EL-GY 6813 / BE-GY 6203 / G16.

4426
Medical Imaging

Physics of Radiography

Jonathan Mamou and Yao Wang

Polytechnic School of Engineering
New York University, Brooklyn, NY 11201

Based on Prince and Links, Medical Imaging Signals and Systems and
Lecture Notes by Prince. Figures are from the book.
 Lecture Outline
• Atomic structure and ionization
• Particulate Radiation
– Focusing on energetic electron interaction
• EM Radiation
– Photoelectric
– Compton scattering
-> Likelihood of each phenomenon
– EM radiation measurement
– Attenuation of radiation
• Radiation Dosimetry
– Exposure, dose

Radiation Physics Yao Wang, NYU 2

 Atomic Structure
• An atom={a nucleus, electrons}
• Nucleus composed of nucleons =
{protons; neutrons}
• mass number A = # nucleons
• atomic number Z = # protons = #
electrons
– Define an element with a
particular symbol: H, C, etc.
– An element is denoted by its A
and Z

12
– Ex: 6 C or C - 12

Radiation Physics Yao Wang, NYU 3

 Stable vs. Unstable States
• Stable nuclides:
– # neutrons ~= # protons (A ~= 2Z)
• Unstable nuclides (radionuclides, radioactive atoms)
– Likely to undergo radioactive decay, which gives off energy and
results in a more stable nucleus

Radiation Physics Yao Wang, NYU 4

 Orbits of Electrons

Ground state: electrons are in the lowest orbital shells and within the lowest
energy quantum states within each shell

Radiation Physics Yao Wang, NYU 5

 Electron Binding Energy
• A free electron has higher energy than when it is bounded to an
nucleus in an atom
• Binding energy = energy required to free electrons from their atomic
orbits
– Depends on the element to which the electron is bound and the shell
within which it resides in ground state
– Sufficient to consider “average” binding energy of a given atom
• One electron volt (eV) = kinetic energy gained by an electron when
accelerated across one volt potential
– 1 eV = 1.6 x 10-19 Joule
• Binding energies of typical elements:
– hydrogen = 13.6 eV
– Air: 29 eV
– Lead: 1 KeV
– Tungsten: 4 KeV (considered a “heavy” element)

Electronvolt (eV) is a unit of energy equal ~1.602×10−19 J. It is the amount of energy gained (or lost) by the
charge of a single electron moving across a 1-V electric potential difference -> 1 volt (= 1 J/C) multiplied by
the elementary charge (e, or ~1.602×10−19 C). 1 eV = 1.602×10−19 J.
Radiation Physics Yao Wang, NYU 6
 Ionization and Excitation
• Ionization is “knocking” an electron out of an atom
– Creates a free electron + ion (an atom with +1 charge)
– Occurs when radiated with energy above the electron binding
energy
• Excitation is “knocking” an electron to a higher orbit
– When the radiation energy is lower than the binding energy
• After either ionization or excitation, an atom has higher
energy

Radiation Physics Yao Wang, NYU 7

 Characteristic Radiation
• What happens to ionized or excited atom?
– Return to ground state by rearrangement of electrons
– Causes atom to give off energy
– Energy given off as characteristic radiation
• infrared
• light
• x-ray

Radiation Physics Yao Wang, NYU 8

 Example
• Consider an electron accelerated through an X-ray tube where the anode is
made of tungsten. If the anode is held at 120 KV, what is the maximum
number of tungsten atoms that can be ionized?
• Solution:
– The electron will have 120 KeV kinetic energy when reaching the anode, by
definition of eV
– The average binding energy of tungsten = 4 KeV
– # ionized atoms = 120/4=30

Radiation Physics Yao Wang, NYU 9

 Ionizing Radiation

Radiation Physics Yao Wang, NYU 10

 Two Types of Ionizing Radiation
• Particulate
• Electro-magnetic (EM)

Radiation Physics Yao Wang, NYU 11

 Particulate Radiation
• Radiation by any particle (proton, neutron or electron) if it
possesses enough kinetic energy to ionize an atom

Kinetic Energy = the energy gained due to motion

m0
Mass of a moving particle : m =
2
1− v
c2
Energy vs. mass : E = mc 2
Kinetic Energy : KE = E − E0 = ( m − m0 )c 2
1 1 v2 1
When v << c, ≈1+ 2 , KE = m0v 2
1− v
2 2 c 2
c2

