Midterm
Midterm
Skin Color Scalp hairs – grow for 3 years; rest for 1 – 2 years
Melanin – pigments responsible for skin, hair, eye color
Arrector Pili – smooth muscles; contraction = hair to
Melanin pigments – yellow (Caucasian), brown stand on end; produces goose bumps
(Asians), black (African)
M o r a n o , M . A .
Glands
I. Sebaceous Glands 3. Vitamin D Production
§ Simple, branched acinar glands § Skin exposed to UV light produces
§ Connected by a duct to the superficial part of cholecalciferol (modified in the liver, then in the
the hair follicle kidneys to produce active vitamin D)
§ Sebum – oily, white substance rich in lipids; § Best sources of Vit. D = fatty fish, vit. D
released by holocrine secretion; lubricates the fortified milk
hair/surface of the skin (prevents drying and § Small amounts of Vit D = eggs, butter, liver
protects against bacteria) § Active Vit. D stimulates the small intestine to
absorb calcium and phosphate (normal bone
II. Sweat Glands growth, normal muscle function)
a. Eccrine Sweat Glands
Ø Simple, coiled, tubular glands 4. Temperature Regulation
Ø Release sweat by melocrine § Normal body temp. = 37oC (98.6 oF)
secretion § Rate of chemical rxns within the body can
Ø Numerous in the palms and soles increased of decreased based on the body temp.
b. Apocrine Sweat Glands § Factors that raise body temperature
Ø Simple, coiled, tubular glands Ø Exercise
Ø Produce a think secretion rich in Ø Fever
organic substances Ø Increase in environmental
Ø Released primary by melocrine temperature
secretion; some glands demonstrate § The skin controls heat loss from the body
holocrine secretion through dilation and constriction of blood
Ø Open into hair follicles, in armpits vessels
and genitalia § Sweat glands produce sweat, which evaporates
Ø Become active at puberty and lowers body temperature
§ Heat is lost by radiation (infrared energy),
III. Other Glands convection (air movement), conduction (direct
a. Ceruminous glands – cerumen (earwax) contact)
b. Mammary glands – milk
5. Excretion
Nails § Skin glands remove water and salt
§ Dead stratum corneum cells § Also removes small amounts of urea, uric acid,
§ Contain a very hard type of keratin ammonia
M o r a n o , M . A .
a. First-degree burns II. Squamous cell carcinoma
Ø Epidermis § Immediately superficial to the s. basale
Ø Red and painful § Cells continue to divide as they produce keratin
Ø Slight edema (swelling) = nodular, keratinized tumor confined to the
epidermis
b. Second-degree burns § Can invade the dermis, metastasize, and cause
Ø Epidermis, dermis death
Ø Epidermis regenerates from the
epithelial tissue III. Malignant melanoma
Ø Dermal damage is minimal; § Rare form of skin cancer that arises from
v Redness, pain, edema, blisters melanocytes; usually from a pre-existing mole
v Healing = 2 weeks § Mole – an aggregation or nest of melanocytes
v No scarring § Large, flat, spreading lesion or deeply
Ø Deep into the dermis pigmented nodule
v Red, tan, or white § Metastasis is common
v Takes several months to heal § Often fatal
v Might scar
FX of Aging on the Integumentary S.
II. Full-thickness Burns § Epidermis thins
a. Third-degree burns § Amount of collagen in the dermis decreases
Ø Epidermis, dermis, and underlying § Skin infections are most likely
tissues are completely destroyed § Repair of skin occurs slower
Ø Recovery occurs from the edges of § Decrease no. of elastic fibers in the dermis and
the burn wound loss of fat (sagging of skin, wrinkles)
Ø Region of the 3rd degree burn is § Decrease of activity of sweat glands = reduced
painless (sensory receptors have ability to regulate body temp.
been destroyed) § Decrease sebaceous gland activity = skin
Ø White, tan, brown, black, deep becomes drier
cherry red § Decrease no. of melanocytes
Ø Take a long time to heal § Some areas, the no. of melanocytes increase =
Ø Form scar tissue age spots
Ø Skin grafts are used to prevent § Increased melanin production = freckles; also,
complications and to speed healing gray/white hair
§ Skin that is exposed to sunlight = shows signs of
Skin Cancer aging more rapidly
§ Most common type of cancer
§ Exposure to UV light from the sun
§ Usually on face, neck, hands
§ Most like to have skin cancer = fair skinned or
older than 50
§ Limiting exposure to sun, using sunscreen;
reduces the likelihood of developing skin cancer
§ Ultraviolet light
Ø UVA
v Longer wavelength
v Causes most tanning of the skin
v Development of malignant
melanoma
Ø UVB
v Most burning of the skin
v Development of basal cell and
squamous cell carcinoma
M o r a n o , M . A .
Actin and Myosin Myofilaments
MUSCULAR SYSTEM Troponin molecules – binding sites for Ca2+; attached at
Functions (M2RPC3) specific intervals along the actin myofilaments
1. Movement of the body.
2. Maintenance of posture. Tropomyosin filaments – cover the attachment sites on
3. Respiration the actin myofilaments; located along the grove bet. the
4. Production of body heat twisted strands of actin myofilaments
5. Communication
6. Constriction of organs and vessels Myosin heads – resemble golf club heads;
7. Contraction of the heart Ø Bind to attachment sites
Ø Bend and straighten
Characteristics of the Skeletal Muscle Ø Break down ATP
Skeletal Muscle
§ Constitutes approx. 40% of body weight Sarcomere
§ Muscles are attached to the skeletal system § Basic structural and functional unit of skeletal
§ Also called Striated Muscle; transverse bands or muscle
striations
Z disk – network of protein fibers forming an
Major Functional Characteristics of Skeletal Muscle attachment site for actin myofilaments
1. Contractility – ability to shorten with force
2. Excitability – capacity to respond to a stimulus I band – consists of actin myofilaments; spans each Z
3. Extensibility – ability to be stretched to their disk
normal resting length
4. Elasticity – ability to recoil to their original A band – darker, central region that extends the length
resting length of the myosin of myofilaments
Skeletal Muscle Structure H zone – second light zone that consists of myosin
Connective Tissue Coverings of Muscle myofilaments
Epimysium/Muscular fascia – connective tissue sheath
that surrounds a skeletal muscle M line – dark-staining bands
Muscle fasciculi – numerous visible bundles that make The arrangement of the actin and myosin filaments in
up the muscle sacromeres gives the myofibrils a banded appearance.
Perimysium – loose connective tissue that surrounds the The alternating I bands and A bands of the sacromeres
muscle fasciculi are responsible for the striations in the skeletal muscle
fibers.
Muscle fibers – several muscle cells that composes a
fasciculus Excitability of Muscle Fibers
Resting membrane potential – cell membranes have a
Endomysium – loose connective tissue that surrounds a negative charge on the inside relative to a positive
muscle fiber charge outside; occurs bcos there is an uneven
distribution of ions
Muscle Fiber Structure 1. Concentration of K+ inside the cell CM >
Sarcolemma – cell membrane of the muscle fiber outside the CM
2. Concentration of Na+ outside the CM > inside
Transverse tubules (T tubules) – tube-like invaginations the CM
w/c occur at regular intervals along the muscle fiber
Different types of Ion Channels
Sarcoplasmic reticulum – highly organized smooth E.R.; Ø Nongated/Leak channels – always open
has a relatively high concentration of Ca2+ (muscle
contraction) Ø Chemically gated channels – closed until a
chemical binds them and stimulates them to
Sarcoplasm – cytoplasm of a muscle fiber open
Myofibrils – threadlike structures composed of: Depolarization – the inside of the CM membrane comes
Ø Actin Myofilaments (thin filaments; purple) more positive than the outside of the cell; Na+ ions
Ø Myosin Myofilaments (thick filaments; green) move into cells
Sarcomere – highly ordered, repeating units of actin + Repolarization – the change back to the resting
myosin myofilaments; joined end to end to form the membrane potential; K+ ions moves out of cells
myofibril
Action Potentials – the rapid depolarization and
repolarization of the CM; results in muscle contraction
M o r a n o , M . A .
