Phlebo India 659
Phlebo India 659
DHARMA G
Age/Gender : 36 Years/Male Sample ID : 20954135, 20954134
Referred by : MR. SELF Reg. No : 0012211160178
Referring Customer : Curis Healthtech Private Limited MPD Code : MP-TSD-200
Sample Type : Plasma-NaF(F) Collected On : 16-Nov-2022 02:15 PM
Received On : 16-Nov-2022 03:59 PM
ITDOSE INFOSYSTEMS PVT. LTD.
BIOCHEMISTRY
Test Name Results Units Ref. Range Method
TSH is synthesized and secreted by the anterior pituitary in response to a negative feedback mechanism involving concentrations of FT3 (free T3) and FT4
(free T4). Additionally, the hypothalamic tripeptide, thyrotropin-releasing hormone (TRH), directly stimulates TSH production.
TSH interacts with specific cell receptors on the thyroid cell surface and exerts two main actions. The first action is to stimulate cell reproduction and
hypertrophy. Secondly, TSH stimulates the thyroid gland to synthesize and secrete T3 and T4
The ability to quantitate circulating levels of TSH is important in evaluating thyroid function. It is especially useful in the differential diagnosis of primary
(thyroid) from secondary (pituitary) and tertiary (hypothalamus) hypothyroidism. In primary hypothyroidism, TSH levels are significantly elevated, while in
secondary and tertiary hypothyroidism, TSH levels are low
TRH stimulation differentiates secondary and tertiary hypothyroidism by observing the change in patient TSH levels. Typically, the TSH response to TRH
stimulation is absent in cases of secondary hypothyroidism, and normal to exaggerated in tertiary hypothyroidism
Historically, TRH stimulation has been used to confirm primary hyperthyroidism, indicated by elevated T3 and T4 levels and low or undetectable TSH levels.
TSH assays with increased sensitivity and specificity provide a primary diagnostic tool to differentiate hyperthyroid from euthyroid patients.
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Correlate Clinically.
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