Radiation Physics Yao Wang, NYU 12

Particulate Radiation by Energetic Electrons
• We are only concerned with an electron accelerated in a X-ray tube
here
– An electron accelerated across a tube with 100 KV potential
possesses 100 KeV kinetic energy

Radiation Physics Yao Wang, NYU 13

 Energetic Electron Interactions
• Two primary interactions
– Collisional transfer
• Most common
• Produces heat
– Radiative transfer
• Produces x-ray
• Characteristic radiation
– Collide with K-shell
• Bremsstrahlung radiation
(“Braking or deceleration radiation”)
– Collide with nucleus
– More common than
characteristic radiation

Radiation Physics Yao Wang, NYU 14

 Collisional Transfer
• The energetic electron collides with an atom in the target
• Typically, a small fraction of the kinetic energy of the electron is transferred
to another electron in the atom
– As the affected atom returns to its original state, infrared radiation (heat) is
generated
• Occasionally, a large fraction of the incident energy is transferred to another
electron, the newly freed electron may form a delta ray
• The incident electron’s path may be redirected, and many other
subsequent interactions may occur, until the kinetic energy of the incident
electron is exhausted

Radiation Physics Yao Wang, NYU 15

 Characteristic X-Ray
• The incident electron collides with a K-shell electron,
exciting or ionizing the atom, leaving a hole in that shell.
– As the atom returns to its ground state, the k-shell hole is filled
by a higher shell electron
– The loss of energy creates an EM photon, known as
Characteristic x-ray
– The energy of the x-ray photon = difference between the energy
of the two shells (element dependent)

Radiation Physics Yao Wang, NYU 16

 Characteristic radiation
• Caused by removal of inner shell electrons and subsequent filling of hole with
electrons from higher shell. The shell-energy difference determines the energy of
characteristic rays
• Lines are named after the lower shell involved in the process; the upper shell involved
is denoted by Greek letters:

Continuum E [keV]
hν 0
N 0.5
- M 3
- - - Kγ
-
- -K
L αβ 11
- Kβ
M L L-lines
- - - Kα
- K αβ γ 70
K-lines
[From Graber, Lecture Note for BMI1-FS05]
Radiation Physics Yao Wang, NYU 17
 Different types of characteristics rays

From http://hyperphysics.phy-astr.gsu.edu/Hbase/quantum/xterm.html#c1

Radiation Physics Yao Wang, NYU 18

 Bremsstrahlung Ray
• As the incident electron approaches the nucleus of an atom, the
positive charge of the nucleus causes the incident electron to bend
around the nucleus and decelerates
– The loss of energy leads to the Bremsstrahlung x-ray (energy vary over
a continuous range, depending on the speed loss)
• Occasionally when the incident electron collides with the nucleus,
the electron is annihilated, emitting a photon with an energy equal to
the kinetic energy of the incident electron (highest possible energy)
• Primary source of x-rays from an x-ray tube

Radiation Physics Yao Wang, NYU 19

 Spectrum of X-Ray
Different curves
are generated
when different Generated when K-shell
voltage electrons are replaced by
potentials different outer shells
applied in a x-ray
tube

When the
incident
electron
collides with
a nucleus

Radiation Physics Yao Wang, NYU 20

 EM Radiation
• EM radiation comprises an electric wave and a magnetic
wave traveling at right angles to each other
• Typical EM waves:
– Non ionizing: radio, microwaves, infrared, visible light, ultraviolet
– Ionizing: X-rays, gamma rays
• Energy of a photon of an EM wave with frequency v:

Radiation Physics Yao Wang, NYU 21

 EM Waves for Medical Imaging
• X-rays and Gamma rays:
– Have energy in the KeVs to MeVs -> Ionizing Radiation
– used in X-ray/CT and nuclear medicine respectively
– X-rays are created by interaction of energetic electrons with
atoms
– Gamma rays are created in the nuclei of atoms due to
radioactive decay or characteristic radiation, typically have
higher energy than X-rays
• Radio waves
– Used to stimulate nuclei in MRI to generate EM radiation
• Visible light
– Used in radiography to improve the efficiency of photographic
film to detect X-rays
• See Table 4.2 for more details
Radiation Physics Yao Wang, NYU 22
 EM Radiation Interactions
• Two main interactions
– Photoelectric effect
• The incoming photon is completely absorbed and ejecting K-shell or
L-shell electrons, producing characteristic x-ray
– Compton scattering
• The incoming photon changes its direction