Nerve Supply Aerobic Respiration – requires O2; breaks down glucose
Motor neurons – specialized nerve cells that stimulate to produce ATP, CO2, H2O
muscles to contract
Anaerobic respiration – doesn’t require O2; breaks
Neuromuscular junction – a branch that forms a down glucose to yield ATP and lactic acid
junction with a muscle fiber
Creatine phosphate – high-energy molecule that can be
Synapse – cell-to-cell junction bet. a nerve cell and stored in muscle fibers
another nerve cell/effector cell
Fatigue
Motor unit – a single motor neuron and all the skeletal § A state of reduced work capacity
muscle fibers it innervates
Muscular Fatigue – when muscle fibers use ATP faster
Presynaptic terminal – enlarged axon terminal than they are produced; when the effectiveness of Ca+ to
stimulate actin + myosin is reduced
Synaptic cleft – the space bet. the presynaptic terminal
and the muscle fiber membrane Physiological contracture – muscles may become
incapable of either contracting or relaxing
Postsynaptic membrane – the muscle fiber membrane
Psychological fatigue – involves the CNS; an individual
Synaptic vesicles – presynaptic terminal that contains perceives that continued muscle contraction is
small vesicles impossible
M o r a n o , M . A .
Intercalated disks – specialized structures that facilitate Depressor anguli oris – frowning & pouting; depresses
action potential conduction bet. cells the corner of the mouth
Belly – part of the muscle bet. the origin & the insertion Hyoid muscles – hold the hyoid bone; elevate the larynx
Agonist – muscle that accomplishes a certain movement Pharyngeal elevators – elevate the pharynx
Antagonist – muscle acting in opposition to an agonist Pharyngeal constrictors – constrict the pharynx from
superior to inferior (forcing food into the esophagus);
Synergists – a group of muscles working together to also open the auditory tube
produce a movement
Neck Muscles
Prime Mover – muscle that plays the major role in Sternocleidomastoid – prime mover of the lateral
accomplishing desired movement muscle group; rotates the head; flexes the neck or
extends the head; prayer muscle
Fixators – muscles that hold one bone in place relative to
the body Torticollis – wryneck; injury to the sternocleidomastoid
M o r a n o , M . A .
External/Internal abdominal oblique & Transversus Wrist and Finger Movements
abdominis – flex and rotate the vertebral column or Retinaculum – fibrous connective tissue that covers the
compress the abdominal contents flexor & extensor tendons and holds them in place
around the wrist
Pelvic Floor and Perineal Muscles
Pelvic Floor – pelvic diaphragm Flexor carpi – flex the wrist
Levator ani – muscle that forms the pelvic floor Extensor carpi – extend the wrist
Perineum – associated with the male/female Flexor digitorum – flexor of the digits/fingers
reproductive structures
Extensor digitorum – extension of the fingers
Perineum bulbospongiosus – constricts the urethra;
erects the penis, clitoris Intrinsic hand muscles – 19 muscles located within the
hand
Perineum ischiocavernosus – compresses the base of
penis/clitoris Interossei – responsible for abduction and adduction of
the fingers
Perineum external anal sphincter – keeps the orifice of
the anal canal closed Tennis elbow – inflammation and pain due to forceful,
repeated contraction of the wrist extensor muscles
III. Upper Limb Muscles
Scapular Movements Palmus longus – tightens palm skin
§ Attach the scapula to the thorax and move the
scapula IV. Lower Limb Muscles
§ Acts as fixators to hold the scapula firmly in Thigh Movements
position when the muscle of the arm contract Iliopsoas – flexes the hip
§ Move the scapula into different positions
v Trapezius Tensor fasciae latae – helps steady the femur on the tibi
v Levator scapulae when a person is standing
v Rhomboids
Gluteus maximus – extends the hip; adducts and
v Serratus anterior
laterally rottes the thigh; contributes most of the mass
v Pectoralis minor
Gluteus medius – extends the hop when the thigh is
Arm Movements flexed at a 45O angle; common site for injections in the
Pectoralis major – adducts the arm and flexes the buttocks (sciatic nerve lies deep to the g. maximus)
shoulder; extend the shoulder from a flexed position
Leg Movements
Latissimus dorsi – swimmer’s muscle; medially rotates
Quadriceps femoris – primary extensors of the knee
and adducts the arm and powerfully extends the
shoulder Sartorius – tailor’s muscle; longest muscle in the body;
flexes the hip and knee; rotates the thigh laterally for
Rotator cuff muscles – attached the humerus to the sitting cross legged
scapula and forms a cuff/cap over the proximal
humerus
Hamstring muscles – flexing the knee
Deltoid – attaches the humerus to the scapula and Adductor muscles – adducting the thigh
clavicle; major abductor of the upper limb
Ankle and Toe Movements
Forearm Movements
Gastrocnemius & Soleus – form the bulge of the calf
Triceps brachii – primary extensor of the elbow
Calcaneal tendon – Achilles tendon; flexors and are
Biceps brachii & brachialis – primary flexors of the involved in plantar flexion of the foot
elbow
Fibularis muscles – primary everters of the foot; aid in
Brachioradialis – posterior forearm muscle; helps flex
plantar flexion
the elbow
Intrinsic foot muscles – flex, extend, abduct, and adduct
Supination and Pronation the toes
Supinator – supination of the forearm or turning the
flexed forearm so that the palm is up Extensor digitorum longus – extends 4 lateral toes,
everts foot
Pronator – pronation, turning other forearm so that the
palm is down
M o r a n o , M . A .
Extensor halluces longus – extends great toe; inverts
foot
M o r a n o , M . A .
Cells of the Nervous System
Nervous System Neurons
Functions (CRIME) § Also called nerve cells
1. Controlling muscles and glands. § Receive stimuli, conduct action potentials,
2. Receiving sensory input. transmit signals
3. Integrating information.
4. Maintaining homeostasis. Cell body – contains a single nucleus; source of
5. Establishing and maintaining mental activity. information for gene expression n
Divisions of the Nervous System Dendrites – extensions of the cell body; receive
I. Central Nervous System information from other neurons; transmit the info
§ Brain and spinal cord toward the neuron cell body
II. Peripheral Nervous System Axon – single long cell process; conduct action
§ Nerves and ganglia potentials from one part of the brain or spinal cord to
a. Sensory Division – afferent (toward) another part
division; conducts action potentials Ø Axon of sensory neurons – conduct action
from sensory receptors to the CNS potentials towards the CNS
• Sensory neurons – neurons Ø Axon of motor neurons – conduct action
that transmit action potentials potentials away from the CNS
from the periphery to the CNS
Axon hillock – where the axon leaves the neuron cell
i. Somatic Sensory Fibers – carry body
info from stimuli coming from
the skin, skeletal, muscles, Nissl bodies – rough ER found in the cell body of a
joints neuron
ii. Visceral Sensory Fibers – Schwann cells – form a myelin sheath (increases speed
transmits impulses coming from of impulse transmission)
the visceral organs
Collateral axons – branches of axons
b. Motor Division – efferent (away)
division; conducts action potentials Types of Neurons
from the CNS to effector organs 1. Multipolar neurons – many dendrites + a single
• Motor neurons – neurons that axon
transmit action potentials
from the CNS toward the 2. Bipolar neurons – two processes: 1 dendrite + 1
periphery axon
M o r a n o , M . A .
