human
10 Matsuzawa human health and diseases health and prevention of human diseases, and
(2) learn health food and food for specified health
uses.
Students deepen their understanding of
11 Matsuzawa Metabolism of chemicals
metabolism of chemicals and drugs.
 Understanding of the mechanisms of
12 Noguchi Toxicity of chemicals (1)
carcinogenesis induced by chemicals and drugs.
Understanding of the mechanisms of tissue
13 Noguchi Toxicity of chemicals (2)
damages induced by chemicals and drugs.
Students understand the effect of endocrine
disruptors and inorganic or organic substance on
14 Noguchi Toxicity of chemicals (3)
human health, and learn their toxicity, methods of
detoxification, and drug abuse.
Safety evaluation and Understanding of safety evaluation, restriction,
15 Matsuzawa
restriction of chemicals and toxicity testing methods of chemicals.
Record and Students are evaluated on the final examination (75%) and the class
evaluation method performance (25%).
“Eisei Yakugaku –Kenkou to Kankyou– ” edited by Akira Naganuma, Seiichiro
Textbook
Himeno, Akira Hiratsuka (Maruzan).
Reference
Preparation Students are required to prepare and review for class according to the goal and
and Review contents of each class.
Language Used in
Japanese
Course
Students should make an advance appointment via E-mail or other means.
Office hours
E-mail: [email protected] TEL: 795-6827
The most of lecture contents are included in pharmacist national examination
In addition
guidelines.
 Subject Pharmaceutics 2
Course
YAL-PHA262J Categories Elective
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Instructor Professor Akita Hidetaka, Lecturer Uchida Yasuo, Lecturer Sakurai Yu

Practical business
The purpose of this course is to apply the physical pharmacy and basic
pharmacokinetics given by Pharmaceutics 1 for the design of dosage regimen in
human. This course will help students understand pharmacokinetic models, moment
Objectives and
analysis, mechanisms and kinetics of drug-drug interaction, various factors affecting
summary of class
pathological changes in pharmacokinetics and individual differences, and
therapeutic drug monitoring (TDM). Small test will be given in each lecture to
evaluate the achievement of understandings.
Upon completion of this class, a student should be able to:
·Explain the concept of pharmacokinetic models such as one-compartment model and
physiologically based pharmacokinetic model
Goal of study ·Explain the mechanisms and kinetics of drug-drug interactions
·Explain the principle of clinical dosage regimen and apply for selecting a route of
drug administration and determining the dose and frequency of administration.
·Explain moment analysis and therapeutic drug monitoring (TDM)
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Basic concept and principle of one-compartment model
Compartment
1 Uchida Application of one-compartment model for bolus intravenous
models-1
administration
Compartment Application of one-compartment model for constant infusion and
2 Uchida
models-2 multiple dosage regimen
Clinical
Principles and clinical significance of the dosage regimen design
3 Uchida pharmaco-
in drug therapeutics
kinetics
Formulation of pharmacokinetic models for constant infusion
Design of dosage
4 Uchida Design of bolus dose and constant infusion rate to achieve a
regimen-1
desired steady state plasma concentration of drugs
Formulation of pharmacokinetic models for multiple dosing
Design of dosage
5 Uchida Design of multiple dosing regimen to achieve a desired steady
regimen-2
state plasma concentration of drugs
Compartment Application of one-compartment model for the actual cases of
6 Uchida
models-3 dosage regimen
Principle of moment analysis as a models-independent analysis
Moment Application of moment analysis for analyzing the release and
7 Akita
analysis absorption of drug delivery system formulations which have the
difficulty in describing models.
Population
8 Uchida Basic concepts of population pharmacokinetics
pharmacokinetics
The values of volume of distribution and rate constant obtained
Physiologically
by the compartment model are conceptual. We outline
based
9 Akita physiological drug kinetics that express pharmacokinetics in
pharmaco-
more detail based on physiological and anatomical findings.
kinetic models
Clearance theory to formulate the elimination process of drugs
Clearance
10 Akita Definitions of total body clearance, organ clearance, intrinsic
theory
clearance and their relationships
 Nonlinear Processes the show saturation characteristics, e.g., metabolism,
11 Akita pharmacokinetic membrane transport, and plasma protein binding
s Principle of nonlinear pharmacokinetics
Pathological Pharmacokinetic factors affecting the pathological changes in
changes and the rate-limiting processes of absorption, distribution,
12 Sakurai
inter-individual metabolism and elimination (ADME) and the inter-individual
differences differences
Special
13 Sakurai Children therapy
population
Basic principle of drug-drug interactions
Drug-drug
14 Akita Changes in the pharmacological effect of drugs by the other
interaction-1
concomitantly administrated drugs
Drug-drug
15 Akita Mechanisms and kinetics of drug-drug interactions
interaction-2
Record and
Students are evaluated on their points from all the small tests (40%), and the
evaluation
midterm and regular examinations (60%).
method
(Japanese) Partner Pharmaceutics, Fourth edition (2022)
Textbook (ISBN:9784524403875)
パートナー薬剤学 改訂第 4 版 原島秀吉ら編集、南江堂（2022）
1. (English) Clinical Pharmacokinetics and Pharmacodynamics: concepts and
applications Fourth Edition Malcolm Rowland and Thomas N. Tozer, Lippincott
Williams and Wilkins (2009) (ISBN:9780781750097)
2. (Japanese) Biopharmaceutics (ISBN:9784567482349)
わかりやすい生物薬剤学 第 5 版 荻原琢男執筆者代表、廣川書店（2014）
Reference
3. (Japanese) Clinical pharmacokinetics (ISBN: 9784524250554)
臨床薬物動態学 第４版 加藤隆一著、南江堂 (2009)
4. (Japanese) Tsuji's pharmacokinetics Episode Pharmacokinetics
(ISBN:9784901789998)
エピソード薬物動態学―薬物動態学の解明、京都廣川書店（2012）
Preparation Getting basic knowledge on each topic using the text book and references above as a
and Review pre-study and Trying several practice problems as a review
Language Used in
Japanese
Course
Please make an advance appointment via e-mail or other means. The contact
Office hours
information for the lecturer will be given in the class.
In addition
 Subject Medicinal Chemistry 1
Course
YAL-PHA228J Categories Elective
Numbering
Preferable
3rd Semester 5 Credits 1
Participants
Instructor Doi Takayuki, Miyata Kazuhiko

Practical business
In this class, students learn history of drug discovery and the current advanced
drug discovery research represented by genomic drug discovery, a patent, and the
Objectives and norms for developing a marketing drug. Students learn the basic knowledge of drug
summary of class research and development.

· Students can explain the flow of drug development and the research methods used.
· Students can explain the significance of intellectual property rights and patents,
and the norms related to new drug development research.
Goal of study · Students can explain about genome-based drug discovery.
· Students can explain drug targets, screening, drug design, and drug discovery
modalities.

Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
The history of pharmaceuticals, the current status of drug
Drug discovery
1 Doi discovery, and the drug discovery process from the early stages of
process (1)
drug discovery
Drug discovery The flow of drug discovery from non-clinical and clinical studies
2 Doi
process (2) to approval and post-marketing surveillance

Drug discovery Disease-related genes and the flow of genome-based drug

3 Doi
research (1) discovery
Drug discovery
4 Doi Biopharmaceuticals, gene therapy, and cell-based therapies
research (2)
Drug discovery High throughput screening system, automated synthesis, and
5 Doi
research (3) computer-aided drug design
Fundamentals of
Intellectual property rights and the significance of the patent
6 Miyata drug
system
development (1)
Fundamentals of
Generic drugs, drug hazards, and the norms for research and
7 Doi drug
development of new drugs.
development (2)
Summary and
8 Doi Summary of the flow of drug development
Examination
Record and
Evaluation is performed comprehensively based on the class performance (20%) and
evaluation
the final examination (80%).
method
Basic Pharmaceutical Textbook Series 6, Pharmaceutical Science and Medicinal
Textbook
Chemistry, Kagakudojin (2011)
The Practice of Medicinal Chemistry, second edition/ C. G. Wermuth, ELSEVIER
Reference
LIMITED (2011)
Preparation Before this course, students are required to read a textbook. After lecture, students
 and Review are required to read the story of drug discovery development under own
investigation.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected]

In addition
 Subject Organic Reaction

Course Numbering YAL-PHA229J Categories Elective

Preferable
3rd Semester 5 Credits 2
Participants
Professor Yoshinori Kondo, Professor Naohiko Yoshikai, Associate Professor
Instructor
Masanori Shigeno, and Assistant Professor Kanako Kumada
Practical business
Biologically active compounds often contain nitrogen, oxygen, and sulfur atoms,
and students will understand the property and synthesis of such
Objectives and
organoheteroatom compounds along with their application to drugs. In addition,
summary of class
students learn organometallic, Brønsted base, and radical chemistry to synthesize
these compounds.
To be able to understand and explain the chemical property, synthesis of nitrogen,
Goal of study
oxygen, and sulfur containing organic molecules and organometallic chemistry
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction to
Kondo
1 heteroatom Outline of organic sulfur and organic phosphorous chemistry
Shigeno
chemistry
Kondo Carbon-heteroato
2 Nature of carbon-heteroatom bonds
Shigeno m bond
Synthesis of
Kondo
3 organosulfur Synthesis of organosulfur compounds
Shigeno
compounds
Reaction of
Kondo
4 organosulfur Transformation of organosulfur compounds
Shigeno
compounds 1
Reaction of
Kondo
5 organosulfur Synthetic reactions using organosulfur compounds
Shigeno
compounds 2
Kondo Reaction of
6 Transformation of deprotonative functionalizations
Shigeno Brønsted base
Kondo
Reaction of
7 Shigeno Transformation of radical reactions
radicals
Kumada
Kondo Summary and
8 Shigeno middle Summary of organoheteroatom chemistry
Kumada examination
Introduction to
9 Yoshikai organometallic History and importance of organometallic chemistry
chemistry
Structure,
10 Yoshikai bonding, and Types of ligands, basics of ligand-field theory, electron counting
properties 1
Structure,
11 Yoshikai bonding, and Nature of different metals and metal-ligand bondings
properties 2
Elementary Elementary reactions of transition metal complexes and their
12 Yoshikai
reactions 1 mechanisms
Elementary Elementary reactions of transition metal complexes and their
13 Yoshikai
reactions 2 mechanisms
Transition
Principles and applications of transition metal-catalyzed
14 Yoshikai metal-catalyzed
organic reactions
organic reactions
 Main group Synthesis and reactions of main group organometallic
15 Yoshikai
organometallics compounds
Record and Evaluated mainly by first examination (40%) and second examination (40%) with
evaluation method partial consideration of attendance (20%)
Textbook none

Reference
Preparation
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.

E-MAIL: [email protected]（根東教授 ）,
Office hours [email protected]（吉戒教授 ）
[email protected]（重野准教授）,
[email protected]（熊田助教）
In addition
 Subject Analytical Chemistry 3
Course
YAL-PHA213J Categories Elective
Numbering
Preferable
3rd Semester 5 Credits 2
Participants
Instructor Professor Oe Tomoyuki

Practical business
Drug analyses for ADME (absorption, distribution, metabolism, and excretion) research
are essential to keep the safety and proper use of drugs. Protein analyses in biomarker
Objectives and
discovery are also essential for drug discovery and diagonosis. This course covers recent
summary of class
practical strategies for advanced separation technologies and highly sensitive analytical
technologies for above purposes.
Better understanding of recent analytical approaches in drug research, basic research,
and clinical research to make it possible to explain practical analytical strategies for
Goal of study
biomolecules including handling/clean-up of biological samples, qualitative/quantitative
use of chromatography/mass spectrometry.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

Introduction: Overviewing clinical analytical chemistry and learning about the

1 Oe clinical analytical methodology, significance, difficulties in analyses of drug and bioactive
chemistry
molecules in biological samples
Handling of
Learning about biological samples in terms of categorization, sampling,
2 Oe biological
specimens handling, and storage.
Reliable analytical Learning about validation of analytical methods and standardization of
3 Oe data clinical data in order to keep the reliability
Clean-up for
4 Oe biological Learning about the clean-up strategies: principle and the characteristics
specimens
High performance
Learning about the retention on HPLC and related chromatographic
5 Oe liquid
chromatography I conditions (mobile phase, pH, stationary phase, etc.)
High performance
Learning about the relationship between the chemical structures and
6 Oe liquid
chromatography II the retention behavior on HPLC
Affinity Learning about the basic theories and the significance of affinity
7 Oe chromatography chromatography
Learning about the basic theory and the characteristics of gel
8 Oe Electrophoresis I
electrophoresis for bio-macromolecules
Learning about the basic theory and the characteristics of capillary
9 Oe Electrophoresis II
electrophoresis
Mass
10 Oe spectrometry I Learning about the basic of LC/MS for small molecules
(advanced)
Mass
Learning about the combination use of stable isotope labeling and mass
11 Oe spectrometry II
(advanced) spectrometry for pharmacokinetics study
Learning about the ionization/fragmentation of proteins/peptides in
12 Oe Proteomics I
mass spectrometry and how to interpret the data
13 Oe Proteomics II Learning about protein identification strategies by mass spectrometry
Learning about the basic theory and the relationship between designing
14 Oe Immunoassay I
hapten immunogen and acquired antibodies in terms of the selectivity
Learning about the basic theories and the significance in the use of
15 Oe Immunoassay II competitive assays for small molecules and non-competitive assays for
macromolecules
Record and
evaluation Based on the written exam
method
Textbook Handouts of the power point slides are provided.
 Analytical Chemistry I (パートナー分析化学 I), 3rd Ed., Ed. J. Haginaka, H. Nohta, M.
Yamaguchi, Nankodo Co., Ltd., 2017 (ISBN 978-4-524-40343-1)
Analytical Chemistry II (パートナー分析化学 II), 3rd Ed., Ed. H. Nohta, J. Haginaka, M.
Yamaguchi, Nankodo Co., Ltd., 2017 (ISBN 978-4-524-40344-8)
Reference
Clinical Chemistry (薬学生のための臨床化学), 3rd Ed., Ed. J. Goto, Y. Katayama,
Nankodo Co., Ltd., 2010 (ISBN 978-4-524-40262-5)
「イメージから学ぶ分光分析法とクロマトグラフィー～基礎原理から定量計算まで」.
Sadakane, Kyoto Hirokawa Publishing Inc., 2009 (ISBN 978-4-901789-19-6)
Preparation
and Review
Language Used in
Japanese
Course
Office hours An appointment required by E-mail ([email protected]) or phone (795-6817)

In addition
 Subject Physical chemistry 3

Course Numbering YAL-PHA216J Categories Elective

Preferable
3rd Semester 5 Credits 2
Participants
Instructor Professor Konno Tomohiro, and Assistant Professor Yoshizaki Yuta

Practical business
The purpose of this course is to learn polymeric biomaterials containing
Objectives and
polymeric aggregates and micelles, colloids, hydrogels, thin films, liposomes,
summary of class
emulsions, microspheres and microcapsules, rheology, and powders.
This course is designated to help students understand the basics and
Goal of study applications of colloid biomaterials, polymer biomaterials for pharmaceutical
sciences and engineering.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Thermal physics
1 Konno of condensed Basics of thermal physics of condensed matter
matter
2 Konno Colloids 1 Characteristic features of colloids

3 Konno Colloids 2 Stability of colloids

4 Konno Detergents 1 Structure and properties of detergents

5 Konno Detergents 2 Thermodynamics of detergents

Polymers
6 Konno Characteristic features of polymers and hydrogels
and hydrogels 1
Polymers Characteristic features and applications of polymers and
7 Konno
and hydrogels 2 hydrogels
Polymers Biomedical and chemical applications of polymers and
8 Konno
and hydrogels 3 hydrogels
9 Konno Rheology 1 Basic principle of rheology

10 Konno Rheology 2 Biomedical application of ideas of rheology

Characteristic features of powders and applications in drug
11 Yoshizaki Powders
preparation
12 Yoshizaki Thin films 1 Monomolecular and multilayer films
Langmuir-Blodgett films and bioanalytical applications of
13 Yoshizaki Thin films 2
thin films
Liposomes
14 Yoshizaki Preparation and use of liposomes and emulsions
and emulsions
Microsphere
15 Yoshizaki and Preparation and use of microspheres and microcapsules
microcapsule
Record and evaluation
Students are evaluated on the small quizzes (20%) and final test (80%).
method
Textbook
“Physical Chemistry 2nd Edition.”, Publisher: Kagaku-Dojin Publishing
Company, (2018) (ISBN: 978-4-7598-1628-0)
Reference
“Biomaterials Science 2nd Edition.”, Publisher: Tokyo-Kagaku-Dojin
Publishing Company, (2018) (ISBM: 978-4-8079-0906-3)
 Preparation
Students are required to read the textbook for the next class.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-mail: [email protected] Phone: 795-6841
In addition
 Subject Pharmacology 4

Course Numbering YAL-PHA254J Categories Elective

Preferable
3rd Semester 5 Credits 2
Participants
Professor Hirasawa Noriyasu, Accistant Professor Segawa Ryosuke, and Professor
Instructor
Moriya Takahiro
Practical business
Pharmacology is a discipline which explores an interaction between drugs and a
human body. It also explores the mechanism of a wide variety of human body
functions through the analysis of drug action. The main objective of this course
is to better understand an interaction between drugs and a human body which is
great necessary for considering the actions, adverse effects and contraindication for
any given drug. In this Pharmacology 4, students learn about the
Objectives and
physiological/pathophysiological roles of various hormones, blood, inflammation
summary of class
and immuno-system and understand the mechanism of the actions, adverse effects
and contraindication for related drugs. Students also learn about the classification,
morphology and structure of pathogenic microbe and understand the mechanism
of the actions, adverse effects and contraindication for several agents to treat
infectious diseases such as antibiotics, synthetic antimicrobial agents, anti-
tuberculosis drugs, antifungals and antivirals.
The purpose of this course is to help students learn the basic knowledge and the
point of view of the pharmacotherapy. Also, students understand the mechanism of
actions and adverse effects of drugs that act on endocrine, blood, hemotogenesis
Goal of study
and inflammation/immuno-system. Students also understand the pathogenic
microbe and infection and develop the ability to consider and to explain the
mechanism of agents to treat infectious diseases.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
In this course, students will understand the
Hirasawa・ Hormone and physiological/pathophysiological roles of hypothalamic hormones,
1
Segawa drugs (1) pituitary hormones and mineralocorticoids and learn about related
drugs.
In this course, students will understand the
Hirasawa・ Hormone and
2 physiological/pathophysiological roles of thyroid hormone, sex
Segawa drugs (2)
hormones and parathyroid hormone and learn about related drugs.
In this course, students will understand the
Hirasawa・ Hormone and
3 physiological/pathophysiological roles of insulin and learn about
Segawa drugs (3)
drugs for Diabetes Mellitus.
Anti-
Hirasawa・ In this course, students will learn about steroidal anti-
4 inflammatory
Segawa inflammatory drugs.
drugs (1)
Anti-
Hirasawa・ In this course, students will learn about Nonsteroidal Anti-
5 inflammatory
Segawa inflammatory Drugs (NSAIDs) and antipyretic analgesics.
drugs (2)
In this course, students will understand the
Hematology physiological/pathophysiological roles of blood and the mechanism
6 Moriya
and drugs (1) of hemostasis and thrombolysis and learn about agents to treat
anemias.
Hematology
7 Moriya In this course, students will learn about antithrombotic drugs.
and drugs (2)
Hematology
8 Moriya In this course, students will learn about hemostatic drugs.
and drugs (3)
 Treatment of This course offers an opportunity to learn about infectious diseases
9 Moriya infectious and pathogenic microbe. Students also learn about the history of
diseases (1) the development of agents to treat infectious diseases.
Treatment of
In this course, students will learn about the classification,
10 Moriya infectious
morphology and structure of pathogenic microbe.
diseases (2)
In this course, students will understand the principle of the action
Treatment of
of chemotherapeutic agent to treat infectious diseases and learn
11 Moriya infectious
the reason why many chemotherapeutic agents exhibit a selective
diseases (3)
toxicity.
This course offers an opportunity to learn about the elementary
Treatment of matters of action of chemotherapeutic agents. Students also
12 Moriya infectious understand the molecular mechanism and clinical application of
diseases (4) cell wall synthesis inhibitors such as penicillins, most popular
antibiotics.
Treatment of In this course, students will learn about the molecular mechanism
13 Moriya infectious and clinical application of protein synthesis inhibitors such as
diseases (5) aminoglycosides and tetracyclines.
Treatment of In this course, students will learn about the molecular mechanism
14 Moriya infectious and clinical application of synthetic antimicrobial agents, anti-
diseases (6) tuberculosis drugs and antifungals.
Treatment of
In this course, students will learn about the molecular mechanism
15 Moriya infectious
and clinical application of antivirals.
diseases (7)
Record and
Students are evaluated on the midterm (50%) and final (50%) examination.
evaluation method
Nabeshima, Toshitaka and Inoue, Kazuhide eds., Mitewakaru Yakugaku Zukai
Textbook
Yakurigaku (1st Edition). Nanzando, 2015.
Tanaka, Chikako and Kato, Ryuichi eds., New Pharmacology (6th Edition). Nankodo,
2011.
Azuma, Masanobu and Oguma, Keiji eds., Simple Biseibutsugaku (5th Edition).
Nankodo, 2011.
Reference Yanagisawa, Teruyuki ed., Shin-yakurigaku nyuumon (3rd Edition). Nanzando, 2008.
Sato, Susumu ed., Shin-yakurigaku text (3rd Edition). Hirokawa Publishing Co., 2011.
Yanagisawa, Teruyuki ed., Shin-yakurigaku nyuumon (3rd Edition). Nanzando, 2008.
Laurence Brunton, Bruce Chabner and Brorn Knollman eds., Goodman & Gilman's The
Pharmacological basis of Therapeutics (Translation supervised by Takaori, Syuzo,
Keitaro Hashimoto, Akaike, Akinori and Ishii, Kunio). Hirokawa Publishing Co., 2013.
Hirasawa: Students are required to prepare knowledge of target organs for drugs
Preparation and pathology related to content of the class using internet and books.
and Review Moriya: Students can previously download the slide files and prepare the contents
with the above textbook.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
The contact information for the lecturer:
Office hours
Hirasawa: E-MAIL: noriyasu.hirasawa.c7@ tohoku.ac.jp TEL: 022-795-6809
Moriya: E-MAIL: [email protected] TEL: 024-932-9156
In addition Materials are provided via ISTU (Moriya).
 Subject Environmental Health Science
Course
YAL-PHA242J Categories Elective
Numbering
Preferable
3rd Semester 5 Credits 2
Participants
Instructor Professor Saito Yoshiro and Assistant Professor Toyama Takashi

Practical business
Environmental health science is a discipline which explores methods for
maintenance of the human health and prevention of disease caused by
environmental pollutants. In this course, students will understand methods to grasp
Objectives and the human health condition and the actual situation of the disease, the
summary of class investigation method of the primary cause (mainly environmental risk) of the
illness and actual methods for the disease prevention. Students also learn about
pollution and purification treatment of water and air which are the most important
factors in maintaining health.
The purpose of this course is to help students better understand the methods for
Goal of study
maintenance of the human health and prevention of disease.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Ter
Lecturer Theme Contents
m
1 Saito Overview History of public health and social significance
Environmental
2 Saito Relation with environmental parameters and the human health
factors
Health
3 Saito Significance of health statistics and method of its evaluation
statistics
4 Saito Epidemiology Method and significance of epidemiology

5 Saito Prevention Significance and effect of disease prevention care

6 Saito Pollutants 1 Human exposure to environmental pollutants

7 Toyama Pollutants 2 Health effects of inorganic pollutants

8 Toyama Pollutants 3 Health effects of organic pollutants

Global
9 Saito Changes in global environment and human life
environment
10 Saito Water 1 Purification system of drinking water

11 Saito Water 2 Water pollution and its evaluation

12 Saito Air Air and health

13 Saito Air pollution Significance and evaluation of air pollution

Occupational
14 Saito Cause of the occupational illness and its prevention
health
Health
15 Saito Law in conjunction with the environmental pollution
administration
Record and
Evaluation is performed comprehensively based on the midterm examination (40%),
evaluation
the final examination (40%) and class performance (20%).
method
Pharmaceutical Health Sciences, eds by A. Naganuma et al., Maruzen Publishing
Textbook
Co. Ltd. (ISBN: 978-4-621-08627-8)
 Reference
Preparation
and Review
Language Used in
Japanese
Course
Office hours Make an advance appointment via e-mail or other means.

