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Question 1 Protein Composition and Structure: |. The functional groups of amino acids in a protein molecule determine its ™ three-dimensional structure. \/ ll. Thegprimary structure of proteins refers to the amino acid séquenc®. lll. The secondary structure of proteins refers to the conformation adopted by boeal regiong of the polypeptide chain.~ IV. Proteins are built from a repertoire of 20 amino acids. / A. 1 statement is correct _ B. 2 statements are correct- C. 3statements are correct _ All statements are correct - E. All statements are incorrect MANOR Review CenterQuestion 2 * The Primary Structure of Proteins: * Amino acids are linked by peptide bonds to form polypeptide chain: * The peptide bond is formed between the carboxyl group of one amino acid and the cal group of the next amino acid” * The peptide bond is electrically charged \4.P— -@X—O- t-cody * The peptide bond is easily hydrolyzed. O A. )1 statement is correct B. 2 statements are correct C. 3 statements are correct D. All statements are correct E. All statements are incorrect MANOR Review CenterIV. Il. 2 statements are correct Ill, 3 statements are correct N Question 3 * The Tertiary Structure of Proteins: ‘ CIOS The tertiary structure describes the overall folding of the polypeptide chain. .~ —— The polypeptide chain folds so that its rt its ruggenbabicgice chains are buried and its -polar charged chains are on the surface Many alpha helices and beta strands are amphipathic; that is, the alpha helix or beta strand has a hydrophobic face, which points into the protein interior, anda more polar face, which-paintsinto e oo Pairing all the fH the main chai d 1 statement is correct #3 the secret of burying a segment of All statements are correct ot OFG All statements are incorrect Od e MANOR Review CenterQuestion 4 * The Secondary Structure of Proteins: |. |. The secondary structure refers to the folded segments of alpha helices, beta strands, and turns that are formed by a regular pattern obond between the peptide N-H and C=Q groups of amino acids that are near one another in a linear sequence. aitffiydrogen bands. ll. The alpha helix is stabilized by in Ill. All amino acids can be readily accommodated in an alpha helix. * IV. Branching at the beta-carbon tends to stabilize alpha- helices A. 1 statement is correct 2 statements are correct 3 statements are correct All statements are correct iy, lertaket E, All statements are incorrect ae f Q MANOR Review CenterQuestion 5 i (ja * Protein Beta Sheets; at |. Beta sheets are stabilized by-H-bonding between polypeptide strands. ll. The beta sheet is composed of 2 or more polypeptide chains called beta strands. - lll. Adjacent strands in a beta sheet can run in opposite directions or in the same direction. ar trection.; IV.xBeta sheets are more structurally diverse than alpha helices@=~< ~~ “O) A. 1 statement is correct ow B. 2 statements are correct © pac ud C. 3 statements are correct 6) All statements are correct © Nv) E. All statements are incorrect oabparaLly DurerQuestion 6 @| * Which of the following proteins is classified as a. protein? A. Amylase — wre fibrinogen ere C. Myosin ~ > Gas —Ulo “Oo musole D. Collagen oy rl 7Question 7 @ . Can show a positive red color upon interaction with a ah¥holic or ring, using the reagent diazotized sulfanilic a acid “A. Nitroprusside test\— Cy Millan's — tyr B. Sakaguchi test wr \s5 Vg. eC Pauly test_ . Biuret test Sage de bonds, MANOR Review CenterQuestion 8_ & * Which vitamin is NOT correctly matched to its derivative cofactor? A. VitamiryBl: TR. V B. wari THE “ C. Vitamin BG: PLP vO ©) Vitamin qe E. NOTA ig a LQuestion 9 | (a * The Lineweaver-Burke plot below is typical for a substrate with what type of inhibitor? A. Competitive u{Vo} Noncompetitive C. UncompetitiveQuestion 10 g| * Which of the following specialized products is/are correctly matched with its amino acid derivative? A. Melanin: Ww B. Choline: * S$ C. Histamine: H C= MANOR Review CenterQuestion 11 @) * State of nitrogen imbalance characterized by severe pfoteisi deficiency with a normal caloric intake. A. Kwashiorker Marasmus Voll Primary malnutrition not Cat a . Secondary malnutrition eatin Veni 998Question 12 & *Given pKaNH2 of 9.82, pKaCOOH of 2.09/and pKaR of 3.86, calculate the isoelectric pH of aspartic acid A) 5.96 2.04 (8) 2.98. Prods ra — avenge of oe, C) 6.84 v on aie D) 5.26 Bao ea — oon h a Z vgger MANOR Review CenterQuestion 13 @| * Level of protein organization characterized by m nuiple secongaly units. A. Secondary © Superse C. Tertiary — wompelv 30 + J ee ide Gua D. Quaternar ture aa) MANOR Review CenterQuestion 14 Which is the catalytic site model, where the substrate induces ‘ onformational change in the enzyme? C Lock-and-Key Model~{\d,\. B. Hill Equation Model C. Quaternary Structure @) Induced-Fit Model — flgya bi gy ———SsPeak Plasma Question 15 Concentration Cirax (absorption rato elimination rate) * Identify the diagram that shows § ' the actual body § § od 5 5 MSC Maxim exposure to drug > 8 & --\t------ mnee um Safe fter th § 3 Concentration after the 8 2 administration of a 3 5 certain dose ofthe = & Lite oe IN aoc MEC Minimum Effective d rug é duration of actions) Concentration %K 1 | Area Under the Curve [onset time SF ae T —+ Time Administration of drugQuestion 16 Which diagram shows how an enzyme can cause kinetic rate enhancement ofa and explains nay reaction rates depend on the concentration-e DurerQuestion 17 * Which diagram demonstrates the Michaelis-Menten Kinetics w