4 – 5. Oligodendrocytes (CNS) and Schwann cells Electrical Signals and Neural Pathways
(PNS) – provide an insulating material that Resting Membrane Potential
surrounds axons Polarized cell membrane – uneven distribution of
charge
Neural Signaling
§ Communication among neurons Resting membrane potential – uneven charge
distribution in an unstimulated/resting cell; polarized
1. Reception – stimuli received by visual receptors Ø Higher concentration of K+ inside CM
in the eye Ø Higher concentration of Na+ outside CM
Ø Greater permeability of CM to K+ than to Na+
2. Transmission – sensory neurons transmit info to
CNS Leak channels – always open
3. Integration – info given is interpreted and an Gated channels – closed until opened by specific signals
appropriate response is determined
Chemically gated channels – opened by
4. Transmission – the CNS transmits info to motor neurotransmitters
neurons
Voltage gated channels – opened by a change in
5. Actual response – muscle/glands receive info membrane potential
and instruction from motor neurons
Sodium potassium pump – required to maintain the
Myelin Sheaths greater concentration of Na+ outside the CM and K+
§ Highly specialized insulating layer of cells inside
Nodes of Ranvier – gaps in the myelin sheath; where Depolarization – a change that causes the inside of the
ion movement can occur CM to become positive
M o r a n o , M . A .
Neurotransmitters – chemical messengers
Reflexes
Reflex – an involuntary reaction in response to a
stimulus applied to the periphery and transmitted to the
CNS
Neuronal Pathways
Converging pathway – two or more neurons synapse
with the same neuron
M o r a n o , M . A .
Spinothalamic tract – transmits pain, light touch, and
Spinal cord deep pressure
§ Extends from the foramen magnum to the 2nd
lumbar vertebra Dorsal column – transmission of proprioception, touch,
§ Provides a two-way conduction pathway to and deep pressure, vibration
from the brain
Spinocerebellar tracts – proprioception to cerebellum
Cauda equina – inferior end of the SC; spinal nerves
exiting there resemble a horse’s tail Descending Tracts
§ Pathways that carry impulses from the brain to
2 Main Functions the periphery
1. Transmits info to and from the brain.
2. Controls many reflex activities of the body. Lateral corticospinal – muscle tone and skilled
movements (hand)
White Matter of the SC
1. Dorsal (posterior) Anterior corticospinal – muscle tone and movement of
2. Ventral (anterior) trunk muscles
3. Lateral Columns
a. Ascending tracts – conduct action Rubrospinal – movement coordination
potentials toward the brain
b. Descending tracts – conduct action Reticulospinal – posture adjustment
potentials away from the brain
Vestibulospinal – posture & balance
Gray Matter of the SC (shaped like the letter H)
1. Posterior horns Tectospinal – movement in response to visual reflexes
2. Anterior horns
3. Small lateral horns Cranial Nerves
§ Transmit info to the brain form the sensory
Central canal – fluid filled space in the center of the cord receptors
§ 12 pairs
Ventral root – formed by ventral rootlets;
Name Specific Function
Dorsal root – formed by dorsal rootlets I. Olfactory S S: smell
II. Optic S S: vision
Dorsal root ganglion – ganglion in a dorsal root M: 4-6 extrinsic eye
III. Oculomotor M muscles; P: constricts
Relfex Action pupils
§ Predictable, automatic response to a specific IV. Trochlear M M: 1 extrinsic eye muscle
stimulus S: face + teeth; M: muscles
V. Trigeminal B
of mastification
1. Reception of the stimulus. VI. Abducens M M: 1 extrinsic eye muscle
2. Transmission of info to the CNS. S: taste; M: facial muscles;
3. Integration (interpretation and determination of VII. Facial B
P: salivary + tear glands
an appropriate response). Acoustic /
4. Transmission of info from the CNS to a muscle. VIII. Vestibulococh- S S: hearing + balance
5. Actual response. lear
S: taste + touch to back of
Spinal Cord Reflexes Glossopharyng
IX. B tongue; M: pharyngeal
Knee-Jerk Reflex -eal
muscles; P: salivary glands
Stretch flex – simplest reflex; muscles contract in S: pharynx, larynx, viscera;
response to a stretching force applied to them M: palate, pharynx, larynx;
X. Vagus B
P: viscera of thorax +
Knee-jerk reflex – patellar reflex; used to determine if abdomen
the higher CNS centers that normally influence this M: 2 neck + upper back
reflex are functional XI. Accessory M
muscles
XII. Hypoglossal M M: tongue muscles
Withdrawal Reflex
Withdrawal Reflex – flexor reflex; to remove a limb Spinal Nerves
from a painful stimulus
§ Arise along the spinal cord; contains mixed
nerves
Ascending Tracts
§ 31 pairs
§ Pathways that carry impulses form the
periphery to various parts of the brain v 8 Cervical
v 12 Thoracic
v 5 Lumbar
M o r a n o , M . A .
v 5 Sacral Autonomic Nervous System
v 1 Coccygeal § Preganglionic neuron
§ Postganglionic neuron
Mixed nerves – contains both sensory and somatic § Maintain internal homeostasis
motor neurons
Autonomic ganglia – where preganglionic neurons
Plexuses – where nerves come together and then synapse with postganglionic neurons
separate
Ø Cervical plexus I. Sympathetic ANS
Ø Brachial plexus § ‘Fight-or-flight’
Ø Lumbosacral plexus § Prepares the body for action
§ Most active during stressful situations
Cervical Plexus § Norepinephrine (main neurotransmitter)
§ Originates from spinal nerves C1 to C4
II. Parasympathetic ANS
Phrenic nerve – most important branc of the CP; § Activities result in conserving and restoring
innervates the diaphragm (responsible for our ability to energy
breathe) § Helps return the body to resting conditions
§ Active during periods of calm and rest
Brachial Plexus § PS fibers are in the vagus nerve
§ Originates from the spinal nerves C5 to T1
Autonomic Neurotransmitters
1. Axillary nerve – innervates 2 shoulder muscles Acetylcholine – neurotransmitters of the
+ the skin over part of it parasympathetic division
2. Median nerve – innervates the anterior forearm Norepinephrine – postganglionic neurons of the
and intrinsic muscles sympathetic division
3. Radial nerve – innervates all the muscles in the Functions of the Autonomic Nervous System
posterior arm and forearm + skin over the Sympathetic Division
posterior surface of the arm, forearm, hand § Prepares a person for action by increasing HR,
BP, respiration, release of glucose
4. Musculocutaneous nerve – innervates the
anterior muscles of the arm + skin over the Parasympathetic Division
radial surface of the forearm § Involuntary activities at rest: digestion of food,
defecation, urination
5. Ulnar nerve – innervates most of the anterior
forearm muscles and some of the intrinsic hand Enteric Nervous System
muscles + skin over the radial side of the hand
§ Consists of plexus within the wall of the
digestive tract
Lumbosacral Plexus
§ Originates from spinal nerves L1 to S4 1. Sensory neurons – connect the digestive tract to
the CNS
1. Obturator nerve – innervates the muscles of the 2. Sympathetic & parasympathetic neurons –
medial thigh + skin over it connect the CNS to the digestive tract
3. Enteric neurons – located entirely within enteric
2. Femoral nerve – innervates the anterior thigh plexus
muscles + skin over it & medial side of the leg
v Capable of monitoring and controlling
the digestive tract independently of the
3. Tibial nerve – innervates the posterior thigh
CNS
muscles, the anterior & posterior leg muscles,
most of the intrinsic foot muscles + skin over the
sole of the foot
M o r a n o , M . A .
