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Action Potential in Smooth Muscle

This document discusses action potentials in smooth muscle. It describes two types of action potentials that can occur: spike potentials and action potentials with plateaus. Slow wave potentials are also discussed, which arise spontaneously within smooth muscle cells and are associated with a basic slow wave rhythm. Local tissue factors and hormones that can cause smooth muscle contraction are also reviewed. The learning objectives are to discuss generation of action potentials in smooth muscle, differentiate slow wave and spike potentials, discuss action potentials with plateaus, and discuss local factors and hormones that cause contraction.

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aswad mehmood
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19 views22 pages

Action Potential in Smooth Muscle

This document discusses action potentials in smooth muscle. It describes two types of action potentials that can occur: spike potentials and action potentials with plateaus. Slow wave potentials are also discussed, which arise spontaneously within smooth muscle cells and are associated with a basic slow wave rhythm. Local tissue factors and hormones that can cause smooth muscle contraction are also reviewed. The learning objectives are to discuss generation of action potentials in smooth muscle, differentiate slow wave and spike potentials, discuss action potentials with plateaus, and discuss local factors and hormones that cause contraction.

Uploaded by

aswad mehmood
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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SMOOTH MUSCLE

Dr. Sumera Gul


Associate Professor
Department of Physiology
Learning Objectives
• At the end of the lecture the student should be able to:

• Discuss the generation of action potential in smooth


muscle.

• Differentiate slow wave potential and spike potential.

• Discuss the action potential with plateau.

• Discuss the local tissue factors and hormones to cause


smooth muscle contraction.
Review of previous lecture
Excitation-Contraction Coupling
Latch Mechanism
ACTION POTENTIAL IN SMOOTH
MUSCLE
Action Potential
Membrane Potentials in Smooth Muscle
-50 to -60 millivolts,

(1)spike potentials

or

(2) action potentials with plateaus.


Spike Potential
Electrical stimulation,

Action of hormones

Action of transmitter substances

By stretch,

Spontaneous generation in the muscle


fiber itself
Action Potential with Plateau
The onset is similar to that of the typical
spike potential.

However, instead of rapid repolarization


of the muscle fiber membrane,

the repolarization is delayed for several


hundred millisecond to as much as 1
second.
Slow Wave Potential

In some smooth muscles , action


potentials arise within the smooth muscle
cells themselves without an extrinsic
stimulus.

This often is associated with a basic slow


wave rhythm of the membrane potential.
Slow Wave Potential

It is a local property of the smooth muscle


fibers.

CAUSE:
1. Waxing & waning of the pumping of Na ions
2. Conductance of the ion channels increase &
decrease rhythmically

Pacemaker waves.
Action Potential
Slow wave potentials Pacemaker potentials
SINGLE MUSCLE TWITCH
Local tissue factors and hormones
• Role of calcium sodium and potassium
channels

• Role of Oxygen, Carbon dioxide and hydrogen


ions.

• Angiotensin, oxytocin, vasopressin


Review
Differentiate
• Action Potential in • Action potential in smooth
Skeletal Muscle muscle

• Fast fibers • Slow fibers

• EC coupling in skeletal • EC coupling in smooth


Muscle muscle

• Myasthenia gravis • Rigor mortis

• Spike potential • Slow wave potential


Differentiate
• Complete tetanus • Incomplete tetanus

• Multiple fiber summation • Frequency summation

• Isotonic contraction • Isometric contraction

• Single unit muscle • Multi-unit muscle

• Motor end plate • Motor unit

• Tetany • Tetanus
Differentiate
• Calmodulin • Calsequestrin

• Muscle Hyperplasia, • Muscle Hypertrophy


• Or Atrophy

• Contraction in skeletal • Contraction in smooth muscle


muscle
• Relaxation in skeletal • Relaxation in smooth muscle
muscle
• Contractile unit in skeletal • Contractile unit in smooth
muscle muscle
Differentiate
• Structural and
functional difference in
of skeletal and smooth
muscle
Questions?

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