Dr Stanfield’s Supplement Stack

Welcome to my stack!
Every supplement here I personally take, and I take them in an effort to extend my healthspan.
Together, these supplements work on different pathways thereby attacking the aging process
from multiple angles.

Legal Stuff
While I have poured countless hours into studying the research around these supplements and
I am extremely excited by their potential, unfortunately there’s no guarantee that they will slow
down the aging process. There are many human trials still to be done.
The content here is not intended to replace your relationship with your own medical
practitioner. Always speak with your doctor before using any of these supplements. Just
because this is my supplement list doesn’t mean it should be yours as well.
Individual results may vary.
The links to the supplements I take are affiliate links.

Discounted Supplements
Discount Code – CheckWithYourDrFirst
Nicotinamide Riboside 300mg: https://bit.ly/3lymvgI
Sulforaphane: https://bit.ly/3rCmHyg
TMG 1g: https://bit.ly/388Ullq
Apigenin 500mg - https://bit.ly/2Np6gDO
Fisetin 1g: https://bit.ly/3mkK8YK
Quercetin 1g: https://bit.ly/2PC3eh5
Hyaluronic Acid 200mg: https://bit.ly/2XaNd1y
My Current Full Stack (as a 30 year old)
WAKE UP:
• Sulforaphane - https://bit.ly/3rCmHyg

SMOOTHIE:
• Collagen 10g - https://amzn.to/3cgIBOw
• Psyllium Husk 4g - https://amzn.to/36Aq0KO

BREAKFAST:
• Niacin (nicotinic acid) 100mg - https://amzn.to/3l3iMHm
• Trimethylglycine (TMG) 1g - https://bit.ly/388Ullq
• Apigenin 500mg - https://bit.ly/2Np6gDO
• Fisetin 1g (mixed with olive oil | for 5 days in a row every month): https://bit.ly/3mkK8YK
• Quercetin 1g (mixed with olive oil | for 5 days in a row every month): https://bit.ly/2PC3eh5
• Vitamin K2 MK-7 120μg - https://amzn.to/2D69ZRU
• Vitamin D3 4,000 IU - https://amzn.to/3sn3Cyk
• Omega-3 (DHA/EPA) two capsules - https://amzn.to/3gEJIrw
• Hyaluronic Acid 200mg - https://bit.ly/2XaNd1y

LUNCH:
• Zinc 8.4mg - https://amzn.to/3mkKvCm

WORKOUT:
• Creatine 2.5g before & after - https://amzn.to/2TAUYwq

NIGHT (one hour before sleeping):

• Ashwagandha 300mg (1 week on, one week off) - https://amzn.to/3mwUwvy
• Melatonin 300mcg - https://amzn.to/3rDbU6X
• Magnesium Taurate 120mg (elemental) - https://amzn.to/3D6uyHc
Workout vs Rest Days
Morning Midday Evening

Everyday · Berry smoothie with · Zinc 20mg · Ashwagandha

collagen 10g, 300mg on
psyllium husk 4g, alternative weeks
pea protein 24g · Magnesium Taurate
· Apigenin 500mg 125mg
· Niacin 100mg · Melatonin 300mcg
· TMG 1g
· Omega-3 2 capsules
· Vitamin D3 4,000
units
· Vitamin K2 120μg
· Hyaluronic Acid
200mg

Workout days · Creatine 2.5g before

and after workout

Rest days · Creatine 5g

· Sulforaphane

5 days in the · Fisetin 1g

month, mixed · Quercetin 1g
with olive oil
Molecules I’ll Add In As I Age
Age 35:
I’ll add in Nicotinamide Riboside (NR) 250mg. This is to further support my metabolism and
NAD+ levels. NR won’t replace niacin, instead I’ll take both niacin 100mg and NR 250mg.

