DEDICATED TO MY BELOVED

PARENTS,
MY LOVELY HUSBAND
AND
LITTLE DAUGHTER
 ACKNOWLEDGEMENTS
This thesis is the culmination of my journey of Ph.D which was just like climbing a high peak step by step
accompanied with encouragement, hardship, trust, and frustration. When I found myself at top experiencing
the feeling of fulfillment, I realized though only my name appears on the cover of this dissertation, a great
many people including my family members, well-wishers, my friends, colleagues and various institutions have
contributed to accomplish this huge task.

At this moment of accomplishment I am greatly indebted to my research guide, Dr. Amrita Bajaj, Former
Professor of Pharmaceutics, C. U. Shah College of Pharmacy and Professor & HOD, Pharmaceutics, SVKM’s
BNCP, who accepted me as her PhD student and offered me her mentorship, motherly love and care. This work
would not have been possible without her guidance and involvement, her support and encouragement on daily
basis from the start of the project till date. Under her guidance I successfully overcame many difficulties and
learnt a lot. Her own zeal for perfection, passion, unflinching courage and conviction has always inspired me to
do more. She has taught me another aspect of life, that,“goodness can never be defied and good human beings
can never be denied”. For all these, I sincerely thank her from bottom of my heart and will be truly indebted to
her throughout my life time.

My earnest thanks to Dr. Hitesh Doshi, Disphar International BV India , for supporting and sponsoring this
project. I am grateful for his valuable advice, constructive criticism, positive appreciation and counsel
throughout the course of the investigations which led to the successful completion of the research work.

No research is possible without infrastructure and requisite materials and resource. For this I extend thanks to
Dr.S Y Gabhe Former Principal ,Dr .K K Singh , Principal and Dr.Supriya Mahajan, Principal Incharge, C.
U. Shah College of Pharmacy for providing me with the requisite institutional facilities throughout my research
tenure.

I greatly appreciate and acknowledge the support received from few institutions and laboratories. Most of the
results described in this thesis would not have been obtained without their support. I am equally thankful to
Mrs. Manjusha, Director; Dr. Joag, Former Director and Ms. Vaishali from M.K.Rangnekar labs for carrying
out IR analysis and helping in HPLC studies., Mr. Sandip Bijamvar, Ideal cures, vasai for coating of pellets ,
Dr D P Chaudhary, Haffkines Institute, Mumbai for carrying out Histopathological examinations.

I am thankful to Indian institute of Technology, Mumbai for giving the permission to carry out the DSC,
NMR amd MS studies. I sincerely thank Dr. Manish Rane, Colorcon, Dr. Vikas Rane, Degussa, Mr. Sudhir
Toraskar, Evonik, Mr. Sagar Balgari, Signet for providing me with samples of excipients for the research work.

My sincere thanks to Dr.Godbole, Septech ,Mumbai for his valuable guidance, timely suggestions and support
throughout my research project work.

I am extremely thankful to Dr. Vitthal Ranade for his help and suggestions during preclinical studies.
I am grateful to Dr. Rajani Athawale, Associate Prof. of Pharmaceutics, Dr. Pratima Tatke, Dr.Milind
Bhitre, C.U.Shah College of Pharmacy, Mumbai for their support, understanding, encouragement and love
when it was most required. All the Non-teaching staff have helped me and thanks are due to all of them for
their silent contributions in particular Mrs. Saili, Mr. Ashok , Mane, Deepak, Vinod, Sujata, Sharad,
Kulkarni, Sudhir, Hasmukh, Jayesh, Santosh, Sadanand, Ramesh and Sameer.

Special thanks are due to former Principal Dr. (Mrs.) S. S Bhalerao, Principal Dr. Paraag Gide, and Mrs
Rachel Geevarghese , HOD Pharmaceutics, Dr. L H Hiranadani college of Pharmacy for their sincere
encouragement and support throughout my thesis writing.

It’s my fortune to gratefully acknowledge the support of my friends, Rupali K, Meenal R, Anjali S for their
support and generous care throughout the research tenure. They were always beside me during the happy and
hard moments to push me and motivate me. Special thanks are extended to Roopali B, Rajeshri W, Prabha S,
Sonali N. and Surekha S. Big thanks to all my fellow colleagues and friends, particularly, Priti, Anita, Vedika,
Shraddha, Sushma, Kunal and Deepa for their co-operation and support.

Finally, I acknowledge the people who mean a lot to me, my parents, Aai and Pappa, for showing faith in me
and giving me liberty to choose what I desired. I salute you all for the selfless love, care, pain and sacrifice you
did to shape my life. Although you hardly understood what I researched on, you were willing to support any
decision I made. I would never be able to pay back the love and affection showered upon by my parents. Also I
express my thanks to my brother Varun, and sister in law Naina for their support and valuable prayers.

Thanks to my sister Shweta for her selfless love, care and dedicated efforts which contributed a lot for
completion of my thesis.

I owe thanks to a very special person, my husband, Rahul for his continued and unfailing love, support and
understanding during my pursuit of Ph.D degree that made the completion of thesis possible. You were always
around at times I thought that it is impossible to continue, you helped me to keep things in perspective. I
greatly value his contribution and deeply appreciate his belief in me. I appreciate my baby, my little girl Swara
for abiding my ignorance and the patience she showed during my thesis writing. Words would never say how
grateful I am to both of you. I consider myself the luckiest in the world to have such a lovely and caring family,
standing beside me with their love and unconditional support.

My heart felt regard goes to my father in law, mother in law for their love and moral support.
I thank the Almighty for giving me the strength and patience to work through all these years so that today I
can stand proudly with my head held high.

Meghana Anil Morde