2. Epithalamus
Brain § Smallest area superior + posterior to the
§ Soft, wrinkled mass of tissue that is highly thalamus
complex and adaptive; 3 pounds § Consists of few small nuclei (emotional and
§ 25 billion neurons visceral response to odors) + pineal gland
§ Requires a continuous supply of oxygen and
glucose Pineal gland – an endocrine gland that may influence
the onset of puberty; role in controlling some long term
I. Brainstem cycles
§ Connects the spinal cord to the remainder of the
brain 3. Hypothalamus
§ Controls the heart rate, blood pressure, and § Most inferior part
breathing § Consists of several small nuclei; maintaining
§ Damage can cause death homeostasis
§ Control of body temp., hunger, and thirst
1. Medulla Oblongata § Sensations such as sexual pleasure, rage, fear,
§ Most inferior portion of the brainstem and relaxation
§ Important reflex actions like vomiting, sneezing,
coughing, swallowing Important Homeostatic Mechanisms
§ Gray matter consists of various nuclei that serve 1. Control center of the ANS.
as vital centers 2. The link bet. the nervous and endocrine
systems.
v Cardiac centers – control HR
3. Helps maintain fluid balance.
v Vasomotor centers – regulates BP bu
controlling blood vessel diameter v Anti-diuretic hormone (ADH) –
regulates water excretion by the kidneys
v Respiratory centers – initiates and
4. Regulates body temperature.
regulates breathing
5. Regulates food intake (appetite and satiety
§ Pyramids – two prominent enalargements centers).
6. Regulates sleep-wake cycles.
2. Pons (bridge) 7. Influences sexual behavior and emotional
§ Relay information bet. the cerebrum and the aspects of sensory input.
cerebellum
§ Resembles an arched footbridge Infundibulum – controlling the secretion of hormones
§ Regulates respiration, swallowing, sleep from the pituitary gland
M o r a n o , M . A .
4 Lobes Right and Left Hemispheres
1. Frontal Lobe Right hemisphere – three dimensional or spatial
§ Control of voluntary motor functions, perception, musical ability
motivation, aggression, mood, olfactory
reception Left Hemisphere – analytical hemisphere; mathematics
§ Primary motor area: consciously move our and speech
skeletal muscles
§ Broca’s area – speech center Memory
§ Prefrontal area – reposible for executive Working memory – stores info required for the
functions immediate performance of a task; 7 digit phone no.
M o r a n o , M . A .
v Subarachnoid space – bet. the Aphasia – absent/defective speech/language
arachnoid and pia matter comprehension
Lateral ventricle – relatively large cavity in each cerebral Brain waves – wave like patterns
hemisphere
Alpha waves – awake but in a quiet, resting state with
Third ventricle – a smaller, midline cavity eyes close
Fourth ventricle – located at the base of the cerebellum Beta waves – occur during intense mental activity
Cerebral aqueduct – a narrow canal that connects the 3rd Delta waves – occur during deep sleep in infants and in
and 4th ventricle patients
Choroid plexus – produces CSF; specialized structures Effects of Aging on the Nervous System
made of ependymal cells § Motor functions decline
§ Mental functions (memory) decline
Arachnoid villi – structures that project from the
arachnoid layer; where blood is reabsorbed
Motor Functions
Involuntary movements – occur without a conscious
thought
Speech
Sensory speech area – Wernicke area; a portion of the
parietal lobe
M o r a n o , M . A .
2. Deep/Visceral Pain – diffuse; action potentials
SENSES are propagated more slowly
§ Ability to perceive stimuli
Local anesthesia – injected near a sensory
Sensation/Perception – conscious awareness of stimuli receptor/nerve resulting in reduced pain
received
General anesthesia – loss of consciousness is produced;
affects reticular formation
GENERAL SENSES Gate control theory – inhibits action potentials carried
§ Have receptors distributed over the body
to the brain by the spinothalamic tract
§ Senses for touch, pressure, pain, temp.,
vibration, itch, proprioception Referred Pain
§ Originate in a region of the body that is not the
1. Somatic Senses – provide sensory info about the
source of the pain stimulus
body and the environment
§ Clinically useful in diagnosing the actual cause
2. Visceral Senses – provide info about various of the painful stimulus
internal organs (pain & pressure) § Occurs bcos the sensory neurons (from the
superficial area) to which the pain is referred,
Transduction – a receptor absorbs energy from stimulus and the neurons (from the deeper, visceral area)
where the pain stimulation originates, converge
Sensory Receptors – sensory nerve endings capable of onto the same ascending neurons in the spinal
responding to stimuli by developing action potentials cord; thus the brain can’t distinguish
12. Pacinian corpuscles – deepest receptors; deep Adaptation – feedback + temporary decreased
pressure, vibration, position sensitivity
Pain
§ Unpleasant perceptual and emotional TASTE
experiences Taste buds – detect taste stimuli
1. Superficial Pain – localized; rapidly conducted Papillae – enlargements on the surfaced of the tongue
action potentials
M o r a n o , M . A .
Taste cells – 40 specialized epithelial cells Ø Medial rectus – turns eye inward
v Oblique muscles – two muscles to the long axis;
Taste hairs – hair-like processes superior and inferior
Ø Superior oblique – rotates counterclock
Taste pore – tiny opening in the surrounding stratified Ø Inferior oblique – rotates clockwise
epithelium
Anatomy of the Eye
Taste sensations Eyeball – hollow, fluid-filled sphere
1. Sour
2. Salty Tunics – 3 layered wall of the eye
3. Bitter v Fibrous tunic – sclera + cornea
4. Sweet Ø Sclera – firm, white, outer connective
5. Umami (savory) tissue; maintains the shape of the eye
Ø Cornea – transparent, permits light to
Neuronal Pathways for Taste
enter; refracts the entering light;
1. Facial Nerve (7) – transmits taste sensations
‘window of the eye’
from the anterior of the tongue
2. Glossopharyngeal nerve (9) – carries taste v Vascular tunic – contains most of the blood
vessels of the eye
sensations from the posterior of the tongue
Ø Choroid – thin structure that consists of
3. Vagus nerve (10) – carries some taste sensations melanin containing pigment cells
form the root of the tongue (causing black appearance); absorbs
light so that it is not reflected inside
4. Gustatory portion of the brainstem nuclei Ø Ciliary body – responsible for
accommodation; near objects = CM
5. Thalamus contracts + lens become rounder; far
objects = CM relaxes + lens become
6. Taste area (Insula) ovoid
• Ciliary muscles – smooth muscles
M o r a n o , M . A .
o Night blindness – difficulty § Optic tracts from the chiasm lead to the
seeing in dims light; caused thalamus.
by vit. A deficiency § Optic radiations extend from the thalamus to
b. Cones – require more light; the visual cortex in the occipital lobe.
provide color vision
o Red, Blue, Green – major Optic nerve – leaves the eye and exits the orbit
types of color sensitive
opsin Optic chiams – where two optic nerves connect
o Color blindness – caused
by lack of three cone types Optic tracts – the route of the ganglionic axons
o Partial color blindness –
lack of one cone type Optic radiations – formed by neurons from the
o Retinal detachment – thalamus
separation of sensory retina
from the pigmented retina Visual cortex – where vision is perceived
M o r a n o , M . A .
