NAME:_________________________________________ DATE: ____________

PLEASE WRITE LEGIBLY

Cell Division and the Cell Cycle

True or False
Write T if the statement is true or F if the statement is false.
_____ 1. Cell division is basically the same in prokaryotic and eukaryotic cells.
_____ 2. Cytokinesis is the division of the cytoplasm.
_____ 3. Mitosis is the process in which the nucleus of the cell divides.
_____ 4. DNA replication results in identical chromosomes.
_____ 5. A cell spends most of its life in growth phase 1 of the cell cycle.
_____ 6. The S checkpoint, just before entry into S phase, makes the key decision of whether the cell should
divide.
_____ 7. The correct order of phases of the cell cycle is G1 → S → G2 → M.
_____ 8. Interphase consists of mitosis and cytokinesis.
_____ 9. In prokaryotic cells, all organelles, such as the Golgi apparatus and endoplasmic reticulum, divide
prior to cell division.
_____ 10. Bacteria divide cells by binary fusion.
_____ 11. A mass of abnormal cells is called a tumor.
_____ 12. Organelles are made during growth phase 2.
_____ 13. In eukaryotic cells, DNA is replicated during the S phase of the cell cycle.
_____ 14. If the cell cycle is not regulated, cancer may develop.
_____ 15. Mitosis occurs in both prokaryotic and eukaryotic cells.
Critical Reading
Read these passages from the text and answer the questions that follow.

The Cell Cycle

Cell division is just one of several stages that a cell goes through during its lifetime. The cell cycle is a repeating
series of events, including growth, DNA synthesis, and cell division. The cell cycle in prokaryotes is quite
simple: the cell grows, its DNA replicates, and the cell divides. In eukaryotes, the cell cycle is more
complicated.

Eukaryotic Cell Cycle

The diagram in the figure below represents the cell cycle of a eukaryotic cell. As you can see, the eukaryotic
cell cycle has several phases. The mitosis phase (M) actually includes both mitosis and cytokinesis. This is
when the nucleus and then the cytoplasm divide. The other three phases (G1, S, and G2) are generally grouped
together as interphase. During interphase, the cell grows, performs routine life processes, and prepares to
divide. These phases are discussed below.

Eukaryotic Cell Cycle. This diagram represents the cell cycle

in eukaryotes. The G1, S, and G2 phases make up interphase
(I). The M (mitotic) phase includes mitosis and cytokinesis.
After the M phase, two cells result.

Interphase

Interphase of the eukaryotic cell cycle can be subdivided into

the following three phases, which are represented in the figure
above:

 Growth Phase 1 (G1): During this phase, the cell

grows rapidly, while performing routine metabolic
processes. It also makes proteins needed for DNA replication and copies some of its organelles in
preparation for cell division. A cell typically spends most of its life in this phase.
 Synthesis Phase (S): During this phase, the cell’s DNA is copied in the process of DNA replication.
 Growth Phase 2 (G2): During this phase, the cell makes final preparations to divide. For example, it
makes additional proteins and organelles.

Cancer and the Cell Cycle

Cancer is a disease that occurs when the cell cycle is no longer regulated. This may happen because a cell’s
DNA becomes damaged. Damage can occur because of exposure to hazards such as radiation or toxic
chemicals. Cancerous cells generally divide much faster than normal cells. They may form a mass of abnormal
cells called a tumor. The rapidly dividing cells take up nutrients and space that normal cells need. This can
damage tissues and organs and eventually lead to death.

Questions

1. What is the cell cycle?

2. What are the phases of the eukaryotic cell cycle?

3. In which phase does a cell spend most of its life? What happens during this phase?

4. What is cancer? What may cause cancer to occur?

5. What is the S phase? What happens during this phase?

Multiple Choice
Circle the letter of the correct choice.

1. Which cells undergo cell division?

a. prokaryotic cells only
b. eukaryotic cells only
c. cancer cells only
d. both prokaryotic and eukaryotic cells
2. Cell division in eukaryotic cells is a complex process because of
a. the multiple chromosomes.
b. the nucleus.
c. the many organelles.
d. all of the above
3. Most routine metabolic processes occur during which phase of the cell cycle?
a. growth phase 1
b. the S phase
c. growth phase 2
d. the M phase
4. The correct order of the eukaryotic cell cycle is
a. G1 → G2 → S → M.
b. S → G1 → G2 → M.
c. M → G1 → S → G2.
d. G1 → S → G2 → M.
5. The correct order of prokaryotic cell division is
a. cytokinesis → DNA replication → chromosome segregation.
b. DNA replication → chromosome segregation → cytokinesis.
c. growth → DNA replication → mitosis.
d. DNA replication→ mitosis → cytokinesis.
6. Which cell cycle checkpoint determines whether the DNA has been replicated correctly?
a. the cell growth checkpoint
b. the DNA synthesis checkpoint
c. the mitosis checkpoint
d. the G2 checkpoint
7. What happens during mitosis?
a. The nucleus of the cell divides.
b. The cytoplasm of the cell divides.
c. The cell divides.
d. The DNA replicates.
8. Cell division in prokaryotic cells is called
a. binary fission.
b. binary fusion.
c. mitosis.
d. cytokinesis.

Vocabulary I
Match the vocabulary word with the proper definition.
Terms
a. binary fission
b. cancer
c. cell cycle
Definitions

_____ 1. the process in which one cell divides to form two daughter cells
_____ 2. the process in which all of the nuclear DNA is copied
_____ 3. a repeating series of events that describes the life of a cell
_____ 4. phase of the cell cycle that includes the G1, S, and G2 phases
_____ 5. the process by which bacterial cells divide
_____ 6. phase of the cell cycle in which the cell's DNA is copied
_____ 7. occurs when the cell cycle is no longer regulated
_____ 8. phase of the cell cycle in which the cell grows rapidly and performs many metabolic processes
_____ 9. phase of the cell cycle in which the cell makes final preparations to divide.
_____ 10. division of the cytoplasm, resulting in two daughter cells
_____ 11. an abnormal mass of cells
_____ 12. the process in which the nucleus of the cell divides
Vocabulary II
Fill in the blank with the appropriate term.
1. Cancer is a disease that occurs when the ________________ is no longer regulated.
2. During ________________, the nucleus of the cell divides.
3. __________________ consists of the G1, S, and G2 phases of the cell cycle.
4. During the ________________ phase, the cell’s DNA is copied in the process of DNA replication.
5. Cell division in _________________ occurs by binary fission.
6. During mitosis, the ________________ are sorted and separated to ensure that each daughter cell receives a
complete set.
7. During cytokinesis, the _________________ divides.
8. ____________ in the cell cycle ensure that the cell is ready to proceed before it moves on to the next phase of
the cycle.
9. After cell division, the new cells are referred to as ____________ cells.
10. Chromosome ____________ refers to the two chromosomes separating and moving to opposite ends of the
cell.
11. In eukaryotes, the first step in cell division is ____________, and the second step is cytokinesis.
12. The cell cycle is controlled by regulatory _______________ at three key checkpoints.