Link: https://nida.nih.

gov/publications/research-reports/methamphetamine/how-
methamphetamine-manufactured

Summary:
Currently, most methamphetamine in the United States is produced by transnational
criminal organizations (TCOs) in Mexico.44 This methamphetamine is highly pure, potent,
and low in price. The drug can be easily made in small clandestine laboratories, with
relatively inexpensive over-the-counter ingredients such as pseudoephedrine, a common
ingredient in cold medications.
To curb production of methamphetamine, Congress passed the Combat Methamphetamine
Epidemic Act in 2005, which requires that pharmacies and other retail stores keep logs of
purchases of products containing pseudoephedrine and limits the amount of those products
an individual can purchase per day. Restrictions on the chemicals used to make
methamphetamine in the United States have dramatically reduced domestic production of
the drug. In 2010, there were 15,256 domestic methamphetamine laboratory incidents—a
figure that has fallen over 80 percent to 3,036 in 2017.44 Data on drug seizures indicate
that most domestic production of methamphetamine is now conducted in small laboratories
that make two ounces or less of the drug using common household items.44
Mexico has also tightened its restrictions on pseudoephedrine and other methamphetamine
precursor chemicals. But manufacturers adapt to these restrictions via small- or large-scale
"smurfing" operations: obtaining pseudoephedrine from multiple sources, below the legal
thresholds, using multiple false identifications. Manufacturers in Mexico are also
increasingly using a different production process (called P2P which stands for
pseudoephedrine’s precursor chemical, phenyl-2-propanone) to make methamphetamine
that does not require pseudoephedrine.
When methamphetamine is smuggled into the United States in powder or liquid form,
domestic conversion laboratories transform it into crystal methamphetamine. These
laboratories do not require a significant amount of equipment, so they can be small in size
and thus easily concealed, which presents challenges to law enforcement agencies.44
Methamphetamine pressed into a pill form intended to resemble ecstasy has also recently
emerged, potentially in an effort to make methamphetamine more appealing to people who
haven’t tried it before.44 As with other illicit drugs like heroin and cocaine,
methamphetamine is also sometimes laced with fentanyl.44
Methamphetamine production is also an environmental concern; it involves many easily
obtained chemicals that are hazardous, such as acetone, anhydrous ammonia (fertilizer),
ether, red phosphorus, and lithium. Toxicity from these chemicals can remain in the
environment around a methamphetamine production lab long after the lab has been shut
down, causing a wide range of damaging effects to health. Because of these dangers, the U.S.
Environmental Protection Agency has provided guidance on cleanup and remediation of
methamphetamine labs.
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Link: https://oxfordtreatment.com/substance-abuse/crystal-meth/how-its-made/

Summary: Many people are more familiar with the drug's street names, such as crystal
meth, meth, and glass.

This page will help you understand how meth is made, the meth ingredients that make it so
dangerous, and the risks of using meth which include crystal meth addiction.

What Is Meth Made Of? Meth's primary ingredients, ephedrine and pseudoephedrine, come
from over-the-counter cold medications and weight loss products.

Illicitly manufactured meth is usually made by combining ephedrine or pseudoephedrine

with other chemicals that are often poisonous or highly flammable.

Problems with skin abscesses, "Meth mouth", weight loss, and internal organ damage are all
the result of methamphetamine being taken in high doses and the impurities associated
with the process of producing meth.

Link: https://windwardway.com/substance-abuse/crystal-meth/how-its-made/

Summary: The meth manufacturing process is completely unstable, and those making meth
are often users themselves, thereby increasing the dangers of these haphazard home cooks.

How Is Meth Made in the U.S. and Who Is Making It? As mentioned, large-scale production of
meth is no longer a major problem in the U.S., as massive labs are now producing meth for
the U.S. market in Mexico.

Instead, the chemicals used to create meth are the sources of highly toxic additives or waste
products being "Left in" the final meth product.
Meth mouth - using meth decreases the amount of protective saliva in the mouth, and meth
users often grind their teeth, clench their jaw, and teeth begin to rot and fall out of the
mouth.

Treatment for meth use disorder must include learning coping skills through therapy with
skilled professionals.

Link: https://www.justice.gov/archive/ndic/pubs13/13853/product.htm

Summary: National Drug Intelligence CenterMethamphetamine Drug Threat

AssessmentMarch 2005UNCLASSIFIED Illegal methamphetamine production occurs in
countries throughout the world; however, only methamphetamine produced in the United
States, Mexico and, to a lesser extent, Southeast Asia is available in any significant quantity
in the United States.

