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Chapter 5. B. Extensions of Mendelian Genetics

The possible genotypes of the mother are: 1. Homozygous dominant for the bald allele (BB) 2. Heterozygous for the bald allele (Bb) So in summary, the mother could be either homozygous dominant or heterozygous for the bald allele.

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52 views

Chapter 5. B. Extensions of Mendelian Genetics

The possible genotypes of the mother are: 1. Homozygous dominant for the bald allele (BB) 2. Heterozygous for the bald allele (Bb) So in summary, the mother could be either homozygous dominant or heterozygous for the bald allele.

Uploaded by

Xilca Jamaimah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Chapter V

» Non Mendelian Genetics


» Certain characteristics may not conform to the
assumptions of Mendelian inheritance:
1) Incomplete Dominance
2) Codominance
3) Multiple Alleles
4) Inheritance related to sex
a. X-linked
b. Y-linked or holandric genes
c. Sex-influenced genes
1. Incomplete Dominance

• Also known as intermediate inheritance


• The dominant allele does not
completely mask the expression of the
recessive allele, hence an intermediate
phenotype is produced between two
extreme types
2. Codominance
• Neither allele is dominant
• Both alleles are equally expressed
Sickle-cell Anemia (Codominance)

Genotypes Phenotypes

HbA HbA Normal

HbA HbS Sickle-cell trait

HbS HbS Sickle –cell anemia


Phenotypes Antigens Present Genotypes
A A IA IA IA i
B B IB IB IB i

AB A&B IA IB
O none ii
Genotypes
Phenotypes

Male Female

Normal Color Vision


XAY XAXA
XAXa
Color Blindness
Xa Y X a Xa
1. Holandric characterisitcs
are exclusively male
characterisitcs since Y
chromosome is transmitted
only to male progenies
(hypertrichosis)
2. There is no skipping of
generations
PHENOTYPES
GENOTYPES

Male Female

BB Bald Bald

Bb Bald Nonbald

bb Nonbald Nonbald
» In Japanese four o'clock plants red (R) color is
incompletely dominant over white (r) flowers,
and the heterozygous condition (Rr) results in
plants with pink flowers. For each of the
following. Give the phenotypic ratios of the
offspring.
a. a red plant and a white plant
b. a red plant and a pink plant
c. a white plant and a pink plant
d. two pink plants
In shorthorn cattle, coat color may be red, white, or roan.
Roan is an intermediate phenotype expressed as a
mixture of red and white hairs. The following data were
obtained from various crosses:

a. red x red
b. white x white
c. red x white
d. roan x roan
What are the genotypes of parents and offspring for each
cross?
Red-flowering snapdragons are homozygous for a
certain allele (RR). White flowering snapdragons
are homozygous for another allele (rr). The
heterozygotes bear pink flower. What
phenotypes should appear in the F1 offspring of the
following crosses?
a. RR x Rr
b. RR x rr
c. Rr x Rr
d. Rr x rr
» With regard to the ABO blood types in humans,
determine the genotype of the following male parent
and female parent:

Male parent: Blood type B; his mother is type O


Female parent: Blood type A; her father is type B

Predict the blood types of the offspring that this


couple may have and the expected proportion of each
A woman homozygous for blood type B
marries a man that is heterozygous for blood
type
A. What are the possible blood types of the
offspring?
B. A man with blood type O marries a woman with
blood type AB. State the possible blood types of
the offspring.
a. A type B woman whose mother was type O marries
a type O man. What are the possible blood types of
their offspring?

b. A type A woman whose father was type B marries a


type B man whose mother was type A. What are
the possible blood types of their offspring?

c. A woman with blood type O marries a man with


blood type AB. They have a child that is blood type
O. What is wrong with this scenario?
» In a disputed parentage case, the child is blood
type O, while the mother is blood type A. What
blood type would exclude a male from being
the father? Would the other blood types prove
that a particular male was the father?
Hemophilia is due to a sex-linked recessive gene
(Xh) and the normal condition to the gene (XH).
A hemophiliac man marries a woman who is
not. Their first son has hemophilia. What are
the chances that their daughter, if they had one
will be hemophiliac?
In humans, normal vision (XN) is dominant to color
blindness (Xn) and is sex-linked.
A normal-visioned man, whose father was color
blind, marries a colorblind woman. What are
the chances that a son will be colorblind. A
daughter will be colorblind?
» Hemophilia is due to a sex-linked recessive gene
(Xh) and the normal condition to the gene (XH).
A hemophiliac man marries a woman who is
not. Their first son has hemophilia. What are
the chances that their daughter, if they had one,
will be hemophilic?
» Marian’s father is colorblind, as is her maternal grandfather (her mother’s
father). Marian herself has normal color vision. Marian
and her husband, Martin, who is also colorblind, have just had their first
child, a son they have named Mickey. Please answer the following questions
about this small family.

a. What is the probability that this child will be colorblind?

b. Three sources of the colorblindness allele are mentioned in this family.


If Mickey is colorblind, from which of these three men (Marian’s
grandfather, Marian’s father, or Martin) did he inherit the allele?

c. If Martin were not colorblind, how would this affect the prediction
about Mickey?
A man with hairy ears marries a woman with no
history of hairy ears in her family. All their sons
have hairy ears but none of their daughters
have the trait. What is the probability that the
their next daughter will have hairy ears? Explain
your answer.
What is the probability of getting a bald female
from a bald man and a heterozygous normal
female?
» If a man becomes bald and his father is not bald
what are the possible genotype(s) of the
mother?

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