Cochlea Inferior colliculus – where neurons in the cochlear
§ Contains receptors for hearing nucleus project to the other areas of the brainstem
§ Snail shell shape
Balance
Spiral lamina – threads of the screw (base) Static equilibrium – vestibule; evaluating the position of
head relative to gravity
Scala vestibuli – extends from the oval window to the
apex of the cochlea Dynamic equilibrium – semi-circular canals; evaluating
changes in the direction and rate of head movements
Scala tympani – extends in parallel with the scala v.
from the apex Vestibule
v Utricle
Vestibular membrane – wall of the ML that lines the v Saccule
scala vestibuli
Maculae – specialized patches of epithelium
Basilar membrane – wall of the ML that lines the scala
tympani Otolithic membrane – gelatinous mass
Cochlear duct – space bet. the VM and the BM; filled Otoliths – gravity detectors composed of protein and
with endolymph calcium carbonate
Spiral organ/Organ of Corti – specialized structure; Semicircular canals – involved in dynamic equilibrium;
contains hair cells enables a person to detect movements in any direction
v Ampulla – expanded base of each SC
Hair cells – specialized sensory cells; contain microvilli v Crista ampullaris – specialized epithelium
formed within each ampulla
Tectorial membrane – acellular gelatinous shelf v Cupula – curved, gelatinous mass contained in
each crista
Cochlear/Spiral ganglion – contains cell bodies of hair
cells Motion sickness – caused by continuous stimulation of
the SC; characterized by nausea & weakness
Cochlear nerve – formed by axons of sensory neurons
Neuronal Pathways for Balance
Vestibulocochlear nerve (CN 8) – formed by cochlear § Axons in the vestibular portion of the
nerve + vestibular nerve vestibulocochlear nerve project to the
vestibular nucleus and on to the cerebral
Glutamate – neurotransmitter for hearing cortex.
Hearing Vestibulocochlear nerve (8) – project to the vestibular
Higher pitches – causes max. distortion of the BM nucleus in the brainstem
Sound volume – function of sound wave amplitude Balance – a complex sensation involving sensory input
Conduction deafness – results from mechanical Effects of Aging on the Senses
deficiencies Presbyopia – lenses’ ability to change shape initially
declines and is eventually lost
Sensorineural hearing loss – caused by deficiencies in
the spiral organ/nerves Presbyacusis – age-related sensorineural hearing loss
Neuronal Pathways for Hearing
§ Soundwaves enter external auditory meatus,
causing the tympanic membrane to vibrate.
§ Malleus, incus, stapes amplify the vibrations,
causing the oval window to vibrate.
§ Vibrations are conducted through perilymph,
and transmitted to the endolymph, causing the
basilar membrane to vibrate.
§ Hair cells in the organ of Corti are stimulated.
§ From the vestibulocochlear nerve, action
potentials travel to the cochlear nucleus and on
the cerebral cortex.
M o r a n o , M . A .
SKELETAL SYSTEM c. Bone substance – EM and cells
§ It consists of the bone, cartilage, tendons and
ligaments. Histology of Bone
§ Skeleton; dried (Greek) Osteoblasts – bone-forming cells; repair and remodeling
of bone
Functions (S2PMB)
1. Support Osteocytes – bone cells located between the lamellae
2. Protection (thins sheets of EM)
3. Movement
4. Storage Lacunae – spaces within the lamellae
5. Blood cell production
Canaliculi – tiny canals within the lamellae
Extracellular Matrix
§ Composed of connective tissues Types of Bone Tissue
a. Compact bone
Collagen – tough ropelike protein § Forms most of the diaphysis of long bones
§ Central Canal / Haversian Canal – concentric
Proteoglycans – large molecules consisting of rings that contains blood vessels; ‘bull’s eye’
polysaccharides attached to core proteins § Osteon / Haversian System – central canal +
lamellae + osteocytes
Tendons & Ligaments – large amounts of collagen fiber
b. Spongy bone
Cartilage – contains collagen & proteoglycans § Located mainly in the epiphyses of long bones
§ Forms the interior of all other bones
Bone – contains collagen and minerals (Calcium & § Consists of trabeculae (interconnecting rods,
Phosphate) plates of bone) without central canals
Epiphyseal line – bone growth stops and the epiphyseal Primary ossification center – where bone first begins to
plate is replaced by bone appear
Medullary Cavity – large cavity in the diaphysis; Osteoclasts – cells that remove calcified cartilage matrix
contains the marrow
Secondary ossification center – form in the epiphyses
Marrow – soft tissue within the cavity
Bone Growth
Yellow Marrow – consists of adipose tissue (fat) § Deposition of new bone lamellae onto existing
bone
Red Marrow – consists of bone forming cells; site of § Bone elongation occurs at the epiphyseal plate;
blood formation leads to increase in height (endochondral
ossification)
Layers of a Bone § Chondrocytes proliferate, enlarge, die, and are
a. Periosteum – outermost layer; surround the replaced by bone
diaphysis; contain blood vessels, nerves,
osteoblasts Appositional growth – increase in bone width or
diameter
b. Endosteum – innermost layer; lines the
medullary cavity (thinner connective tissue)
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Bone Remodeling AXIAL SKELETON
§ Removal of existing bone by osteoclasts § Composed of the skull, vertebral column, and
§ Deposition of new bone by osteoblasts thoracic cage
§ Responsible for change in bone shape, bone § Form the longitudinal axis of the body
adjustment, repair, and calcium ion regulation
I. Skull
Bone Repair § 22 bones
§ Clot is formed in the damaged area
§ Blood vessels and cells invade the clot and form Braincase
a callus (network of fibers and islets of cartilage) § 8 bones
§ Osteoblasts enter the callus and from a spongy § Covers and protects the fragile brain tissue
bone
§ Bone is slowly remodeled to compact bone 1. Frontal Bone – forehead, bony projections
under the eyebrow, part of the eye’s orbit
Bone and Calcium Homeostasis
§ Osteoclasts remove calcium = blood calcium 2 - 3. Parietal Bone (paired) – the superior and
levels increases lateral walls of the cranium; coronal suture
§ Osteoblasts deposit calcium = blood calcium
levels decrease 4 - 5. Temporal Bone (paired) – lies inferior to
the parietal bone; squamous suture
Hormones that maintain Calcium Homeostasis Ø External Auditory Meatus (EAM) – a
1. Parathyroid hormone (PTH) canal that leads to the eardrum and the
§ Parathyroid gland; middle ear
§ Increase bone breakdown & increase blood Ø Styloid process – a sharp, needlelike
calcium levels; structure located inferior to the EAM
§ Stimulates the kidneys to from active vitamin D Ø Zygomatic process – a bridge of bone
that joins with the cheekbone anteriorly
2. Calcitonin Ø Mastoid Process – a rough projection
§ Thyroid gland posterior and inferior to the EAM
§ Decrease bone breakdown and decrease blood
calcium levels 6. Occipital Bone – inferior and posterior bone
of the cranium; lambdoid suture
General Considerations of Bone Anatomy Ø Foramen magnum – where the spinal
§ 206 bones = adult cord joins the brain
§ 276 bones = newborn baby Ø Occipital condyles –rests on the first
vertebra of the vertebral column
Foramen – hole in a bone Ø Foramen ovale – allows the fiber of
cranial nerve 5 to pass
Canal / Meatus – elongated hole in a tunnel like body
7. Sphenoid Bone – butterfly-shaped bone that
Fossa – depression in a bone spans the width of the skull
Ø Sella Turtica – saddle-shaped structure
Tubercle / Tuberosity – lump on a bone at the central region; contains the
pituitary gand
Process – projection from a bone
8. Ethmoid Bone –
