SAS For Biochemistry BIO 024 Module 5
SAS For Biochemistry BIO 024 Module 5
Productivity Tip:
Watch this video about some basic of vitamins https://www.youtube.com/watch?v=SmsCJpBuNrE to get an
overview. After, try getting a dose of your daily vitamins or if not, ask someone (family member or friend)
about the vitamins they are taking. Check the label or the content of your/their vitamins. List it down or simply
just take note of it. Later, once you are done with this module, explain the best benefits of the vitamins you or
they are taking.
A. LESSON PREVIEW/REVIEW
1) Introduction (2 mins)
As the Covid-19 pandemic continues to spread, the need to understand which populations are
most at risk of developing severe disease or dying from Covid-19 grows ever more critical. Although
recent studies have found an association between certainly mentioned vitamin (C and D) and Covid-19
severity and mortality, many other scientists continue to make a dispute about such claim since these
studies are only observational and that the association of low level of these vitamins may just be a
marker of being less healthy.
However, since we are not only fighting for this unprecedented pandemic and that we must
continue in our well-being, meanwhile, there’s a wealth of data that shows the role that good nutrition
plays in supporting the immune system. It is well established in journals and scientific evidences that
vitamins and minerals are vital for our immune system. As a society we need to be doing a better job of
getting that message across along with the other important, more common messages.
The only problem left is that people simply are not eating enough of these nutrients. This in turn
could destroy our resistance to infections, or worse, deficiencies of these nutrients can leave us more
susceptible to infections or less able to shake off illness. Consequently, we will see an increase in
disease and all the extra burdens that go along with that increase.
Now, we are paused with the idea of which vitamins should we take to boost our immunity
against infections or might be for the novel coronavirus that has been threatening the health of the
public and ravaging our social and economic progress; or maybe just to simply continue living in good
and better health. Hopefully, with this module, you will be able to learn and get some of the answers.
Instructions: "In this chart, reflect on what you know now. Do not worry if you are sure or not sure of
your answers. This activity simply serves to get you started on thinking about our topic. Answer only
the first column, "What I know" based on the question of the second column. Leave the third column
"What I learned" blank at this time.
Vitamins, vita, meaning “life,” and from the fact that these
substances were all thought to contain the amine functional group, are
organic compound, essential in small amounts for the proper functioning
of the human body, that must be obtained from dietary sources because
the body cannot synthesize it.
Vitamins differ from the major classes of nutrients in foods (carbohydrates, lipids, and proteins)
in the amount required; for vitamins, it is microgram to milligram quantities per day compared with 50–
200 grams per day for the major food nutrients categories. To better understand the small amount of
vitamins needed by the human body, consider the recommended daily allowance (RDA) of vitamin B12,
which is 2.0 micrograms per day for an adult. Just 1.0 gram of this vitamin could theoretically supply the
daily needs of 500,000 people. A well-balanced diet usually meets all the body’s vitamin requirements.
However, supplemental vitamins are often required for women during pregnancy and for people
recovering from certain illnesses. One of the most common myths associated with the nutritional
aspects of vitamins is that vitamins from natural sources are superior to synthetic vitamins. In truth,
synthetic vitamins, manufactured in the laboratory, are identical to the vitamins found in foods. The
body cannot tell the difference and gets the same benefits from either source. Vitamins and minerals in
supplements are synthetic forms of the nutrients. The word "synthetic" does not necessarily mean
inferior, however. Even those supplements that claim to have "natural"
ingredients contain some synthetic ingredients. Indeed, if a pill contained
only natural ingredients, it would be the size of a golf ball.
For the most part, our bodies appear to absorb synthetic forms as
well as they do natural forms. The one exception seems to be vitamin E,
which in natural form (RRR-alpha tocopherol) is better absorbed than in
Solubility characteristics divide the vitamins into two major classes: the water-soluble vitamins (9 or
nine) and the fat (lipid)-soluble vitamins (4 or four).
Water-soluble vitamins must be constantly replenished in the body because they are rapidly
eliminated from the body in the urine. They are carried in the bloodstream, are needed in frequent,
small doses, and are unlikely to be toxic except when taken in unusually large doses. The fat-soluble
vitamins are found dissolved in lipid materials. They are, in general, carried in the blood by protein
carriers, are stored in fat tissues, are needed in periodic doses, and are more likely to be toxic when
consumed more than need. An important difference exists, in terms of function, between water-soluble
and fat-soluble vitamins. Water-soluble vitamins function as coenzymes for several important
biochemical reactions in humans, animals, and microorganisms. Fat-soluble vitamins generally do not
function as coenzymes in humans and animals and are rarely utilized in any manner by
microorganisms.