There are no conclusive worldwide methamphetamine production estimates, nor are there
conclusive production estimates for the three principal methamphetamine source areas
that supply U.S. drug markets.

On February 7, 2004, agents from the Stanislaus Drug Enforcement Agency, California
Multijurisdictional Methamphetamine Enforcement Team, and Central Valley HIDTA
arrested five Mexican nationals and seized an operational methamphetamine laboratory
located in a residence in Modesto.

Foreign Production Law enforcement reporting and seizure data show that
methamphetamine produced in Mexico and Southeast Asia, as well as in Canada, is available
to varying degrees in U.S. drug markets; however, only Mexican methamphetamine is
smuggled into the United States in quantities adequate for national-level distribution.

Methamphetamine tablet production also has been reported in Malaysia and Fiji; however,
there are no estimates as to the amount of methamphetamine tablets produced in those
countries nor are there specific reports of methamphetamine tablets produced in Malaysia
or Fiji available in the United States.
Link:
https://www.emcdda.europa.eu/publications/eu-drug-markets/methamphetamine/main-
production-methods-europe_en

Summary: BMK has limited legitimate uses; in Europe it is mostly used to produce
amphetamine, and increasingly, for the production of methamphetamine.

The manufacture of methamphetamine requires additional production steps, the chemicals

required for which can provide more information on the trends and scale of
methamphetamine production in Europe.

These data confirm what has been found in illicit laboratories: that large quantities of
methamphetamine are being produced in Europe in industrial-scale laboratories, using
methods associated with Mexican methamphetamine producers.

As well as indicating the level of sophistication involved, bearing in mind that these
reagents are required in small amounts, the quantities seized provide further evidence of
the scale of methamphetamine production using BMK methods in Europe.

Until the advent of methamphetamine production based on BMK in the Netherlands and
Belgium, European production of methamphetamine was mostly based on ephedrine or
pseudoephedrine precursors; this is still the method typically found in small- to medium-
sized laboratories in Czechia and neighbouring countries and also involves the use of iodine
and red phosphorous.

Link: https://en.wikipedia.org/wiki/Methamphetamine

Summary: In the United States, methamphetamine hydrochloride, under the trade name
Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and
children; however, the FDA also indicates that the limited therapeutic usefulness of
methamphetamine should be weighed against the inherent risks associated with its use.

A systematic review and meta-analysis from 2019 assessed the efficacy of 17 different
pharmacotherapies used in RCTs for amphetamine and methamphetamine addiction; it
found only low-strength evidence that methylphenidate might reduce amphetamine or
methamphetamine self-administration.

At high doses, both enantiomers of methamphetamine can induce similar stereotypy and
methamphetamine psychosis, but levomethamphetamine has shorter psychodynamic
effects.

Methamphetamine is excreted by the kidneys, with the rate of excretion into the urine
heavily influenced by urinary pH. When taken orally, 30-54% of the dose is excreted in
urine as methamphetamine and 10-23% as amphetamine.

Harm reduction Methamphetamine and Native Americans Methamphetamine in Australia

Methamphetamine in Bangladesh Methamphetamine in the Philippines Methamphetamine
in the United States Montana Meth Project, a Montana-based organization aiming to reduce
meth use among teenagers.

Link: https://www.google.com/patents/US20120046432

Summary:

United States
Owner name: NIPPON SHOKUBAI CO., LTD., JAPAN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SUGIMOTO,
TAKASHI;REEL/FRAME:027142/0191
Effective date: 20111021
Free format text: PATENTED CASE
Year of fee payment: 4
Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL
EVENT CODE: M1552); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY
Year of fee payment: 8
Link: https://www.banyantreatmentcenter.com/2020/10/15/how-meth-is-made-stuart/

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Link: https://www.dodgecity.org/227/Methamphetamine-Production

Summary: Illicit manufacture of meth involves the process of combining multiple chemicals
to another substance to create methamphetamine.

The tablets containing pseudoephedrine are crushed, then the powder is dissolved and
mixed with various chemicals to create the reactions that convert the pseudoephedrine to
methamphetamine.

The process of combining these chemicals creates hazardous conditions, including a strong
risk of fire, explosion or toxic gases, as well as a substantial amount of hazardous chemical
waste.

There are a number of different "Recipes" or methods of producing methamphetamine, each

involving the use of various chemicals.
Suspicious Odors You should also be suspicious of strong chemical odors associated with
the process of making meth.

Link: https://dep.wv.gov/environmental-advocate/reap/ppod/Documents/Shake%20and
%20Bake%20Method.pdf

Summary: