Name__________________ class number

Capsules

1 Are solid dosage forms in which the medicinal agents and/or inert
substances are enclosed in a small gelatin shell.
2
Two type of capsule
3
4 Used by community pharmacist in extemporaneous compounding of
prescriptions
5 Commonly employed in clinical drug trials to compare investigational drug
to another drug or a placebo.
Hard gelatin capsule consist of Two pieces of cylinders closed at one end.
The shorter piece is called the _________. This cap fits over the open end
of longer piece called _________
6 Added to make hard gelatin capsule opaque
7 Components of capsule shell (3)
8 Clear, colorless and essentially tasteless
9 Colorant added to capsule shell
10 • partial hydrolysis of collagen obtained from the skin, white
connective tissue, and bones of animals.
• Gelatin is stable in air when dry ,
if moist-microbial decomposition
11 Hard gelatin capsule contains _______ moisture
12 Vegetarian capsules are made up of ______
13 If the capsule is placed in _________ and additional moisture is absorbed-
distorted and lose their rigid shape
14 If the capsule is placed in _________________, moisture present in the
gelatin capsules is lost- brittle and crumble
15 added to protect product from moisture
16 Types of desiccant
17
18
Smallest capsule size
19 Biggest for human
20 Commonly used capsule size used by veterinary
21 produce the proper capsule fill volume
Examples: Lactose, microcrystalline cellulose and starch
22 assist break-up and distribution of the capsule contents in the stomach
Examples: pregelatinized starch, croscarmellose, sodium starch glycolate
23 improve flow properties of powder mixture
Examples: Fumed silicon dioxide, magnesium stearate, calcium stearate,
stearic acid or talc
24 facilitates wetting of powder by the GI fluids Example: Sodium lauryl sulfate
25 Used to polish or clean the capsule shell
26 Added to make the soft gelatin capsule elastic or plastic like
27 Soft gelatin capsule contain more moisture than hard gelatin capsules thus
contains preservatives like______
28 Why there is preparation like capsule in a capsule or tablet in a capsule
29 oldest commercial process that uses set of molds to form capsules
30 a continuous process
two plasticized gelatin ribbons are continuously and simultaneously fed
 with
liquid or paste fill between the rollers of the rotary die mechanism
31 The gelatin ribbons are fed between a set of vertical dies that continually
open and close to form rows of packets in gelatin ribbons
32 packaging for dispensing single dose capsule
33 Packaging for dispensing multiple dose capsule
34 Capsule shell that are not easily tampered and protected from premature
opening due to indentations
Advantages of capsule
1. They may be used to mask the unpleasant tastes, aromas, or appearance of a drug.
2. They allow powders to be dispensed in an uncompressed form, thus allowing for quicker dissolution and
absorption of the drug following oral dosing (as compared with tablets).
3. They offer the pharmacist versatility to prepare any dose desired for a variety of administration routes (e.g. oral,
inhalation, rectal, or to be diluted for vaginal, rectal, oral or topical use).
4. They may be easier than tablets for some people to swallow.
5. They can be make to alter the release rate of the drug.

Disadvantages of capsule
– Hygroscopic drugs are not suitable for filling into capsules , because they absorb water present in capsule shell
makes shell very brittle and ultimately lead to crumble into pieces
– The concentrated solutions which require previous dilution are unsuitable for capsules because if administered
as such lead to irritation into stomach

Steps in Filling Hard Gelatin Capsule (4)

Methods in filling hard gelatin capsule (2)

Method in filling soft gelation capsule (3)

Preparation that can fill a hard gelatin capsule (5)

Preparation that can fill a soft gelatin capsule (4)

Liquid that can be encapsulated in SGC (3)