Age 50:
There’s research to suggest that our metabolism TANKS around age 60, and this increases the
risk of age-related diseases.
https://pubmed.ncbi.nlm.nih.gov/34385400/

Until we know the root cause of this decline and can treat it, I want to support my metabolism as
best as possible. Therefore, I plan to take a combination of metabolic activators:
the potent glutathione precursors L-serine and N-acetyl-l-cysteine to reduce oxidative stress
(https://www.medrxiv.org/content/10.1101/2021.07.28.21261293v1.full.pdf), and I’ll also
increase my Nicotinamide Riboside dose to 500mg
Molecules I’m Excited About & Awaiting More Data

Rapamycin
Over and over again when the Interventions Testing Program trials Rapamycin in genetically
diverse mice, it extends both male and female lifespan.
Because of its mechanism of action, I’ve chose to set up a clinical trial combining regular
exercise with either Rapamycin or Placebo to see if Rapamycin improves muscle performance.

While I’m very excited about Rapamycin’s potential, I don’t think it should be used outside of
clinical trials to assess that it’s both safe and effective

17-Alpha Estradiol
This is a “non-feminizing” type of estrogen that the Interventions Testing Program demonstrated
a lifespan extension in males. There’s also data showing an improvement in muscle strength.

Similar to Rapamycin, I’m very excited about this molecule, however I don’t think that it should
be used outside of clinical trials to assess both safety and efficacy.

Finasteride (for males only)

Finasteride is a molecule that blocks the conversion of Dihydrotestosterone to Testosterone,
and is used in clinical medicine to reduce male pattern baldness and shrink the size of the
prostate.
There’s interesting observational data suggesting that males who take Finasteride have lower
rates of prostate cancer, and I’m eagerly awaiting more data on this to be published. I wonder if
most males will eventually use this to reduce prostate cancer rates?
Molecules I Used To Take But Have Now Stopped
NMN:
I focus on stopping my NAD from declining by using Apigenin, Quercetin, Fisetin, Niacin, regular
exercise, a great diet, periods of safe fasting, and restful sleep.
Since I’m 30, there’s not a reason for me to take NMN in addition to the above strategies at the
moment.
As I enter my mid-30s, if my NAD levels are going down I will start taking NR.
At this stage, there is far more published human data on NR compared with NMN. NR also has
its Generally Recognized As Safe (GRAS) certification from the FDA. For those reasons, I
would start NR, and not NMN.

Resveratrol/Pterostilbene:
The research around using molecules to activate sirtuin-1 is very conflicting. We may not need
to further activate sirtuin-1 if we already exercise, fast, and have a great diet.

Furthermore, it’s unlikely that resveratrol/pterostilbene directly activates sirtuin-1 anyway. There
was a paper published in 2020 that used CRISPR technology that explored how
resveratrol/pterostilbene work and the authors found the following:
“The ability of resveratrol to inhibit cell proliferation and S phase transit was independent of the
histone deacetylase sirtuin 1, which has been implicated in lifespan extension by resveratrol.
These results establish that a primary impact of resveratrol on human cell proliferation is the
induction of low-level replicative stress.”
https://pubmed.ncbi.nlm.nih.gov/32755594/

Until there’s more compelling research, I’ve stopped taking both of these molecules.

Metformin/Berberine:
Metformin is a medication that I prescribe to my Type 2 Diabetic patients, and the initial data
suggested that it could extend lifespan.
However, when the Interventions Testing Program (ITP) trialed metformin in 2016, there was no
lifespan benefit: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013015/

Towards the end of 2021 a randomized, placebo-controlled, human trial that ran for 21 years
was published. This trial took people at high risk of developing Type 2 Diabetes, and tested
whether metformin would improve death rates, heart disease, and cancer when compared with
placebo. Unfortunately, there was no benefit seen:
https://diabetesjournals.org/care/article/44/12/2775/138471/Effect-of-Metformin-and-Lifestyle-
Interventions-on
Furthermore, there’s good data showing that metformin blunts the positive exercise effects:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351883/
This data has convinced me to stop taking metformin altogether.