HArmonyCa

Composite Matrix Dermal Filler

 OUR COMPOSITE
HArmonyCa

MATRIX FILLER
HArmonyCa dermal filler is designed to restore facial volume and correct deficiencies by promoting the
generation of natural endogenous collagen. HArmonyCa is based on a composite matrix of cross-linked
Hyaluronic Acid embedding Calcium Hydroxyapatite microspheres.

Composition
• Calcium Hydroxyapatite (55.7%)
• Sodium Hyaluronate gel (20 mg/ml), cross-linked
(BDDE <2 ppm)
• Phosphate buffer
• 0.3% lidocaine
HArmonyCa is provided in a box of 2 x 1.25 mL syringes

WHY
HArmonyCa?
ADVANTAGES

• Provides a strong volumising, lifting effect

• Susceptible to Hyaluronidase
• Reduced side effects, such as burning sensation, edema and pain
• Promotes generation of natural collagen
• Non-animal origin Hyaluronic Acid
• Biocompatible and biodegradable
 THE SYNERGY
OF TWO
OUR TECHNOLOGY

IN ONE
HArmonyCa contains both Calcium Hydroxyapatite & Hyaluronic Acid

CaHA HA

ONE SYRINGE COLLAGEN HYDRATION

The concentration of each active Collagen stimulation increases due to the The presence of Hyaluronic Acid
ingredient is similar to that of Calcium combination of both active ingredients, elevates skin hydration and moisture.
Hydroxyapatite and Hyaluronic Acid providing a long lasting effect.
dermal fillers combined in one syringe.

STABLE FIXATION MATRIX

Calcium Hydroxyapatite is added The Composite Matrix gel can prevent Calcium Hydroxyapatite stimulates
during the cross-linking process, microspheres aggregation and collagen production, while Hyaluronic
generating a stable, inseparable gel. dispersion, keeping the microspheres Acid forms a supporting extracellular
within their desired location. matrix, which modulates fibroblasts
proliferation.
 MECHANISM
OF ACTION
HOW IT WORKS

IMMEDIATE - A volumising effect and a full glowing look is immediately apparent due to the
presence of Hyaluronic Acid.

LONG LASTING - The Calcium Hydroxyapatite microspheres form a scaffold supporting

fibroblasts ingrowth. The Hyaluronic Acid binds to fibrin, which generates the supporting
extracellular matrix. A “hyaline cartilage like” formation is generated by differentiating
fibroblasts cells into chondroblasts, which deposit endogenous collagen- the natural lifting
agent of the skin. Degradation of the gel is synchronous with neo-collagen production
resulting in a natural, youthful, long-lasting appearance.

Facial lesion due to Immediate volumising CaHA microspheres form a Material degradation
collagen and HA depletion effect created by the HA scaffold and stimulate fibroblast synchronous with neo-collagen
within the composite matrix production of new collagen deposition providing a long
lasting, natural, youthful look
Collagen Fibroblasts HArmonyCa

HYALURONIDASE
SUSCEPTIBILITY
hyaluronidase
t=30 min

HArmonyCa Calcium
Hydroxyapatite HArmonyCa Calcium
Hydroxyapatite

The Hyaluronic Acid gel component is 70% of the syringe volume and can be completely dissolved thus
breaking the composite matrix infrastructure.
 PHYSIOLOGICAL
LEVEL
HOW IT WORKS

COMPARISON
The osmolarity of CaHA dermal fillers
reaches ~ 2200 mOsm/kg, more than 2200
double the amount in sea water. This

Osmolarity [mOsm/kg]
generates a strong burning sensation, as
well as edema, pain and swelling.
In comparison, HArmonyCa’s osmolarity is
~ 300 mOsm/kg, similar to that of saline, 1000
allowing a comfortable treatment and
substantially less side effects.

300 300

CaHA Sea Water HArmonyCa Saline

MICROSPHERE
Solution

MORPHOLOGY
HArmonyCa composite matrix is comprised of Calcium
Hydroxyapatite microspheres that are strongly embedded within
high quality cross linked Hyaluronic Acid.
• The Calcium Hydroxyapatite microspheres are round, non-porous and smooth, enabling easy
extrusion.
• The microsphere diameter (25-45 microns) minimizes risk of particle migration and phagocytosis
which, in addition to the microspheres’ integration within a net of cross-linked Hyaluronic Acid,
ensures a smooth appearance.
• Microspheres embedded within cross-linked Hyaluronic Acid helps preserve the balance between
microsphere consolidation and dissemination.

Scanning Electron
Micrographs x600
TREATMENT AREAS

Eyebrow
Temple

Bridge of
Nose
Cheek
Bones

Nasolabial
Folds
Jawline

Marionette
Lines

Chin

Back of
Hand
 AFTER
BEFORE
BEFORE & AFTER
 LUMINERA DERM
1 Bat Sheva Street, Lod, Israel
Tel: +972-(0) 72-2744141
[email protected] www.luminera.com