Substrate concemmation |S] DurerQuestion 18 * Which diagram demonstrates Raoult’s LBW) MANOR Review CenterQuestion 19 * Which diagram demonstrates enzyme @ope The curve res oT cooperation between subunits. The binding of a substrate to one active site in a molecule increases the likelihood that the substrate will bind to other active sites Percere wuturation (x * Key for 15-19% BEECD MANOR Review CenterQuestion 20 (a! * Trypsin mechanism (A) Promotion of a reaction that is immeasurably slow at neutral pH, B. Achievement of high absolute rate of reaction, suitable for integration with other rapid physiological processes. C. Attainment of a high degree of specificity. D. Utilization of the free energy associated with the hydrolysis of ATP. — —————————————— MANOR Review CenterQuestion 21 - circ anys) = dregs = balance A. Promotion of a reaction that is immeasurably slow at neutral pH. GB.) Achievement of high absolute rate of reaction, suitable for integration with other rapid physiological processes. C. Attainment of a high degree of specificity. D. Utilization of the free energy associated with the hydrolysis of ATP. Hr (2, + HO * ©.) MANOR Review CenterQuestion 22 @| * Restriction endonucleases — prevse, Cvthay Of mceic aude A. Promotion of a reaction that is immeasurably slow at neutral pH. B. Achievement of high absolute rate of reaction, suitable for integration with other rapid physiological processes. C_ Attainment of a high degree of specificity. D. Utilization of the free energy associated with the hydrolysis of ATP. _——————————————————_— DurerQuestion 23 *Chymotrypsin romotion of a reaction that is immeasurably slow at neutral pH. | (al B. Achievement of high absolute rate of reaction, suitable for integration with other rapid physiological processes. C. Attainment of a high degree of specificity. D. Utilization of the free energy associated with the hydrolysis of ATP. a DU reerQuestion 24 N ¢Myosins A. Promotion of a reaction that is immeasurably slow at neutral pH. B. Achievement of high absolute rate of reaction, suitable for integration with other rapid physiological processes. C. Attainment of a high degree of specificity. Co Utilization of the free energy associated with the poral MANOR Review CenterQuestion 25 @| ; Ave je *lt is a nonpolar vitamin; mixture of tocopherols} serves as an antioxidant in biomembranes, protecting these and embedded proteins against oxidative attack of free radicals and peroxides. A. Vitamin A —velic B{ Xitaming C. Vitamin D —cora twok ODWitamin E E. Vitamin K — \comyd so hm MANOR Review CenterQuestion 26 | most or all of the needs of a normal healthy adult; it serves as a cofactor in xylatiomreactions. : A. ammeee Fak sul Vitomny “(Cote [B.\ Vitamin Bq (bitin) C. Vitamin D-\narmonts D. Vitamin E— E. Vitamin K— Gola yre — Lay (" is made by the gut bacteria; the bacterial source can “oomQuestion 27 @| its ability to accept and donate electrons one ata time is quite valuable. 6 Vitamin pe, B} Vitamin redo % —3C,) Vitamin|B: ‘| rami pi tAKOA D. Vitamin|B = TS Z E. Vitamin B12 i serves as a cofactor in numerous biochemical index reaction, “y = MANOR Review CenterQuestion 28 * Vitamin that is required for the ¢otting blood. A. Vitamin A B. Vitamin B C. Vitamin D D. Vitamin E © Vitamin K = DurerQuestion 29 * This vitamin is really three separate but chemically related compounds: retinol, retinal and retinoic acid. When converted to the retinal form they serve as an essential feyipon for the protein rhodopsin, which is responsible for vision in rod cells. Vitamin A B. Vitamin B C. Vitamin D D. Vitamin E E. Vitamin K MANOR Review CenterQuestion 30 * Which of the following statements best describe D and L isomerism in sugars? 1. When the -OH group in the carbont5)of glucose is on the right, the sugar is ~~ dextrorotatory. Il. Most mgnosaccharides in mammals are of the D configuration. Tl. The asymmetric carbon atom confers optical activity on the sugar. ‘WC Sugars of the D series rotate plane polarized light to the left. @ Linn, = Q- ke) rc / ~ LUV, OX 1, IHL IV oH wo ipmiw Lo Ce& HWA MANOR Review CenterQuestion 31 * Which of the following tests are used to detect the presence of reducing sugars? = Molisch’s Testx - Maillard Reaction ?,? Tollen’s Test Benedict’s Test A.Syll, Ill B. AIL, IV C. AF IIL IV Dy) I, HL IV MANOR Review CenterQuestion 32 * Which of the following is not a pentose? A. Arabinose~ ®& — hunse Keo@ C. Ribose ~ D. Lyxose / eng HAD? E. Xylose ~ kolo (jalQuestion 33 * Which sugar when tested for its identity will give the profile below: * Fehling’s: brick red ppt (+) edu * Mucic Acid Test:‘Soluble broomlike crystals OX Se ee onl * Bial’s: green solution (r\ * Seliwanoff’s: cherry red solution (x) —————— Ft. 9»U A.) Ribulose B. Ribose i Fructose we Galactose JK Trehalose MANOR Review CenterQuestion 34 a) Which of the fi ing statements regarding glycosidic linkages of common carbohydrates r are true? lyogen I. te branched because of alpha-1,6 linkages ~~ Ino rhea is more branched than starchy Ill. Maltose is composed of alpha-1,4 linkages while cellobiose is composed of beta 147 lin IV, Suctose-consists of §1-b2) linkages between glucose and fructose, locking the two anomeric carbons and Making it nonreducing A. 1, IV B. 1, IL IV C.1, ML)IV D.1, 1, {ll (©, WNL IVQuestion 35 * Sugar D is tested by various lab tests. Listed below are the results: * Which of the following carbohydrates will be most likely Sugar D? “AcSucrose Swe < | lodine test Eee olaace cle ¢ C,)Fructose / TCM Chi ie Cn nae aice) *D. Glucose Seo) °E. Ribose ’ |. Eeeeeeecas feed creat unem icici STE e lait] eee eels late ema a Lc Toto) 01 a(0)4) If Osazone test Bide len Lea clQuestion 36 . ; alia and D-Get3-fructofuranose A) Anomers B. Epimers On C. Diastereomers ao “y D. Enantiomers 6Question 37 * Which complex carbohydrates are characterized by their émind and uronic acid contents? A. Glucosamine, -spiu h6 Glycosaminoglycans (h(a °& Glycoproteins Dé Neuramines (&! MANOR Review CenterQuestion 38 *Ketones A. Phloroglucinol test B. Keller-Kiliani test C. Molisch’s test () SeliGanoff’s testQuestion 39 * Pentoses—@ra\ ¢ A. Selivanoff’s test B.Phloroglucinol test, C. Keller-Kiliani test D. Molisch’s testQuestion 40 * Deoxysugars (A) Keller-Kiliani test — Carnac glywsdy ¢ B. Phloroglucinol test C. Molisch’s test D. Osazone testQuestion 41 * All carbohydrates A. Selivanoff’s test B. Phloroglucinol test C. Keller-Kiliani test D. Molisch’s test DurerQuestion 42 * All monosaccharides Ko anameng C, —> a A. Phloroglucinol test B. Molisch’s test C.)Fehling’s t D. Osazone testQuestion 43 * Which of the Tonowinesieyerments is TRUE regarding lipids? a< All bonds of unsa ed fatty acids are sp3 hybridized( =——-_—~. (B) he solid form of saturated fatty acids can be attributed to a “ greater amount of van der Waals’ interaction and stacking.
ik Gaucher disease is a genetic aoa in which a sphingolipid accumulates in the body due to the deficiency of be gles Zz Pip oxonanicleope ficient on both Tay-Sachs disease and sat. disease with th oxrperalso.defigient in hexosaminidase-B Farber disease is aif X-linked inherited disorder due to mutations leading to the deficiency of alpha-galacto nayme. ei abry's A.l 1, UI, UL B. Ill Ul, Ul, IV C1, Il MANOR Review CenterQuestion 52 * Select the statements that best characterize cell membranes: |. The two faces of biological membranes are always the samex Il“ Membrane potential plays a vital role in transport, energy conversion, and excitability IZ Membrane lipids spontaneously form closed biomolecular sheets in aqueous media sr esieraed to the flow of polar molecules yh Giyssiipi jor class of membrane lipids 5 2, HL, HL, IV. 4 ®:. nn OKI, HL, IV. we IL Ill DurerQuestion 53 * Select the correct statements about the common types of membrane lipids: : |, /The 3 major kinds of membrane lipids are ph invds, glycolipids and Y Phospholipids derived from glycerol are called phosphoglycerides I / The simplest g i is cefebrosida Monosac, IVA phospholipid consists of one or more fatty acids, a platform acids are attached, a phosphate and an/alcohol attached to the phosphate A. TV glyco B. Il, Ill, | C. 1, Il, IV > 1, HH, I, IV MANOR Review CenterQuestion 54 * Select the correct statements about membrane channels: {Membrane permeability is conferred by 3 classes of membrane proteins: pumps, carriers and channels NO e&. ¥ SPumpjaction is an example of passive transport vst HP Webicise, ll|“Channels provide a membrane pore through which ions can flow very rapidly in a thermodynamically downhill direction onnt. - ewe (XC The transport of molecules across a membrane is alwayeby active transport A. 1,11, HL IV B, Il, Ill, IV C.)1, Il Dz IL, IV MANOR Review CenterQuestion 55 * Select the correct statements about membrane fluidity: f (a Membrane fluidity is controlled by fatty acid composition and eae content. Fatty acid chains in membrane bilayers can exist as an ordered, rigilstate or ina relatively disordered, fluid state. >. 4 The transition from righ te state takes place abruptly as the temperature is (Mlesont below the melting temperature. —— — « The presence ofGuurateany acid residues favors theGuig state because their straight chain fairs interact favorably with one another. A. 1, IIL IV —cghih @ uu ume b liqg— svid wy Cc. 1, Il, Ill, IV Dz Il, Ill, IV MANOR Review CenterQuestion 56 fF ie the correct statements about mem! Pumps use a source of energy such a: thermodynamically uphill transport o! Mosta relative to th ium. MHC The ionic gradient are generated by a specific transport system, the fla-Kpump or the Na-K ATPase WK the hydro of ALP by the pump provides the energy needed for the transport of[Na.out of the cell and K. Kions \nto the cell. [a1 > B. Il, IV cell c. 11, 1V ey D. Mil, IV MANOR Review CenterQuestion 57 * Heparin and Heparan: *% Heparin is a fraction of heparans sy Heparin has a structure consisting of a repeating disaccharide of diconhine andiduronate, that is heavily sulfated e We Heparin has a great affinity for antithrombin IIL a plasma protein that inhibits proteases involved in forming blood clots aac usually prepared from intestinal mucosa, which is rich is heparan sulfate ‘oflycans — 2) A, 1statement is correct 2 statements are correct ~ 3 statements are correct D. All statements are correct E. All statements are incorrect a MANOR Review CenterQuestion 58 * Blood group antigens < The membrane of white-blood cells contain glycolipids that carry oligosaccharides recognized of by the immune system f The oligosaccharide is composed of glucose linked directly to the lipid, followed by galactose) sidue, an N- acetylglucosamine residue, and then a galactose residue “ff. {The exact sequence of sugars, and the manner in which they are linked and branched by the) lycosyltransferase enzymes, determines the blood group type A. 1 statement is correct iE] 2 statements are correct . 