irregularly shaped bone that
Condyle – end of a bine that forms a joint with another lies anterior to the sphenoid bone
bone
Facial bones
Facet – small flattened articular surface § 14 bones; 13 solidly connected, 1 movable
(mandible)
Crest – prominent ridge § Holds the facial muscles in place
§ Joined together by sutures (interlocking,
Trochanter – tuberosity found only on proximal femur immovable)
Fissure – cleft 1-2. Maxillae – main bones of the face; carries
the upper teeth
Sinus – cavity
3-4. Palatine Bones – lies posterior to the
Suture – a joint uniting the bones of the skull palatine processes of the maxilla
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7-8. Lacrimal Bones – bones forming part of the Ø Vertebral canal – where the spinal cord is
medial wall of each orbit located; protects the spinal cord from injury
9-10. Nasal Bones – bones forming the bridge Ø Intervertebral foramina – where spnal nerves
of the bone exit the spinal cord
11-12. Inferior Nasal Conchae – thin curved Ø Articular process – where the vertebra articulate
bones projecting from the lateral wall of the with each other
nasal cavity
Ø Articular facet – smooth ‘little face’
13. Vomer Bone – single bone in the median of
the nasal cavity Regional Differences in Vertebrae
1. Cervical Vertebrae – very small bodies,
14. Mandible – lower jaw; only freely movable dislocation and fractures are common int his
joint of the face area
Ø Atlas – 1st CV; holds up the head; ‘yes’ shaking
Hyoid Bone – U-shaped bone; provides attachment to Ø Axis – 2nd CV; considerable amount of rotation;
tongue muscles; elevates the larynx during speech and ‘no’ shaking
swallowing
v Dens – where the rotation occurs
II. Vertebral Column
2. Thoracic vertebrae – long, thin spinous
§
Central axis of the skeleton processes; articulate the ribs
§
26 individual bones;
Ø 7 cervical vertebrae 3. Lumbar vertebrae – large, thick bodies; heavy,
Ø 12 thoracic vertebrae rectangular transverse + spinous processes;
Ø 5 lumbar vertebrae carry large amount of weight; ruptured
Ø 1 sacral bone intervertebral disks are common
Ø 1 coccyx bone
Functions 4. Sacrum – five sacral vertebrae fused in one
1. Supports the weight of the head and the trunk. Ø Median Sacral Crest – spinous process of the 1st
2. Protects the spinal cord. four SV
3. Allows the spinal nerves to exit the spinal cord. Ø Sacral Hiatus – inferior end of the sacrum; the
4. Site for muscle attachment. 5th process of the SV that does not form;
5. Permits movement of the head and trunk. common side of caudal anesthetic injections
Ø Sacral Promontory – anterior edge of the 1sy SV
Kyphosis – posterior curvature; hunchback that bulges; landmark felt during vaginal
examination; reference point in vaginal delivery
Lordosis – anterior curvature; swayback condition of a baby
Scoliosis – lateral curvature 5. Coccyx – tailbone; fusion of 4 or more/less
fused vertebrae; easily broken
General Plan of the Vertebral Column
Body – weight-bearing portion III. Rib Cage
Ø Intervertebral disks body – separates the § Also called the thoracic cage
vertebral bodies § Protects the vital organs
§ Prevents thorax collapse during respiration
Ø Vertebral arch – surrounds the vertebral
foramen 1. Rib Cage
v 2 Pedicles – extends from the body to § 12 pair of ribs
the transverse process Ø 1 – 7 true ribs (attached directly to the sternum)
v 2 Laminae – extends from the transverse Ø 8 – 12 false ribs (do not attach directly to the
to the spinous process sternum)
v Provides attachment sites for the muscles v 11 – 12 floating ribs (do not attach to
that move the vertebral column; the sternum)
• Transverse process – extends
laterally bet. the lamina and 2. Sternum
pedicle § Also called the breastbone
• Spinous process – projects Ø Jugular notch – a depression bet. the ends of the
dorsally where the two laminae clavicles where they articulate with the sternum
meet Ø Sternal angle – a slight elevation felt at the
junction of the manubrium and the sternum;
Ø Vertebral foramen – a large opening important landmark bcos it identifies the 2nd rib
M o r a n o , M . A .
Ø Xiphoid process – important landmark of the 4. Hand – 5 metacarpal bones are attached to the
sternum during CPR carpal bones
Ø Phalanges – 3 small bones on each finger
APPENDICULAR SKELETON
§ 126 bones III. Pelvic Girdle
§ Consists of the bones of the upper and lower § Where lower limbs attach to the body
limbs, as well as the girdles
Coxal bones – hip bones; join each other anteriorly and
I. Pectoral Girdle the sacrum posteriorly to form a ring of bone called the
§ Also called the shoulder girdle pelvic girdle
§ Consists of 4 bones; 2 scapulae + 2 clavicles Ø Ilium – most superior
Ø Ischium – inferior and posterior; sit down bone
1. Scapula – shoulder blade; where muscles Ø Pubis – inferior and anterior
extending to the arm are attached
Iliac crest – seen along the superior margin of each ilim
2. Glenoid cavity – 4th fossa; where the head of the Ø Anterior Superior Iliac Spine – important hip
humerus connects to the scapula landmark; anterior end of the iliac crest
Ø Spine – a ridge that runs across the posterior
surface fo the scapula Pubic symphysis – where coxal bones join anteriorly
Ø Sacroiliac joints – joins the sacrum posteriorly
3. Acromion process – extends from the scapular
spine to form the point of the shoulder Acetabulum – socket of the hip joint
4. Clavicle – collarbone; articulates with the Obturator foramen – large hole in each coxal bone
scapula art the acromion process
Pelvic inlet – formed by the pelvic brim and the sacral
5. Coracoid process – provides for the attachment promontory
of arm and chest muscles
Pelvic outlet – bounded by the ischial spines, pubic
II. Upper Limb symphysis, and coccyx
1. Arm – region bet, the shoulder and the elbow;
contains the humerus; has two tubercles: greater Male pelvis: larger and massive; Female pelvis; broader
tubercle and lesser tubercle
Ø Deltoid Tuberosity – where the deltoid muscle IV. Lower Limbs
attaches 1. Thigh – region bet. the hip and the knee;
Ø Epicondyles – provide attachment sites for contains the femur
forearm muscles Ø Head of the femur – articulates with the
acetabulum of the coxal bone
2. Forearm Ø Condyles – articulates with the tibia
Ø Radius – lateral to the thumb Ø Epidondyles – points of ligaments attachments
v Radial tuberosity – where the arm Ø Trochanters – lateral to the head after the neck
muscles (biceps brachii) attaches Ø Patella – knee cap; enables the tendon to bend
Ø Ulna – medial to the little finger over the knee
v Trochlear notch – forms most of the
elbow joint 2. Leg – region bet. the knee and the ankle
v Coronoid process – helps complete the Ø Tibia – shinbone; larger; major weight-bearing
grip of the ulna bone of the leg; medial malleolus
v Olecranon process – extension of the Ø Fibula – thin and sticklike that forms the lateral
ulna side of the leg; lateral malleolus
v Styloid process – articulates with the
bones of the wrist 3. Ankle – 7 tarsla bones
Ø Talus – ankle bone
3. Wrist – short region bet. the forearm and the Ø Calcaneus – heel bone
hand; 8 carpal bones (SLTPHCTT) Ø Cuboid
Ø Scaphiod Ø Navicular
Ø Lunate Ø Cuneiforms; medial, intermediate, lateral
Ø Triquetrum
Ø Pisiform 4. Foot
Ø Hamate Ø Metatarsal bones and phalanges – arranged
Ø Capitate and numbered in a similar manner to the hand
Ø Trapezoi Ø Has 3 primary arches
Ø Trapezium
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JOINTS Types
§ Also called an articulation 1. Plane/Gliding Joints – two opposed flat
§ Where two bones come together surfaces that glide over each other
M o r a n o , M . A .
