Scribd
Upload
3K views

Pathophysio CRF2 - Revised

- The document describes the progression of end-stage renal disease, noting the reduction of renal capillaries and scarring of glomeruli leads to atrophy and fibrosis of renal tubules, impairing the kidneys' ability to filter waste from the blood. - As kidney function declines, nitrogenous wastes accumulate in the bloodstream, impairing platelets and decreasing erythropoietin production, which can cause anemia, bleeding tendencies, and pulmonary edema. - Later stages are characterized by edema, hypertension, heart failure, pericarditis, and decreased immune function, eventually leading to multiple organ failure and death if renal replacement therapy is not initiated.

Uploaded by

deborah malnegro
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
3K views

Pathophysio CRF2 - Revised

- The document describes the progression of end-stage renal disease, noting the reduction of renal capillaries and scarring of glomeruli leads to atrophy and fibrosis of renal tubules, impairing the kidneys' ability to filter waste from the blood. - As kidney function declines, nitrogenous wastes accumulate in the bloodstream, impairing platelets and decreasing erythropoietin production, which can cause anemia, bleeding tendencies, and pulmonary edema. - Later stages are characterized by edema, hypertension, heart failure, pericarditis, and decreased immune function, eventually leading to multiple organ failure and death if renal replacement therapy is not initiated.

Uploaded by

deborah malnegro
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
You are on page 1/ 1

- Reduction in renal

capillaries > 90 % of
-Scarring of Glomeruli kidney
- Atrophy & Fibrosis of damage
Renal tubules

Nitrogenous Decreased Toxins irritate Toxins impair Urea


Malfunction of wastes impairs Erythropoietin pericardial sac immune deposits
RAAS platelets Production system on the
skin
Continuous Pericarditis
Bleeding decline in Decreased
Na & H2O tendencies renal function Immune
system Uremic
retention Cardiac frost
Tamponade
ANEMIA -fatigue
- weakness Risk for
superinfection
Toxins
┼ affect
Decreased Increased Pulmonary Stage IV Sepsis CNS
Urine blood Edema Edema, END-STAGE RENAL
Output pressure Peripheral DISEASE
Edema (ESRD)
GFR <10%
Oliguria
Hypertension
Continuous Multisystem
Uremic
Affectation
┼ Encephalopathy

Multiple Organ Failure


Heart Failure -changes in
mentation/
psychiatric
DEATH symptoms
┼
-irritability
┼ -fatigue
-insomnia

You might also like