3 statements are correct D. All statements are correct E. All statements are incorrect MANOR Review Centerestion 59 —Gle- uk GleMee —Oal WL KK pea ceramide 8 - GalNac ~ Gal ~ Fuc ~ Gal ; nue * 1 statement is correct w Type 8: GalNac - ramidgl- Gie - 64 - Gic * 2 statements are correct Fue * 3 statements are correct * All statements are correct DK Type 8 GaniD- Glc ~ Gal ~ GalNge ~ Gal ~ Gal te statements are incorrect Fuc IW “Type 0: ceramide ~ Gle - Gal - Galyge - Gal I Fuc MANOR Review CenterQuestion 60 @| ) soterente/ 4 The immune system can produce antibodies against the various short oligosaccharides MANOR @ People with A - blood type will produce antibodies against the B — type oligosaccharides. — Conversely, people with B — blood type will produce antibodies against the A — type antigen. aT The antigens can cause the blood cells to clump together. / WM) People with O - type antigen are called universal reeipiomts ADnur X ¥. SPeople with O - type antigen are universal donors, in recognition of the fact that people with A-—or B-type blood lack antibodies to the O antigen. ee A. 1statement is correct sf Unwee ko Me 2 statements are correct ve of e tr B. CJ 3 statements are correct D. All statements are correct E All statements are incorrect MANOR Review CenterQuestion 61 @| (ire reducing eu ar Gucosp has a free aldehyde that reacts with@minokroups, so that glucose can e covalently linked to-a protein through the side chain amino group. a XThe extent of glcomlatinn of a common proteinysuch as hemoglobin in circulating erythrocytes, depends on the Concentration of free glucose. Yi.\\, Glucose levels in the blood are unusually high in patients with diabetes mellitus so thatHb becomes glycosylated (HbA). (The major sugar derivative, HbA1c is formed from the reaction of glucose with the amino terminal 5 ve roup of the beta subunit of Hb \ \\. The lifetime of a typical erythrocyte is 110-120 days, so the amount of HbA1g, is a record of the average level of glucose in the blood over the previous couple of months. A. 1statement is correct \e Mc es \. ated 2 statements are correct 3 statements are correct All statements are correct E. All statements are incorrectQuestion 62 * Which of the following serves as the mRNA binding site for the translation of prokaryatic mRNA? A. Kozak~wk. Shine-Dalgarno C. Either D. None _ DurerQuestion 63 ge) licing is a post-transcriptional process that r oves exegowhtig binding the remaining the i portions Wig’ tapping Rod polyadenylation is done to the spliced mRNA to produce a mature mRNA strand. A. Only the first statement is false. B. Only the first statement is true. . Both statements are true. Both statements are false.Question 64Question 65 * Which of the following is not a nucledt}de? /’« Adenosine monophosphate~ ¥20y B- Guanosine diphosphat © Cytosine —\vase D. Thymidyflic acid = mo vo? Oy ra (4 Seen DurerQuestion 66 @ * Which among the choices is the pyrimidine. base that can forn{ 3) hydrogen bonds with its partner? A. Cytidine ruiyal: B. Uracil C. Uridine At A Woody D. Adenine EJ cytosine Oz ) Weenie MANOR Review CenterQuestion 67 * The(RNA)complementary strand of EReTTGATCGACGTCGA CG Aw X.GOKGGAACTAGCTGCAGCT (B) GCUGGAACUAGCUGCAGCU = €. CGUCCAACUACGUCGACGU 7 GCUGGAAGTAGCUGCAGCU i (ja MANOR Review CenterQuestion 68 * Which of the following is NOT associated with the operation of the : central dogma in prokaryotes? A. NfMet / Kozak sequence— us C. Shine-Dalgarno s' ce — pind d Se D. Pribnow Box] E. OricQuestion 69 * Select the statements that best describe DNA molecules |. DNA is deoxyribose acid composed of two chains, iJ around each other to forma sibeleihelix carrying genetic instructions. ,) ye The four bases in DNA that are responsible for éncoding genetic information are thymine, adenine, cytosine and 5 AM. In DNA, adenine pairs with thymine, and cytosine with guanine. IV. DNA replication occurs in all living organisms. V. The keto tautomers of purines and pyrimidines form the base to base H-bonds that (is important for base pairing in DNA. B. ai Cc. will D. Yell, Ill DurerQuestion 70 * Select the statements that best characterize RNA molecules. JX RNA naturally occurs as a duplex of,twue-separate strands The secondary structure of tRNA molecules resemble a clover leaf OH The base pairs in RNA molecules are adenine and thyeaiié, uracil and cytosine. = AW. RNA is ribonucleotide JCA NI YeRNA i is synthesized from DNA by an enzyme RNA polymerase during transcription, \/ 1 MN, LV BL LL IV AV Vall i (i MANOR Review CenterQuestion 71 * Select the statements that best describe protein synthesis. (ja * Proteins are synthesized stepwise by the polymerization of amino acids in a unidirectional manner, beginning at the,f-terminus and ending at the N-terminus. ll, The mRNA provides the instruction for the synthesis of a specific protein. a lIL~ The information encoded in mRNAs translated by the tRNA.molecules that bind to the mRNA at one end and carry specific amino acids at the other end,~ The synthesis of the growing polypeptide is carried out on teposomes that contain RNA and associated proteins. \nlgo A. 1,11 Ill B. 1, Il, Ill, IV © uu MANOR Review CenterQuestion 72 * Which statements best describe DNA replication? The first step in DNA replication is the “unzipping” of 9 of . the double helix structure of the DNA molecule. Nl. DNA polymerases are enzymes that synthesize a DNA polymer. fu WW ly. A polymerase adds nucleotides to an existing strand. —— pe \V. Ato oisorerase cuts and rejoins the helix. we é joins the two separate strands: 1,11, WL AV. B. Il, Ill, IV, V Cc. 1, I, I IV, V D. 1, IIL IV (a!Question 73 * Which statements best describe nucledSides? to Poy Pa L~ Nucleoside consists of a nucleobase and a five-carbon sugar > a Nucleogides are precursors for nucleic acid