2023 Lecture 01
2023 Lecture 01
BB101 Biology
March – June 2023
Lecture 01
BB101 Biology
2
BB101 Biology
March – June 2023 BB101 Biology
Lecture 01
PERCEPTION
https://en.wikipedia.org/wiki/Darwin%27s_finches#/media/File:Darwin's_finches_by_Gould.jpg
8
BB101 Biology
March – June 2023
Lecture 01
Recording observations: now...
50 µm
10 µm
Fluorescence Confocal (without) Confocal (with)
10 µm
Deconvolution
PERCEPTION
Chandrayaan-2
2019-07-22, 14:23
Photo: ISRO
Chandrayaan-2
2019-07-22, 14:23
Photo: ISRO
CYTOSKELETON:
Microfilaments
Intermediate filaments
Microtubules
Ribosomes
Microvilli
Golgi apparatus
Peroxisome
Lysosome Figure 6.8 from
Mitochondrion Campbell’s Biology
15
BB101 Biology
Complex, self-regulated systems – rich vocabulary
March – June 2023
Lecture 01
Across the globe, Biology teaching has moved towards bringing out
(i) the beauty of life,
(ii) the benefits of understanding how they work,
(iii) challenges associated with the study, and
(iv) exploiting such a knowledge for a better living
16
BB101 Biology
March – June 2023 Busting myths
Lecture 01
PERCEPTION
www.finedininglovers.com/blog/food-drinks/list-of-herbs-and-spices/
18
BB101 Biology
Vaccines and repurposing drugs in record time...
March – June 2023
Lecture 01
https://onlinelibrary.wiley.com/doi/10.1002/prot.26250
19
BB101 Biology
March – June 2023
Lecture 01
Tracking development of every cell...
https://en.wikipedia.org/wiki/Caenorhabditis_elegans http://www.wormbook.org/chapters/www_organformation/organformation.html
20
BB101 Biology
March – June 2023
Lecture 01
Traditional Biology
§ Tardigrade is an invertebrate
§ Lives in temporary ponds Hydrated (normal) form
(~85% water)
§ When water evaporates...
• It shrinks to a dormant state
• It can stay dormant for a decade or more
§ When finds itself in water...
Dehydrated form
• becomes active within hours (< 2% water)
Order
Regulation
Evolutionary Reproduction
adaptation
Energy processing
Response
to the
Growth and environment
development
50 µm
10 µm
5. Organisms
3. Communities
8. Cells
10. Molecules
Field of vision: same
Depth of focus: variable 1 µm
9. Organelles
Niels Bohr
BIOLOGY
Edison
Computer Design
Science
Chemistry Energy
Science
BIOLOGY
Chemical Environmental
Engineering Science
Electrical
Engineering Civil
Materials Systems &
Control Engineering
Science
35
BB101 Biology
March – June 2023
Lecture 01
https://www.wisdomtimes.com/wp-content/uploads/2012/04/destructive-behaviour.jpg
39
BB101 Biology
Reverse engineering with invisible components?
March – June 2023
Lecture 01
Manual Manual
available available?
Hewlett - Packard
https://commons.wikimedia.org/wiki/File:CocaColaGlassBottle.jpg
DNA image – from Prof. Swati Patankar
41
BB101 Biology
March – June 2023 Flow of information from DNA, THE manual
Lecture 01
https://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology
42
BB101 Biology
March – June 2023 Human DNA manual is huge: ~3 billion bp
Lecture 01
25 kb per page
Human being
1500 pages per
3000 Mb
volume
80 volumes
(2 inches thick)
https://ib.bioninja.com.au/standard-level/topic-3-genetics/32-chromosomes/genome-size.html
44
BB101 Biology
March – June 2023 De-constructing biological systems
Lecture 01
AGCTTTTCATTCTGACTGCAACGGGCAATATGTCTCTGTGTGGATTAAAAAAAGAGTCTCT
GACAGCAGCTTCTGAACTGGTTACCTGCCGTGAGTAAATTAAAATTTTATTGACTTAGGTC
ACTAAATACTTTAACCAATATAGGCATAGCGCACAGACAGATAAAAATTACAGAGTACACA
ACATCCATGAAACGCATTAGCACCACCATTACCACCACCATCACCACCACCATCACCATTA
CCATTACCACAGGTAACGGTGCGGGCTGACGCGTACAGGAAACACAGAAAAAAGCCCGCAC
CTGACAGTGCGGGCTTTTTTTTCGACCAAAGGTAACGAGGTAACAACCATGCGAGTGTTGA
AGTTCGGCGGTACATCAGTGGCAAATGCAGAACGTTTTCTGCGGGTTGCCGATATTCTGGA
AAGCAATGCCAGGCAGGGGCAGGTGGCCACCGTCCTCTCTGCCCCCGCCAAAATCACCAAC
CACCTGGTGGCGATGATTGAAAAAACCATTAGCGGCCAGGATGCTTTACCCAATATCAGCG
ATGCCGAACGTATTTTTGCCGAACTTCTGACGGGACTCGCCGCCGCCCAGCCGGGATTCCC
GCTGGCGCAATTGAAAACTTTCGTCGACCAGGAATTTGCCCAAATAAAACATGTCCTGCAT
GGCATTAGTTTGTTAGGGCAGTGCCCGGATAGCATTAACGCTGCGCTGATTTGCCGTGGCG
CCATTATCTCGGTGGTAGGTGATGGTATGCGCACCTTGCGTGGGATCTCGGCGAAATTCTT
50
BB101 Biology
March – June 2023 Sequencing data looks like this…
Lecture 01
AGCTTTTCATTCTGACTGCAACGGGCAATATGTCTCTGTGTGGATTAAAAAAAGAGTCTCT
§ Are there words and paragraphs?