Active coenzyme
Vitamin B1 Uses/function Deficiency Sources
forms:
Active coenzyme
Vitamin B2 Uses/function Deficiency Sources
forms:
•Riboflavin •Part of an enzyme •Blood shot eyes • Large amounts in • Active forms: takes part
• Dairy products in REDOX reaction
•Vitamin G needed for energy •Glossitis • eggs
metabolism; •Flavin Mononucleotide
•Yellow vitamin •Cheilosis • Legumes
(FMN)
important for normal • meats
•Seborrheic dermatitis •Flavin Adenine
vision and skin health • Small amounts in
• leafy green vegetables Dinucleotide (FAD)
• enriched grains
Active coenzyme
Vitamin B3 Uses/function Deficiency Sources
forms:
• Niacin •energy production •Pellagra (3Ds) •Meat, poultry, fish, • Nicotinamide Adenine
• Niacinamide, •maintenance of skin •- Dementia/ whole-grain or Dinucleotide (NAD+)
• Nicotinamide, and tongue Delusions enriched breads and • Nicotinamide Adenine
• Nicotinic acid cereals, vegetables Dinucleotide Phosphate
•improves circulation •- Dermatitis/ Scaly (NAP+)
• Anti-black tongue factor skin sores (mushrooms,
•adjunctive therapy in •
• Antipellagra factor asparagus, and leafy
primary •- Diarrhea
• Pellagra preventing green vegetables),
hyperlipidemia
factor peanut butter
Active coenzyme
Vitamin B5 Uses/function Deficiency Sources
forms:
•Pantothenic acid • Part of an enzyme •Burning foot •Widespread in foods • Coenzyme A (CoA)
•Chick antidermatitis needed for energy syndrome
factor metabolism
Active coenzyme
Vitamin B6 Uses/function Deficiency Sources
forms:
• Pyridoxine (Plants) • role in the prevention of •Sideroblastic anemia •Widespread in foods; • Pyridoxine-5'-
pre-eclampsia Pyrophosphate (PNP)
•Pyridoxal (animals) •peripheral also produced in
• Production of red blood • Pyridoxal-5'-
•Pyridoxamine cells neuropathy intestinal tract by
bacteria Pyrophosphate (PLP)
(animals) • reduce muscle spasm, •Note: too much
cramps and numbness • Pyridoxamine-5'-
intake causes Pyrophosphate (PMP)
• supplement to TB patient permanent nerve
taking Isoniazid to prevent
peripheral neuropathy
damage
Active coenzyme
Vitamin B7 Uses/function Deficiency Sources
forms:
Active coenzyme
Vitamin B9 Uses/function Deficiency Sources
forms:
•Folic acid • Part of an enzyme • Macrocytic anemia •Leafy green •Tetrahydrofolic acid
needed for (megaloblastic)
•Folate making DNA and new
vegetables and
• Neural tube defects: legumes, seeds,
•Pteroylglutamic acid, cells, especially red blood
Spina bifida and
cells orange juice, and
• neede by pregnant women anencephaly liver; now added to
to avoid fetal defects most refined grains
Active coenzyme
Vitamin B12 Uses/function Deficiency Sources
forms:
•Cobalamin (methy or • Part of an enzyme • Pernicious anemia •Meat, poultry, fish, •5-deoxyadenosyl
cyanocobalamin) needed for making (megaloblastic) seafood, eggs, milk cobalamin (necessary
new cells; important and milk products; for the synthesis of
to nerve function not found in plant DNA
foods
•Ascorbic acid • cosubstrate in the • Scurvy (bruising easily, • fruits and vegetables, • Sodium ascorbate,
synthesis of colagen (also bleeding gums, and especially citrus fruits, (buffered, salt form,
•Cevitamic acid for wound healing) tendency for bones to vegetables in the cabbage
fracture) family, cantaloupe, less acidic and
• General antioxidant
• fatigue and joint pain strawberries, peppers, stomach friendly)
• synthesis of
neurotransmitter dopamine • Weight loss tomatoes, potatoes,
& norepinephrine from lettuce, papayas,
• slow healing of wounds
tyrosine & neutransmitter mangoes, kiwifruit
and fractured bones
serotonin from tryptophan • irritable
•Beta-carotene (vit.A •Needed for vision, • Nyctalopia (night • Vitamin A from animal • Retinol (major natural
blindness) sources (retinol): fortified and usable form)
precursor) healthy skin and milk, cheese, cream,
• Xeropthalmia – prolonged • Retinal (aldehyde form
•Note: Anti-infective mucous membranes, deficiency (dry, thickened butter, fortified margarine,
vitamin bone and tooth and wrinkles cornea and eggs, liver of retinol)
growth, immune conjunctiva) • Retinoic acid (active
system health • Growth retardation • Beta-carotene (from plant form, utilized by the skin
• Impotence sources): Leafy, dark
green vegetables; dark
orange fruits (apricots,
• Large doses causes
cantaloupe) and
hypervitaminosis A
vegetables (carrots, winter
squash, sweet potatoes,
pumpkin)
•Sunshine vitamins •Needed for proper •Rickets - for children • Egg yolks, liver, • Active form: 1,25-
•D2- ergocalciferol absorption •Osteomalacia - for fatty fish, fortified dihydroxycholecalciferol
•D3- cholecalciferol of calcium; stored in adult milk, fortified
bones margarine. When
•One of the hormone
like vitamin exposed to
•Large doses causes sunlight, the skin
hypervitaminosis D can make vitamin
D.