synthesis. tien, Nucleosides and nucleoside analogs are used in antiviral and anticancer drug therapy. IW Nucleosides are composed of nucleobases covalently attached to a 5-carbon sugar. V, The nucleobases of nucleosides are nor=aeemxdfic heterocyclic compounds ~ containing N. U1, II, IV w 1, IL, IV mM. 1,11, UL, IV IV. 1,11, IIL, IV, V DurerQuestion 74 @| What mutation/s happens _, AV G UCUUA GA GGG one when the 3 uracil from ——- aa codon 3 is removed? + UCU: Serine A) Frameshift, missense + UAU: Tyrosine Wau — Gad (9 Frameshift, nonsense- * AGA: Arginine ramesntr woe F * GGG: Glycine C) Point, nonsense GGA. Glyci D) Point, silent “en MANOR Review CenterQuestion 75 ge Which of the following ee at best describes the lutation/s that happen/s + UCU: Serine 4 hen the last guanine in * UAU: Tyrosine Gdg — 3-64 is replaced by an + AGA: Arginine Gy) adenine base? * GGG: Glycine / A)Frameshift, silent * GGA: Glycine G lent B) Frameshift, nonsense oint, transition a Dy Point, transversion MANOR Review CenterQuestion 76 *How is process 5 called? A. glucogenesis 6.) gluconeogenesis C. glycogenesis D. glycolysis E. glycogenolysis és ] eco ephegten) [Fnmen] (Glucone 6 phosphate 38 2> [Ribose 5-phosphate 6 (ame) (aQuestion 77 *In process 2, what enzymes are involved? A. glycogen phosphorylase @. glycogen synthase/ yl < C. debranching enzym' D. two of the choices E. all of the choicesQuestion 78 @ *In process 3, what are the required molecules? A. Glucose“ > [iieeont pieespiate B. Hexokinase™” 5 Cc. D. all of the choices A z, \E] two of the choices ‘Amano acide us iaQuestion 79 * In process number 4, what relevant enzyme is isolated in only a single organ of the body, such that no other part of the > (Rie body can perform this 6 process? A. phosphofructokinase (8) glucase-6-phesphatase Z ls . C. pyruvate carboxylase Amino acids | ,; [Lactate | Aewtyh CoA | D. PEP carboxykinaseQuestion 80 * What is the goal of step — pyid- NAOPH number 6? NOME - bd A. To generate energy 1)] ||2 B. To produce energy inthe quam ‘ a Sana me +> [Rites 8 phephate ES — ae > aes form of sucrose So 4 “ eo = C.\To produce antioxidant 5 molecules ~— D. To produce fats ¥ NG > es = [Acetyr Goa ] MANOR Review CenterQuestion 81 In process 8, what enzyme is responsible? Glycogen A. pyruvate carboxylase we) a|]l2 pyruvate hydrogenase 5 wa a pyruvate dehydrogenase oN / pyruvate transaminase_ 9, %, Satt [Amane ac & [ecm] Aewtyh CoA | C. pyruvate decarboxylase — fam. DurerQuestion 82 ge ; ennnles) Ce A. Suécinyl CoA synthetase Oxaloacetate Pp B. Succi hydrogenase - ow 5 Ee Cee hese Ny c, eeneeviioee we tie Two of the above ar | Oo @ E. NOTA = eae *" Fumarate Q ALY “rapid rR FAD’ Succinate *” succinyl COA NapH ATP_aop Rs Figure 1. Krebs CycleQuestion 83 @| * Which reaction among the sessed : choices demonstrates cess cat 6 conversion of aS*sarbon mre compound to 4 4-garbon ae compound? Matate (3 est 4 ”. A roma . Reaction 5 2° Fumarate IS C. Reaction 6 2 s sone —- 00. D. Reaction 7 1) No pointe RC Succiny! COA NapH ATP_aop Rs Figure 1. Krebs Cycle MANOR Review CenterQuestion 84 In the ETC, electron transport and ATP production occur simultaneously and are tightly led.-In the same bioenergetics >hrocess, NACH)and FADED are nr = if ADP i is available for~ available fe aaa to ATP. (A FOniy the Rak tatomentie ta wl . Only the second statement is true. C. Both statements are true. pe D. Both statements are false. —\\[\) | (alQuestion 85 | * End product of protein metabolism A. Bilirubin B. Uric Acid — pons a (o Blood Urea Nitrogen D. Creatinine _ MANOR Review CenterQuestion 86 @| *In terms of. eee ees) en metabolism, what term best describes humans? A) ie Sa B. Ammoniotelic met, rot ev C. Uricotelic ——_—_o D. HomeostaticQuestion 87 & * What is the keto-acid produced from the transamination of : Aspartate ce Or—-@ Oxaloacetate S ie C. Fumarat D. sucdavicel sé — A E. Acetyl CoArt Question 88 * Deficiency of this fat-soluble vitamin may lead to night blindness and xerophthalmia (A)Vitamin A B. Vitamin D C. Vitamin E D. Vitamin K _————————————————————————————— MANOR Review CenterQuestion 89 * Affects the lysosomal phsiphotructolste enayme A. GSDO — B. Von Gierke’s Disease— ai C. Hers’ disease =f, Tarui’s disease E. Pompe’s disease Q (a!Question 90 &) * Affecting the lysosomal alpha glucosidase enzyme, it is also known as = re —eervee—’ acid maltase deficiency Gso# 2 A. McArdle’s Disease ~ (&)Pompe’s Disease C. Von Gierke’s Disease D. Cori’s Disease E. Andersen’s Disease MANOR Review CenterQuestion 91 @| * Condition that develops when the body is starved for glucose during prolonged fasting or starvation (A) ketosis B. Diabetes insipidus C. Diabetes mellitus, type | D. Diabetes mellitus, type II E. Wernicke-Korsakoff syndrome MANOR Review CenterQuestion 92 € *A pituitary disorder that directly affects kidney function, NO unusual leveLof glucose in the urine is observed A. Ketosis pho) pe ee Ko . Di Li D. Diabetes , E. Wernicke-Korsakoff syndromeQuestion 93 € * Beta-cells of the pancreas are goneso insu produced; condition ee is controlled by daily injections of ins' A. Ketosis B._ Diabetes insipidus Gey (G.) Diabetes mellitus, type | D. Diabetes mellitus, type uly Ss. E. Wernicke-Korsakoff syndrome ——Question 94 @| *A normal amount of insulin is produced; either it is not released fast enough when blood sugar rises or the target tissues have a reduced responsiveness. A. Ketosis B. Diabetes insipidus C. Diabetes mellitus, type | Diabetes mellitus, type II E. Wernicke-Korsakoff syndromeQuestion 95 ge) * A neuropsychiatric disorder that