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Gene Mutations - Practise

The document describes different types of point mutations in DNA including missense, nonsense, silent, deletion, and insertion mutations. It provides a table to convert letters to codons and asks the reader to perform sample mutations on their name converted to DNA and describe the resulting phenotypes.

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Ivka Zemiakova
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53 views

Gene Mutations - Practise

The document describes different types of point mutations in DNA including missense, nonsense, silent, deletion, and insertion mutations. It provides a table to convert letters to codons and asks the reader to perform sample mutations on their name converted to DNA and describe the resulting phenotypes.

Uploaded by

Ivka Zemiakova
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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GENE MUTATIONS = POINT MUTATIONS

Task 1
Turn your name into DNA sequence using table below.

Our Alphabet Amino Acid Name Codon


A Alanine GCA GCC
B GCG GCT
C Cysteine TGC TGT
D Aspartic acid GAC GAT
E Glutamic acid GAA GAG
F Phenylalanine TTC TTT
G Glycine GGA GGC
H Histidine CAC CAT
I Isoleucine ATA ATC ATT
J GGG GGT
K Lysine AAA AAG
L Leucine TTA TTG CTA CTC CTG CTT
M Methionine ATG
N Asparagine AAC AAT
O CCG CCT
P Proline CCA CCC
Q Glutamine CAA CAG
R Arginine AGA AGG CGA CGC CGG CGT
S Serine AGC AGT TCA TCC
T Threonine ACA ACC
U ACG ACT (codon for Threonine)
V Valine GTC GTG
W Tryptophan TGG
X GTA GTT
Y Tyrosine TAC TAT
Z TCG TCT

Your name in DNA sequences: :…………………………………….


Task 2
Using your notes, do the following mutations
1. Substitution
a. missense –changes one nucleotide in a codon, which can result in a completely different amino
acid being added to the protein; e.g. Sickle cell anaemia
Your DNA:…………………………………….
Phenotype of your DNA after missense: :…………………………………….

b. nonsense –changes the codon sequence for one amino to a STOP codon (TAA, TGA, TAG) that
stops the cell from adding more amino acids to the protein; it shortens the protein; e.g.
Thalassaemia
Your DNA:…………………………………….
Phenotype of your DNA after nonsense: :…………………………………….
c. silent substitution - changes the codon sequence for one amino to another codon of the same
amino acid
Your DNA:…………………………………….
Phenotype of your DNA after silent substitution: :…………………………………….

2. Deletion
Your DNA:…………………………………….
Phenotype of your DNA after deletion: :…………………………………….

3. Insertion
Your DNA:…………………………………….
Phenotype of your DNA after insertion: :…………………………………….

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