Mannitol in Tablet Formulation
Uploaded by
Dharmesh PatelMannitol in Tablet Formulation
Uploaded by
Dharmesh PatelMannitol in Tablet Formulation
Mannitol as Excipient
Mannitol is an alcohol sugar and it is present in many plants and animals. It is
hexahedral alcohol widely used as an excipient in tablet formulation in pharmaceutical industries
Uses of Mannitol
Mannitol has many different uses as an excipient e.g
It is used as Plasticizer.
It is used as Diluent 10-90%
It is a sweetening agent.
Tonicity agent.
Parentally used as osmotic diuretics.
General properties of Mannitol
Mannitol gives laxative effect when it is used in large quantities.
It is non hygroscopic so mannitol is used in moisture-sensitive products.
It is also used in direct compression because of its spray-dried grade.
Processing time with mannitol is short because the drying time of mannitol is less. Mean when mannitol
is used as a diluent in wet granulation its drying time is short, it dry in a short period.
In Chewable Tablets
Mannitol has widely used excipient in chewable tablets because it gives a sweet taste and mouth-feel so
because of this effect it is used in chewable tablets.
Spray-dried Mannitol.
Mannitol is also available as spray-dried grade and spray dried grade is used in direct compression tablet
formulation.
Tablets produced with spray-dried grade give more hardness than powdered mannitol.
Spray-dried mannitol flow rate is better than powder mannitol.
Disintegration time of spray-dried mannitol is also short.
Powder mannitol has poor flow because it is in the form of fine powder. So when powder mannitol is
used as a diluent in wet granulation of tablet manufacturing, it should be used intra-granular. When
Mannitol is used in wet granulation it also reduces the drying time.