arises from lack of thiamine in the diet, poor absorption of thiamine from the gut, or poor proper storage of thiamine in the liver. A. Ketosis B. Diabetes insipidus C. Diabetes mellitus, type | D. Diabetes mellitus, type II CE) Wernicke-Korsakoff syndrome aX: on ata n e, Mernicke-Korsakort syndromQuestion 96 * This is caused by a deficiency in folate derivatives during early pregnancy because of the important role of these derivatives in the synthesis of DNA precursors. I a A. Severe combined immunodeficiency B. Gout C. Lesch-Nyhan syndrome (0) Neural tube defectsQuestion 97 & * This pathological condition results from the absence of adenosi deaminase, an enzyme in the purine degradation pathway. @) Severe combined immunodeficiency ScAD B. Gout C. Lesch-Nyhan syndrome D. Neural tube defects _———————————————————— MANOR Review CenterQuestion 98 A. Severe combined immunodeficiency (B) Gout C. Lesch-Nyhan syndrome D. Neural tube defects _ MANOR Review CenterQuestion 99 @| *A genetic disease characterized by(self-mutilatioh, mental deficiency and gout. A. Severe combined immunodeficiency Gout CJ Lesch-Nyhan syndrome D. Neural tube defects DurerQuestion 100 . . Hope : + A disease caused by the absence of hypoxanthine- guan oribosyl transferase that is essential for the synthesis of purine nucleotides A. Severe combined immunodeficiency B. Gout oO Lesch-Nyhan syndrome D. Neural tube defectsQuestion 101 ge) * Which of the following plant constituents are biosynthesized via the shikimate_ shikimate_ pathway? hON-ald mah Oromehc. ’s Morphine * Prunasin * Vanillin a) yell >a 9 “SAlll, V 5} ML, LV,Question 102 * Which of the following compounds are biosynthesized via the mevalonate pathway? \} Terpineol ~ Vv Vol S \s \y Camphor sm S temmds wip Hyoscyaming< IN° Squatene 1 \* Methyl salicylater Squalicess7 oh) sHrols a) ott o 1 UAV C00 O-iwvv Sy NeQuestion 103 @| * Select the statements the best describe the methylerythritol phosphate pathway (MEP): |. The precursor, 1-deoxy-D-xylulose-5-phosphate, is formed from glucose, which i: formed by the condensation of pyruvate and glyceraldehyde-3-phosphate. - Subsequent steps, including a skeletal rearrangement, yield isopentenyl yt The MEP pathway was identified in eubacteria, green algae and higher plants. IV. Plants have both MEP and MVA (Mevalonic Acid) Pathways. A. 1 IIL, IV B. Kl, IV © lL Ky) Wwe DurerQuestion 104 * Select the statements that best describe the shikimate pathway: x The pathway is found both in plants and antwals It is a seven step metabolic route for the biosynthesis of folates and aromatic amino icids |. Products of this pathway represent essential amino acids B. c, hate oo, aQuestion 105 * Select the statements that differentiate the mevalonate pathway (MVP/MVA) and the methylerythritol phosphate pathway (MEP): Deter is a metabolic pathway for the biosynthesis of the isebrenoid precursors, while the MVA is for the biosynthesis o cheap 1 19M, 7 § A The MEP pathway occurs Ta tRe pIstfide-of plants while the MVA occurs in the cyt6S6l of plants d ————_—. lll. The MVP starts with the condensation of two molecules of acetyl-CoA to form acetoacety=—~ CoA, while the MEP starts with the condensation of pyruvate and glyceraldehyde-3- phosphate to form glucose. X& The end product of MEP is geranyl pyrophosphate while the end product of MVA is isopentenyl(diphosphate A. Intl, LIV RYO 6am FSI, IIQuestion 106 * Insoluble in water, neutral solvents, salt, and alcohol but soluble in dilute acid or bas A. Prolamine i cy \t B. Albumin Alcohol | Acid/base Co Glutelin Albumin) | Y4 Yes Yes D. Globulin No Yes Yes Yes No Yes Yes @Question 107 *Comminuted drug is extracted of its soluble constituents by the slow passage of suitable solvent through a column of drug . Soxhlet extraction — reprodeg, Tet extrachio! B.S itical fluid extraction C. Sonication Souq 4, () Percolation,Question 108 * Known as theG@alibesad> addition of spurious material to a genuine portion with the intent to defraud Admixture S istication C. Substitution D. DeteriorationQuestion 109 & *The phosph pyruvate from the start of the shikimate pathway comes from which bioenergetics pathway? (a7Glycolysis B. Mevalonate pathway C. Pentose phosphate pathway D. DOXP pathway DurerQuestion 110 *Substrate UL A Dehydroquinic Acid B. Shikimic Acid ) Prephenic Acid D. Pyruvic AcidQuestion 111 * Which structure represents tryptophan?Question 112 *Soft, fluffy staple fiber that grows around the seeds of plants of the genus Gossypium in the family Malvaceae. AJCotton B. Absorbent wool C. Pyroxylin D. Flax E. Alginate fibers [ daiak a tlre her vesQuestion 113 ¢A flammable mixture of cellose nitrates usually with less than 12.5% nitrogen, that is sotublé in a mixture of ether and alcohol or other organic solvents. A. Cotton B. Absorbent wool Pyroxylin . CG Flax WihocalWlgze, |suuae guncotton E. HempQuestion 114 . *A member of the genus Linum) which is a food and fiber crop cultivated in cooler regions of the world. A. Cotton B. Absorbent wool C. Pyroxylin D} Flax E. HempQuestion 115 *The fiber and seed part of Cannabis sativa. A. Alginate fibers B. Absorbent wool C. Pyroxylin Bee HOQuestion 116 & *The fibers are made from a natural polymer extracted from : brown seaweeds. A. Cotton “ B. Absorbent wool C. Flax D. Hemp E dilpinate fibers.Question 117 *In the processing of cow’s milk, the liquid separated from the coagulum is called: (&) Whey Chude B. Cheese C. Buttermilk D. Skim latQuestion 118 *Cellulose product used as a surgical aid due to its fibrous nature. It is allowed to contain N 