Active coenzyme
Vitamin E Uses/function Deficiency Sources
forms:
Active coenzyme
Vitamin K Uses/function Deficiency Sources
forms:
Lippincott, 7th ed
Activity 3: Skill-building Activities (with answer key) (25 mins + 5 mins checking)
A. Tabulate the difference between the characteristics of the class of vitamins. Check your answers
against the Keys to Correction found at the last pages of this SAS. Write your score ________
B. Matching Type. MATCH the letter from Column A on items given in column B and C. Write the
letter only on the space provided before the number. Score: __________
COLUMN A: COLUMN B: NAMES COLUMN C: DEFICIENCY
VITAMINS: _____1.Cevitamic
M acid A
_____1.Beri-beri
A. B1 _____2.Biotin
F C
_____2.Pellagra
B. B2 A
_____3.Thiamin B
_____3.Cheilosis
C. B3 D
_____4.Pantothenic acid M
_____4.Scurvy
D. B5 E
_____5.Pyridoxine D
_____5.Burning foot syndrome
E. B6 G
_____6.Pteroylglutamic acid E
_____6.Peripheral neuropathy
F. B7 I
_____7.Retinol J
_____7.Osteomalacia
G. B9 J
_____8.Sunshine vitamin I
_____8.Nyctalopia
H. B12 H
_____9.Cyanocobalamin K
_____9.Sterility
I. A B
_____10.Riboflavin F
_____10.Alopecia
J. D K
_____11.Alpha-tocopherol G
_____11.Megaloblastic anemia
K. E L
_____12.Menadione H
_____12.Pernicious anemia
L. K C
_____13.Niacin L
_____13.Hemorrhage
M. C
Instruction: Now it’s time for you to figure this one out on your own! Take time to read, analyze, and
understand the following scenarios. For this instance, you will not have the chance to check if you have
the correct answers since there are no more keys to correction.
MULTIPLE CHOICE: WRITE the letter of your choice before each number.
4. Patient with tuberculosis undergoing treatment may result to which of the following
condition.
a. Streptomycin precipitated peripheral neuropathy
b. Rifampicin-B6 deficiency
c. Ethambutol associated anemia
d. Isoniazid-induced pellagra
5. Which of the following vitamin therapy may resolve the condition associated (in question
no. 4) upon administration?
a. B5
b. C
c. B6
d. B3
6. These vitamins are part of an enzyme needed for energy metabolism, EXCEPT FOR:
a. C b. B7 c. B5 d. B1
10. The deficiency of this vitamin leads to haemorrhage and decrease in red blood cell fragility.
a. A b.C c.E d. K
b. Vitamin A
c. Vitamin B9
d. Vitamin B2
D. LESSON WRAP-UP
FAQs
2.What are the vitamins that are to be avoided for pregnant women? Ans. While supplementing
with some micronutrients, like folate, is safe for pregnant women, many of them should be avoided.
For example, excessive amounts of vitamin A during pregnancy has been shown to cause congenital
birth defects. Supplementing with vitamin E has not been shown to improve outcomes for either
mothers or babies and may instead increase the risk of abdominal pain and premature rupture of the
amniotic sack
Storage circulate in the water-fi lled parts of Found in cells associated with
the body fats
Toxicity not likely to reach toxic levels when likely to reach toxic levels when
consumed from supplements consumed from supplements
B. MATCHING TYPE
COLUMN B: NAMES
1.M 2.F 3.A 4.D 5.E 6.G 7.I 8.J 9.H 10.B 11.K 12.L 13.C
COLUMN C: DEFICIENCY
1.A 2.C 3.B 4.M 5.D 6.E 7.J 8.I 9.K 10.F 12.G or H 12. H 13.L
C. CASE ANALYSIS
1. Vitamin C deficiency or scurvy
2. Any from these: irritability, sweating, poor appetite (which a family had history with children
having malnutrition may lead to weight loss) swollen leg, hair was dry and cracked, prominent
gingival bleeding and only one tooth was present.
3. Advice for vitamin C supplementation and other nutrient such as proteins and carbohydrates.
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