TISSUES §
§
Cilia – propel materials
Goblet Cells – specialized mucus-‐‑producing
§ A group of cells with similar structure and cells
function that have similar extracellular
substances located between them. Cell Connections
§ Tight Junctions -‐‑ bind adjacent cells together
Histology and form permeability barriers; prevent the
The microscopic study of tissue structure passage of materials between epithelial cells
§ Desmosomes – mechanical links that bind cells
Epithelial Tissue together
§ Covers external and internal surfaces; Ø Hemidesmosomes -‐‑ anchor cells to the
§ Has a basement membrane, basement membrane
§ Little EM (extracellular matrix), § Gap Junctions – allow small molecules and ions
§ No blood vessels. to pass
Functions of Epithelial Tissues (PAPSA) Glands
1. Protecting underlying structures. Glands – secrete substances onto a surface
2. Acting as a barrier. a. Exocrine – secrete through ducts
3. Permitting the passage of substances. Ø Unicellular
4. Secreting substances. Ø Multicellular
5. Absorbing substances. v Simple – non branched
v Compound -‐‑ branched
Classification of Epithelium • Tubular
Accdg. To Layers o Straight
1. Simple E. – single layered o Coiled
2. Stratified E. – multi-‐‑layered • Acinus (grapelike) or
3. Pseudostratified Columnar E – single layered Alveolus (small cavity)
but appears to be stratified
4. Transitional E – stratified x can be greatly Mode of Secretion
stretched Ø Merocrine – products are released but
no actual cellular material is lost;
Accdg. To Shape pancreas
1. Squamous – flat Ø Apocrine – secretory products are
a. Non-‐‑keratinized -‐‑ in the deepest and released as fragments; mammary glands
outermost layers, moist Ø Holocrine -‐‑ shedding of entire cells;
b. Keratinized -‐‑ composed of dead cells sebaceous glands
containing the protein keratin; durable,
moisture-‐‑resistant, dry character. b. Endocrine -‐‑ release hormones that are absorbed
2. Cuboidal – cube-‐‑like directly into the blood
3. Columnar – tall and thin
Connective Tissue
Functional Characteristics § Large amounts of EM
Cell Layers and Cell Shapes
§ Simple E. -‐‑ diffusion, filtration, secretion, or Functions of Connective Tissue (EC2S2PT)
absorption; found in organs: to move materials 1. Enclosing and separating other tissues.
§ Stratified E. -‐‑ protection 2. Connecting tissues to one another.
§ Squamous Cells -‐‑ diffusion and filtration 3. Supporting and moving parts of the body.
§ Cuboidal and Columnar Cells – secretion and 4. Storing compounds.
absorption 5. Cushioning and insulating.
6. Transporting.
Free Surfaces 7. Protecting.
§ Smooth free surface – reduces friction
§ Microvilli – increase the free surface are
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Cells of Connective Tissue II. Supporting Connective Tissue
§ Blast (germ) – froms the matrix 1. Cartilage
§ Cyte (cells) – maintains § Composed of chondrocytes, in spaces called
§ Clast (break) – breaks down lacunae
§ Flexibility and strength
§ Adipocytes – contain large amount of lipids § Provides support
§ Macrophages – WBCs that move about and a. Hyaline – most abundant, covers the
ingest foreign substances ends of bones, can withstand repeated
§ Mast Cells – play an important role in compressions
inflammation b. Fibro – more collagen, able to resists
§ Mesenchymal Cells – have the potential to pulling or tearing, found in disks
differentiate to form adult cell types between vertebrae and some joints
(knee and jaw)
Extracellular Matrix c. Elastic – contains elastic fibers, able to
§ Protein Fibers recoil to its original, external ear,
Ø Collagen Fibers – microscopic ropes; epiglottis, auditory tube
flexible but resist stretching
Ø Reticular Fibers – fine, short that 2. Bone
branch; support network § Hard connective tissue
Ø Elastic Fibers – coiled; can recoil back to § Consists of living cells, mineralized matrix
shape § Osteocytes (bone cells), are located within
§ Ground Substance – shapeless background lacunae
where cells and collagen fibers can be seen; § Support and protect other organs
highly structured molecules a. Spongy
Ø Proteoglycans – pine trees: branches = b. Compact
proteins, pine needles =
polysaccharides; trap large quantities of III. Fluid Connective Tissue
water a. Blood – liquid matrix: enables blood to
§ Fluid flow rapidly; carry nutrients, oxygen,
waste products
Classification of Connective Tissue Ø RBCs
Adult Connective Tissue Ø WBCs
I. Connective Tissue Proper Ø Platelets
1. Loose Connective Tissue b. Hemopoietic -‐‑ forms bloods cells
§ Few protein fibers, numerous spaces
a. Areolar – EM: collagen fibers and few Muscle Tissue
elastic fibers § Has the ability to contract.
b. Adipose – consists of adipocytes (fat § Muscle fibers – resemble tiny threads
cells): contain large amounts of lipid (for
energy storage); EM: loose arranged Types of Muscular Tissue
collagen and reticular fibers, scattered I. Skeletal (striated voluntary)
elastic fibers § Large, long, cylindrical cells
c. Reticular § Multinucleated
§ Attached to bones
2. Dense Connective Tissue § Responsible for body movement
§ Large amount of protein fibers
a. Collagenous – EM: collagen fibers II. Cardiac (striated involuntary)
b. Elastic – abundant elastic fibers (stretch § Cylindrical cells
and recoil) in its collagen fibers § Branched and connected to one another by
intercalated disks
§ Single nucleated
§ Found in the heart
§ Pumps the blood
M o r a n o , M . A .
III. Smooth (nonstriated involuntary) Tissue Damage and Inflammation
§ End tapered cells Inflammation – occurs when tissues are damaged
§ Single nucleated
§ Found in hollow organs: stomach, intestine; Histamine & Prostaglandins – chemical mediators of
skin, eyes inflammation
§ Regulates size of organs, forces fluid through
tubes, controls the amount of light entering the Edema -‐‑ swelling
eye, produces ‘goose bumps’
Neutrophil – phagocytic WBC that fights infection
Nervous Tissue
§ Found in the brain, spinal cord, and nerves Pus – mixture of dead neutrophils, other cells, fluid
§ Responsible for coordinating and controlling
Chronic Inflammation
Action potentials – ability of nervous tissue cells to § Results when the agent causing injury is not
communicate with one another by means of electric removed or something else interferes with the
signals healing process
Neurons – responsible for conducting action potentials Tissue Repair
Ø Cell Body – contains the nucleus; site of general § Substitution of viable cells for dead cells
cell functions § Can occur by regeneration or by fibrosis
Ø Dendrites – receive electric impulses
Ø Axon – conduct electric impulses Regeneration – new cells are the same type as those that
were destroyed
Membranes
§ A thin layer of tissue that covers a structure Fibrosis/Replacement – a new type of tissue develops
§ Mostly consists of epithelium and connective that eventually causes scar production
tissue
Stem Cells – self-‐‑renewing, undifferentiated cells that
I. Mucous Membrances continue to divide throughout life
§ Consists of epithelium and loose connective
tissue Clot – contains protein fibrin (binds the edges of a
§ Line the digestive, respiratory, reproductive wound together and stops the bleeding)
tracts
§ Protection, absorption, secretion Scab – dried surface of a clot; seals the wound and helps
prevent infection
II. Serous Membranes
§ Simple squamous epithelium and loose Granulation Tissue – delicate, granular appearing
connective tissue connective tissue that consists of fibroblasts, collagen,
§ Line the trunk cavities and cover the organs capillaries
within it
§ Serous fluid prevents damage from abrasion Effects of Aging on Tissues
§ Cells divide more slowly.
a. Pleural – lungs § Injuries heal more slowly.
b. Pericardial – heart § EM containing collagen & elastic fibers
c. Peritoneal – abdominopelvic cavity becomes less flexible and less elastic.