725% of T, A. MictOcrystalline cellulose g (8) Purified rayon, se 0 AbsorbentQuestion 119 *Major product ofStarchhydrolysis via A. Liquid glucose B. Dextrin evulose - D. se. 0 (yo “9 4o_ oo 5Question 120-124 C)+ Locust bean. gy * Pectin . &) * Xanthan & 8) *Kelp 2D. E hy Tragacanth Shrubs or Tree Exudates Marine Species Seeds Plant Extractives MicrobesQuestion 125 * Refers to the number of mg of potassium hydroxide required to | (a! neutralize the [neutralize the frge acid if an (and jélhydrolyze the esters|in 1 g of the u Tpewtralize the GV A. Acid value D. lodine value fea eenitatin value . Ester value Dy N* / = \av) E. Acetyl valueQuestion 126 ; *Refers to the difference between saponification and acid. values. A. Saponification value Sv = av (Bester value zie -pv -@ C. Peroxide value Sy AY D. Acid value E. lodine valueQuestion 127 *Refers to the number of mg of potassium hydroxide required toneutralize the acetic acid freed by the hydrolysis of the écetylated tat or other substances. A. Acid value B. Saponification value C. Ester value D. lodine value & Acetyl valueQuestion 128 A. Acetyl value B. Peroxide value C. Ester value ydroxyl value E. lodine value MANOR Review CenterQuestion 129 v . *It measures the degree of of the oil. Those which are partially resinify on exposure to air have high values. A. Ester value B. Acetyl value lodine value D. Acid value E. Saponification valueI. Sesame oil” aa Ill. Corn oil # IV. Peanut oi|-~ A. 1,11, I, IV B. 1, IL and IV . HL Il, and IV c Oy 1, Ill, and IV Question 130 * Which of the following are fixed oils used for intramuscular injection? lL semidny “~y C6n Cotten Ye any Sag@nRy-Question 131 What is the delta notation for OLEIC acid? ® @ Ba satvded) 9 b. 18: 24912 _ \indlerc 8: 349. 12, 15 —o¢-(ndenic, : 4A9, 12, 15, 18.Question 132 True about volatile oils jorrn= heed Leaves ap t transluscent spot on the paper in spot Test. MK Canbef be distilled. ah Can, be saponified by alkalis. IV. Resinifies upon oxidation. A. X11, Ill C.of I, Il, IV D.1,0V)Question 133-136 | (al *Citrus sinensis Sweet wanp * Bergamot Oil *iilicium verum Sov Gabe * Cardamom Oil Ree *Syzygium aromaticum _* Clove Oil“ é *Anthemis nobilis “oY * Sweet Orange Oil pte him oman dhamennle, * Lavender Oil 7 A Gerimah chonewslt, *Star anise oil_ ~ %*!”>. Moavicaria * Boman chamomile oil rows ta) *Lemon oilQuestion 137-140 *Lemon peel - 4. (Alcohols ho *Nutmeg — ohenolic uth Aydrocarbon Ry nice * Absinthe — Keone, Ketone / t nek, *Cajuput/ | Aldehyde~ ® tavahphy vl oxide PKeno sseens Phenolic ether OxideQuestion 141 irre * The following are ineerrectlymatched EXCEP-— ~ Bawang: Antihyperlipidemic ~ Bayabas: Astringent_— C. Yerba Buena: Carminative_~ D. Tsaang gubat: Stomachic AOTA (aQuestion 142 * Which of the following is correctly matched? A, abiatae: Trichomes- B, Mmbelliferae: Oil Tubes or vittae_~ Pinaceae; Parenchymal Cells “« ioe of the above L, querer: ‘ Ves\n dod (craw ly si yenos duck) (aQuestion 143 Which of the following plants produce a blue colored oil? A. Achillea millefolium _ — yerdud B. Humulus Jupulus C. Juniperus communis D. Syzigium aromaticum — eve, Former - Esaeene — caryaphy!lus 7 enienthe ”Question 144 *The method of obtaining volatile oil that utilizes sharp tiny projections where a specimen can be rolled. (A Ecuelle a piquer B. Enzymatic Action 0,0 C. Enfleurage— 2 D. Distillation E. None of the above MANOR Review CenterQuestion 145 *Gives the minty odor to peppermint A. Camphor Menthol Hearmin+ C. (+) carvone D. (2) carvon, MANOR Review CenterQuestion 146 * Evening Primrose Oil A. Cynips tinctoria —insek Oenothera biennis— GLA gamma-vrolemc awd C. Helianthus annuus ~ «VU prk\o D. Brassica napus —capesud MANOR Review CenterQuestion 147-150 *Gamboge Qum ¢tsin @ . f ° Mayaprle,. soon ms sin OReresin *Colophony, * l@ ih \p *Gum resin a— Yesin a * Balsam of Copaiba *Oleo-gum resin eer = Loltor tin “Balsam tou ~ Leman - prayQuestion 151 *The aglycone released fro A. Acrinylisothiocyanate ow B. Salicyl alcohol — w i \law (C)Hydroquinone D. Allylisothiocyanate E. Mandelonitrile —Question 152 * Which of the following are true for phytochemical screening tests? fe Guignard test is useful for detecting cyanogenic glycosides he Borntrager-test is useful for detecting arppyepas? _ On Mangus he Wilstatter Cyanidin test is useful for detecting cyanophore glycosides Rovonai\ ) lonly B. llonly Cc. Illonly D. land Il E. Iland Ill ET DurerQuestion 153 @ on the following statements: Nonhydrolyzable tannins result from the condensation of catechin and | anidin we Hydrolyzable tannins are called pyrogallotannins_ quypaness ‘oduct upon Ms Condensed tannins form a red inscluble aphumeriztlon W Sr Pyrogallotannins are decolorized: when subjected to the KMnO4 test h yo honky M0 — he Pelee muh A. Only one statement is true B. Two statements are true z dish\aton Three statements are true D. All statements are true E. All statements are falseQuestion 154-158 *Oleander~ Carkiay, *Saponin *Salicin- al\uho& *Cyanophore * Rhein —arthraysh ae *Anthraquinone *Milk thistle — fysonpl, * Cardiac Clumari ; *Bergamottin - Lackdye *lsothiocyanate Sat “Aono * Flawonnds « Laktne,Question 159 + A sample was tested, and yielded the following: * Kedde’s test) leksré * Keller-kiliani test (-)___ deorafs uy ~Geikowsibtest -) — shes K * The sample is most likely to be what? a can Ae TET B. Digoxin @) Coumarin ~ laden, Daaiieonprlivese. HdQuestion 160 *Rutin and Hesperidin in combination is also known as A. Viearnine — ICL Y lindlenic EFA B) vitamin Pevmeatility C. Vitamin H —boh? D. Vitamin