GACAGCAGCTTCTGAACTGGTTACCTGCCGTGAGTAAATTAAAATTTTATTGACTTAGGTC
ACTAAATACTTTAACCAATATAGGCATAGCGCACAGACAGATAAAAATTACAGAGTACACA
§ Is there punctuation?
ACATCCATGAAACGCATTAGCACCACCATTACCACCACCATCACCACCACCATCACCATTA
§ What do these data mean?
CCATTACCACAGGTAACGGTGCGGGCTGACGCGTACAGGAAACACAGAAAAAAGCCCGCAC
CTGACAGTGCGGGCTTTTTTTTCGACCAAAGGTAACGAGGTAACAACCATGCGAGTGTTGA
§ How to decode this information?
AGTTCGGCGGTACATCAGTGGCAAATGCAGAACGTTTTCTGCGGGTTGCCGATATTCTGGA
AAGCAATGCCAGGCAGGGGCAGGTGGCCACCGTCCTCTCTGCCCCCGCCAAAATCACCAAC
CACCTGGTGGCGATGATTGAAAAAACCATTAGCGGCCAGGATGCTTTACCCAATATCAGCG
§ What skills are required to decode this information?
ATGCCGAACGTATTTTTGCCGAACTTCTGACGGGACTCGCCGCCGCCCAGCCGGGATTCCC
§ Domain knowledge, computer programming,
GCTGGCGCAATTGAAAACTTTCGTCGACCAGGAATTTGCCCAAATAAAACATGTCCTGCAT
machine learning algorithms, ideas from natural
GGCATTAGTTTGTTAGGGCAGTGCCCGGATAGCATTAACGCTGCGCTGATTTGCCGTGGCG
language processing, ...
CCATTATCTCGGTGGTAGGTGATGGTATGCGCACCTTGCGTGGGATCTCGGCGAAATTCTT
51
BB101 Biology
March – June 2023 Differences in genomes
Lecture 01
https://ib.bioninja.com.au/standard-level/topic-3-genetics/35-genetic-modification-and/dna-profiling.html
58
BB101 Biology
March – June 2023 Paternity testing
Lecture 01
https://ib.bioninja.com.au/standard-level/topic-3-genetics/35-genetic-modification-and/dna-profiling.html
59
BB101 Biology
March – June 2023 Whose baby is it?
Lecture 01
https://twitter.com/purwarrahul2
62
BB101 Biology
March – June 2023 Point-of-care screening for sickle cell anemia
Lecture 01
https://www.bio.iitb.ac.in/~dpaul/research.html
63
BB101 Biology
March – June 2023
Lecture 01
64
BB101 Biology
March – June 2023
Lecture 01
Pearson publishers
Division D3 Division D4
Weekly lecture 1 of 2 Wednesday Tuesday
Venue: LA 201 11:05 am to 12:30 pm 2:00 to 3:25 pm
Weekly lecture 2 of 2 Friday Friday
Venue: LA 201 11:05 am to 12:30 pm 2:00 to 3:25 pm
Tutorial (one per week) Thursday Tuesday
Venue: in next slide 8:30 to 9:25 am 11:35 am to 12:30 pm
71
BB101 Biology
March – June 2023 Teaching Assistants
Lecture 01
72
BB101 Biology
March – June 2023 Course Instructors
Lecture 01
Division D3 Division D4
Chemical Engineering (CL) Aerospace Engineering (AE)
Computer Science and Eng. (CS) Civil Engineering (CE)
Mathematics (MA) Chemistry (CH)
Total 358 students Energy Science and Eng. (EN)
Total 338 students