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Key To Correction Part 2 and 3

This document compares the original and mutated DNA, RNA, protein sequences, and protein types of two gene sequences that underwent mutations. The first gene sequence experienced five point mutations - three missense mutations and two nonsense mutations. The second gene sequence underwent a four base pair deletion, resulting in a frame-shift mutation. The third gene sequence had a triple base pair insertion, also causing a frame-shift mutation. In total, the document scored 100/100 for correctly identifying the mutation types.

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sabilyn villaneuva
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32 views

Key To Correction Part 2 and 3

This document compares the original and mutated DNA, RNA, protein sequences, and protein types of two gene sequences that underwent mutations. The first gene sequence experienced five point mutations - three missense mutations and two nonsense mutations. The second gene sequence underwent a four base pair deletion, resulting in a frame-shift mutation. The third gene sequence had a triple base pair insertion, also causing a frame-shift mutation. In total, the document scored 100/100 for correctly identifying the mutation types.

Uploaded by

sabilyn villaneuva
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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1 2 3 4 5 6 7 8 9 10 11 12

Original DNA AAA TGA ACG AAA 1 pt ATA TGT TCG CTT 1 pt CAT TCA TTG GTA 1 pt
Original RNA UUU ACU UGC UUU 1 pt UAU ACA AGC GAA 1 pt GUA AGU AAC CAU 1 pt
Protein Phe Thr Cys Phe 1 pt Tyr Thr Ser Glu 1 pt Val Ser Asn His 1 pt
Type NP P P NP 1 pt P P P A 1 pt NP P P B 1 pt

13 14 15 16 17 18 19 20
CAC AAT CCT AGG 1 pt CTA CCC CGA ATT 1 pt
GUG UUA GGA UCC 1 pt GAU GGG GCU UAA 1 pt
Val Leu Gly Ser 1 pt Asp Gly Ala Stop 1 pt
NP NP NP P 1 pt A NP NP Stop 1 pt

1 2 3 4 5 6 7 8 9 10 11 12
Mutated DNA AAG TCA ACG ACC 1 pt ATA TGA TCG CAT 1 pt CAT TTA GTG CTT 1 pt
Mutated RNA UUC AGU UGC UGG 1 pt UAU ACU AGC GUA 1 pt GUA AAU CAC GAA 1 pt
Protein Phe Ser Cys Trp 1 pt Tyr Thr Ser Val 1 pt Val Asn His Glu 1 pt
Type NP P P NP 1 pt P P P NP 1 pt NP P B A 1 pt

13 14 15 16 17 18 19 20
CAA AAT ACT AGG 1 pt CTA CCC CGA ATT 1 pt
GUU UUA UGA UCC 1 pt GAU GGG GCU UAA 1 pt
Val Leu Stop 1 pt 1 pt
NP NP Stop 1 pt 1 pt

Codon 1 – Point, Missense, Silent Mutation


Codon 2 – Point, Missense, Conservative Mutation
Codon 4 – Point, Missense, Conservative Mutation
Codon 6 – Point, Missense, Silent Mutation
Codon 8 – Point, Missense, Non-Conservative Mutation
Point Mutation
Total = 60/60
Codon 10 – Point, Missense, Conservative Mutation
Codon 11 – Point, Missense, Non-Conservative Mutation
Codon 12 – Point, Missense, Non-Conservative Mutation
Codon 13 – Point, Missense, Silent Mutation
Codon 15 – Point, Nonsense Mutation

Note: 2 points each Mutation (1 point for Codon Number, 1 point for complete name of mutation)
Original DNA ATG CCA TGC GAT 1 pt TAC GAG TCG ACG 1 pt
Original RNA UAC GGU ACG CUA 1 pt AUG CUC AGC UGC 1 pt
Name of Protein Tyr Gly Thr Leu 1 pt Met Leu Ser Cys 1 pt
Type of Protein P NP P NP 1 pt NP NP P P 1 pt

Mutated DNA ATG CCA TGC GAT 1 pt ACG AGT CGA CG 1 pt


Mutated RNA UAC GGU ACG CUA 1 pt UGC UCA GCU GC 1 pt
Name of Protein Tyr Gly Thr Leu 1 pt Cys Ser Ala 1 pt
Type of Protein P NP P NP 1 pt P P NP 1 pt
Frame-Shift, Deletion Mutation (4points)

Original DNA CGA TTA GCC TAG 1 pt CAT GCG GTC 1 pt


Original RNA GCU AAU CGG AUC 1 pt GUA CGC CAG 1 pt
Name of Protein Ala Asn Arg Ile 1 pt Val Arg Gln 1 pt
Type of Protein NP P B NP 1 pt NP B P 1 pt

Mutated DNA CGA TTA GGC CAT 1 pt AGC ATG TCG GTC 1 pt
Mutated RNA GCU AAU CCG GUA 1 pt UCG UAC AGC CAG 1 pt
Name of Protein Ala Asn Pro Val 1 pt Ser Tyr Ser Gln 1 pt
Type of Protein NP P P NP 1 pt NP P P P 1 pt
Frame-Shift, Triple Insertion Mutation (4points)

Frame-Shift Mutation
Total = 40/40

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