In addition
 Subject General Training in Analytical Chemistry
Course
YAL-PHA210J Categories Required
Numbering
Preferable 2 (including General
2nd Semester 4 Credits Training in Physical
Participants Chemistry)

Instructor Staff and graduate students of Bio-analytical Chemistry Lab (Professor Oe Tomoyuki)

Practical business
The purity of drugs not only affects the pharmacological activity, but also could cause
adverse effects. Therefore, accurate and reliable analytical approach is necessary to
keep better patients’ QOL. In this training, students can experience typical volumetric
Objectives and analyses based on chemical equilibrium in order to acquire basic theories and skills of
summary of class typical quantitative analyses. For this training, comprehensive knowledge (including
physical, inorganic, and organic chemistries) is required. Through this course, students
are expected to learn not only for concept of analytical chemistry, but also the scientific
way of thinking.
The principles and operation procedures of volumetric analyses in Japanese
Goal of study Pharmacopoeia, 16th Ed (JP16) are studied in order to perform the analyses
practically.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

This training aims to help students learn basic knowledges on chemical equilibrium and covers: preparation
of standard solutions, standardization of the solutions by primary or secondary standard reagents,
quantification of drugs by standardized standard solutions, judgement of equivalent point/titration
end-point by indicator’s color-change, and calculation of the contents/concentrations.
（１）Acid-base titration
Learning about acid-base reactions in aqueous solution, the titration curves, difference between
equivalent point and titration end-point, and color-changing mechanism of indicator. Also, performing
quantification of aspirin (analgesic) for better understanding of the theory and procedure.
１）Preparation and standardization of 0.1 mol/L NaOH solution
Learning about the procedure for the preparation of NaOH solution and the standardization using
sulfamic acid and HCl solution as the primary standard reagent and secondary standard reagent,
respectivery.
２）Quantification of aspirin
To understand back titration in acid-base titration, aspirin is analyzed.
（２）Chelatometric titration
Learning about chelation between metal ion/multidentate ligand and color-changing mechanism of
metal indicator. Also, performing quantification of calcium pantothenate (vitamin B 5 , Ca salt) for
better understanding of the theory and procedure..
１）Preparation and standardization of 0.01 mol/L EDTA solution
Learning about the procedure for the preparation of EDTA solution and the standardization using
zinc as the primary standard reagent
２）Preparation and standardization of 0.01 mol/L MgCl 2 solution
Learning about the procedure for the preparation of MgCl 2 solution and the standardization using
EDTA solution as the secondary standard reagent.
３）Quantification of calcium pantothenate
To understand chelatometric titration, calcium pantothenate is analyzed as calcium ion.
Record and
Based on the attendance, attitude/activity in the laboratory, and the final report.
evaluation
Submitting report is mandatory.
method
Textbook
 Reference Japanese Pharmacopoeia, 17th Ed (JP17) Manual (第１７改正日本薬局方解説書), Editing
Committee of Japanese Pharmacopoeia Manual, Hirokawa-Shoten Ltd., 2016 (ISBN
978-4-567-01532-5)
Analytical Chemistry I (パートナー分析化学 I), 3rd Ed., Ed. J. Haginaka, H. Nohta, M.
Yamaguchi, Nankodo Co., Ltd., 2017 (ISBN 978-4-524-40343-1)
Quantitative analysis (図解とフローチャートによる定量分析), Ed. S. Asada, S. Uchide, M.
Kobayashi, Gihodo Shuppan Co., Ltd., 1987 (ISBN 4-7655-0342-9)
Preparation
and Review
Language
Used in Japanese
Course
Office hours An appointment required by E-mail ([email protected]) or phone (795-6817)

In addition
 Subject General Training in Physical Chemistry
Course
YAL-PHA210J Categories Required
Numbering
Preferable 2 (including General
2nd Semester 4 Credits Training in Analytical
Participants Chemistry)
Teaching staff of Laboratory of Biointerface Chemistry and Laboratory of Bio-
Instructor
Structural Chemistry. Contact: Nakabayashi Takakazu
Practical business
Physical chemistry serves as an important base for various methods which are
utilized in pharmaceutical research studies. In this course, students will learn
Objectives and about the principles and measurements of several spectroscopic and
summary of class electrochemical techniques. This course trains students to be able to determine
various kinetic and equilibrium parameters such as the rate of a chemical reaction,
and analyze the molecular structure.
(1) The purpose of this course is to help students understand the principles and
operations of instrumental analysis methods.
Goal of study
(2) Students will be able to find an appropriate method for solving their own specific
analytical problem.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

General training in physical chemistry consists of 6 courses described below. An instructor of each course
works with a small group of students up to 15. Students make an original project based on the general
training courses and perform it at the final stage of the training.
(1) Ion selective electrode
Students will learn about the constitution and principle of ion selective electrodes. Students can deepen
their understanding of the properties and operations of electrodes through determining solute
concentration in a test sample.

(2) Buffer
Students will learn about the theory and preparation of a pH-meter and buffer solutions. Students
perform neutralization titration, and understand the buffer capacity and the working pH range by
analyzing the obtained titration curve.

(3) Acid dissociation constant

Students will learn about the principles and operations of a UV-visible spectrophotometer. Students will
be able to determine the acid dissociation constant of dye molecules from the pH dependence of the
absorption spectrum.

(4) Fluorescence spectroscopy

Students will learn about the principles and operations of a fluorescence spectrofluorometer.
Fluorescence spectrum of a protein is applied for estimation of the environment of tryptophan residues
in protein molecule.

(5) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of proteins

Students will learn about the methods for determinations of molecular weight and concentration of
proteins using SDS-PAGE and UV absorption, respectively.

(6) Infrared absorption spectroscopy

Students will learn about the operations of an infrared spectrometer, and the preparation of samples for
the spectral measurements. In order to obtain information on the molecular structure from the infrared
spectrum, students understand why the frequency of a molecular vibration is altered by the isotope
substitution or hydrogen bonding.
Record and
Evaluation is performed comprehensively based on submitted report, attendance and so
evaluation
on.
method
Textbook
Atkins' Physical Chemistry (10th edition), Peter Atkins and Julio de Paula, Oxford
Reference
University Press, ISBN: 978-0199697403.
Preparation
Students are required to prepare for each training session using the training manual.
and Review
Language
Used in Japanese
Course
Office hours Make an advance appointment via e-mail or other means.

In addition
 Subject General Training in Organic Chemistry 1
Course
YAL-PHA220J Categories Required
Numbering
Preferable
2nd Semester 4 Credits 2
Participants
Faculty staff of Organometallic Chemistry Laboratory, Medicinal Chemistry
Laboratory, Synthetic Chemistry Laboratory, Heterocyclic Chemistry Laboratory,
Molecular Transformation Laboratory, Natural Products Chemistry Laboratory,
Instructor
and Botanical Garden for Pharmacological Herbs.
Contact: Yoshinori Kondo (Molecular Transformation Laboratory), Asai Teigo
(Natural Products Chemistry Laboratory)
Practical business
This course provides practical training in the basic techniques of the standard
organic chemistry laboratory, such as separation and characterization techniques.
Objectives and
Experiments involving the synthesis and reaction of simple organic compounds are
summary of class
introduced. Fieldwork in the Experimental Station for Medicinal Plant Studies is
also included in this course.
Students will develop their skills in the organic chemistry laboratory and their
Goal of study
abilities necessary to interpret spectra of organic molecules.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Lecture:
Introduction to organic chemistry experiments and structure analysis of organic compounds

Laboratory training:
1. Introduction of basic techniques
(1) Extraction and drying, (2) Distillation and recrystallization, (3) Melting point determination, (4)
Qualitative analysis, (5) Glasswork techniques, (6) Spectroscopic analysis

2. Reaction and structure determination of organic compounds

(1) Electrophilic aromatic substitution reaction
(2) Functional group transformation
(3) Reactivity of organometallic reagents
(4) Identification of organic molecules

3. Fieldwork in the Experimental Station for Medicinal Plant Studies

(1) Observation of medicinal plants
(2) Component of medicinal plants
(3) Intended purpose, pharmacological action, and used part of medicinal plants

Record and Evaluation is performed comprehensively based on their level of class participation (60%),
evaluation the final examination (20%), the submitted report (i.e., the submitted laboratory
method notebook) (10%), and fieldwork in the experimental station for medicinal plant studies
(10%).
Textbook 令和４年度—令和５年度 創薬化学実習（Soyaku Kagaku Jissyu）
 Reference Handbook of Experimental Organic Chemistry 1. Sample Handling and Purification
Techniques (Japanese), Ed. by T. Goto et al. Kagaku Dojin (1988)
Handbook of Experimental Organic Chemistry 3. Organic Reactions [1] (Japanese), Ed.
by T. Goto et al. Kagaku Dojin (1990)
Basic Heterocyclic Compounds, New Edition (Japanese), written by H. Yamanaka, T.
Hino, M. Nakagawa, and T. Sakamoto, Kodansya (2004)
Advanced Heterocyclic Compounds, New Edition (Japanese), written by H. Yamanaka, T.
Hino, M. Nakagawa, and T. Sakamoto, Kodansya (2004)
The Organic Chem Lab Survival Manual -A Student's Guide to Technique- Sixth Edition,
written by J. W. Zubrick, John Wiley & Sons (2004)
Reactions and Syntheses: in the Organic Chemistry Laboratory, Second, Completely
Revised and Updated Edition, written by L. F. Tietze, T. Eicher, U. Diederichsen, A.
Speicher, and N. Schützenmeister, Wiley-VCH (2007)
Spectrometric Identification of Organic Compound, 8th Edition, written by R. M.
Silverstein, F. X. Webster, D. J. Kiemle, and D. L. Bryce Wiley (2016)
Preparation Students must read the relevant sections in the textbook and Classroom and understand
and Review the contents in advance.
Language
Used in Japanese
Course
Make an appointment in advance.
Office hours E-mail: [email protected], Phone: 022-795-6804
E-mail: [email protected], Phone: 022-795-6822
In addition
 Subject General Training in Organic Chemistry 2
Course
YAL-PHA320J Categories Required
Numbering
Preferable
3rd Semester 5 Credits 1
Participants
Faculty staff of Organometallic Chemistry Laboratory, Medicinal Chemistry
Laboratory, Synthetic Chemistry Laboratory, Heterocyclic Chemistry Laboratory,
Molecular Transformation Laboratory, Natural Products Chemistry Laboratory,
Instructor
and Botanical Garden for Pharmacological Herbs.
Contact: Yoshinori Kondo (Molecular Transformation Laboratory), Asai Teigo
(Natural Products Chemistry Laboratory)
Practical business
In continuation of General Training in Organic Chemistry 1, the first half of this
course continues to provide practical training in the basic techniques of the
Objectives and standard synthetic organic chemistry laboratory. The second part of this course
summary of class provides practical training in the basic techniques of the isolation, derivative
synthesis and characterization of natural products. Fieldwork in the Experimental
Station for Medicinal Plant Studies is also included in the second part.
Students will develop basic skills in the organic chemistry laboratory and natural
Goal of study product chemistry, and their abilities necessary to interpret spectra of organic
molecules.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Lecture:
Introduction to organic chemistry experiments and structure analysis of organic compounds

Laboratory training and fieldwork:

1. Introduction of basic techniques
(1) Extraction and drying, (2) Distillation and recrystallization, (3) Melting point determination, (4)
Qualitative analysis, (5) Optical resolution, (6) Spectroscopic analysis

2. Reaction and structure determination of organic compounds

(1) Reaction of aromatic compounds
(2) Synthesis and reaction of organometallic compounds
(3) Pericyclic reaction

3. Multi-step synthesis of protoberberine alkaloids

4. Isolation of natural products, Synthesis of their derivatives, and Structure determination

(1) Isolation of rutin
(2) Synthesis of rutin derivatives
(3) Structure analysis of rutin

5. Fieldwork in the Experimental Station for Medicinal Plant Studies

(1) Observation of medicinal plants
(2) Component of medicinal plants
(3) Intended purpose, pharmacological action, and used part of medicinal plants

Record and
Evaluation is performed comprehensively based on their level of class participation, the
evaluation
submitted report (i.e., the submitted laboratory notebook), and the final examination.
method
Textbook 令和３年度—令和４年度 創薬化学実習（Soyaku Kagaku Jissyu）
 Reference Handbook of Experimental Organic Chemistry 1. Sample Handling and Purification
Techniques (Japanese), Ed. by T. Goto et al. Kagaku Dojin (1988)
Handbook of Experimental Organic Chemistry 3. Organic Reactions [1] (Japanese), Ed. by T.
Goto et al. Kagaku Dojin (1990)
Basic Heterocyclic Compounds, New Edition (Japanese) written by H. Yamanaka, T. Hino, M.
Nakagawa, and T. Sakamoto, Kodansya (2004)
Advanced Heterocyclic Compounds, New Edition (Japanese), written by H. Yamanaka, T.
Hino, M. Nakagawa, and T. Sakamoto, Kodansya (2004)
The Organic Chem Lab Survival Manual -A Student's Guide to Technique- Sixth Edition,
written by J. W. Zubrick, John Wiley & Sons (2004)
Reactions and Syntheses: in the Organic Chemistry Laboratory, Second, Completely Revised
and Updated Edition, written by L. F. Tietze, T. Eicher, U. Diederichsen, A. Speicher, and N.
Schützenmeister, Wiley-VCH (2007)
Spectrometric Identification of Organic Compound, 8th Edition, written by R. M.
Silverstein, F. X. Webster, D. J. Kiemle, and D. L. Bryce Wiley (2016)
Preparation Students must read the relevant sections in the textbook and understand the contents in
and Review advance.
Language
Used in Japanese
Course
Make an appointment in advance.
Office hours E-mail: [email protected], Phone: 022-795-6804
E-mail: [email protected], Phone: 022-795-6822
In addition
 Subject General Training in Life Sciences
Course
YAL-PHA230J Categories Required
Numbering
Preferable
3rd Semester 5 Credits 3
Participants
Molecular and Cellular Biochemistry, Molecular Genetics, Molecular Biology and
Instructor
Metabolism, Gene Regulation
Practical business
This course aims to improve students’ ability to handle biological materials
including tissues, cells, and bacteria, in biochemical and molecular biological
methods, to learn methodologies for analyzing physiology and pharmacology of
Objectives and
organisms: i.e. students learn how to analyze structure of organs and tissues, how
summary of class
to measure enzymatic activities, and gene expression, and methods for protein
purification, bacterial isolation, DNA amplification, and restriction enzyme
mapping.
- Understanding the structure of organs and tissues
- Learning the fundamental biochemical procedures through the experiments
with protein and enzymes
- Developing the ability of cell culture and assays using cultured cells.
- Understanding the principle of the gene expression and developing the
methodological skills for the detection of gene expression.
Goal of study - Developing the experimental technique including instrument sterilization,
aseptic manipulation and bacteria handling, and understanding the basic
knowledge about microorganisms.
- Learning the methods and handling skills of RNA for the detection of mRNA in
the cell. Obtaining the purification techniques of huge cellular
ribonucleoprotein complex. Understanding of the quality control system to
maintain the gene expression homeostasis.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

【Observation of organs and tissues, and fundamental biochemical procedures】

1) Observation of rat organs and tissues
Anatomy of rat and observation of its organs and tissues
2) Separation and quantification of proteins/enzymes
Separation of proteins by gel electrophoresis, determination of protein concentration and enzyme
activities
3) Handling of animal cells
Preparation of rat peritoneal mast cells, evaluation of mast cell activation and quantification of
histamine
4) Gene transfer to cultured cells
Lipofection of plasmid DNA into a human cell line
5) Ligand activity toward G-protein-coupled receptors
Measurement of agonistic and antagonistic activities of ligands for histamine receptors
【 Gene expression and Enzymatic reactions】
1) Principles of Gene Expression
Analyzing the induction of lacZ gene expression in E. coli via measuring the enzymatic activity of the
products. Analyzing tissue-specific expression of reporter genes by substrate staining of the enzymatic
reaction.
2) Principles of enzyme reaction and protein purification
Purification of β-galactosidase by affinity chromatography. Analyses of protein expression and
purification by SDS-PAGE and the enzyme activity.
3) Analyses of gene expression using reporter genes
Detecting the expression of innate immune responsive genes using reporter genes in cultured cells.
【Microorganisms and chemotherapeutic agent】
1) Handling of microorganisms
This practical training performs the sterilization, disinfection, aseptic manipulation, pipetting, and
medium preparation.
2) Culture and identification of microorganisms
This practical training observes the colonization of bacteria on solid medium and growth of bacteria in
liquid medium after inoculating the bacteria into the medium. Furthermore, this practical training
performs the identification of bacteria by PCR.
3) Antibacterial spectrum
This practical training performs the antibacterial spectrum and biological assay of various antibiotics.
4) Gene transfer
This practical training aims to understand the gene transfer between E. coli (bacterial conjugation) by
observing the newly acquired phenotypes. Furthermore, this practical training performs the
introduction of gene into the E. coli (transformation).
【Molecular Biology】
1) Detection and quantification of mRNA I (RT-PCR)
mRNA is first converted into a complementary DNA (cDNA) by reverse transcriptase, and then amplified
by PCR.
2) Detection and quantification of mRNA II (Northern Blotting)
mRNA in the cell is analyzed by Northern Blotting.
Discussion about the differences between RT-PCR and Northern Blotting.
3) Purification of RNP (Ribonucleoprotein complex) by immunoprecipitation.
Ribosome, which is protein synthesis machine in the cell, is purified by immunoprecipitation via
ribosome protein fused epitope tag.
Record and
Evaluate submitted report (50%) and class performance (50%).
evaluation
Details will be explained in the first lecture session.
method
Textbook A textbook for the course (Seimei-yakugaku Jisshusho) is provided in the class.

Reference
Preparation Students are required to read relevant sections of the textbook and understand details of
and Review training sessions in advance.
Language
Used in Japanese
Course
Office hours An advance appointment via e-mail is required.

In addition
 Subject General Training in Biopharmacy and Pharmacy Practice
Course
YAL-PHA250J Categories Required
Numbering
Preferable
3rd Semester 5 Credits 2
Participants
Lab. of Pharmacology, Lab. of Health Chemistry, Lab. of Membrane Transport and
Instructor
Drug Targeting
Practical business
In this course, students deepen their understanding of Biopharmacy and
Pharmacy Practice, and learn analytical methods commonly used in the field. In
the first section, students learn the principle and technique on pharmacological
actions of central, peripheral and cardiovascular systems. Especially, students will
understand the five practical exercise themes of cardiac function, blood pressure,
ilea function, convulsion, and anatomy of animal. In the second section, students
Objectives and work on two practical exercises; one is biochemical analysis of antioxidant
summary of class responses mediated by biomolecules, and the other one is polymorphism analysis of
detoxification enzymes. The exercises will provide insight into the detoxification
mechanisms and the individual differences derived from diverse genetic
backgrounds. In the last section, students will study on the pharmacokinetic
analysis affecting pharmacological and toxicological effects of drug after the
administration. Several simulation works will be performed to understand the
clinical pharmacokinetics for the design of dosage regimen.
The purpose of this course is to learn and understand the following subjects: the
mechanism of pharmaceutical regent, the method of drug evaluation, the
Goal of study
detoxification responses for drug toxicity and the analytical methods for genetic
polymorphisms, the pharmacokinetic analysis, the design of dosage regimen.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents
1. Mechanism of drug actions and evaluation of drug efficacy
(1) Anatomy of target organs for drugs (brain, intestine, heart and vessels)
(2) Pharmacology of sympathetic and parasympathetic nervous and cardiac systems with isolated
intestine and heart. Measurement of blood pressure under anesthesia
(3) Pharmacology of central nervous system (anti-epileptic drugs etc.)
2. Drug toxicity and detoxification responses
(1) Biochemical analysis of antioxidant responses mediated by biomolecules
(2) Analysis of a genetic polymorphism of metabolic detoxification enzymes
3. Pharmacokinetics, design of dosage regimen, and general tests, processes and apparatus
(1) Estimation of pharmacokinetic parameters, calculation of the constant infusion rate and the
frequency of oral drug administration for the effective drug therapy
(2) Therapeutic Drug Monitoring (TDM) and moment analysis
(3) Dissolution test of drug
Record and
evaluation Evaluate class performance (40%) and submitted report (60%).
method
Textbook Textbooks will be provided.

Reference References will be provided as necessary.

Preparation Students should read the relevant sections in the textbook and understand the contents
and Review in advance.
Language
Used in Japanese
Course
Make an appointment via e-mail before visiting the office. The contact information for
Office hours
the lecturers will be on the textbook.
In addition
 Subject Natural Products Chemistry
Course
YPS-PHA321J Categories Elective
Numbering
3rd
Preferable
[Pharmaceutical Semester 6 Credits 2
Participants
Sciences]
Instructor Professor Asai Teigo, Associate professor Taro Ozaki

Practical business
Natural products are very important for developing drugs. This course aims to learn
Objectives and
about biosynthesis of natural products as well as their structures, chemical
summary of class
properties and biological activities.
The aim of this course is to help student understand the importance of natural
Goal of study
products in drug discovery and pharmaceutical sciences.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction of
This lecture aims to introduce the study of natural products
1 Asai Natural products
biosynthesis.
biosynthesis
Fatty acid
2 Asai This lecture aims to learn about fatty acid biosynthesis.
biosynthesis
This lecture aims to learn about fatty acid synthase based on
3 Asai Fatty acid synthase
domain function.
Introduction of
4 Asai polyketide synthase This lecture aims to introduce polyketide biosynthesis.
(PKS)
Biosynthetic This lecture aims to learn about biosynthetic machinery of
5 Asai
machinery of PKS 1 PKS.
Biosynthetic This lecture aims to learn about biosynthetic machinery of
6 Asai
machinery of PKS 2 PKS.
Biosynthetic
machinery non- This lecture aims to learn about biosynthetic machinery of
7 Asai
ribosomal peptide NRPS.
synthase (NRPS)
Biosynthetic
This lecture aims to learn about biosynthetic machinery of
8 Ozaki machinery of
terpene cyclase.
terpene cyclase
Biosynthesis of This lecture aims to learn about biosynthesis of natural
9 Ozaki
natural product. product.
Modification This lecture aims to learn about enzymes responsible for
10 Ozaki
enzyme 1 modification step in natural product biosynthesis.
Modification This lecture aims to learn about enzymes responsible for
11 Ozaki
enzyme 2 modification step in natural product biosynthesis.
Modification This lecture aims to learn about enzymes responsible for
12 Ozaki
enzyme 3 modification step in natural product biosynthesis.
Frontier research
This lecture aims to learn about frontier research on natural
13 Ozaki on natural product
product chemistry.
chemistry 1.

Frontier research
This lecture aims to learn about frontier research on natural
14 Ozaki on natural product
product chemistry.
chemistry 2.
Frontier research This lecture aims to learn about frontier research on natural
15 Asai
on natural product product chemistry.
 chemistry 3.

Record and
evaluation Evaluated by examination (50%) and submitting report (50%).
method
Textbook
「医薬品天然物化学」 海老塚豊 監訳、南江堂（2004）
Reference 「天然物化学」菅原二三男、浅見忠男、葛山智久、倉持幸司、新家一男、永田晋治、コロナ
社（2019）
Preparation
Review frequently using textbooks and handouts distributed during lectures.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means before students will visit
Office hours office.
E-mail: [email protected] Tel: +81-795-6822
In addition
 Subject Organic Synthesis
Course
YPS-PHA322J Categories Elective
Numbering
3rd
Preferable
[Pharmaceutical Semester 6 Credits 2
Participants
Sciences]
Instructor Iwabuchi Yoshiharu, Tokuyama Hidetoshi, Ueda Hirofumi, Hiroyuki Yamakoshi

Practical business
The purpose of this course is to help students deepen their understanding of
Objectives and
synthetic organic chemistry and improve their ability to plan tactics for synthesizing
summary of class
complex small organic molecules.
Students will develop their ability to design and analyze synthetic strategy of
Goal of study
complex small organic molecules.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction to
Iwabuchi/ Introduction to the retrosynthetic analysis,
1 Yamakoshi
the Total
What is total synthesis, What is convergence and linearity in total synthesis
Synthesis
Iwabuchi/ C-C Disconnections next to the alkyne group, Synthetic design using the reactivity
2 Yamakoshi disconnections of carbonyl group
Iwabuchi/ Two-group 1,2-Disconnections and 1,3-disconnections next to heteroatoms,
3 Yamakoshi disconnections Functional group interconversion between alcohols and ketones
Iwabuchi/ 1,3-Dicarbonyl Disconnections of β-hydroxycarbonyl compounds, α,β-unsaturated carbonyl
4 Yamakoshi compounds compounds, and 1,3-dicarbonyl compounds
Iwabuchi/ 1,5-Dicarbonyl Disconnections of 1,5-dicarbonyl compounds using a retro-Claisen reaction,
5 Yamakoshi compounds Synthetic utilities of Robinson annulation and Mannich reaction
Iwabuchi/ Natural reactivity and umpolung, Disconnections of 1,2-difunctional
6 Yamakoshi
Umpolung
compounds
Iwabuchi/
7 Yamakoshi
Chemoselectivity Chemoselective transformation, Protective group in organic synthesis
Iwabuchi/
8 Yamakoshi
Regioselectivity Regioselective transformations and their reaction mechanisms
Tokuyama/
9 Ueda
Stereoselectivity Stereoselective transformations and their reaction mechanisms
Tokuyama/ Asymmetric
10 Ueda synthesis
Optical resolution, Enantioselective reaction, Chiral pool, Enzymatic reaction
Tokuyama/
11 Ueda
Terpene Selected total synthesis of terpenes
Tokuyama/
12 Ueda
Steroid Selected total synthesis of steroids
Tokuyama/
13 Ueda
Prostaglandin Selected total synthesis of prostaglandins
Tokuyama/
14 Ueda
Macrolide Selected total synthesis of macrolides
Tokuyama/
15 Ueda
Alkaloid Selected total synthesis of alkaloids

Record and
Students are evaluated on their points from all the short test and the final examination
evaluation
(80% total) and the level of class participation (20%)
method
Textbook
 Organic Synthesis (Oxford Chemistry Primers, 31), written by C. L. Willis and M. Willis,
Oxford University Press (1996)
Organic Chemistry, Second Edition, written by J. Clayden, N. Greeves, and S. Warren,
Oxford University Press (2012)
Reference Classics in Total Synthesis, written by K. C. Nicolaou, and E. J. Sorensen, VCH (1996)
Classics in Total Synthesis II, written by K. C. Nicolaou and S. A. Snyder, Wiley-VCH
(2003)
Classics in Total Synthesis III, written by K. C. Nicolaou and J. S. Chen, Wiley-VCH
(2011)
Before class, it is important for students to review fundamental knowledge of
Preparation organic transformations, which have been learned in Organic Chemistry 1~5.
and Review After lecture, students are required to review reaction mechanisms and rational of
stereoselectivities involved in each total synthesis.
Language Used in
Japanese
Course
Make an appointment in advance via e-mail.
[email protected] (Iwabuchi)
Office hours [email protected] (Tokuyama)
[email protected] (Ueda)
[email protected] (Yamakoshi)
In addition
 Subject Medicinal Chemistry 2

Course Numbering YPS-PHA323J Categories Elective

3rd
Preferable
[Pharmaceutical Semester 6 Credits 1
Participants
Sciences]
Instructor Professor Hidetoshi Tokuyama and Lecturer Hirofumi Ueda

Practical business
In this class, students learn about the biological mechanisms and the structures of drugs and
Objectives and
targets.
summary of class
Students learn about the fundamental knowledge required for drug discovery.
· Students can explain about drug discovery, pharmacophore, biological equivalence, and
structure-activity relationships.
Goal of study
· Students can illustrate and explain the biological mechanisms based on the structures of drugs
and targets.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Tokuyama
1 Target Molecules Structures and functions of cells, and intracellular signal transduction
Ueda
Structure and
Tokuyama
2 Function of Structures and functions of nucleic acids, proteins, sugars, and lipids
Ueda
Biomolecules
Tokuyama Enzymes
3 Molecular-level interactions between enzymes or receptors and drugs
Ueda Receptor
Tokuyama Ion Channel Molecular-level interactions between ion channel or transporter and
4
Ueda Transporter drugs
Tokuyama
5 Structure of Drug Pharmacophore and biological equivalence in the structures of drugs
Ueda
Tokuyama
6 Typical Drug (1) Biological mechanisms based on the structures of drugs and targets
Ueda
Tokuyama
7 Typical Drug (2) Presentation of drug development (1)
Ueda
Tokuyama
8 Typical Drug (3) Presentation of drug development (2)
Ueda
Record and
Students are evaluated by examination (70%) and class performance (30%).
evaluation method
Basic Pharmaceutical Textbook Series 6, Pharmaceutical Science and Medicinal Chemistry,
Textbook
Atsushi Kittaka Ed., Kagakudojin (2011)
MEDICINAL CHEMISTRY/ N. Dunlap and D. M. Huryn, Garland Science (2018)
Reference The Practice of Medicinal Chemistry, second edition/ C. G. Wermuth, ELSEVIER LIMITED
(2011)
Preparation
Read the story of drug discovery development under own investigation
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected], [email protected]
In addition SGD:7th and 8th
 Subject Structure Analysis of Organic Compound
Course
YPS-PHA324J Categories Elective
Numbering
3rd
Preferable
[Pharmaceutical Semester 6 Credits 2
Participants
Sciences]
Kondo Yoshinori, Iwabuchi Yoshiharu, Doi Takayuki, Tokuyama Hidetoshi, Asai
Teigo, Yoshikai Naohiko, Shigeno Masanori, Ozaki Taro, Ueda Hirofumi, Sasano
Instructor Yusuke, Sugawara Akihiro, Yamakoshi Hiroyuki, Ohsawa Kosuke, Sakata Juri,
Kumada Kanako, Nagasawa Shota, Tahara Atsushi, Kohyama Aki, and Kikuchi
Jun
Practical business
This course aims to improve students’ ability to interpret different types of spectra
(MS, IR, NMR, and UV-vis) of simple organic compounds and to identify their
Objectives and molecular structures through the spectral analysis. After general introduction to
summary of class these spectroscopic methods, each class will be conducted in the form of
problem-solving exercise, in which the students should expect to actively
participate.
After successfully completing this course, the students will gain basic skills for the
Goal of study interpretation of spectra of organic compounds and the determination of their
molecular structures through the spectral analysis.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
NMR, MS,
Principles of nuclear magnetic resonance (NMR) spectrometry,
Yoshikai/ IR and
1 ultraviolet (UV)-visible (vis) spectroscopy, mass spectrometry (MS) and
Kikuchi UV-vis
infrared (IR) spectroscopy
spectroscopy
Kondo/ Aliphatic
2 Spectrometric identification of aliphatic compounds
Sugawara compounds-1
Iwabuchi/ Aliphatic
3 Spectrometric identification of aliphatic compounds
Yamakoshi compounds-2
Doi/ Aliphatic
4 Spectrometric identification of aliphatic compounds
Ohsawa compounds-3
Tokuyama/ Aromatic
5 Spectrometric identification of aromatic compounds
Sakata compounds-1
Asai/ Aromatic
6 Spectrometric identification of aromatic compounds
Kumada compounds-2
Shigeno/ Aromatic
7 Spectrometric identification of aromatic compounds
Nagasawa compounds-3
Ozaki/
8 Alcohols Spectrometric identification of alcohols
Tahara
Ueda/
9 Aldehydes Spectrometric identification of aldehydes
Kohyama
Sasano/
10 Ketones Spectrometric identification of ketones
Kikuchi
Sugawara/ Carboxylic
11 Spectrometric identification of carboxylic acids
Kumada acids
Yamakoshi
12 Esters Spectrometric identification of esters
/Nagasawa
Ohsawa/
13 Amines Spectrometric identification of amines
Tahara
Sakata/
14 Phenols Spectrometric identification of phenols
Kohyama
Yoshikai/
15 Summary Summary of spectrometric identification of organic molecules
Kikuchi
 Record and
Class performance including presentation (25%), the midterm and final examinations
evaluation
(75%)
method
Textbook
Spectrometric identification of organic compound, 8th edition (translated in Japanese),
Reference written by R. M. Silverstein, F. X. Webster, D. J. Kiemle and D. L. Bryce, translated by
N. Iwasawa, S. Toyota, S. Murata, Tokyo Kagaku Dojin (2016)
Preparation
and Review
Language Used in
Japanese
Course
Make an appointment in advance via e-mail.
Office hours E-MAIL: [email protected]
TEL 022-795-6812
In addition
 Subject Principles of Clinical Medicine

Course Numbering YPS-PHA301J Categories Elective

3rd
Preferable
[Pharmaceutical Semester 6 Credits 2
Participants
Sciences]
Nobuyuki Takahashi, Jun-ichi Kameoka, Tatsuma Okazaki, Shinobu Ohnuma,
Instructor Yukio Katori, Shojiro Sawada, Akira Koarai, Tomonori Ishii, Takahiro Arima,
Yugo Ashino, Toshiaki Abe, Akira Inoue, Yoichi Kakuta
Practical business 〇
This course provides students with basic knowledge necessary for diagnosis,
Objectives and pathogenesis, pathophysiology, and pharmacotherapy on various diseases.
summary of class Faculty staff members of the Graduate School of Medicine provide lectures, in an
"omnibus" style.
The purpose of this course is to help students better understand practical
Goal of study medication based on pathophysiology of each disease, and updated diagnostic
approach for various diseased states.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students learn about diagnostic process for various
General Internal
1 Takahashi disease including medical interviews, physical
Medicine
examinations, clinical laboratory tests, and so on.
Students learn about the concept of chronic kidney disease
Recent Advance in
2 Takahashi (CKD) which is important as an underlying condition of
CKD
end-stage renal failure and cardiovascular disease.
This course covers recent advance in the diagnosis and
treatment for hematological disorders including anemia,
3 Kameoka General Hematology
thrombocytopenia, leukemia, malignant lymphoma, and
so on.
In this course, students will understand the
characteristics of diseases developed in the aged people by
4 Okazaki General Geriatrics learning about the pneumonia in aged people and the
pathogenesis of sarcopenia (age related decline in the
skeletal muscle power, mass, and physical function)
This course covers recent advance in endoscopic surgery
5 Ohnuma General Surgery
including colorectal surgery and bariatric surgery.
Otorhinolaryngology, This course covers clinical characteristics of disease in
6 Katori from the General to otolaryngology and influences for functions of hearing,
the Particular smell, taste, phonation and swallowing.
The changes of lifestyle in recent years induced several metabolic
disorders for instance visceral fat obesity and diabetes mellitus in
Japanese people. These disorders give hardly uncomfortable
Principles of metabolic symptoms to the body, therefore reconsideration of the lifestyle i.e.
disorders: visceral fat
7 Sawada diet and exercise and effective treatment should be postponed, so
obesity and diabetes
that the patients lapse into myocardial infarction, stroke, uremia and
mellitus
the other severe complications. In this lecture, the basic approach
to pathophysiology ， prevention, therapeutic strategy and
pharmacotherapy for the metabolic disorders will be presented.
This course covers recent advance in the diagnosis and
8 Koarai Respiratory Disease
treatment for respiratory diseases.
This course covers recent advance in the diagnosis and
Rheumatism and
9 Ishii treatment for collagen diseases including rheumatoid
Collagen Diseases
arthritis.
General This course covers general aspects of reproductive
10 Arima
Reproductive medicine. In addition, students learn about the
 Medicine precautions in a medication of pregnant female.

This course covers recent advance in the diagnosis and

11 Ashino Infectious Diseases treatment for various infectious diseases including HIV
infection.
Students learn about the ophthalmologic information-
General processing system, and about the recent advance in
12 Abe
Ophthalmology ophthalmic treatment including gene-based therapy and
regenerative medicine.
Palliative Medicine, Students learn about assessment and treatment using
13 Inoue from the General to opioids NSAIDs and adjuvant analgesics, etc. for cancer-
the Particular related pain.
Hypertension is a common disease, and is important as a
factor of the metabolic syndrome. However, its
Kidney and mechanisms are still unclear. Students learn about the
14 Takahashi
Hypertension role of the kidney and humoral factors on developing
hypertension, and understand diagnosis and treatments of
hypertension.
This course covers the recent medical treatments for some
Gastroenterology,
important gastroenterological diseases, such as H. pylori
15 Kakuta from the General to
infection, inflammatory bowel diseases, viral hepatitis and
the Particular
acute pancreatitis.
Record and Students are evaluated based on submitted reports (80%) and class performance
evaluation method (20%).
Textbook The textbook will be designated at the beginning of the course.

Reference References are handed out at every class.

Preparation
and Review
Language Used in
Japanese
Course
The office hours are from 14:00 to 16:00 on Tuesdays. Make an appointment in
Office hours
advance via e-mail: [email protected] (Nobuyuki Takahashi).
In addition This class is an omnibus lecture series.
 Subject Drug Design and Development

Course Numbering YPS-PHA302J Categories Elective

3rd
Preferable
[Pharmaceutical Semester 6 Credits 2
Participants
Sciences]
Ikeda Koji, Nagatomi Ryoichi, Yoshinari Koichi, Kamiyama Yoshiteru, Miura
Shinichi, Fujita Shigekazu, Hashimoto Tomohiro, Nakamura Ryuta, Takamatsu
Instructor
Shoji, Arakawa Noriaki, Saito Yoshiro, Uchida Wataru, Taniguchi Nobuaki, Doi
Katsuyo
Practical business 〇
In order to find and select some drug candidate compounds by some drug efficacy
screening tests or a non-clinical test using an experimental animal, it is important to
understand the pharmacokinetics and toxicity of candidate compounds for use as a safe
and effective drug in humans. Even after launch, it is necessary to pay attention to
Objectives and
the information of adverse reactions through post-marketing surveys. In this class,
summary of class
students will learn the basics of pharmacokinetics and toxicity related to drug discovery
and development, also learn the outline of new drug development in actual companies.
In addition, students will also learn about drug approval and application, including
regulatory science and systems for post-marketing surveillance.
Understand the pharmacokinetics and side effects (toxicity) mechanisms of drugs, and
explain the importance of pharmacokinetic and safety research to develop effective and
Goal of study safe novel medicines. In addition, understand the mechanism from drug discovery and
development to post-marketing surveillance, and explain the outline of new drug
development
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Drug discovery Outline: Outline how pharmaceutical companies proceed with drug
and development
1 Miura at Pharmaceutical
development. Understand internationalization and translational
companies (1) research in drug development research at pharmaceutical companies
Drug discovery Role of pharmacokinetic and safety research: Understand how
and development
2 Kamiyama at Pharmaceutical
pharmacokinetic and safety research is conducted in drug
companies (2) development in pharmaceutical companies and its significance.
Drug discovery
and development Factory: Learn the flow of process research from drug development
3 Fujita at Pharmaceutical research to launch in pharmaceutical companies. (Case 1)
companies (3)
Drug discovery
and development CRO: Learn the flow of process research from drug development
4 Hashimoto at Pharmaceutical research to launch in pharmaceutical companies. (Case 2)
companies (4)
Drug discovery Development new medicine in pharmaceutical companies.
and development Understand how to proceed New Drug Application of Allery
5 Doi at Pharmaceutical immunotherapy (sublingual tablet) for Japanese cedar pollinosis
companies (5)
in Japan.
Development of
drugs and medical Understand how to support development of basic research,
6 Ikeda devices at bridging research, and clinical research, and their significance.
universities
Pharmaceutical Understand how PMDA conducts screening of drugs, medical devices,
7 Nakamura reviews. and its significance.
Drug Safety and
Understand how PMDA implements safety measures for drugs,
8 Takamatsu Health Damage
Relief medical devices, and how to rescue health damage and its significance
Earn the importance of safety research in drug discovery. Learn about
9 Yoshinari Safety (1) the major general toxicities (genotoxicity, carcinogenicity,
developmental toxicity) of pharmaceuticals.
Learn the importance of safety research in drug discovery. Learn
10 Yoshinari Safety (2)
about the major organ toxicities (liver, kidney, cardiovascular) of
 drugs.

Drug Development The current status of biomarker research will be reviewed, and risks
11 Arakawa and biomarker and benefits of drug development will be discussed.
Safety evaluation
using post- Learn about administrative policy and measures related to post-
12 Saito marketing medical marketing safety of pharmaceuticals and the current state of research
information using related medical information.
database
The Graduate School of Medical Engineering has collaborated with
Development of Stanford Biodesign, an advanced program for developing human
human resources resources for medical device, and offers the Japan Biodesign (JBD)
13 Nagatomi for medical program jointly with the University of Tokyo and Osaka University.
engineering
In this lecture, we will introduce the essence of JBD, starting from
thoroughly identifying needs from the site.
The purpose of this lecture is to understand the outline of new drug
Drug discovery research and development, and learn the importance of new drug
14 Uchida through open basic research and the fun of developing new drugs, through
innovation learning new drug discovery research and development activities in
actual pharmaceutical companies.
In this lecture, students will learn about the basics of the patent
Patent strategy in system and understand the importance of patents in corporate
15 Taniguchi drug development activities and patent strategies for the effective protection of
inventions in drug development.
Record and
Evaluate based on each report (100%)
evaluation method
Textbook Not specified

Reference Not specified

Preparation: Read related items in the reference book specified by the lecture time.
Preparation Work on assignments that are designated as preparations before SGD. Review:
and Review Summarize the outline of the lecture content. Learn the parts of the lack of
understanding in the reference book related items to deepen your understanding.
Language Used in
Japanese
Course
E-MAIL appointments:
Office hours
[email protected]、[email protected]
In addition
 Subject Imaging Diagnosis

Course Numbering YPS-PHA303J Categories Elective

3rd
Preferable
[Pharmaceutical Semester 6 Credits 1
Participants
Sciences]
Professor Furumoto Shozo, Professor Zhang Ming-Rong, Associate Professor Kotaro
Instructor
Nagatsu
Practical business 〇
This course provides an overview of radiopharmaceuticals used in medical imaging,
from their preparation methods to the principles of diagnostic imaging using in vivo
Objectives and kinetics. Imaging techniques using radiopharmaceuticals play an important role in
summary of class elucidating the mechanism of drug efficacy and evaluating therapeutic effects in the
development of new drugs. In the lecture, the application and utilization of
radiopharmaceuticals will be outlined.
Students will learn about imaging diagnosis in nuclear medicine and relationship
between biofunctions and tracer distribution in vivo, and then understand their
Goal of study
principle and mechanism of action. Students will learn the relationships between PET
imaging and drug development researches, too.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students learn radiochemistry of compounds labeled with a
1 Furumoto Introductions positron emitter and imaging principles and instruments of
PET and SPECT.
Students learn tumor uptake mechanisms and diagnostic
2 Furumoto Tumor imaging (I) utilities of typical tumor imaging agents such as derivatives
of glucose and amino acids labeled with a positron emitter.
This class provides state-of-the-art knowledge of PET probes
3 Furumoto Tumor imaging (II) for imaging tumor specific enzymes or receptors and
evaluating the efficacy of radiation therapy.
Cardiovascular Students learn basics and application of radiopharmaceuticals
4 Furumoto
disease imaging for cardiovascular disease.
Students learn development and application of PET probes
Imaging agents for for imaging neuro receptors, enzymes, transporters, and
5 Zhang
neurotransmission other proteins in relation to Parkinson’s disease and
Alzheimer’s disease.
PET In this class, students learn the production, quality control
6 Zhang radiopharmaceuticals and safety evaluation of PET radiopharmaceuticals for
for clinical use clinical usefulness.
In this class, students learn the usefulness of PET and
PET imaging for drug
7 Zhang molecular probes in microdosing clinical study and
development
developmental study of new drugs.
In this class, students will learn about the production and
8 Nagatsu Radiotherapy with RI utilization of radioisotopes (RIs) for cancer therapy and
their relationship to diagnostic imaging.
Record and
Students are evaluated on their reports. (100%)
evaluation method
Textbook Handouts of the lecture will be given at each class.

Reference No reference will be used.

Preparation
Review with materials distributed at the lecture.
and Review
Language Used in
Japanese
Course
 Students can contact Prof Furumoto by email or telephone.
Office hours
Email: [email protected] TEL: 022-795-7801
In addition
 Subject Pharmaceutic Laws 1
Course YPS-PHA381J Elective[Pharmaceutical Sciences]
Categories
Numbering YPH-PHA381J Required[Pharmacy]
Preferable
3rd Semester 6 Credits 1
Participants
Instructor Kimura Takahiro, Ishibashi Tsuyoshi

Practical business 〇
In this course, students will learn the system from development to marketing about
Objectives and medicine and medical device, understanding “Pharmaceutical and Medical Device
summary of class Act” to play a key role and the rule of its ordinance to become the approval permission
requirement.
Students will understand the importance of pharmaceutical related laws in the
development of medicine and medical device, and touch it to watch the basic thought
Goal of study
that can support problems, classifying the global expansion into the field of vision in
the future.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( Report )
Term Lecturer Theme Contents
Learning the system about the new medicine development
and the investigational significance, and understanding the
Medicine development
1 Kimura rule of GLP, GCP.
related laws (1)
Learning the difference in system with the generic
medicine.
Learning the pharmaceutical system of production sale,
Medicine development
2 Kimura product, and measures after the marketing, and
related laws (2)
understanding the rule of GMP, GQP, GVP, and GPSP.
Medical device Learning the system about the medical device from
Kimura
3 development related development to marketing, and understanding the
Ishibashi
laws (1) difference with the medicine development.
Medical device Learning ISO13485 concerned international rule in
4 Ishibashi development related medical device product, and understanding the attempt to
laws (2) international consistency.
“Pharmac Medicine development
Learning the concrete processes from development to
eutical and pharmaceutical
5 marketing in a pharmaceutical company, and
products related laws in the
understanding the action to pharmaceutical related laws.
company” company
Medical device
“Medical Learning the concrete processes from development to
development and
6 device marketing in a medical device product company, and
pharmaceutical related
company” understanding the action to pharmaceutical related laws.
laws in the company
Understanding the importance of the pharmaceutical
Quality assurance
related laws through the action of the quality assurance
Kimura against pharmaceutical
7 against the development of pharmaceuticals, medical
Ishibashi development and
devices, regenerative medicine products.
global expansion
Learning the problem on global expansion.
Medical device
Learning the concrete process of medical device
development by
Kimura development by industry-academia-government
8 industry-academia-
Ishibashi collaboration, and understanding the importance of
government
collaboration pharmaceutical related laws.
Record and
evaluation Evaluation is performed based on the final examination (80%) and reports (20%).
method
Textbook
 “The introduction to pharmaceutical products development,” Jihou
“The commentary of pharmaceutical laws, system, and ethic, 2020-21 version,”
Yakujinippou Corporation
Reference
“The pharmaceutical related laws, revision 4th version,” Nankodo Corporation
“The commentary of Pharmaceutical and Medical Device Act, Pharmacist Act, and
Poisonous and Deleterious Substances Control Act,” Yakujinippou Corporation
Preparation
and Review
Language Used in
Japanese
Course
Office hours
Lectures pharmacist national examination questions criteria
In addition (http://www.jshp.or.jp/cont/10/1015-1.pdf ')
It will be mainly carried out the items that have been published in.
 Subject Advance Training in Pharmaceutical Sciences
Course
YPS-PHA300J Categories Required
Numbering
3rd
Preferable
[Pharmaceutical Semester 6 Credits 6
Participants
Sciences]
Instructor Supervisor of the laboratory

Practical business
Students will develop skills to solve research themes by organic association of the
Objectives and practical knowledge and basic experiment skills studied in basic pharmaceutical
summary of class trainings. This training are located to develop skills that are necessary for
Research Training held in 4th grade.
The purpose of this course is to understand research themes and do experiments
Goal of study
thinking the purpose to achieve themes logically.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Students do trainings based on the theme given by the supervisor of the laboratory. Moreover, students
are required to participate in the seminar held in the laboratory.

Record and
evaluation Evaluated by the supervisor of the laboratory.
method
Textbook

Reference
Preparation
and Review
Language
Used in Japanese
Course
Office hours

In addition
 Subject Research Training
Course
YPS-PHA400J Categories Required
Numbering
4th
Preferable
[Pharmaceutical Semester 7・8 Credits 20
Participants
Sciences]
Instructor Supervisor of the laboratory

Practical business
Research Training is the most important subject scheduled in the last grade as a
general decision of undergraduate education. Students belonging in each
laboratories are given their research theme by their supervisor and do the research
along the objective plan made by themselves. Students also make a summary of
Objectives and
their research results as a graduation thesis and make a presentation of
summary of class
achievement and question-and-answer session in front of the research staff,
undergraduate students and graduate students. Therefore, this subject is expected
not only the basic preparation education for students to be a researcher but also
useful for their career.
・To help students seek and evaluate research achievements by for now related to
their theme.
・To help students extract some problems to solve to achieve their theme.
・To help students make a research plan.
・To help students develop their observation eyes to grasp phenomena exactly
Goal of study
through their theme.
・To help students summarize their research results.
・To help students consider and evaluate their research results.
・To help students presence their research achievement and question-and-answer
exactly.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Students do their research given the theme obey to each specialized field by their supervisor of the
laboratory. Research will be going obey to each laboratory’s program; for example, participation in the
seminar held in the laboratory, to audit some lectures.

Record and
evaluation Evaluated by the supervisor of the laboratory.
method
Textbook

Reference

Office hours

In addition
 Subject General Introduction to Various Forms of Illness

Course Numbering YPH-PHA371J Categories Elective

3rd
Preferable
[Pharmaceutical Semester 6 Credits 2
Participants
Sciences]
Nobuyuki Takahashi, Jun-ichi Kameoka, Tatsuma Okazaki, Shinobu Ohnuma,
Instructor Yukio Katori, Shojiro Sawada, Akira Koarai, Tomonori Ishii, Takahiro Arima,
Yugo Ashino, Toshiaki Abe, Akira Inoue, Yoichi Kakuta
Practical business 〇
This course provides students with basic knowledge necessary for diagnosis,
Objectives and pathogenesis, pathophysiology, and pharmacotherapy on various diseases.
summary of class Faculty staff members of the Graduate School of Medicine provide lectures, in an
"omnibus" style.
The purpose of this course is to help students better understand practical
Goal of study medication based on pathophysiology of each disease, and updated diagnostic
approach for various diseased states.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students learn about diagnostic process for various
General Internal
1 Takahashi disease including medical interviews, physical
Medicine
examinations, clinical laboratory tests, and so on.
Students learn about the concept of chronic kidney disease
Recent Advance in
2 Takahashi (CKD) which is important as an underlying condition of
CKD
end-stage renal failure and cardiovascular disease.
This course covers recent advance in the diagnosis and
treatment for hematological disorders including anemia,
3 Kameoka General Hematology
thrombocytopenia, leukemia, malignant lymphoma, and
so on.
In this course, students will understand the
characteristics of diseases developed in the aged people by
4 Okazaki General Geriatrics learning about the pneumonia in aged people and the
pathogenesis of sarcopenia (age related decline in the
skeletal muscle power, mass, and physical function)
This course covers recent advance in endoscopic surgery
5 Ohnuma General Surgery
including colorectal surgery and bariatric surgery.
Otorhinolaryngology, This course covers clinical characteristics of disease in
6 Katori from the General to otolaryngology and influences for functions of hearing,
the Particular smell, taste, phonation and swallowing.
The changes of lifestyle in recent years induced several metabolic
disorders for instance visceral fat obesity and diabetes mellitus in
Japanese people. These disorders give hardly uncomfortable
Principles of metabolic symptoms to the body, therefore reconsideration of the lifestyle i.e.
disorders: visceral fat
7 Sawada diet and exercise and effective treatment should be postponed, so
obesity and diabetes
that the patients lapse into myocardial infarction, stroke, uremia and
mellitus
the other severe complications. In this lecture, the basic approach
to pathophysiology ， prevention, therapeutic strategy and
pharmacotherapy for the metabolic disorders will be presented.
This course covers recent advance in the diagnosis and
8 Koarai Respiratory Disease
treatment for respiratory diseases.
This course covers recent advance in the diagnosis and
Rheumatism and
9 Ishii treatment for collagen diseases including rheumatoid
Collagen Diseases
arthritis.
General This course covers general aspects of reproductive
10 Arima
Reproductive medicine. In addition, students learn about the
 Medicine precautions in a medication of pregnant female.

This course covers recent advance in the diagnosis and

11 Ashino Infectious Diseases treatment for various infectious diseases including HIV
infection.
Students learn about the ophthalmologic information-
General processing system, and about the recent advance in
12 Abe
Ophthalmology ophthalmic treatment including gene-based therapy and
regenerative medicine.
Palliative Medicine, Students learn about assessment and treatment using
13 Inoue from the General to opioids NSAIDs and adjuvant analgesics, etc. for cancer-
the Particular related pain.
Hypertension is a common disease, and is important as a
factor of the metabolic syndrome. However, its
Kidney and mechanisms are still unclear. Students learn about the
14 Takahashi
Hypertension role of the kidney and humoral factors on developing
hypertension, and understand diagnosis and treatments of
hypertension.
This course covers the recent medical treatments for some
Gastroenterology,
important gastroenterological diseases, such as H. pylori
15 Kakuta from the General to
infection, inflammatory bowel diseases, viral hepatitis and
the Particular
acute pancreatitis.
Record and Students are evaluated based on submitted reports (80%) and class performance
evaluation method (20%).
Textbook The textbook will be designated at the beginning of the course.

Reference References are handed out at every class.

Preparation
and Review
Language Used in
Japanese
Course
The office hours are from 14:00 to 16:00 on Tuesdays. Make an appointment in
Office hours
advance via e-mail: [email protected] (Nobuyuki Takahashi).
In addition This class is an omnibus lecture series.
 Subject Pharmacostatistics

Course Numbering YPH-PHA351J Categories Required

Preferable 3rd
Semester 6 Credits 1
Participants [Pharmacy]
Nobuyuki Takahashi, Masaki Matsuura, Hironori Nakamura, Ichiro Tsuji,
Instructor
Michihiro Satoh, Takuhiro Yamaguchi, Naoyuki Kurokawa,
Practical business 〇
Statistics is an important discipline which supports an objective and accurate
Objectives and evaluation of the efficacy of medical treatment. This course offers an opportunity
summary of class to study practical knowledge and skill on pharmacostatistics associated with drug
development process, clinical research, and pharmacy operation.
This course is designed to help students explain (1) for what purpose the
pharmacostatistics is applied, (2) how to use the pharmacostatistics, (3) what kind
Goal of study
of statistical tools should be used for a specified matter, and (4) in what way the
results of clinical researches should be evaluated.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Statistics
Students learn about practical pharmacy operation using
1 Matsuura of Pharmacy
pharmacostatistics
Operation
Statistics Students learn about practical application of statistics to
2 Nakamura Application to health and medical field, and about the attitude to
Healthcare epidemiological study.
Students learn about principal statistical tools used in the
3 Lu Basic Statistics
field of pharmacostatistics.
Statistics of Students learn about investigative research such as
4 Satoh Investigative pharmacoepidemiology associated with pharmacist activity,
Research and learn about the related statistical methods.
Students learn about the concept of evidence-based
5 Tsuji Statistics of EBM
medicine, and about the related statistical methods.
Students learn about the necessity of statistics in the
Statistics of Drug
6 Yamaguchi clinical research, and about its crucial role on the drug
Development
development.
Introduction to Students learn about the concept of meta-analysis, and
7 Kurokawa
Meta-analysis about the related statistical methods.
Summary of Students exchange diverse opinions and discuss about
8 Takahashi
Pharmacostatistics pharmacostatistics learned in this class.
Record and Students are evaluated based on submitted reports (80%) and class performance
evaluation method (20%).
Textbook The textbook will be designated at the beginning of the course.

Reference References are handed out at every class.

Preparation
and Review
Language Used in
Japanese
Course
The office hours are from 14:00 to 16:00 on Tuesdays. Make an appointment in
Office hours
advance via e-mail: [email protected] (Nobuyuki Takahashi).
In addition This class is an omnibus lecture series.
 Subject Immunology
Course
YPH-PHA331J Categories Elective
Numbering
Preferable 3rd
Semester 6 Credits 2
Participants [Pharmacy]
Instructor Associate Professor Yano Tamaki

Practical business
Beyond the importance of the immune reaction as the defense system against
microbes, the essential concept of Immunology is the recognition of the self and non-
Objectives and
self. With tremendous studies on the mechanism of self and non-self recognition, and
summary of class
repertoire making of immunoglobulins, Immunology has given a great contribution
on Biology.
This course provides students the basic knowledge and deeper understanding of
Goal of study
immune system, and diseases caused by immune disorder.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
History and concept of To understand the concepts of the immune system though
1 Yano
immunology reviewing history and results of immunological studies.
To learn the molecular mechanism of gene
Generation of
2 Yano rearrangement and to understand how diversity of
immunoglobulin diversity
immunoglobulin is generated.
Antigen presentation to T To learn about MHCs and their functions, antigen
3 Yano
lymphocytes presentation to T lymphocytes.
Development and survival To learn the generation of lymphocytes in bone marrow
4 Yano
of lymphocytes and thymus.
To learn signaling pathways though antigen receptors,
Signaling though
5 Yano and other pathways that contribute to lymphocyte
immune system receptors
behavior.
To understand the mechanism of the production of effector
6 Yano T-cell mediated immunity
T cells and their functions.
Humoral immune To learn about the B-cell activation, functions of
7 Yano
responses immunoglobulin isotypes, and Fc receptors.
Summary of the first half To confirm the contents that are handled in the first half
8 Yano
of this course of this course.
To understand the importance of innate immunity as a
9 Yano Innate immunity frontline of host defense, and learn about the innate
immune system.
To learn complement pathways and the functions of
10 Yano Complement system
complement in immunity.
To understand the characteristic properties of mucosal
11 Yano Mucosal immune system
immune system, especially intestinal immunity.
Disorder of host defense To understand the host-pathogen interactions and learn
12 Yano
mechanism about immune-deficiency syndrome.
13 Yano Allergy To learn effector mechanisms in allergic reactions.
To understand that autoimmune responses are directed
14 Yano Autoimmunity against self-antigens, and learn the mechanism under
the autoimmune disease.
To learn techniques using antibodies and lymphocytes as
15 Yano Immunologists’ toolbox
research and diagnostic tools.
Record and
Evaluation is based on the midterm examination (50%) and the final examination
evaluation
(50%).
method
 Textbook No textbook will be designated. References are handed out at every class.

Reference Immunobiology Charles A. Janeway et al. ISBN: 978-081534-1239

Preparation
Review based on reference textbook and handout is expected.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-4555
In addition
 Subject Food Hygiene and Safety
Course
YPH-PHA342J Categories Required
Numbering
Preferable 3rd
Semester 6 Credits 2
Participants [Pharmacy]
Instructor Saito Yoshiro, Toyama Takashi, and Arisawa Kotoko
Practical
business
Objectives and This course provides the classification and nature of food contaminants such as the
summary of food additive, microorganism and chemical. In this course, students will understand
class the effects of food contaminants on human health.
The purposes of this course are to help students better understand the following
items.
1) Food and human health
2) Infection disease (including food poisoning) and its prevention
Goal of study 3) Cause of health damage by food contaminants including microorganisms and
chemicals, and its prevention
4) Type, nature, functional mechanism and ingestion pathway of food contaminants
that affect human health
5) Method of safety assessment of chemicals
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
System and law relating to food hygiene administration, food
1 Saito Overview
poisoning occurrence and food contaminants
Social significance which relates to consider human health from
Food and human
2 Arisawa eating habits
health
Novel type food with health function
Diversified food contamination
3 Saito Food safety Basic measures to ensure the food safety
General food safety evaluation method
Oral infections Difference of between food poisoning and oral infection
4 Saito and food Characteristic of pathogens involving food poisoning and oral
poisoning infection
Distribution of microorganisms involving food poisoning
Food poisoning occurrence and poisoning symptoms
5 Saito Microorganisms
Characteristic and function of toxins involving food poisoning
Problem and preventive measure on food hygiene
Plant toxin and animal toxin
6 Saito Natural toxin
Mycotoxin
Mutagen and Initiation and promotion in carcinogenesis
7 Toyama
carcinogen Oncogene and tumor suppressor gene
8 Saito Food spoilage Food spoilage and its prevention
Food
9 Saito Organic halogen compounds and metal remaining in the food
contamination 1
Food Endocrine disrupting substances and radioactive substances
10 Saito
contamination 2 remaining in the food
Pesticide
11 Saito Pesticide residues and its safety
residues
12 Saito Food additive Food additive and its safety
Genetically
13 Saito modified Genetically modified organism and its safety
organism
 Safety
Chemical substances control law
14 Toyama assessment of
Guidelines for the testing of chemicals
chemicals
Group
15 Saito In this class, students discuss a recent food safety issue.
discussion
Record and
Evaluation is performed comprehensively based on the midterm examination (40%),
evaluation
the final examination (40%) and class performance (20%).
method
Food Hygienic Sciences, eds by M. Nasu and K. Wada, Nankodo Publishing Co. Ltd.
Textbook
(ISBN: 978-4-524-40272-4)
Reference
Preparation
and Review
Language Used
Japanese
in Course
Office hours Make an advance appointment via e-mail or other means.

In addition
 Subject Infectious Diseases

Course Numbering YPH-PHA332J Categories Elective

Preferable 3rd
Semester 6 Credits 2
Participants [Pharmacy]
Tomioka Yoshihisa, Akiyama Yasutoshi, Aoki Yoshiko, Koike Satoshi, Nishikawa
Instructor
Kiyotaka, Nishimura Shuichi
Practical business 〇
In this study for infectious diseases, students learn fundamental knowledge of the
classification, structure, and growth mechanism of pathogenic microorganisms such as
Objectives and
viruses, and understand the etiology and pathology of infectious diseases. In addition,
summary of class
understand the routes of transmission, treatment, pharmacotherapy, and prophylaxis
of typical infectious diseases, and understand their advantages and problems.
Acquire fundamental knowledge about pathogenic microorganisms, list the main
Goal of study infectious diseases, and explain the pathophysiology and causes, routes of infection,
medical treatment, pharmacotherapy, and prevention.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Prevention Outline the management of infectious disease outbreaks. Understand
1 Tomioka / Protection and explain concretely the sterilization and disinfection methods. Outline
(1) the relationship between medical devices and infection risk.
Prevention Explain hand hygiene. Explain the type of personal protective equipment
2 Tomioka / Protection and precautions for use. Explain cough etiquette. Explain the handling of
(2) medical waste.
Outline community-acquired and hospital-acquired infection factors,
Prevention
outbreak factors, infection routes, causative microorganisms, and
3 Tomioka / Protection
preventive measures. Understand standard precautions for infectious
(3)
diseases.
Classify antibacterial drugs, antiprotozoal and parasite drugs, antifungal
drugs and antiviral drugs, and explain the mechanism of action and
4 Akiyama Therapy (1)
clinical application of typical drugs. Understand antimicrobial use
guidelines.
Finding out "questions" from the pathological conditions, infection
patterns, and treatment methods caused by various pathogens.
Microorgan
5 Tomioka Search for answers to questions through research and analysis.
isms (1)
Deepen understanding through group discussions, presentations, and
questions and answers.
Finding out "questions" from the pathological conditions, infection
patterns, and treatment methods caused by various pathogens.
Microorgan
6 Tomioka Search for answers to questions through research and analysis.
isms (2)
Deepen understanding through group discussions, presentations, and
questions and answers.
Finding out "questions" from the pathological conditions, infection
patterns, and treatment methods caused by various pathogens. Search
Microorgan
7 Tomioka for answers to questions through research and analysis. Deepen
isms (3)
understanding through group discussions, presentations, and questions
and answers.
Finding out "questions" from the pathological conditions, infection
patterns, and treatment methods caused by various pathogens. Search
Microorgan
8 Tomioka for answers to questions through research and analysis. Deepen
isms (4)
understanding through group discussions, presentations, and questions
and answers.
Finding out "questions" from the pathological conditions, infection
Microorgan patterns, and treatment methods caused by various pathogens. Search
9 Tomioka
isms (5) for answers to questions through research and analysis. Deepen
understanding through group discussions, presentations, and questions
 and answers.

Understand how to obtain and use information on side effects of

10 Tomioka Side effects
infectious drugs.
Understand the methods and concepts of research by having researchers
Research
11 Nishikawa conducting infectious disease research introduce the most advanced
(1)
infectious disease research.
Understand the methods and concepts of research by having researchers
Research
12 Koike conducting infectious disease research introduce the most advanced
(2)
infectious disease research.
Understand the methods and concepts of research by having researchers
Research
13 Nishimura conducting infectious disease research introduce the most advanced
(3)
infectious disease research.

Explain the mechanism of acquiring resistance of major

chemotherapeutic drugs. Explain the measures against major multidrug-
14 Tomioka Therapy (2) resistant bacteria. List the major side effects of major chemotherapeutic
drugs and explain their symptoms. Through PBL / SGD, we can propose
prescription drugs for infectious diseases.
Clarify the problems of scenario issues that imitate the clinical
setting, then promote further information gathering and information
15 Tomioka Therapy (3) organization through group discussions (materialization,
visualization, simplification, etc.), and propose practical action plans
and preventive measures.
Record and
Evaluate based on submitted reports (100%).
evaluation method
Textbook

Reference
Preparation: Read related items in the specified textbook / reference book by the lecture
time.
Preparation
Review: Summarize the outline of the lecture content. For the part with insufficient
and Review
understanding, learn with related items in textbooks and reference books to deepen
understanding.
Language Used in
Japanese
Course
Office hours E-MAIL: [email protected]

In addition
 Subject Pathology

Course Numbering YPH-PHA375J Categories Elective

Preferable
3rd Semester 6 Credits 2
Participants
Suzuki Takashi, Yamazaki Yuto, Inoue Chihiro, Takagi Kiyoshi, Miki Yasuhiro,
Instructor Takaki Takashi, Shibahara Yukiko, Nakamura Yasuhiro, Endo Mareyuki,
Takeyama Junji, Sasaki Masaru, Akahira Junichi, and Sato Ikuro
Practical business 〇
An understanding of pathology is a fundamental requirement for fully
understanding various human disorders and their corresponding treatments,
including the pharmacological targeting of the underlying causes of disease. In
addition, basic knowledge of pathology is also required for understanding the side
effects or toxicology of medications.
Coursework will focus on teaching the fundamentals of pathology and in parallel,
how these apply to various human diseases. Experts in relevant fields provide
Objectives and
comprehensive and thought provoking lectures in an “omnibus” fashion in various
summary of class
diseases including the potential toxicological aspects of medical treatment. In
parallel to the theoretical component above, it is imperative for the students in
pharmacy to observe the practical elements involved in pathological work in order
to fully understand the theory above. Therefore students may be able to observe
the autopsy and how the histology or cytology specimens are produced in the
laboratory, thus giving them a practical as well as theoretical understanding of
pathology.
Students are expected to acquire the minimum knowledge of pathological aspects
Goal of study
of human disorders.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
The basic concept of diseases and how diseases afflict humans.
Pathology in
In addition, as relevant to pharmaceutical science, how
1 Suzuki therapeutic
histopathology could contribute to select which patients to be
efficacy
treated in oncology.
Antineoplastic therapy has become one of the most important
Pathology of
2 Suzuki topics in the field of pharmaceutical science. Therefore, in this
cancer
course, students will learn the basic concept of cancer.
3 In drug development, clinical and molecular pathology plays
Toxicology and important roles in the evaluation of toxicology studies. These
Miki
Pathology lectures will cover the toxicological pathology, drug-induced
4
injury and experimental pathology.
Pathological examination is done by light microscopic
Processing of
observation of tissues or cells from body. This lecture covers how
5 Takagi pathological
specimens are processed for pathological examination (fixation,
specimens
staining etc).
These lectures will focus on the following four contents.
1) Microscope basics：Difference between optical microscope and
Basics and electron microscope
significance of 2) Points to keep in mind when observing morphology using a
6 Takaki
microscopy in microscope
morphology 3) Trends in worldwide research on electron microscopes
4) Tips for research using a microscope

The histology of the skin is closely related to drug metabolism and

Histopathology of its adverse effects. This lecture will cover the basic structure and
7 Shibahara
Skin metabolism of the skin, general skin pathology, including psoriasis,
dermatitis including drug eruption, infectious and tumorous
 lesions.

The respiratory system including lungs exhibits a variety of

histological changes in response to external antigens and/or
Respiratory drugs. In this lecture, we will review histology of the lung tissue
8 Inoue
pathology and its changes in response to external stimuli, pathology of
pulmonary tumor, and the relationship between histopathology
and drug therapy.
Pathology of
These lectures will focus on the basic pathology of endocrinology,
Endocrinology,
9 Nakamura metabolism and reproduction associated with pharmacokinetics
Metabolism and
and clinical diseases
Reproduction
These lectures will focus on the pathology of liver and kidney
Pathology of
disorders. Particularly relevant to students of pharmacology,
Liver,
10 Endo the lectures will also include a focus on pathological changes
Gastrointestinal
associated with the side effects of medicines. As a learning tool
tract, and Kidney
case studies of the latter will be covered in this lecture
This component focuses on the physiology and histology of
Prenatal
11 Takeyama placenta. Placental pathologies related with fetal development
pathology
are also covered.
The oral cavity is an important organ with a variety of functions.
Of particular interest to pharmacists is the barrier system of the
12 Sasaki Oral pathology
oral mucosa. In this lecture, the etiology of lesions of the oral
cavity and salivary glands will be discussed.
Pathology These lectures will explain the pathology of gynecologic normal
and cytology of to neoplastic lesions, mainly focus on endometrial hormonal
13 Akahira
gynecological changes. At the same time, the uterine cervical cytology will be
field lectured.
1. molecular pathology of carcinogenesis
Chromosomal instability, Abnormality of transcription and
translation, Abnormality of DNA repair, Cell cycle checkpoint,
Molecular Immune checkpoint, etc.
14 Sato diagnosis 2. molecular target of cancer therapy
of cancer Growth factor receptor
Signal transduction, etc.
3. molecular diagnosis of cancer
ISH, PCR, IHC etc.
Practical The application of histology sections can be not only for practical
application of medicine as well as divergent spectrums of translational
histopathological research, including genomic analysis for precision medicine.
15 Yamazaki
sections for Many sophisticated approaches for research application which
translational everybody will experience in near future will be introduced in
research this lecture.
Record and Students are evaluated on the results of final report (50%) as well as
evaluation method performance of individual class attendance (50%)
Textbook Simple Pathology Revised 8 Edition NANKODO

Reference None
Preparation
None
and Review
Language Used in
Japanese
Course
Make an appointment in advance via email or other means.
Mizuki Kato, Administrative assistant
Office hours Department of Pathology Tohoku University School of Medicine
2-1 Seiryo-machi Aoba-ku Sendai Miyagi Japan 980-8575
Tel+81-22-717-8050
 [email protected]

During winter breaks (form December to January), students (applicants) may

In addition
possibly observe autopsy in Tohoku University Hospital.
 Subject Human Genomics

Course Numbering YPH-PHA333J Categories Required

Preferable 3rd
Semester 6 Credits 1
Participants [Pharmacy]
Instructor Inada Toshifumi

Practical business
This course covers the treatment mutation and its pathology of the gene. In particular,
students will understand about the quality control mechanism to abnormal mRNA
Objectives and recognizes the exclusion to hold a major cause mutation nonsense mutation of the
summary of class genetic disease. Students will learn about the molecular basis of the genetic disease
treatment due to modification of the translation reaction, and the association between
abnormal and disease expression control at the RNA levels.
Students learn about the mutation and repair mechanisms of gene, and quality control
mechanism of gene expression. This course also covers the treatment by the
Goal of study
modification of-gene expression, and genetic disease cased by abnormality at the RNA
level.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

1 Inada Basis of heredity Basics of genes and genetics.

2 Inada Basis of heredity Meiosis, recombination and sex-linked inheritance.

The causes of inducing human mutations and its repair
3 Inada Mutation and repair
mechanisms.
Recombinant protein The features and usefulness of the safety of recombinant
4 Inada drugs and gene pharmaceutical products. The principles of ethical problems of
therapy gene therapy.
Quality control for Quality control mechanisms to guarantee the accuracy of gene
5 Inada
gene expression expression.
Modification of gene
6 Inada expression and drug Drug therapy by the modification of the translation.
discovery I
Modification of gene
Current state of drug discovery by the modification of protein
7 Inada expression and drug
synthesis system.
discovery II
Modification of gene
8 Inada expression and drug Drug therapy by the modification of RNA processing reactions.
discovery III
Record and Valuation is performed based on short tests (about 10%) and the final examination
evaluation method (about 90%).
Textbook

Reference
Preparation Preparation: Reading the textbook for the next lecture
and Review Review: Answer of the small test and commentary by the lecture
Language Used in
Japanese
Course
Office hours E-MAIL: [email protected] TEL: 795-6874

In addition
 Subject Bioorganic Chemistry

Course Numbering YPH-PHA321J Categories Required

Preferable 3rd
Semester 6 Credits 2
Participants [Pharmacy]
Instructor Asai Teigo, Sugawara Akihiro, Doi Takayuki, Tahara Atsushi

Practical business
This course aims to learn about sugars, lipids, proteins (amino acids), nucleic acids
Objectives and
(nucleoside, nucleotide) to understand chemical principle of life. In addition, this
summary of class
course will provide the method of structural analysis of these compounds.
The aim of this course is to help student understand the chemical structures and
physiological activities of sugars, lipids, proteins (amino acids), and nucleic acids
(nucleoside, nucleotide).
Goal of study
The aim of this course is to help student acquire the method of structural analysis
of biofunctional molecules by using NMR spectroscopy, infrared spectroscopy, and
mass spectrometry.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
The chemistry This lecture aims to understand about monosaccharides,
1 Asai
of sugars (1) polysaccharides, and glycosides.
The chemistry This lecture aims to understand about physiological activities of
2 Asai
of sugars (2) polysaccharide.
The chemistry This lecture aims to understand about chemical structures of
3 Asai
of lipids (1) lipids.
The chemistry This lecture aims to understand about chemical structures and
4 Asai
of lipids (2) physiological activities of lipid derivatives.
The chemistry
This lecture aims to understand about chemical structures and
5 Doi of amino acids
physiological activities of amino acids and peptides.
and peptides
The chemistry This lecture aims to understand about secondary and tertiary
6 Doi
of proteins structures and physiological activities of proteins.
The chemistry
This lecture aims to understand about chemical structures and
7 Doi of nucleic acids
physiological activities of nucleic acids, RNA and DNA.
(1)
The chemistry
8 Doi of nucleic acids The same as above
(2)
This lecture aims to learn about principle of NMR spectroscopy,
Asai, Structure
9 infrared spectroscopy, and mass spectrometry and understand
Sugawara analysis (1)
structure analysis by the use of these methods.
Asai, Structure
10 The same as above
Sugawara analysis (2)
Asai, Structure
11 The same as above
Sugawara analysis (3)
Asai, Structure
12 The same as above
Sugawara analysis (4)
Structure
13 Tahara The same as above
analysis (5)
Structure
14 Tahara The same as above
analysis (6)
Structure
15 Tahara The same as above
analysis (7)
 Record and
Evaluated by examination (100%).
evaluation method
Textbook 「生体分子の化学」相本三郎、赤路健一著、化学同人
「有 機 化合 物 のス ペ クト ルに よ る同 定 法 -MS, IR, NMR の 併 用 第 ７版 」R .M .
Silverstein, F. X. Webster, D. J. Kiemle 著 荒木峻ら訳、東京化学同人 (2006)
「ヴォート 生化学 第３版（上） 」；D. Voet、J. G. Voet 著、田宮信雄ら訳、東京化学同
Reference
人 (2005)「スミス 基礎有機化学 第３版（下） 」 J. G. Smith 著、山本尚ら監訳、化学
同人 (2012)
「ブルース 有機化学 第５版（下） 」 P. Y. Bruice 著、大船泰史ら訳、化学同人 (2009)
Preparation Problem-solving sessions will be in terms 10-15. Prepare problems of structural analysis in
and Review each term.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means before students will visit
office.
Office hours
The contact informations for the lecturers are referred at the end of the student
handbook.
In addition
 Subject Health Chemistry 2

Course Numbering YPH-PHA341J Categories Required

Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Instructor Professor Matsuzawa Atsushi, Associate Professor Noguchi Takuya

Practical business
Health Chemistry is the research field to find the method by which protect
human from various types of stress including environmental stress, emerging
infectious diseases, and drugs, leading to maintenance and increase of human
Objectives and health and prevention of human diseases. Therefore, the important theme is
summary of class changed by the needs of the times. In this course, students can especially deepen
their understanding of infection by microorganisms and their prophylaxis,
immunity and food allergy, epidemiology and prophylaxis of life style-related
diseases such as cancer, cardiovascular disease, and diabetes.
1. Understanding of infection by microorganisms and their prophylaxis,
immunity and food allergy.
Goal of study
2. Understanding of epidemiology and prophylaxis of life style-related diseases.
3. Understanding of relationship between various type of stress and diseases.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students understand mechanisms of infection, types
1 Matsuzawa Mechanisms of infection of infectious diseases, infection routes, and their
factors.
Students understand recent trends of infectious
Prophylaxis of infectious
2 Matsuzawa diseases, and learn methods for prophylaxis of
diseases (1)
infectious diseases.
Students understand related laws for prophylaxis of
Prophylaxis of infectious
3 Matsuzawa infectious diseases, especially infectious diseases
diseases (2)
control law, their classification, and their transition.
Students understand the prophylactic vaccination
Prophylaxis of infectious
4 Matsuzawa against infectious diseases and their recent
diseases (3)
problems.
Students learn types and classification of pathogens,
5 Matsuzawa Toxicity of pathogens (1)
understand specific toxicity of each pathogen.
Students learn types and factors of food poisoning
6 Matsuzawa Toxicity of pathogens (2)
caused by pathogens.
Students learn food contamination by chemicals,
7 Matsuzawa Food contamination pathogens, and natural toxin, and understand the
effect on human health.
8 Noguchi Immune system Understanding of basic immune system.
Students learn the mechanisms of allergy by
Immunity and food
9 Noguchi immunity, and especially understand the factors of
allergy
food allergy.
Maternal and child Understanding of infection of infant from mother and
10 Noguchi
health neonatal mass screening.
Students learn types and characteristics of life
style-related diseases such as cancer, cardiovascular
Mechanisms of life
11 Matsuzawa disease, and diabetes, and understand their factors,
style-related diseases
their mechanisms, and past and recent trends of
these diseases.
 Epidemiology and
Understanding of epidemiology and prophylaxis of
12 Matsuzawa prophylaxis of life
cancer.
style-related diseases (1)
Epidemiology and
Understanding of epidemiology and prophylaxis of
13 Matsuzawa prophylaxis of life
cardiovascular disease.
style-related diseases (2)
Epidemiology and
Understanding of epidemiology and prophylaxis of
14 Matsuzawa prophylaxis of life
diabetes.
style-related diseases (3)
Epidemiology and Students deepen their understanding of the
15 Matsuzawa prophylaxis of life relationship of various diseases with life style such
style-related diseases (4) as dietary life and smoking.
Record and Students are evaluated on the final examination (75%) and the class
evaluation method performance (25%).
“Eisei Yakugaku –Kenkou to Kankyou– ” edited by Akira Naganuma, Seiichiro
Textbook
Himeno, and Akira Hiratsuka (Maruzen).
Reference
Preparation Students are required to prepare and review for class according to the goal and
and Review contents of each class.
Language Used in
Japanese
Course
Students should make an advance appointment via E-mail or other means.
Office hours
E-mail: [email protected] TEL: 795-6827
The most of lecture contents are included in pharmacist national examination
In addition
guidelines.
 Subject Fundamentals of Practical Pharmacy

Course Numbering YPH-PHA361J Categories Elective

Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Tomioka Yoshihisa, Naoe Kiyotaka, Toyama Akira, Hayakari Makoto, Suzuki
Instructor
Naoto, Yamaguchi Hiroaki, Shimanuki Eiji
Practical business 〇
The environment surrounding medical treatment in recent years is facing a rapid
decline in medical resources as the birthrate and aging population ages. Efficient
and effective use of medical expenses, which are medical resources, especially
pharmaceutical expenditure accounting for a large proportion of them, has become
a national policy, and since 2003 the diagnostic group classification comprehensive
evaluation (DPC / PDPS: Diagnosis Procedure Combination / Per-Diem Payment
System) was started to a specific function hospital such as a university hospital. At
the same time, however, the medical field is also required to improve the quality of
medical care, including medical safety that originated from medical accidents
Objectives and caused by misdiagnosed patients. A wide range of measures including medical
summary of class safety, infection control, measures against high-risk medicine, clinical trials and
medical management are indispensable, as well as proper use of medicines.
In the clinical pharmacy pay, we introduce fundamental tasks such as dispensing
and pharmaceutical product management, which are mainly performed in the
hospital pharmacy department, and also provide pharmaceutical care such as drug
management guidance practice (including patient education) Based on the practice,
as well as the addition of 'ward drug work execution addition' introduced by
revision of medical treatment fee 2012 and its work, even hospital management
work including advanced clinical research work and hospital management,
university hospital pharmacy department Learn by giving examples in practice.
· Explain changes in the environment surrounding pharmaceuticals and changes
in the role of pharmacists.
· Understand basic pharmacist's work based on proper use of medicines.
· Understand the transition of team medical care and the qualities, skills and
knowledge required of pharmacists.
· Understand the new role of pharmacists in hospitals.
Goal of study · Understand medical ethics, medical system, medical treatment remuneration
system in using pharmaceutical products.
· Understand the role of pharmacists in hospital management operations including
hospital management.
· To understand the importance of learning a wide range of specialized subjects by
forecasting a broad academic field to be learned from the faculty of pharmacy in
the future.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
To understand the health care system and national health insurance
system. Based on these, understand the transition of the concept and
Dispensing
1 Toyama work contents accompanying the change of the medical environment,
practice
the medical safety and the medical system concerning dispensing
practice (in the narrow sense).
To understand the importance and significance of supply management
Pharmaceutic
for requiring special attention such as narcotics / psychotropics and
2 Toyama al product
blood derived products. To explain pharmacist’s role and
management
responsibility.
 Recently, numerous medical incidents have been reported. In addition,
there are many more incidents (adverse events that are not medical
Risk
accidents) in the hospital. Among them, the proportion of adverse
management
3 Toyama events related to medicine is high. Understand how the pharmacist /
and role of
medicine department is involved in improving these events. Also
pharmacy
understand the role of the medical safety manager who is set up in the
hospital.
Hospital We also understand the existence of medical institutional, economic
pharmacy and ethical issues for in-hospital formulations and special hospital
4 Suzuki
compounding formulations that have benefited patients in advanced medical care
products and rare disease.
Information necessary for proper use of pharmaceuticals is
indispensable for better medication treatment. The drug information
Drug management service (hereinafter referred to as DI service) handles
5 Suzuki information this drug information (Drug Information) extensively. Understand the
service contents of information collection, arrangement, evaluation, storage,
processing, provision etc. of DI operations and knowledge and
technical ability necessary for carrying out their work.
Logically explain the change of prescription contents from the case
where a small question felt in the medical field eventually leads to
Science mind
drug discovery and the result of TDM analysis in medication guidance
6 Tomioka for clinical
From the above cases, the importance of scientific viewpoints will be
settings
mentioned, and further practical countermeasures will be proposed
through group discussions.
Drugs expenses were sought in the pharmaceutical department.
Pharmacy
Toyama Understand the role of pharmacists necessary in comprehensive
7 administratio
medical systems, such as clinical path management, generic drug
n
countermeasures, pharmaceutical formula management, etc.
In the acute phase hospital, after the introduction of DPC, the medical
treatment system has changed dramatically, and accordingly the
hospital infection is a serious problem for the hospital, and in severe
Infection
8 Yamaguchi cases of the basic disease, the treatment of infectious diseases is It
control
connects directly. Understand administration practices of nosocomial
infection prevention measures and administration method based on
PK / PD theory in antimicrobial therapy.
TDM serves as a means of improving the efficacy and safety of drug
therapy. Factors affecting drug dynamics, collection of patient
9 Suzuki TDM
information, clinical background, understanding pharmacokinetic
analysis, drug interaction and administration design.
Clinical ethics When advancing medical care, overview the ethical viewpoint to be
10 Naoe
and pharmacy learned and understand points to be noted in medicine work.
Each medical field has developed to a high degree, and a pharmacist
specialized and certified pharmacist system was started to raise
Team medical
expertise. Understand the pharmacist's involvement as a member of
11 Toyama and
the ICT, NST, cancer chemotherapy team, etc., as well as understand
pharmacist
drug administration guidance work and "addition of ward drug service
work addition" and outline of its work.
In emergency medicine such as drug addiction, information provision
of drugs and drugs of abuse, analysis of drugs, measurement of blood
Emergency
concentration, administration of antidotes, etc. are required.
12 Yamaguchi and drug
Regarding prevention of drug abuse, educational activities for
abuse
schoolchildren and students by pharmacists are required. Understand
the role of pharmacists in these poisoning medicine
Understand how pharmacists are involved in clinical trials as clinical
Clinical trials
research coordinators (CRC) etc, along with problems such as
13 Suzuki and
elimination of drug lag and response to international joint clinical
pharmacists
trials.
 Understand the changes in the environment surrounding
pharmaceuticals and the role of pharmacists from the viewpoint of
Community insurance pharmacies. In particular, understand the deepening and
14 Shimanuki Pharmacy differentiation of insurance pharmacy functions required by the
Practice revision of the Pharmaceutical Machinery Act, etc., and how to
cooperate with medical institutions (specific examples of drug-drug
cooperation).
Efficacy and safety of drugs are confirmed by clinical trials and others,
and they are subject to manufacturing approval. However, right after
Evaluation
marketing, proper use information is insufficient. Understand why it
15 Toyama and
is insufficient (limits of clinical trial), understand how to select and
development
select medicines in a situation where information is insufficient and
understand how to accumulate information
Record and
Evaluation is performed based on examination (above 60 points)
evaluation method
Textbook

Reference
Preparation: Read related items of reference book specified by lecture time.
Preparation
Review: Summarize the outline of lecture content. For the lack of understanding,
and Review
learn from reference book related items and deepen their understanding.
Language Used in
Japanese
Course
Office hours Contact: [email protected]

In addition SGD,PBL
 Subject Pharmacotherapeutics 1

Course Numbering YPH-PHA372J Categories Elective

Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Instructor Tomioka Yoshihisa, Matsumoto Yotaro, Tsukamoto Hiroki

Practical business
Pharmacotherapy learns basic knowledge on how to use medicines and how to
select medicines based on individual patient information and medicinal
information based on the understanding of the pathology and symptoms of typical
diseases, and from the perspective of patient QOL and proper use of medicine
Understand that contributing to drug treatment from.
Objectives and Pharmacotherapy 1 learns the outline of each disease regarding blood /
summary of class hematopoietic disorders, nerve and muscle diseases, mental disorders, ear and nose
and throat diseases, eye diseases, infectious diseases, and malignant tumors,
Estimate etiology and disease name from laboratory findings and understand how
to decide therapeutic policy and prescription. Learn the points of caution in using
individual drugs. Classes, along with lectures, conduct surveys, presentations and
discussions by small group.
Based on the symptoms and laboratory tests, a treatment policy can be planed and
Goal of study
specific prescription can be suggested.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
To explain what treatment is, the position of drug treatment and non-
drug treatment, and the role of pharmacist. Discuss the role of drug
Generals of
Tomioka treatment in representative diseases. It can be explained based on
1 Pharmacothe
medicinal pharmacology, pharmacokinetics, drug interaction for
rapy
selection of an appropriate therapeutic agent. Discuss representative
phytotoxicity and substance abuse.
Blood / Representative diseases in blood / hematopoietic devices can be
Tomioka
2 hematopoietic mentioned. It can explain the therapeutic agent against anemia
disorders (I) and the attention on its use.
Blood / Purpura, leucopenia, thrombus/embolism can be outlined for drug
Tomioka
3 hematopoietic therapy. Can outline drugs, pathology, and treatment of malignant
disorders (II) tumors.
Explain the therapeutic agent against disseminated intravascular
Blood /
Tomioka coagulation syndrome (DIC) and the attention on its use. It can
4 hematopoietic
explain the therapeutic agent for hemophilia and the attention on
disorders (III)
its use.
Leukemia, malignant lymphoma, osteosarcoma, and precautions
Tomioka Oncology
5 on its use. Explain care plan against adverse events/side effects
Pharmacy (I)
caused by antineoplastic drugs.
It can explain therapeutic agents for gastrointestinal malignancies
(gastric cancer, esophageal cancer, liver cancer, colon cancer,
Tomioka Oncology
6 gallbladder / bile duct cancer, pancreatic cancer, etc), and precautions
Pharmacy (II)
on its use. Explain care plan against adverse events/side effects
caused by antineoplastic drugs.
It can explain therapeutic agents for lung cancer, pancreatic
cancer, head and neck cancer and malignant tumors of sensory
Oncology
Tomioka organ (brain tumor, retinoblastoma, larynx, pharynx, nasal cavity
7 Pharmacy
/ paranasal sinus, oral cavity malignant tumor etc.) and cautions
(III)
on its use. Explain care plan against adverse events/side effects
caused by antineoplastic drugs.
 It can explain therapeutic agents for reproductive malignancies
Oncology (prostate cancer, uterine cancer, ovarian cancer etc.), malignant
Tomioka
8 Pharmacy tumors of renal / urinary system (renal cancer, bladder cancer),
(IV) breast cancer, and cautions on its use. Explain care plan against
adverse events/side effects caused by antineoplastic drugs.
Tomioka Oncology It can explain supportive care for cancer chemotherapy and
9
Pharmacy (V) terminal care and palliative care.
It can explain the remedy for dizziness (Meniere's disease, motion
sickness, etc.) and typical eye diseases (glaucoma, cataract, age-
Otorhinolaryn related macular degeneration etc.) and attention on its use.
Tsukamoto
10 gology Representative diseases related to otolaryngology and eyes
Eye disease (allergic rhinitis, hay fever, sinusitis, otitis media, stomatitis /
pharyngitis / tonsillitis, pharyngitis, conjunctivitis, retinopathy,
uveitis, retinitis pigmentosa etc. ).
List the major infections and explain their condition and cause.
Tsukamoto
11 Infection Antibacterial drugs, antiprotozoa / parasitic drugs, antifungal
drugs, antiviral drugs, and their usage attention can be explained.
Neurological Representative diseases related to nerve and muscle can be cited.
Matsumoto
12 and muscle Therapeutic agents for cerebrovascular diseases, epilepsy,
disease (I) remedies for Parkinson's disease, and cautions on its use.
Alzheimer's disease, cerebrovascular dementia, and precautions on
its use. It can explain the therapeutic agent for headache
Neurological
Matsumoto (migraine, tension headache, cluster headache) and attention on
13 and muscle
its use. Medical therapy can be outlined about myasthenia gravis,
disease (II)
encephalitis / meningitis, febrile convulsion, brain tumor, transient
ischemic attack, Guillain-Barre syndrome.
Representative mental illness can be cited. Can explain
therapeutic agents against schizophrenia and cautions on its use.
Neurological
Matsumoto It can explain therapeutic agents for mood disorders (depression,
14 and muscle
manic depressive disorder) and attention on their use. About drug
disease (III)
therapy about neurosis, psychosomatic disease, drug addiction,
alcohol dependence can be outlined.
About prescription cases for diseases covered in Pharmacotherapy
Matsumoto
15 Summary 1, you can explain medication therapy from the viewpoint of
patient QOL and proper use of medicine.
Record and
Evaluate based on the normal point (15%) and the written test (85%).
evaluation method
Textbook

Reference
Preparation: Read related items of reference book specified by lecture time.
Preparation
Review: Summarize the outline of lecture content. For the lack of understanding,
and Review
learn from reference book related items and deepen their understanding.
Language Used in
Japanese
Course
Office hours E-MAIL appointments: [email protected]

In addition
 Subject Medical Informatics

Course Numbering YPH-PHA362J Categories Elective

Preferable
4th Semester 7 Credits 2
Participants
Mano Nariyasu, Maekawa Masamitsu, Fujimori Kenji, Obara Taku, Matsuura
Instructor Masaki, Sato Mayumi, Akasaka Kazutoshi, Oyanagi Gen, Noda Aoi, Ishikawa
Tomofumi, Tsuchiya Masami
Practical business 〇
This course provides students with basic knowledge of medical information
Objectives and
necessary for pharmaceutical care. Faculty and medical staff members in Tohoku
summary of class
University Hospital provide lectures, in an omnibus style.
The purpose of this course is to help students explain the methods of collection,
processing, and provision of medical information necessary for medical staffs and
Goal of study
patients. Students will understand the utilization of medical information for the
optimization of drug therapy.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction: In this course, students summarize the position of various
Related laws and kinds of medical information and the outline of the law
rug information
1 Mano related to pharmaceuticals and pharmacist works. And they
obtained in drug
will understand the flow of drug development and drug
development
research
information obtained in the process.
Study design on
In this course, students understand research design to
Obara efficacy of
2 evaluate data on the effectiveness of drugs produced by
Ishikawa pharmaceutical
products
clinical research and epidemiological studies
Through critical examination on clinical research papers for
Critical investigating the effectiveness and safety of drugs, students
Obara, examination of practically understand statistical parameters, thinking about
3
Noda clinical research the interpretation and evaluation of information described in
thesis the papers to acquire reading comprehension and English
language skills.
In this course, students learn the pharmaceutical safety
Pharmacovigilance
monitoring system in Japan, and understand the flow and
and post
4 Obara utilization of information collected in the process of post
marketing
surveillance
marketing surveillance and the related pharmacy regulatory
system.
Types and features In this course, students understand the legal basis of drug
of drug package inserts, confirm the items listed, and understand
5 Oyanagi information how to read and read them. Also students understand the
sources (1) meanings of the terms used in the package insert, the degree
Package insert of processing of the drug information source and how to use it.
Types and features
In this course, students understand how to read and use
of drug
interview forms. Also students understand the position in the
6 Oyanagi information
source of drug information, the degree of processing of drug
sources (2)
Interview form information sources and how to use them.
Students understand the structure of Diagnosis Procedure
Medical policy in Combination (DPC) while looking over the overall health
7 Fujimori Japan and DPC policy in Japan, and learn about the information of medical
system institutions that can be read from and the examples of their
use.
 Pharmacists should not dispense medication unless they solve
Utilization of
doubts caused by verification with medication history
medical
information or examination value data in prescription
information in
8 Sato examination. In this course, students understand patient
prescription
information to be utilized in prescription examination and
inspection and risk
management various medical information. Students also learn about
medical safety information related to medicines.
In this course, students learn through practical examples
Utilization of
about the use of information on bringing medicine at the time
medical
of hospitalization, prescription in ward work, medication
9 Akasaka information and
history, examination value data, electronic medical records
medical records in
ward work and pathology, and understand the meaning of description of
medical records .
Utilization of In this course, students learn through actual examples about
medical
the collection of necessary information for advanced medical
information and
and emergency centers and ICU and providing them to
10 Akasaka medical record in
medical staff. Students also understand the differences
Advanced Critical
Care Center and between information sources and medical records with
ICU general wards.
Medication In medicine therapy in perinatal period (pregnant women,
therapy and lactating women, neonates), the information obtained during
11 Obara information the drug development stage is limited. In this course,
utilization in students learn about the information to be aware of, in order
perinatal period to secure the safety of medication therapy in perinatal period.
In this course, students understand the cooperation between
hospitals in the area - insurance pharmacies in the area and
hospitals - hospitals, and make use of information such as
Regional medical
12 Matsuura treatment contents, prescription medicines, examination
cooperation
values and side effects to be provided to the family pharmacy
etc learn. Students also understand the current state of
information networks on regional medical care.
In this course, students understand the flow of information
Pharmaceutical
gathering related to the use of medicines such as unapproved
13 Mano safety
and their utilization, and learn about the well-known way of
management
information for promoting proper use.
In this course, students are required to promote cancer
Utilization of genome medicine and combine information such as blood
medical
concentration and gene analysis results indispensable for
information in the
14 Maekawa precision medical treatment individually optimized,
promotion of
information such as electronic medical records, medical
personalized
medicine records, and interviews with patients Learn practical
examples of prescription design utilizing medical information.
Big data in
Obara Students understand the nature of various big data generated
15 medical care and
Tsuchiya by medical care and learn about its use.
its application
Record and Evaluation is based on the written examination in principle, considering class
evaluation method performance.
Do not specify textbooks. Each lecturer will introduce reference books, documents,
Textbook
etc. as necessary.

Reference References will be handed out at every class.

Please make an appointment by e-mail before visiting.
Office hours
E-MAIL: [email protected]

In addition
 Subject Kampo Medicine
Course
YPH-PHA376J Categories Elective
Numbering
Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Instructor Professor Arai Makoto

Practical business 〇
In this course, students will mainly understand the basic theories, characteristics,
Objectives and
and adverse reactions of Kampo (Japanese traditional) medicine, and develop their
summary of class
abilities to apply it clinically.
The purpose of this course is to discuss the differences among Kampo, Traditional
Goal of study Chinese, Western and complementary and alternative medicine, and explain the
Kampo basic theories, Sho, diagnostic explanation and adverse reactions.
Lecture・Practice・Training・On-site training・SGD・PBL・Role-play・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Students learn about the history, characteristics,
1 Arai Introduction application of Kampo medicine and relationship with
modern medicine.
Students learn yin and yang and deficiency and excess, and
2 Arai Basic theory 1
explain them clinically.
Students learn cold and heat, exterior and interior, qi, blood
3 Arai Basic theory 2 and fluid, six stages of disease transformation, and explain
them clinically.
Students learn how to use Kampo medicine, for example,
4 Arai Clinical theory
Sho-based therapy with the theory of clinical reasoning.
Students are familiar with Kampo medicine through
5 Arai Formulation practice
adjusting and tasting Kampo decoction, extract and powder.
Students learn the Kampo treatment of respiratory
Therapeutics 1/
6 Arai diseases and decide the appropriate Kampo prescriptions
respiratory diseases
for the patient through exercises.
Therapeutics 2/
Students learn the Kampo treatment of upper
upper
7 Arai gastrointestinal diseases and decide the appropriate Kampo
gastrointestinal
prescriptions for the patient through exercises.
diseases
Therapeutics 3/
Students learn the Kampo treatment of lower
lower
8 Arai gastrointestinal diseases and decide the appropriate Kampo
gastrointestinal
prescriptions for the patient through exercises.
diseases
Therapeutics 4/ Students learn the Kampo treatment of gynecological
9 Arai gynecological diseases and decide the appropriate Kampo prescriptions
diseases for the patient through exercises.
Therapeutics 5/ Students learn the Kampo treatment of geriatric diseases
10 Arai geriatric diseases and and pain disorders, and decide the appropriate Kampo
pain disorders prescriptions for the patient through exercises.
11 Arai Pharmacology Students learn the pharmacokinetics of Kampo medicine.
Adverse reaction
Students learn the adverse reactions and clinical
12 Arai Medication
medication instruction.
instruction
Students practice exercises to decide appropriate Kampo
13 Arai Diagnostic exercise 1
prescriptions for the patient in small groups
Students discuss the results obtained from the exercise 1 by
14 Arai Diagnostic exercise 2
the workshop.
15 Arai Special lecture Students learn about practical Kampo medicine treatment
Record and
evaluation Evaluated by class performance (50%) and report (50%)
method
Textbook A handout is distributed every time.
Shorei de wakaru Kampo-yaku nyumon (Introduction to Kampo medicine) by
Reference
Makoto Arai (Nichu shuppan)
Preparation
Review based on the handout texts and reference books.
and Review
Language Used in
Japanese
Course
Office hours Available anytime by e-mail; [email protected].

In addition
 Subject Clinical Pharmacology

Course Numbering YPH-PHA352J Categories Elective

Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Nobuyuki Takahashi, Emiko Sato, Naoki Kawamorita, Shin Fukudo, Takafumi
Instructor Hasegawa, Shigehito Miyagi, Kei Takase, Mariko Miyazaki, Atsuhiro Nakagawa,
Jun Takahashi, Toshio Yamagishi, Ken Saijo, Akira Sugawara, Junichi Sugawara
Practical business 〇
This course provides students with basic knowledge on pharmacotherapy
Objectives and necessary for bed-side medication and drug development. Faculty staff members
summary of class of the Graduate School of Medicine (including the Institute of Development, Aging
and Cancer), experts in each field, provide lectures, in an "omnibus" style.
The purpose of this course is to help students better understand (1) practical
medication based on pathophysiology of each disease, (2) updated diagnostic
Goal of study approach for various diseased states, and (3) responsibility as a leading
pharmacist having basic knowledge useful for clinical practice and drug
development.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others)
Term Lecturer Theme Contents
Etiology and
N.
1 Treatment of Students learn about the etiology and treatment of renal disease.
Takahashi
Renal Disease
Etiology and
Students learn roles of genes regulating blood pressure on the
N. Treatment of
2 metabolic syndrome, and understand current therapies of the
Takahashi Hypertension and
metabolic syndrome.
Metabolic Syndrome
Targeting the gut The involvement of intestinal microbiota in the pathogenesis of renal
microbiota for the disease is clear. Students learn about the relationship between gut
3 Sato
treatment of renal microbiota and renal diseases, and about the treatment targeting gut
diseases microbiota.
Overactive bladder is common disease in elderly people. The purpose
Treatment for
4 Kawa-morita of this course is to understand the pathophysiology of overactive
Overactive Bladder
bladder and to learn the current therapies.
Psychosomatic This course covers recent advance in the diagnosis and treatment for
5 Fukudo
Medicine psychosomatic disease.
Etiology and
This course explains neurological diseases in an easy manner to
6 Hasegawa Treatment of
understand and helps students to understand how to treat the diseases.
Neurological Disease
Students learn about the outline of organ transplantation. The purpose
Organ Transplantation of this course is to understand the vascular thrombosis and rejection
7 Miyagi
and Pharmacotherapy after transplantation, and to learn the pharmacotherapy to preserve
the transplant organs as long as possible.
Basics of diagnostic
To learn basics of diagnostic imaging such as CT, MRI, nuclear
imaging using contrast
8 Takase medicine, and ultrasound examinations using contrast materials and
materials and
nuclear pharmaceuticals.
radiopharmaceuticals.
With the advent of super-aging society, medical staffs encounter an
Medication Treatment
increasing number of patients with potential renal insufficiency.
9 Miyazaki for the Patients with
Students learn about treatment precaution for the patients with renal
Renal Failure
failure.
Cerebrovascular disorders are roughly classified as cerebral
Cerebrovascular infarction, cerebral hemorrhage, and subarachnoid hemorrhage.
10 Nakagawa Disease / Medical Minimum essential knowledge, including symptoms and signs,
Innovation pathophysiology, diagnosis, treatment, and prevention will be
discussed. Latter half of the lecture will be allocated for medical
 innovation. It covers variety of issues including finding and defining
the needs to regulatory and reimbursement process. Minimum
essential knowledge for pharmaceutical professionals will be
discussed including the experience at Tohoku University Hospital.
Ischemic heart disease (IHD) is a leading cause of death in many
Ischemic Heart
J. countries and most often results from coronary artery atherosclerosis,
11 Disease; Pathogenesis
Takahashi thrombosis and vasospasm. Treatment involves risk factor
and Management
management, antiplatelet therapy, and antianginal medications.
Electrolyte
This course provides explanations of the classification of electrolyte
12 Yamagishi Abnormalities and
abnormalities and pharmacotherapy based on clinical examples.
Pharmacotherapy
Cancer Chemotherapy, Students learn about (1) characteristics of cancer cells, (2)
K.
13 from the General to carcinogenesis and metastasis, (3) recent advance in cancer
Saijo
the Particular chemotherapy, (4) genetic diagnosis and treatment for cancer.
Students learn about general endocrinology including classical
Endocrinology, endocrine organs such as hypothalamus, pituitary, thyroid,
A.
14 from the General to parathyroid, adrenal, pancreas, and testis/ovary, and novel
Sugawara
the Particular endocrine organs such as adipose tissues, vasculatures, and
heart.
Pharmacotherapy
J. This course provides comprehensive knowledge of
15 in Obstetrics and
Sugawara pharmacotherapy on reproductive health
Gynecology
Record and Students are evaluated based on submitted reports (80%) and class performance
evaluation method (20%).
Textbook The textbook will be designated at the beginning of the course.

Reference References are handed out at every class.

Preparation
and Review
Language Used in
Japanese
Course
The office hours are from 14:00 to 16:00 on Tuesdays. Make an appointment in
Office hours
advance via e-mail: [email protected] (Nobuyuki Takahashi).
In addition This class is an omnibus lecture series.
 Subject Clinical Pharmaceutics
Course
YPH-PHA363J Categories Elective
Numbering
Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Instructor Professor Akita Hidetaka, Lecturer Uchida Yasuo, Lecturer Sakurai Yu

Practical business
The purpose of this class is to understand the advanced application of the physical
Objectives and pharmacy and pharmacokinetics given by Pharmaceutics 1 and 2 in the clinics.
summary of class Small test will be given in each lecture to evaluate the achievement of
understandings.
Upon completion of this class, a student should be able to:
·Formulate two-compartment model and explain its application for dosage regimen
Goal of study
·Explain the concept of pharmacodynamics and its application in clinics
·Design drug dosage regimens in clinics
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Concept and principle of two compartment model
Clinical application of Formulation of two compartment model
1 Uchida
compartment models Clinical application of two-compartment model for the design of
drug dosage regimen
Computer-based simulation by physiologically based
pharmacokinetic models
Practice on pharmaco-
2 Uchida Analysis of time-concentration curves in the blood and tissues after
kinetic modeling-1
intravenous administration
Design of basic pharmacokinetic parameters
Analysis of time-concentration curves in the blood and tissues after
Practice on
oral administration
3 Uchida pharmacokinetic
Estimation of area under the blood concentration curve (AUC)
modeling-2
Analysis of administration route-dependence
Practice on pharmaco- Effect of changes in the kinetic parameters on time-concentration
4 Uchida
kinetic modeling-3 curves in the blood and tissues under pathological conditions
Computer-based simulation by physiologically based
Practice on pharmaco-
5 Uchida pharmacokinetic model of intravenous administration at a constant
kinetic modeling-4
rate
Basic concept of pharmacodynamics (PD)
Basic pharmaco- Relationship between the efficacy and the blood-concentration of
6 Uchida
dynamics drugs
Principle of pharmacokinetic (PK) and PD theory
Applied pharmaco-
7 Uchida Clinical application of the PK/PD theory
dynamics
An overview and the mechanism by which individual changes in
Circadian rhythm and
8 Akita pharmacokinetics and drug efficacy occur are outlined with clock
clock genes
genes
Various enzymes are involved in drug metabolism, but the most
important enzyme is cytochrome P450 (CYP). There are many
molecular species of CYP, some of which show genetic
9 Akita Pharmacogenetics 1
polymorphism. We will outline the mechanism by which individual
differences in drug efficacy occur, focusing on individual
differences in CYP genetic polymorphisms and drug metabolism
Explain the genetic polymorphisms and individual differences of
10 Akita Pharmacogenetics 2 drug-metabolizing enzymes other than CYP, drug transporters and
drug receptors.
 Calculate The package insert contains the information necessary for
11 Akita pharmacokinetics from pharmacokinetic analysis. We will explain how to extract
package insert information from the package insert and predict its dynamics.
Drugs which have close windows between effective and side effect
concentrations require therapeutic drug monitoring (TDM) in the
12 Akita TDM1
patient being treated. Introducing the drugs for which TDM is
actually performed and their importance.
We will explain and practice how to obtain and analyze data to
13 Akita TDM2
maintain an appropriate blood concentration by TDM.
Biopharmaceutics Set issues related to biopharmaceutics, and conduct preliminary
14 Akita
exercise surveys, exercises, and explanations.
Physical Pharmaceutics / Set issues related to physics pharmaceutics and formulation, and
15 Sakurai
Pharmaceuticals exercise conduct preliminary surveys, exercises, and explanations.
Record and
Students are evaluated on their points from all the small tests (40%), the regular
evaluation
examinations (40%), and the reports (20%).
method
Textbook No textbook will be used.
1. (English) Clinical Pharmacokinetics and Pharmacodynamics: concepts and applications Fourth
Edition Malcolm Rowland and Thomas N. Tozer, Lippincott Williams and Wilkins (2009)
(ISBN:9780781750097)
2. (Japanese) Tsuji's pharmacokinetics Episode Pharmacokinetics (ISBN:9784901789998)
エピソード薬物動態学―薬物動態学の解明、京都廣川書店（2012）
Reference 3. (Japanese) Biopharmaceutics (ISBN:9784567482349)
わかりやすい生物薬剤学 第 5 版 荻原琢男執筆者代表、廣川書店（2014）
4. (Japanese) Clinical pharmacokinetics (ISBN: 9784524250554)
臨床薬物動態学 第４版 加藤隆一著、南江堂 (2009)
5. (Japanese)製剤化のサイエンス 第 3 版 山本恵司監修、Elsevier (2016).
Preparation Getting basic knowledge on each topic using the references above as a pre-study and
and Review Trying several practice problems as a review
Language Used in
Japanese
Course
Please make an advance appointment via e-mail or other means. The contact
Office hours
information for the lecturer will be given in the class.
In addition
 Subject Prescription Analysis
Course
YPH-PHA364J Categories Elective
Numbering
Preferable 4th
Semester 7 Credits 2
Participants [Pharmacy]
Instructor Kikuchi Masafumi