U— & adenary\merhion ae (cps)Question 161 | *This enzyme is found in almonds, and it causes the hydrolysis of beta glucosides. (i.e. Amygdalin hydrolyzed into glucose, benzaldehyde, and HCN) A. Invertase — suce’s — > lus eis B. Myrosin — Qhucarinslorc> ais Re (C)emulsin, = amygdalos + pronase APE D. Maltase— mane, ee ee DurerQuestion 162 Gossypol is classified as a (A) Sesquiterpene B. Diterpene ~ qoute, C. Monoterpene— wet \p\ D. Tetraterpene— B -cartene, oilyQuestion 163-166 beats alk. OMINEG AAutumn erocue *lsoquinoline os Baring Nga-nga-Ayecn YP *Imidazole Kola nuts ~ — *Steroidal guecu *Alkaloidal Amines ¢Pyridine-piperidine | (aQuestion 167 * Which is true about alkaloidal reagents ae Wagner's Reagent is composed of Potassium Mercuric lodidg QW") WZ Scheibler’s Reagent is composed of Phosphotungstic acid- I jonnencheim’s Reagent is composed Phosphomolybdic acid = WV Bouchdart’s Reagent is composed of lodine in Potassium lodide. A. 1,11, Hl B. 1, IIL, IV Cc. 11L1V oO I, HL, IV E. LHL, TL IVQuestion 168 Alkaloids that contain a ring nitrogen, but donot come from amino acids O@treudealtaeid . Protoalkaloid C. True alkaloid D. Flavonoid TRG Reo) | —saqv0D. DU reerQuestion 169 & *German pharmacist who obtained an impure alkaloid from Atropa belladonna fam. Solanaceae A. P. Robiquet - codune B. F. Serturner — movphre C. F. FluckiWger — dehwio DR. Brandes E. J. Caventou + Peller — QuintQuestion 170 *A mixture of pforphiné and g6caine used as analgesic in terminally ill cancer patients. 2 Paregoric : # Faregorie® oneMm ~ Aachny BeLaudanum Dover's Powder — moraine x \yetau Brompton’s Cgcktail E ” Apmrsustgilaaty | (aQuestion 171 * Select the statements that best describe the biosynthesis of hyoscyamine: |/ Feeding studies with labeled.ornithine have shown that this is incorporated tereospecifically to form the pyrrolidine ring of tropana ‘, Ce is the precursor of tropic acid i 8 UNG Esterification of tropic acid with tropine produces hyoscyamine \y@ Hyoscyamine is dextrarotatory_ C8) aes Rreagne A. Il, Ill a B. I, II, IV hyos ugar ith, gem © Q Aue (land DurerQuestion 172 | ie the statements that best describe sola BBW aflaloids: J The a alkaloids are most abundant in the plant after the fruits have ned jee principal solanaceous alkaloids are hyoscyarfiine, atropine and scopofamine. Wf Atropine-and scopolamine are competitive with acetylcholine die ————- synapse of the parasympathetic nervous system producing ana Sco} is also known as hyoscyamine, and atropine is also known as hyoscine. B. IIL IV D. Hi Il Rrapar
. Areca catechu — Nigotitie ovewln& = Lobelia inflata — Fryesting \eouhio D. HI, Ill, IVQuestion 174 * Select the statements that pest fesenbe the following alkaloids: Atropine is racemic hyoscy: Il. Hyoscyamine is the ester of tropic acid and tropine Ca Scopolamine is abundant in Datura metel. M« On hydrolysis, scopolamine yields tropic acid ath Dylon 1 Al, UL se as Ly fe tyr wa ne = eC ah B. 1, i, ill, huypseyoms e Awe hyssine/ = tragic aud + saQPnG D. |, Sco Wlaminy DurerQuestion 175 * Select the pairs that are correctly matched: Belladonna— spasmolytic agent aoa local anesthetic WStramonium—spasmolytic agent see eas rt A. 1, Ill, IV Sok @ 1, tl, IV a ete D. 1,1, 1VQuestion 176-180 * Morphine ‘wo *Isoquinoline *Ergotamine w4ie— + Indole * Quinind— Qoger, *Quinoline *Caffeine -\qaidazole 9 \dcés pus *Atropine pantt *Tropane Lyrapoun®y *Purine Key: CDABEZQuestion 181 *A condensation product decrees and piperidine, and where inn also participates in their biosynthesis A>Quinoline alkaloids B. Pyridine-piperidine alkaloids C. Isoquinoline alkaloids (©) Tropane alkaloids E. Indole alkaloids (AlQuestion 182 * The class to which opium alkaloids belong A. Quinoline alkaloids lsoquinoline alkaloids C. Indole alkaloids D. Purine alkaloids Es (jal Imidazole alkaloidsQuestion 183 (a * The class to which ergonovine, reserpine and strychnine belong. A. |soquinoline alkaloids B. Imidazole alkaloids i ff ©) Indole alkaloids Q, vigor / D. Tropane alkaloids Stylin, , E. Purine alkaloids bajso CSAPQuestion 184 * The class to which quinin: inidine;cinchonine and cinchonidi belong A. Tropane alkaloids Chacha — CB} Quinoline alkaloids C. Isoquinoline alkaloids D. Purine alkaloids E. Steroidal alkaloidsQuestion 185 *The class to which caffeine and theobromine belong. A. Pyridine-piperidine alkaloids B. Tropane alkaloids C. Quinoline alkaloids Purine alkaloids E. Steroidal alkaloidsQuestion 186 * This was the first growth hormone discovered; it was first isolated from human urine; found in growing stems and roots; ‘and promotes flowering in plants @) Auxins B. Gibberellins Qhow Ah C. Cytokinins D. Abscisic acid E. EthyleneQuestion 187 * There are 100 kinds of this hormone, It lengthens the stem of sugarcane; hastens maturity period in group of conifers and promotes early seed production (8 A. Auxins B.Gibberellins C. Abscisic acid D. Cytokinins E. EthyleneQuestion 188 * Exists in areas where rapid cell division takes place and delays leaf senescence _ A. Gytokinins” Lptobrew B. Ethylene C. Auxins D. Gibberellins E. Abscisic acidQuestion 189 | * Induces dormancy in seeds and helps withstand unfavorable growth factors A. Auxins _- B. cowie rowdy C, Cytokinins~ D. Ethylene Abscisic acid — nongew\@| i \ Question 190 + Hasten fruitripering and increases root growth and root hair formation, thereby increasing their absorption surfacearea A. Auxins B. Gibberellin C. Cytokinin: D. Abscisic acid EthyleneQuestion 191Question 192 an 2 a / 3 Kayerl HG
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