§ Skin wrinkles.
III. Synovial Membranes § Elasticity in blood arteries is reduced.
§ Formed by connective tissue § Bones break more easily.
§ Line the inside of joint cavities
§ Synovial fluid – reduce friction to allow smooth
movement within the joints
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CELL STRUCTURES Crenation – cell shrinking
Intracellular – substances inside the cell Exocytosis – secretion of materials from cells
M o r a n o , M . A .
Peroxisomes Two Phases of the Cell Life Cycle
§ Enzymes that digest fatty acids and amino acids 1. Interphase – non-dividing phase
§ Enzymes that catalyze the breakdown of 2. Cell Division – formation of daughter cells from
hydrogen peroxide a single parent cell
Cytoskeleton Mitosis
§ Holds organelles in place; enables the cell to 1. Prophase – chromatin condenses
change shape
2. Metaphase – chromosomes align at the center
§ Microtubules – support the cytoplasm; assist in
3. Anaphase – chromatids separate at the
cell division
centromere and migrate to opposite poles
Microfilaments – involved in cell movement
4. Telophase – chromosomes unravel to become
chromatin
Intermediate filaments – provide mechanical support
Differentiation
Centrioles
Centrosome – where microtubule formation occurs § Cells develop specialized structures and
functions
Centrioles – specialized zone of the cytoplasm
Apoptosis
Spindle fibers – involved in separation of chromosome § Programmed cell death
during mitosis
Cellular Aspects of Aging
Cillia, Flagella, and Microvilli 1. Cellular clock.
Cilia – moves substances over the surface 2. Death genes.
3. DNA damage.
Flagella – propel sperm cells 4. Free radicals.
5. Mitochondrial damage.
Microvilli – increase the surface area of cells; aids in
absorption
Whole-Cell Activity
Gene Expression
Gene – sequence of nucleotides
Nucleotide Pairs
Cytosine Guanine
Thymine Adenine
Uracil Adenine
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Compound – two or more diff. types of atoms that are
CHEMICAL BASIS chemically combined
OF LIFE Dissociation
Basic Chemistry § Separation of ions in an ionic compound by
Chemistry – concerned with atomic composition and polar water molecules
structure of substances and the reactions they undergo
Electrolytes – dissociated ions
Matter, Mass, and Weight
Matter – anything that occupies space and has mass Chemical Rxns
§ Substances interact either to form or to break
Mass – amount of matter in an object; kilogram chemical bonds
Weight – gravitational force acting on an object Reactants – substances that enter into a chemical
reaction
Elements and Atoms
Element – simplest type of matter having unique Products – substances that result from the chemical rxn
properties
Classification of Chemical Rxns
Atom – smallest particle of an element 1. Synthesis – combination of reactants
2. Decomposition – breakdown of larger reactants
Atomic Structure 3. Exchange – decomposition + synthesis
Neutrons – no electrical charge
Anabolism – synthesis rxns that occur in the body
Protons – positive charges
Catabolism – decomposition rxns that occur in the body
Electrons – negative charges
Metabolism – anabolic + catabolic rxns in the body
Nucleus – formed by protons and neutrons
Reversible Rxns
Electron cloud – where electrons are most likely to be § Reactants can form products, products can form
found reactants
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Alkalosis – blood pH rises above 7.45 Polyunsaturated fats – two or more double covalent
bonds; safflower, sunflower, corn, fish oils
Salts
§ Forms when an acid reacts with a base Trans fats – unsaturated fats tha have been altered by
addition of H atoms
Buffer
§ Chemicals that resist changes in pH Phospholipids – phosphorus containing molecues
Oxygen and Carbon Dioxide Hydrophobic – water fearing; non polar end is repelled
Oxygen – involved with the extraction of energy from by water
food molecules
Eicosanoids – important chemicals derived form fatty
Carbon Dioxide – by-product of the breakdown of food acids; important regulatory molecules
molecules
Prostaglandins – regulates secretion of hormones, blood
Water clotting, and some reproductive functions
1. Stabilizing body temperature.
2. Protection; lubricant/cushion. Steroids – carbon atoms in four ring-like structures
3. Facilitating chemical reactions.
4. Transporting substances Cholesterol – important steroid bcos steroid molecules
are synthesized from it; important component of cell
Organic Molecules membranes
§ Carbon containing
Proteins
Carbohydrates § CHON + S
§ CHO § Regulate chemical reactions
§ Serve as structural components
Monosaccharides – smallest carbohydrates; simple § Cause muscle contraction
sugars
Ø Glucose – blood sugar Amino acids – building blocks of proteins; amine group
Ø Fructose – fruit sugar + carboxyl group; 20 basic types: 12 simple org.
molecules + 8 obtained in diet
Disaccharides – 2 monosaccharides
Ø Sucrose – table sugar Denaturation – change in shape caused by abnormally
high temp. or change in pH
Polysaccharides – many monosaccharides
Ø Glycogen – animal starch Enzymes – protein catalysts; lower the activation energy
v Plant starch
Activation energy – energy needed to start a chem rxn
v Cellulose
Lock-and-key model – the shapes of an enzyme and
Lipids
those of the reactant allow the enzymes to bind easily to
§ Substances that dissolve in non polar solvents the reactants
§ CHO + P + N
Nucleic Acids: DNA + RNA
Fats – important energy-storage molecules; pad and Deoxyribonucleic acid (DNA) – genetic material of cells
insulate the body
Ribonucleic acid (RNA) – important role in gene
Glycerol & Fatty Acids – building blocks of fats expression/protein synthesis
Triglycerides – most common type of fat molecules Nucleic acid – large molecules composed of CHONP
Saturated Fatty Acid – single covalent bond; beef, pork, Nucleotides – basic building clocks of DNA + RNA
whole milk, cheese, butter, eggs, coconut oil, palm oil
Adenosine Triphosphate (ATP)
Unsaturated Fatty Acid – one of more double covalent
§ Important organic molecule
bonds
§ Energy currency of cells
Mono-unsaturated fats – double covalent bonds bet. § Stores and provides energy
carbon; olive and peanut oil
M o r a n o , M . A .
5. Development – changes an organism undergoes
THE HUMAN through time
ORGANISM 6. Reproduction
cells/organisms
– formation of new
Anatomy
§ Study of the structures of the body
Homeostasis
§ Anatomy; to dissect, or cut apart, or separate
§ Ability to maintain relatively stable internal
Approaches to the Study of Anatomy conditions
1. Systemic Anatomy – study of the body by § Homeo: same; stasis: standing still
organ system § Balance / Equilibirum
2. Regional Anatomy – study of the body by areas Homeostatic mechanisms – normally maintain body
temp near an ideal normal value; sweating, shivering
Gen. Ways to Examine the Internal Structures
1. Surface Anatomy – study of external features; Variables – conditions that can change
superficial structures to locate deeper structures
Set point – ideal value
2. Anatomical Imaging – non-invasive method for
examining deep structures; x-ray, CT scan, PET Normal range – acceptable range of values on which
scan, MRI HM can still be met
M o r a n o , M . A .
Directional Terms LOWER LIMB
Hip Coxal
Inferior Lower Thigh Femoral
Superior Higher Kneecap Pat`ellar
Leg Crural
Anterior Front
Posterior Back Foot Pedal
Ankle Talus
Ventral Belly Top of foot Dorsum
Dorsal Back Toes Digital
Hand Manual
Wrist Carpal
Palm Palmar
Fingers Digital
M o r a n o , M . A .
Planes
Body Cavities
Thoracic cavity – bounded by ribs and the diaphragm
Ø Mediastinum – partition containing the heart,
thymus, trachea, esophagus
Serous Membranes
§ Line the trunk cavities and cover the organs
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