Practical business 〇
In the process of dispensing, it is essential to analyze and interpret a prescription.
Students learn about basic knowledge of prescription and appropriate
Objectives and
pharmacotherapy for patients throughout case analyses. Also this course provides
summary of class
students with opportunities to recognize directions and methods for solving
problems by self-learning, small group discussions, and presentations.
The purpose of this course is to help students understand and interpret the
Goal of study
prescription.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction
1 Kikuchi Prescription and Dispensing Process
(1)
Introduction Drug Information for the Analyses
2 Kikuchi
(2) Guidance for Group Work and Self-Learning
Basic case
3 Kikuchi Hypertension, Diabetes Mellitus; group work and self-learning
analysis (1)
Basic case
4 Kikuchi Hypertension, Diabetes Mellitus; presentation and discussion
analysis (1)
Basic case
5 Kikuchi Cardiovascular Disorders, Thrombosis; group work and self-learning
analysis (2)
Basic case
6 Kikuchi Cardiovascular Disorders, Thrombosis; presentation and discussion
analysis (2)
Basic case
7 Kikuchi Psychiatric Disorders; group work and self-learning
analysis (3)
Basic case
8 Kikuchi Psychiatric Disorders; presentation and discussion
analysis (3)
Basic case
9 Kikuchi Gastrointestinal Disorders; group work and self-learning
analysis (4)
Basic case
10 Kikuchi Gastrointestinal Disorders; presentation and discussion
analysis (4)
Basic case
11 Kikuchi Immune disorders, Allergies; group work and self-learning
analysis (5)
Basic case
12 Kikuchi Immune disorders, Allergies; presentation and discussion
analysis (5)
Basic case Respiratory Disease, Infectious Disease; group work and self-
13 Kikuchi
analysis (6) learning
Basic case Respiratory Disease, Infectious Disease; presentation and
14 Kikuchi
analysis (6) discussion
Advanced Neoplastic Disorders; group work, self-learning, presentation and
15 Kikuchi
case analysis discussion
Record and
evaluation Minute Paper 70 %, Report 25 %, Presentations 5 %
method
Textbook

Reference References will be handed out at every class.

 Preparation
and Review
Language Used in
Japanese
Course
Office hours are from 9:00 to 17:00 on Wednesdays. Make an appointment in advance
Office hours
via e-mail. The contact information for the lecturer will be given in class.
In addition You must attend the first class session.
 Subject Pharmacotherapeutics 2

Course Numbering YPH-PHA373J Categories Required

Preferable 4th
Semester 8 Credits 2
Participants [Pharmacy]
Instructor Associate Professor Hiratsuka Masahiro

Practical business 〇
In this course, students will learn about bone･joint disease, skin disease, allergy･
Objectives and immune disease, and respiratory ･ chest disease and understand a means of
summary of class estimating a disease cause and a disease name from a patient’s condition and
inspection findings and determining a treatment policy and the prescription drugs.
The purpose of this course is to help students develop a treatment policy from
Goal of study
inspection findings and present a specific prescription example.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Bone/joint disease
1 Hiratsuka Students will learn about osteoporosis and rheumatoid arthritis.
(1)
Bone/joint disease
2 Hiratsuka Students will learn about osteoarthritis and osteomalacia.
(2)
Respiratory/chest Students will learn about chronic obstructive pulmonary disease
3 Hiratsuka
disease (1) and bronchial asthma.
Respiratory/chest Students will learn about upper respiratory infection and
4 Hiratsuka
disease (2) influenza.
Respiratory/chest Students will learn about pneumonia and interstitial
5 Hiratsuka
disease (3) pneumonia.
Respiratory/chest
6 Hiratsuka Students will learn about pulmonary tuberculosis.
disease (4)
Allergy/immune Students will learn about anaphylactic shock and acquired
7 Hiratsuka
disease (1) immunodeficiency syndrome.
Allergy/immune Students will learn about systemic lupus erythematosus and
8 Hiratsuka
disease (2) other immune diseases.
9 Hiratsuka Skin disease (1) Students will learn about atopic dermatitis and dermatomycosis.

10 Hiratsuka Skin disease (2) Students will learn about urticaria and drug eruption.

11 Hiratsuka Skin disease (3) Students will learn about bullous dermatosis and psoriasis.
Students will learn about contact dermatitis, photosensitivity,
12 Hiratsuka Skin disease (4)
and pressure ulcer.
Other drug therapy
13 Hiratsuka Students will learn about transplantation and blood transfusion.
(1)
Other drug therapy Students will learn about general anesthesia and palliative
14 Hiratsuka
(2) medicine.
Other drug therapy Students will learn about supportive therapy and genital
15 Hiratsuka
(3) disease.
Record and
Students are evaluated on the final examination (100%).
evaluation method
Textbook

Reference Pharmacotherapy (Nanzando)

Preparation The session time is limited and therefore self-directed learning is important.
and Review Students are required to prepare and review for each class.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
[email protected]
In addition
 Subject Pharmacotherapeutics 3

Course Numbering YPH-PHA374J Categories Required

Preferable 4th
Semester 8 Credits 2
Participants [Pharmacy]
Instructor Takahashi Nobuyuki, Sato Emiko

Practical business 〇
This course provides students with basic knowledge on the etiology and
Objectives and
therapeutic strategy in the treatment of cardiovascular disease, kidney and
summary of class
urinary tract disease, endocrine disease, and digestive system disease.
The purpose of this course is to help students propose treatments and
Goal of study prescriptions for patients, based on their chief complaints, symptoms, physical
examinations, and laboratory findings.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others ( )
Term Lecturer Theme Contents
Cardiovascular Students learn about the pathophysiology of ischemic heart
1 Takahashi
system disease 1 diseases, arrhythmias, and so on.
Students learn to plan therapeutic strategy, formulation, and
2 〃 〃 basic precautions in the treatment of ischemic heart diseases,
arrhythmias, and so on.
Cardiovascular Students learn about the pathophysiology of hypertension,
3 Takahashi
system disease 2 congestive heart diseases, and so on.
Students learn to plan therapeutic strategy, formulation, and
4 〃 〃 basic precautions in the treatment of hypertension,
congestive heart diseases, and so on.
Kidney and
Students learn about the pathophysiology of nephritis,
5 Takahashi urinary tract
nephrotic syndrome, prostatic hypertrophy, and so on.
system disease
Students learn to plan therapeutic strategy, formulation, and
6 〃 〃 basic precautions in the treatment of nephritis, nephrotic
syndrome, prostatic hypertrophy, and so on.
Endocrine system Students learn about the pathophysiology of endocrine
7 Takahashi
disease diseases, diabetes mellitus, and so on.
Students learn to plan therapeutic strategy, formulation, and
8 〃 〃 basic precautions in the treatment of endocrine diseases,
diabetes mellitus, and so on.
Digestive System Students learn about the disease status of gastritis, peptic
9 Sato
Disease 1 ulcer, and so on.
Students learn about the planning of therapeutic strategy,
10 〃 〃 formulation, and basic precautions in the treatment of
gastritis, peptic ulcer, and so on.
Digestive System Students learn about the disease status of hepatitis, liver
11 Sato
Disease 2 cirrhosis, and so on.
Students learn about the planning of therapeutic strategy,
12 〃 〃 formulation, and basic precautions in the treatment of
hepatitis, liver cirrhosis, and so on.
Digestive System Students learn about the disease status of cholecystolithiasis,
13 Sato
Disease 3 cholecystitis, pancreatitis, bowel disorders, and so on.
Students learn about the planning of therapeutic strategy,
14 〃 〃 formulation, and basic precautions in the treatment of
cholecystolithiasis, cholecystitis, pancreatitis, and so on.
 Students learn about the planning of therapeutic strategy,
15 〃 〃 formulation, and basic precautions in the treatment of bowel
disorders, and so on.
Record and Students are evaluated comprehensively based on a written examination (80%)
evaluation method and class performance (20%).
Textbook The textbook will be designated at the beginning of the course.

Reference References are handed out at every class.

Students deepen understanding and improve how to plan therapeutic strategy,
Preparation
formulation, and basic precautions in the treatment of various diseases as
and Review
pharmacists.
Language Used in
Japanese
Course
The office hours are from 14:00 to 16:00 on Tuesdays. Make an appointment in
Office hours
advance via e-mail: [email protected] (Takahashi Nobuyuki).
In addition
 Subject Clinical Laboratory Medicine

Course Numbering YPH-PHA311J Categories Elective

Preferable
4th Semester 8 Credits 2
Participants
Associate Professor Matsumoto Yotaro, Associate Professor Maekawa Masamitsu,
Professor Takahashi Kazuhiro, Professor Sugawara Akira, Assistant Professor
Instructor
Hiratsuka Masahiro, Assistant Professor Kanamori Hajime and Medical technologist
Katsumi Makoto
Practical business 〇
Clinical tests in medical care are used for diagnosis and medical treatment, because
the objective evidence of physiological changes resulted from disease can be obtained.
Therefore, studying each clinical test is important to understand the symptom
Objectives and
resulted from a disease. This course covers how to read clinical data together with
summary of class
patient background (genetic, age, physiological, complication, etc.) and aims to help
students understand the relationship between clinical test and disease specific
symptoms.
Basic knowledge of typical symptoms and the meaning of clinical data are acquired in
order to understand each disease by physiological change. Basic knowledge for
Goal of study
personalized medicine are acquired in order to make an administrating plan for
individual patient
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Introduction: Clinical Overviwing clinical laboratory medicine and personalized
1 Matsumoto
Laboratory Medicine medicine: how to utilize the clinical data for patients
Learning about the relationship between the genetic
2 Matsumoto Personalized medicine I
predisposition and PK/PD of drugs
Personalized medicine Learning about the concern for drug treatment to newborn,
3 Matsumoto
II infant, and elderly patients
Personalized medicine Learning about the concern for drug treatment to pregnant,
4 Matsumoto
III lactating, and obesity patients
Personalized medicine Learning about the concern for drug treatment to renal,
5 Matsumoto
IV hepatic, and cardiovascular patients
Learning about the administration plan based on individual
Personalized medicine
6 Matsumoto PK/PD parameters with concerning of the population
V
pharmacokinetic methods and circadian rhythm
Learning about the typical symptoms (fever, headache,
7 Maekawa Symptoms eruption, jaundice, cyanosis, etc.) together with each cause
and related disease.
Learning about the typical clinical laboratory tests using
Analysis of endogenous
8 Maekawa urine and feces samples to estimate the related diseases
compounds
with the data
Learning about the typical clinical laboratory tests for
9 Takahashi Endocrinology test I endocrine and metabolic disorder to estimate the related
disease from the data
Learning about the typical clinical laboratory tests for
10 Sugawara Endocrinology test II endocrine and metabolic disorder to estimate the related
disease from the data
Learning about genetic testing to estimate the typical
11 Hiratsuka Genetic test I
diseases from the data.
Learning about genetic testing to estimate the typical
12 Hiratsuka Genetic test II
diseases from the data
Learning about microbiology test to estimate the typical
13 Kanamori Microbiology test
diseases from the data
Practical work for blood Learning about the practical work in clinical laboratories
14 Katsumi
and physiological tests through blood and physiological tests
15
Record and
Based on the results of quiz/report by each lecturer.
evaluation method
Textbook Handouts of the power point slides are provided.
Laboratory Medicine (薬剤師のための臨床検査ハンドブック), 2nd Ed., Ed. M. Maeda, Y.
Takagi, Maruzen Publishing Co., Ltd., 2011 (ISBN 978-4-621-08420-5)
Reference
Clinical Chemistry (薬学生のための臨床化学), 3rd Ed., Ed. J. Goto, Y. Katayama,
Nankodo Co., Ltd., 2010 (ISBN 978-4-524-40262-5)
Preparation
and Review
Language Used in
Japanese
Course
Office hours An appointment required by E-mail or phone

In addition
 Subject Pharmaceutic Laws 2
Course
YPH-PHA381J Categories Required[Pharmacy]
Numbering
Preferable
4th Semester 8 Credits 1
Participants
Instructor Kimura Takahiro, Ishibashi Tsuyoshi

Practical business 〇
In this course, students will understand several laws to be necessary when they will
be active as a pharmacist in society in the future: e. g. “Pharmaceutical and Medical
Objectives and Device Act,” “Pharmacist Act,” “Narcotics and Psychotropics Control Act,”
summary of class “Poisonous and Deleterious Substances Control Act,” and other pharmaceutical
related laws, medical service related laws, social security related laws, and those
system.
A pharmacist state examination is contemplated, and students will understand
“Pharmaceutical and Medical Device Act,” and medical service and insurance related
laws to be necessary when the pharmacist is active in society in the future. The aim
Goal of study
of this course is to help students learn the purposes and changes of these laws,
recognize what the pharmacist as a medical bearer is required, and utilize the laws
concerned.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Mission and ethic of the Recognizing the history of medicine and pharmacy,
pharmacist, understanding the role of the pharmacist as a medical
1 Kimura
Pharmaceutical related bearer, and to wear the mission as the pharmacist and the
laws outline ethics of the medical life.
Understanding the license, duty, and business rules of the
2 Kimura Pharmacist Act pharmacist to be active as a pharmacist concerned a person
and society.
Learning the purpose and the definition of pharmaceuticals
etc., and the pharmacy, the pharmaceutical and medical
Pharmaceutical and
3 Kimura device sales business on “Pharmaceutical and Medical
Medical Device Act (1）
Device Act,” and to understand the rule about the
treatment of medicine.
Learning the processes and the legal norms from
Kimura Pharmaceutical and
4 development of drugs to approval, and understanding the
Ishibashi Medical Device Act (2)
post-marketing surveillance and safety measures.
Learning about the rule of narcotics, psychotropics, and
Narcotics and
Kimura stimulant raw materials, and understanding the
5 Psychotropics Control
Ishibashi preventive regulations against abuse about stimulants,
Act
cannabis, opium and designated drugs.
Understanding the rules about the handling of poisonous
Poisonous and
and deleterious substances.
6 Kimura Deleterious Substances
Learning about the handling of the creature origin products
Control Act
and the regenerative medicine, the blood supply system.
Medical Act, The Understanding the medical idea, the duty of medical
history of the harmful bearer, and the rule of Medical Service Act about medical
7 Kimura effect, offer system.
Side effect victim relief Learning about a pharmacist's role in the relief system of
system the healthy damage.
 The health insurance
method, Price
standards for medicines Learning the present conditions of the Japanese social
8 Kimura prescribed under the security system, and understanding the local cooperation
Health Insurance system of health, medical care, and welfare.
System, Medical
treatment charge rule
Record and
evaluation Evaluation is performed comprehensively based on the final examination (100%).
method
Textbook
“The commentary of the pharmaceutical law, system and ethic, 2020-21 version,”
Yakujinippou Corporation
Reference
“The commentary of Pharmaceutical and Medical Device Act, Pharmacist Act, and
Poisonous and Deleterious Substances Control Act,” Yakujinippou Corporation
Preparation
and Review
Language Used in
Japanese
Course
Office hours
Lectures pharmacist national examination questions criteria
In addition (http://www.jshp.or.jp/cont/10/1015-1.pdf ')
It will be mainly carried out the items that have been published in.
 Subject Non-Prescription Medications and Care

Course Numbering YPH-PHA377J Categories Elective

Preferable 4th
Semester 8 Credits 1
Participants [Pharmacy]
Tomioka Yoshihisa, Kamo Masayuki, Takahashi Fumiaki, Saito Ryoko, Kutsuwa
Instructor
Motoharu, Saga Toshihide, Sakino Ken-ichi, Komiya Jun
Practical business 〇
This course is related to the Higashi Nihon Dai-shin-sai (Great East Japan
Earthquake) and is related to self-care and self-medication support for local residents
from normal times, and self-care and health management, disease prevention, public
health, disaster prevention and mitigation, disaster medical care, etc., which are
required as emergency responders. Learn knowledge and attitude for then. Learn about
Objectives and
proper use of OTC drugs. Learn triage by pharmacists and how to respond. You will
summary of class
also learn about the importance of the family pharmacist system, multi-professional
collaboration, and the role of a member of team medicine in a broad sense, and the
future role of a pharmacist working in hospitals, pharmacies, governments, companies,
and universities. Classes include lectures and tours, as well as small group discussions
and presentations.
Based on each patient's symptoms and laboratory findings, treatment strategies or
Goal of study support can be planning and formulated and specific prescription examples can be
presented.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Learn basic knowledge of OTC medicines, self-care and self-
1 Tomioka Overview medication. Learn about the response and activities of university
faculty members during the Great East Japan Earthquake.
Learn the laws related to OTC drugs, classification of OTC drugs, and
2 Sakino OTC (1)
self-medication using OTC drugs and pharmacy drugs.
Learn the laws related to OTC drugs, classification of OTC drugs, and
3 Sakino OTC (2)
self-medication using OTC drugs and pharmacy drugs.
3 Komiya OTC (3) Learn communication and counseling sales in OTC drug sales.

4 Komiya OTC (4) Simulate communication and counseling sales in OTC drug sales.
Community Learn primary care and self-medication in pharmacies through
5 Saito
pharmacy (1) lecture exercises.
Community Learn primary care and self-medication in pharmacies through
7 Kutsuwa
pharmacy (2) lecture exercises.
Kamo Mobile
8 Learn the support of pharmacists during the Great East Japan Earthquake.
Takahashi pharmacy (1)
9 Saga Hospital Learn the support of pharmacists during the Great East Japan Earthquake.

Record and
Evaluate based on reports (100%).
evaluation method
Textbook

Reference
Preparation: Read related items in the reference book specified by the lecture time.
Preparation
Review: Summarize the outline of the lecture content. Learn the parts of the lack of
and Review
understanding in the reference book related items to deepen your understanding.
Language Used in
Japanese
Course
Office hours E-MAIL: [email protected]
In addition 8th ; On-site training (Mobile Pharmacy)
 Subject Clinical Communication Skills

Course Numbering YPH-PHA301J Categories Required

Preferable 4th
Semester 8 Credits 1
Participants [Pharmacy]
Instructor Tomioka Yoshihisa, Hirasawa Noriyasu, Tominaga Atsuko, Sato Kenta

Practical business 〇
Through dialogue with patients / consumers and other occupations, acquire the
Objectives and fundamental ability to understand the psychology, position, and environment of the
summary of class other person and to build trust. In the class, surveys, role play/presentations, and
discussions are conducted by small groups together with lectures
Based on each patient's symptoms and laboratory test’s data,
Goal of study pharmacotherapy/treatment strategies can be planned and presented of actual
prescription examples
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Learn about communication and fundamental social
1 Tomioka communication skills. Explain how to give bad news and the basics
Case study (1)
2 Tominaga of dealing with complaints. Learn how to respond to drug addicts
(no smoking guidance) through role play
3
Tominaga Case study (2) Learn how to deal with dementia patients through role play.
4
5
Tominaga Case study (3) Learn how to deal with dementia patients through role play.
6
Basics of
Hirasawa interpersonal Learn interpersonal communication skills through exercises and
7
Sato communicatio role play
n (1)
Basics of
Hirasawa interpersonal Learn interpersonal communication skills through exercises and
8
Sato communicatio role play.
n (2)
Basics of
Hirasawa interpersonal Learn interpersonal communication skills through exercises and
9
Sato communicatio role play.
n (3)
Record and
Evaluate based on each report (100%).
evaluation method
Textbook

Reference
Preparation: Read related items in the reference book specified by the lecture time.
Preparation
Review: Summarize the outline of the lecture content. Learn the parts of the lack
and Review
of understanding in the reference book related items to deepen your understanding.
Language Used in
Japanese
Course
Office hours Contact: [email protected]

In addition
 Subject Pharmaceutical English

Course Numbering YPH-PHA302J Categories Required

Preferable 4th
Semester 8 Credits 2
Participants [Pharmacy]
Prof. Nakabayashi Takakazu, Prof. Matsuzawa Atsushi, Prof. Takahashi
Instructor Nobuyuki, Prof. Tomioka Yoshihisa, Prof. Oe Tomoyuki, and Prof. Yoshikai
Naohiko
Practical business
Pharmacy English is important for acquiring knowledge and information in
advanced pharmaceutical fields from an international perspective and for globally
Objectives and
exchanging information from a professional standpoint of view. In this lecture, we
summary of class
aim to learn the terms and expressions used in pharmaceutical fields and to
develop a sense of international communication.
Understand the specialized English terms and usage of chemistry, biology,
Goal of study medical care which are considered to be necessary for pharmaceutical English,
and can be used for collecting, exchanging and transmitting information.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

1 Nakabayashi Guidance Lecture overview

English reading and Learn composition of the paper to read and write it by
2 Matsuzawa
writing in biology yourself.
English communication Learn English communication based on a lecture by a
3 Takahashi
in medical care native speaker.
English reading and Understand medical documents and learn English
4 Tomioka
writing in medical care sentences in various scenes.
English communication
5 Oe Learn basic English conversation at a laboratory.
in chemistry
6 Yoshikai English presentation Learn scientific presentation in English.

7 Nakabayashi Practice Practice English presentation

8 Nakabayashi Practice Practice English presentation

Record and
Evaluated by class performance (50%) and report (50%)
evaluation method
Textbook Not specified

Reference
Preparation
and Review
Language Used in
English and Japanese
Course
Make an advance appointment via e-mail to the lectures.
Office hours
See e-mail addresses in a student handbook.
In addition Lecture schedule will be notified in Classroom and on a message board.
 Subject Advance Training in Pharmacy 1
Course
YPH-PHA391J Categories Required
Numbering
Preferable 3rd
Semester 6 Credits 6
Participants [Pharmacy]
Instructor Supervisor of the laboratory

Practical business
Students will develop skills to solve research themes by organic association of the
Objectives and practical knowledge and basic experiment skills studied in basic pharmaceutical
summary of class trainings. This training are located to develop skills that are necessary for
Research Training held in 5th and 6th grade.
The purpose of this course is to understand research themes and do experiments
Goal of study
thinking the purpose to achieve themes logically.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Students do trainings based on the theme given by the supervisor of the laboratory. Moreover, students
are required to participate in the seminar held in the laboratory.

Record and
evaluation Evaluated by the supervisor of the laboratory.
method
Textbook

Reference
Preparation
and Review
Language
Used in Japanese
Course
Office hours

In addition
 Subject Advance Training in Pharmacy 2
Course
YPH-PHA392J Categories Required
Numbering
Preferable 4th
Semester 7・8 Credits 12
Participants [Pharmacy]
Instructor Supervisor of the laboratory

Practical business
Students will develop skills to solve research themes by organic association of the
Objectives and practical knowledge and basic experiment skills studied in basic pharmaceutical
summary of class trainings. This training are located to develop skills that are necessary for
Research Training held in 5th and 6th grade.
The purpose of this course is to understand research themes and do experiments
Goal of study
thinking the purpose to achieve themes logically.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Students do trainings based on the theme given by the supervisor of the laboratory. Moreover, students
are required to participate in the seminar held in the laboratory.

Record and
evaluation Evaluated by the supervisor of the laboratory.
method
Textbook

Reference
Preparation
and Review
Language
Used in Japanese
Course
Office hours

In addition
 Subject Basic Training in Biopharmacy and Pharmacy Practice
Course
YPH-PHA493J Categories Required
Numbering
Preferable 4th
Semester 8 Credits 4
Participants [Pharmacy]
Clinical Pharmacology and Therapeutics, Oncology Pharmacy Practice and Science,
Instructor Pharmacotherapy of Life-Style Related Diseases, Social Pharmacy Management,
Pharmacy Education and Research Center
Practical business 〇
Learn the knowledge, skills and attitudes that form the basis of the pharmacist's
duties, such as dispensing, preparation, medication instruction, etc., in order to
participate in the medical and health insurance business and open up the next
generation.
Objectives and This practice is done inside the university prior to pharmacy practice in hospital and
summary of class in community.
The first half is the basic practice and the second half is the development practice
with the clinical pharmacy exercise 2 (OSCE exercise) and the OSCE in between.
Mainly in accordance with the core education model core curriculum, in development
practice, we add original contents of our university.
This training will comply with the "Model Core Curriculum for Pharmacy
Education -2015 version" Based on a patient-oriented perspective, in order to
become active as a pharmacist at clinical sites such as hospitals and pharmacies,
the students need to acquire the basic matters necessary for practicing drug
therapy and participating in team medicine and community health care.

(1) Fundamentals of Pharmacy Practice

In order to properly practice the activities required as a medical person, the
students learn about the basic mental attitude and the basic flow of
pharmacological management at clinical sites.
◎ Mental attitude in clinical practice
◎ Basics of clinical training

(2) Prescription Processing, Medication Preparation, and Dispensing

In order to safely and properly carry out dispensing work based on prescription, the
students acquire basic dispensing work including supply and management of
medicines.
◎ Understanding and complying with laws and regulations
Goal of study ◎ Prescription and doubt inquiry
◎ Preparation of prescription medicines
◎ Patient and visitor responses, medication instruction, patient education
◎ Supply and management of chemicals
◎ Safety management

(3) Practical Application of Pharmacotherapy

In order to provide safe and optimal medication therapy to patients, the students
properly evaluate the medical conditions by appropriately gathering patient
information, propose and apply medication therapy suitable for each patient based
on appropriate medicinal information, and then evaluate applied medical therapy.
◎ Understanding patient information
◎ Collection and utilization of drug information
◎ Practice of prescription design and drug therapy (Prescription design and
proposal)
◎ Practice of prescription design and drug therapy (Evaluation of efficacy and
side effects in drug therapy)
 (4) Participation on Interprofessional Collaborative Work
In order to actively participate in team-centered team medicine in which multiple
types of medical workers collaborate and cooperate in medical institutions and
communities, the students understand the role and significance of multi-occupation
in team medicine, share information, propose and practice better medical
examination with other co-workers.
◎ Medical institution team medicine
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Contents
Basic training:
It aims to provide students with the confidence, skills and knowledge needed to efficiently and effectively
carry out their responsibilities as trainee in the hospital and clinical pharmacy.

Learning outcomes
◎ Verify the legality, safety and appropriateness of prescription order.
◎ Prepare the medicines (powdered, liquid, tablet) in accordance with a prescription.
◎ Inspection that the quantities of medication are dispensed accurately.
◎ Listen to the patients, and understand their needs and what matters to them.
◎ Advise patients on the safe and effective use of their medicines and devices.

Advanced training：
Demonstrate the characteristics of a prospective professional pharmacist by learn a more specialized
knowledge and techniques of the pharmaceutical care.
Acquire the ability to keep professionally throughout their careers with developments in medicine and
pharmacy.
(Main contents: "Vital signs" "Side effects and physical assessment" "Informed consent" "Pathological
analysis and case presentation" "Sterile preparation of anticancer drugs" "Radiopharmaceuticals"
"Pharmaceutical management" "Danger prediction training" " Small group discussion ")

Record and
Grading will be decided based on class performance (50%), reports (20%), rubric
evaluation
(10%), and the quality of the student’s practical training performance (10%).
method
Textbook OSCE Visual Guide

Reference
Preparation
and Review
Language Used in
Japanese
Course
Office hours Make an advance appointment via e-mail or other means.

In addition
 Subject Pharmacy Practice in Hospital
Course
YPH-PHA494J Categories Required
Numbering
Preferable 5th
Semester 9 Credits 10
Participants [Pharmacy]
Instructor Lecturer of Department of Pharmacy

Practical business 〇
In this training, students will understand the practices and responsibilities of
Objectives and hospital pharmacists and acquire basic knowledge, skills and attitudes about
summary of class pharmacist skills such as dispensing and preparation, patient’s education, etc. so
that they can participate in team medicine.
Goal of study
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents
Pharmacy Practice in Hospital will comply with the "Model Core Curriculum for Pharmacy Education -
2015 version" and carry out the following contents. In addition, there are opportunities to attend,
observe, and experience the contents of distinctive operations at the training facility.

Contents:
Fundamentals of Pharmacy Practice, Prescription Processing, Medication Preparation, and Dispensing,
Practical Application of Pharmacotherapy, Participation on Interprofessional Collaborative Work,
Participation in Community Healthcare, Medical Care, and Welfare (things related to works
characteristic of the facility, etc.)

Record and Grading will be decided based on class performance (20%), WEB system (diary / weekly
evaluation report / self-evaluation), result report (40%), evaluation by faculty (20%), evaluation by
method supervising pharmacist (20%).
Textbook

Reference
Preparation
and Review
Language
Used in Japanese
Course
Office hours

In addition
 Subject Pharmacy Practice in Community
Course
YPH-PHA495J Categories Required
Numbering
Preferable 5th
Semester 8・9 Credits 10
Participants [Pharmacy]
Instructor Lecturer of Department of Pharmacy

Practical business 〇
In this training, students will understand the practices and responsibilities of
Objectives and community pharmacists and acquire basic knowledge, skills and attitudes about
summary of class pharmacist skills such as dispensing and preparation, patient’s education, etc. so
that they can participate in team medicine.
Goal of study
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Pharmacy Practice in Community will comply with the "Model Core Curriculum for Pharmacy
Education -2015 version" and carry out the following contents. In addition, there are opportunities to
attend, observe, and experience the contents of distinctive operations at the training facility.

Contents:
Fundamentals of Pharmacy Practice, Prescription Processing, Medication Preparation, and
Dispensing, Practical Application of Pharmacotherapy, Participation on Interprofessional
Collaborative Work,
Participation in Community Healthcare, Medical Care, and Welfare (things related to works
characteristic of the facility, etc.)

Record and Grading will be decided based on class performance (20%), WEB system (diary / weekly
evaluation report / self-evaluation), result report (40%), evaluation by faculty (20%), evaluation by
method supervising pharmacist (20%).
Textbook

Reference
Preparation
and Review
Language
Used in Japanese
Course
Office hours

In addition
 Subject General Training in Biopharmacy and Pharmacy Practice 1
Course
YPH-PHA491J Categories Required
Numbering
Preferable 4th
Semester 8 Credits 2
Participants [Pharmacy]
Instructor
Objectives and
summary of class
Goal of study
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Pharmacy and
1 ―
Society
Physical
2 ―
Pharmacy(1)
Physical
3 ―
Pharmacy(2)
Chemical
4 ―
Pharmacy(1)
Chemical
5 ―
Pharmacy(2)
Chemical
6 ―
Pharmacy(3)
Biological
7 ―
Pharmacy(1)
Biological
8 ―
Pharmacy(2)
Health
9 ―
Pharmacy
10 ― Biopharmacy(1)

11 ― Biopharmacy(2)

12 ― Biopharmacy(3)

13 ― Biopharmacy(4)

14 ― Biopharmacy(5)
Clinical
15 ―
Pharmacy
Record and
evaluation Evaluation is performed based on attendance and CBT pre-test.
method
Textbook

Reference
Preparation
and Review
Language Used in
Japanese
Course
Office hours

In addition
 Subject General Training in Biopharmacy and Pharmacy Practice 2
Course
YPH-PHA492J Categories Required
Numbering
Preferable 4th
Semester 8 Credits 1
Participants [Pharmacy]
Instructor
Objectives and
summary of class
Goal of study
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

10

11

12

13

14

15
Record and
evaluation
method
Textbook

Reference
Preparation
and Review
Language Used in
Japanese
Course
Office hours

In addition
 Subject Practice in Pharmaceutical sciences
Course
YPH-PHA400J Categories Required
Numbering
Preferable 6th
Semester 12 Credits 2
Participants [Pharmacy]
Instructor
Objectives and
summary of class
Goal of study
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

10

11

12

13

14

15
Record and
evaluation
method
Textbook

Reference
Preparation
and Review
Language Used in
Japanese
Course
Office hours

In addition
 Subject Research Training
Course
YPH-PHA400J Categories Required
Numbering
Preferable 5th / 6th
Semester 10・11・12 Credits 20
Participants [Pharmacy]
Instructor Supervisor of the laboratory

Practical business
Research Training is the most important subject scheduled in the last grade as a
general decision of undergraduate education. Students belonging in each
laboratories are given their research theme by their supervisor and do the research
along the objective plan made by themselves. Students also make a summary of
Objectives and
their research results as a graduation thesis and make a presentation of
summary of class
achievement and question-and-answer session in front of the research staff,
undergraduate students and graduate students. Therefore, this subject is expected
not only the basic preparation education for students to be a researcher but also
useful for their career.
・To help students seek and evaluate research achievements by for now related to
their theme.
・To help students extract some problems to solve to achieve their theme.
・To help students make a research plan.
・To help students develop their observation eyes to grasp phenomena exactly
Goal of study
through their theme.
・To help students summarize their research results.
・To help students consider and evaluate their research results.
・To help students presence their research achievement and question-and-answer
exactly.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Training Contents

Students do their research given the theme obey to each specialized field by their supervisor of the
laboratory. Research will be going obey to each laboratory’s program; for example, participation in the
seminar held in the laboratory, to audit some lectures.

Record and
evaluation Evaluated by the supervisor of the laboratory.
method
Textbook

Reference

Office hours

In addition
 Subject Chemistry A

Course Numbering ZDN-CHE111J Categories Elective

Preferable
1st Semester 1 Credits 2
Participants
Instructor Professor Nakabayashi Takakazu

Practical business
Objectives and This course provides basic concepts of atomic structures and chemical bonds based
summary of class on quantum mechanics.
Students will be familiar with the fundamentals of quantum mechanics including
Schrödinger equation and wave function and will understand the basic concepts
Goal of study
of atomic orbitals, electronic configurations of atoms, hybrid orbitals, molecular
orbitals, and chemical bonds based on quantum mechanics.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Basic Quantum Limitations of Classical Mechanics, Planck's Quantum Theory,
1 Nakabayashi
Mechanics I Photoelectric Effect
Basic Quantum Bohr's Theory, De Broglie Wave, Basic Principles of Quantum
2 Nakabayashi
Mechanics II Mechanics
Basic Quantum
3 Nakabayashi
Mechanics III
Basic Principles of Schrödinger Equation
Basic Quantum
4 Nakabayashi
Mechanics IV
Properties of Wave Function
Basic Quantum
5 Nakabayashi
Mechanics V
Application of Schrödinger Equation, Properties of Light
Atomic
6 Nakabayashi
Orbitals I
Derivation, Shapes and Energies of Hydrogen Atomic Orbitals
Atomic
7 Nakabayashi
Orbitals II
Configuration of Electrons Using the Building-Up Principle
Atomic
8 Nakabayashi
Orbitals III
Physical Properties of Atoms Based on Electron Configurations
Midterm
Examination,
9 Nakabayashi
Molecular
Wave Functions and Energies of Hydrogen Molecular Ion
Orbitals I
Molecular Wave Functions and Their Energies of Homonuclear Diatomic
10 Nakabayashi
Orbitals II Molecules
Molecular Electron Configurations and Bonding Properties of Diatomic
11 Nakabayashi
Orbitals III Molecules
Hyblid
12 Nakabayashi
Orbitals I
Hybrid Orbitals of sp1, sp2, sp3
Hyblid
13 Nakabayashi
Orbitals II
Application of Hybrid Orbitals, Concept of Resonance Effect
π-Electron
14 Nakabayashi
Approximation
Fundamentals and Application of π-Electron Approximation
Term
Examination,
15 Nakabayashi
Intermolecular
Metallic Bonds, Fundamentals of Intermolecular Interactions
Interactions
Record and Students are evaluated on their points from the midterm examination (~30%), the
evaluation method term examination (~60%), and mini tests (~10%).
Textbook
 "Physical Chemistry for the Chemical and Biological Sciences" R．Chang,
University Science Books（2000）
Reference
"Physical Chemistry: A Molecular Approach" D. A. McQuarrie、J. D. Simon,
University Science Books（1997）
Preparation Students are required to prepare and review for each class using handouts and
and Review references.
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
MAIL: [email protected] TEL: 795-6855
In addition
 Subject Chemistry B

Course Numbering ZDN-CHE112J Categories Elective

Preferable
1st Semester 2 Credits 2
Participants
Instructor Professor Konno Tomohiro

Practical business
Objectives and The purpose of this course is to learn chemical thermodynamics and kinetics of
summary of class chemical reactions.
This course is designated to help students understand the basics and applications
Goal of study
of chemical thermodynamics and kinetics of chemical reactions
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Ter
Lecturer Theme Contents
m
An outline of this
1 Konno Overview of this class
class
Chemical
2 Konno Molecular theory of gases
thermodynamics 1
Chemical
3 Konno Potential energy, enthalpy, entropy
thermodynamics 2
Chemical
4 Konno First law of thermodynamics
thermodynamics 3
Chemical
5 Konno Free energy
thermodynamics 4
6 Konno Phase equilibria 1 Phase rule

7 Konno Phase equilibria 2 Immiscible liquids, solid-liquid system

8 Konno Phase equilibria 2 Phase equilibria of 2-component and 3-component systems

Kinetics of chemical Rate of chemical reactions, zero- and first-order rate
9 Konno
reactions 1 reactions
Kinetics of chemical
10 Konno Second-order rate reactions
reactions 2
Kinetics of chemical
11 Konno Reversible reactions, complex rate equations
reactions 3
Kinetics of chemical
12 Konno Reaction rate and temperature, activation energy
reactions 4
Kinetics of chemical
13 Konno Catalysts in chemical reactions
reactions 5
Kinetics of chemical
14 Konno Acid-base rate reactions
reactions 6
Kinetics of chemical
15 Konno Enzyme-catalyzed reactions
reactions 7
Record and
Students are evaluated on the small quizzes (40%) and final test (60%).
evaluation method
Textbook
“Physical Chemistry 2nd Edition.”, Publisher: Kagaku-Dojin Publishing Company,
(2018) (ISBN: 978-4-7598-1628-0)
Reference
“Atkins' Physical Chemistry, 10th Edition.”, Publisher: Tokyo-Kagaku-Dojin
Publishing Company, (2017) (ISBN: 978-4-8079-0908-7)
Preparation
Students are required to prepare and review using handouts and textbook.
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-mail: [email protected] Phone: 795-6841
In addition
 Subject Chemistry C
Course
ZDN-CHE113J Categories Elective
Numbering
Preferable
1st Semester 1 Credits 2
Participants
Instructor Associate Professor Masanori Shigeno
In this course, students will learn about structure, bonding, and concepts of hybridization and
understand the basics of organic chemistry. And they will also study about resonance and
Objectives and electronegativity and understand acid-base reactions and acidity. The course will outline the
summary of class property and reactivity of common functional groups and introduce important roles of organic
molecules in vivo. They will learn about understand conformation and Fisher projection and
understand nomenclature, physical properties, and reactivity of alkanes.
· Students will be able to illustrate structure and bonding of organic molecules as well as
hybridization.
· Students will understand Brønsted–Lowry acids and bases, acid strength, and pKa and be able
Goal of study to predict the outcome of acid-base reactions.
· Students will understand properties of common functional groups and be able to explain about
important roles of organic molecules in vitamins, lipids, and the cell membrane.
· Students will understand nomenclature, physical properties, and conformation of alkanes.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents
Structure and Students will understand ionic bonding, covalent bonding, and Lewis
1 Shigeno
Bonding (1) structures.
Structure and Students will understand resonance, molecular shape, and how to draw organic
2 Shigeno
Bonding (2) structures.
Structure and Students will understand hybridization, and three different kinds of bonding;
3 Shigeno
Bonding (3) ethane, ethylene, and acetylene.
Structure and Students will understand bond length, bond strength, electronegativity, and
4 Shigeno
Bonding (4) bond polarity.
Acids and Students will understand Brønsted–Lowry acids and bases, acid strength, and
5 Shigeno
Bases (1) pKa.
Acids and Students will be able to predict the outcome of acid-base reactions and
6 Shigeno
Bases (2) understand factors that determine acid strength.
Acids and Students will understand common acids and bases, aspirin, and Lewis acids and
7 Shigeno
Bases (3) bases.
Organic
Molecules
8 Shigeno and Students will understand functional groups and intermolecular forces.
Functional
Groups (1)
Organic
Molecules
9 Shigeno and Students will understand physical properties, vitamins, and soap.
Functional
Groups (2)
Organic
Molecules
Students will understand the cell membrane, functional groups, reactivity, and
10 Shigeno and
biomolecules.
Functional
Groups (3)
11 Shigeno Alkanes (1) Students will understand nomenclatures of acyclic and cyclic alkanes.
Students will understand common names, physical properties of alkanes and
12 Shigeno Alkanes (2)
conformation of ethane.
Students will understand conformation of butane and cyclic alkanes including
13 Shigeno Alkanes (3)
cyclohexane.
 Students will understand substituted cyclic alkanes, oxidation of alkanes and
14 Shigeno Alkanes (4)
lipids.
15 Shigeno Summary and Examination
Record and
evaluation Evaluated mainly by examination (80%), with partial consideration of class performance (20%)
method
Textbook ‘Organic Chemistry — 5th edition’ J. G. Smith

Reference
Preparation
and Review
Language Used in
Japanese
Course
Make an advance appointment via e-mail or other means.
Office hours
E-MAIL: [email protected] TEL: 795-5917
In addition
 Subject Biology A

Course Numbering ZDN-BIO111J Categories Elective

Preferable
1st Semester 1 Credits 2
Participants
Instructor Professor Matsuzawa Atsushi

Practical business
Objectives and The purpose of this course is to learn the functions and structure of the cell and
summary of class the principle of gene expression.
Students will understand the functions and structure of the cell, the molecular
Goal of study
basis of DNA replication, repair, transcription, RNA processing, and translation.
Lecture・Practice・Training・On-site training・SGD・PBL・Roleplay・e-learning・
Method of class
Others( )
Term Lecturer Theme Contents

1 Matsuzawa Introduction to cells Constitution and function of cells

2 Matsuzawa Organelles Names and functions of organelles

Chemical component of
3 Matsuzawa Amino acids, nucleic acids, lipids
cells
Energy, catalysis and
4 Matsuzawa Glycolysis and ATP synthesis
biosynthesis
Structure of polypeptide, protein secondary structure, non-
5 Matsuzawa Protein structure
covalent interaction
DNA and
6 Matsuzawa Genes are made up of DNA
chromosomes
7 Matsuzawa From DNA to protein Transcription

8 Matsuzawa From DNA to protein Mechanism of meiosis

Analyzing genes and
9 Matsuzawa Principle of PCR, cloning, fluorescent protein, RNAi, etc.
genomes
10 Matsuzawa Membrane transport Transport between organelles

11 Matsuzawa Mitochondria Energy metabolism, cell death

12 Matsuzawa Signal transduction Intracellular signal transduction

13 Matsuzawa Cytoskeleton Structure and function of the cytoskeleton

Cell cycle and
14 Matsuzawa Cell cycle control, cell division
proliferation
Cell communications
15 Matsuzawa Cancer cells, oncogenes, tumor suppressor genes
and cancer
Record and Students are evaluated on their points from attendance (10%) and the final
evaluation method examination (90%).
Textbook Essential Biology V

Reference
Students are required to prepare lessons of each part and review thoroughly the
Preparation
points of each class and deepen the knowledge of the related and interesting
and Review
contents.
Language Used in
Japanese
Course
Office hours E-MAIL: [email protected] TEL: 022-795-6827

In addition