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PODCAST #67 DR.B The Vet Show - Drh. Syavira Ekdhiasmara

This document discusses Feline Infectious Peritonitis (FIP), including its etiology, pathogenesis, clinical signs, diagnosis, and case studies. It covers the differences between effusive and non-effusive FIP. Key points include that FIP is caused by feline coronavirus (FCoV) mutation, leads to fibrin accumulation and vasculitis, and has clinical signs of pyrexia, ascites, neurological issues, and organ enlargement. Diagnosis involves laboratory tests showing leukopenia, hyperglobulinemia, low albumin-globulin ratio, and serology. Case studies demonstrate diagnosis of dry and wet FIP based on history, clinical signs, and laboratory abnormalities.

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Lailatun Nafisah
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36 views26 pages

PODCAST #67 DR.B The Vet Show - Drh. Syavira Ekdhiasmara

This document discusses Feline Infectious Peritonitis (FIP), including its etiology, pathogenesis, clinical signs, diagnosis, and case studies. It covers the differences between effusive and non-effusive FIP. Key points include that FIP is caused by feline coronavirus (FCoV) mutation, leads to fibrin accumulation and vasculitis, and has clinical signs of pyrexia, ascites, neurological issues, and organ enlargement. Diagnosis involves laboratory tests showing leukopenia, hyperglobulinemia, low albumin-globulin ratio, and serology. Case studies demonstrate diagnosis of dry and wet FIP based on history, clinical signs, and laboratory abnormalities.

Uploaded by

Lailatun Nafisah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Hi Kolegaa..

Drh Syavira Ekdhiasmara


Kedokteran Hewan Universitas Airlangga 2014

Laboratorium patologi klinik Rumah Sakit Hewan Universitas Brawijaya 2020-sekarang


Praktisi vet lab. Malang Animal Clinic 2022-sekarang
Feline Infectious
Peritonitis
Diagnostic Laboratory
APA SAJA YANG AKAN KITA BAHAS?

01 Tentang FIP
etiologi, patogenesa dan
02 FIP EFFUSIVE
Diagnosa lab
gejala klinis

FIP NON EFFUSIVE Kasus


03 Diagnosa lab 04
01
Tentang FIP
etiologi, patogenesa dan gejala klinis
Etiologi
• Coronaviridae
• Protein spike
• Contagious
Patogenesa
(FIPV)

(FCoV/FECV)

Menyerang monosit Fibrin berlebih


dan makrofag
Peroral Cairan eksudat
Bereplikasi pada sel Vaskulitis
enterosit Perivaskulitis
(Cecum,colon,Lgl pyogranulomatus
mesenterika,liver)
Gejala Klinis

70% 10% 10% 10%

Ascites Neuro syndrome Gangguan organ uveitis


Renomeghali,
Effusive Ataxia, nystagmus, Aniscoria, iritis,
Hiperplasia Lgl chorioretinitis
thorax/pericardial Seizure,
mesenterica,
hyperaesthesia
Pyogranulomatus
pneumonia, Hepatic
disorder.
02
EFFUSIVE FIP
Diagnosa Klinik, Diagnosa Penunjang
EFFUSIVE FIP
gx Pyrexia,Ascites,Pleural effusion,Pericardial effusion

EFFUSION test

Sensitifity 91,3% 1. Total Protein ≥ 2,5 g/dL


Specificity 65.5%
PPV 58,4%
Rivalta test Cytologi test
(Jellyfish like, tear drop) 2. Dominasi sel neutrophil dan makrofag
NPV 93,4%
(Fisher,2012)
EFFUSIVE FIP
gx Pyrexia,Ascites,Pleural effusion,Pericardial effusion
EFFUSIVE FIP
gx Pyrexia,Ascites,Pleural effusion,Pericardial effusion

BLOOD tests

Hematology Leukopenia
Limfositopenia

Bloodchemistry
Low Ratio A/G
≤ 0,4 𝐹𝐼𝑃 𝐿𝑖𝑘𝑒𝑙𝑦 Hiperproteinemia
> 0,8 (𝐹𝐼𝑃 𝑈𝑛𝑙𝑖𝑘𝑒𝑙𝑦) Hiperglobulinemia

Liver enzyme
(ALT,ALP,GGT)
Hiperbilirubinemia
EFFUSIVE FIP
gx Pyrexia,Ascites,Pleural effusion,Pericardial effusion

Serologi test

Screening test Rapid test Fcov

PCR

ELISA
03
NON EFFUSIVE FIP
Diagnosa klinik
NON EFFUSIVE FIP
Pyrexia (Lebih dari 4 hari)
Weight Loss

Anorexia
Neurological signs

Enlarge mesenteric Lgl

Intraocular sign
Icterus
NON EFFUSIVE FIP
High FcoV Antibody titre (Screening test)
Hyperglobulinemia
Low ratio A/G ≤ 0,4
Lymphopenia
Hiperbilirubinmeia
NON EFFUSIVE FIP

BLOOD tests

Hematology Leukopenia
Limfositopenia

Bloodchemistry
Low Ratio A/G
≤ 0,4 𝐹𝐼𝑃 𝐿𝑖𝑘𝑒𝑙𝑦 Hiperproteinemia
> 0,8 (𝐹𝐼𝑃 𝑈𝑛𝑙𝑖𝑘𝑒𝑙𝑦) Hiperglobulinemia

Liver enzyme
(ALT,ALP,GGT)
Hiperbilirubinemia
NON EFFUSIVE FIP

Serologi test

Screening test Rapid test Fcov

PCR

ELISA
General laboratory VS Journal
Ratio A/G
(Jung Yen, 2021)
04
STUDI KASUS
KASUS 1

Signalment : Kucing N, dSH, betina, 3 tahun


Anamnesa : Lethargy, bcs 2/5, demam intermitten, jaundice
Histori : Owner memiliki kucing resque 6 ekor, pernah
terjadi kematian pada beberapa ekor dengan gejala tiba-tiba
kejang.

Pemeriksaan umum : suhu 40,5, BB : 2,7 kg


KASUS 1

• Limfositopenia
• Hiperglobulinemia dengan A/G 0,4
• Hiperamilasemia dengan Lipase normal
• ALT,GGT dan ALP normal namun Hiperbilirubinemia

Hasil Bloodsmear :

Ukuran dan bentuk sel eritrosit normal


dan tidak ditemukan parasit darah.
KASUS 1

Diagnosa : Dry Feline infectious peritonitis


KASUS 2

Signalment : Kucing Z, kucing ras, betina, 4 bulan


Anamnesa : distensi abdomen, hasil Xray dan USG Ascites
Histori : Makan dan minum baik, masih aktif,perut
membesar sudah 1 minggu
Pemeriksaan umum : suhu 38,6, BB : 2,1kg
KASUS 2

• Leukoitosis, granulositosis dan limfositopenia


• Albumin,globulin dan A/G : 0,6
KASUS 2

Diagnosa : wet feline infectious peritonitis


TERIMAKASIH

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