Radiation Physics Yao Wang, NYU 23

 Photoelectric Effect
• An incoming photon interacts with the nucleus of an atom, causing
ejection of a K-shell or L-shell electron (photoelectron)
– Atom completely absorbs incident photon and all energy is transferred
– The photoelectron propagates away with energy E − = hv − E
e B

– The affected atom produces characteristic x-ray, while outer electrons fill
the K-shell.
– Sometimes the characteristic x-ray transfers its energy to an outer
electron (called Auger electron)
• Both photo electron and Auger electron are energetic electrons that
can interact with the matter as discussed before

Radiation Physics Yao Wang, NYU 24

 Photoelectric Effect

Radiation Physics Yao Wang, NYU 25

 Compton Scattering
• An incoming photon ejects an outer shell electron,
yielding a Compton electron
• The incident photon loses its energy and changes its
direction (Not completely absorbed by the atom!)
• The scattered photon is called Compton photon

Radiation Physics Yao Wang, NYU 26

• The energy of the scattered photon depends on the
scatter angle

– The maximum energy loss occurs when the photon is deflected

backward (θ = 180o), backscattering
– When E is higher, more photons scatter forward
– The kinetic energy of the Compton electron = E-E’

Radiation Physics Yao Wang, NYU 27

 Which interaction is better?
• Photoelectric effect helps to differentiate different human
tissues/organs
• Compton scattering causes incident photons to deviate
from straight path, and causes unnecessary exposure of
x-ray to untargeted areas
• In medical imaging, we want to increase the likelihood of
photoelectric events, while minimizing Compton
scattering

Radiation Physics Yao Wang, NYU 28

 Probability of Photoelectric Effect
• Recall that a photoelectric event happens when incident photons
interact with the Coulomb field of the nucleus of an atom
• More likely when colliding with an atom with more protons (i.e.,
larger Z number)
• Less likely when incident photons have higher energy (higher
frequency)

– The probability increases abruptly when the photon energy rises above
the binding energy of L-shell or K-shell electrons (so as to eject the
electrons), then begins to diminish
– Rationale behind the use of “contrast agent”
– Z numbers: soft tissue: 7.4 soft, bone: 13.8
– More contrast with low energy x-ray
– Photoelectric effect dominate over Compton scattering at low energy

Radiation Physics Yao Wang, NYU 29

 Probability of Compton Scattering
• Recall that Compton scattering occurs when an incident photon
collides with outer shell electrons
• Likelihood proportional to the number of electrons per kilogram of
the material (the electron density or ED)
• Relatively independent of incident photon energy in biological
materials

N AZ
ED =
Wm
N A : Avogadro' s number (atoms/mole)
Z : atomic number (electrons/atom)
Wm : molecular weight (grams/mole)

• ED is approximately constant for various biological material, ~

3*1026, except for hydrogen (6*1026)
• Does not provide tissue contrast
Radiation Physics Yao Wang, NYU 30
 Relative Likelihood
• Compton scattering is equally likely in various materials
and invariant of incident energy
• Photoelectric effect is more likely in high Z material and
less likely with high incident energy
• Overall, Compton scattering is more dominant with
higher incident energy in the same material
• But the percent of energy deposited due to photoelectric
event is larger because all incident energy is absorbed.

Radiation Physics Yao Wang, NYU 31

 Measures of X-ray Beam: Photon Count

• N: number of photons
• A: area
Radiation Physics Yao Wang, NYU 32
 Measures of X-ray Beam: Energy Flow

Radiation Physics Yao Wang, NYU 33

 Spectrum of X-Ray
• The x-ray beam produced by an x-ray tube (mainly
Bremsstrahlung) is polyenergetic (consisting photons
with different energies or frequencies)
• X-ray spectrum S(E):
– The number of photons with energy E per unit area per unit time

Radiation Physics Yao Wang, NYU 34

 Spectrum of X-Ray
Different curves
are generated
when different
voltage Generated when K-shell
potentials electrons are replaced by
applied in a x-ray different outer shells
tube

When the
incident
electron
collides with
a nucleus

Radiation Physics Yao Wang, NYU 35

 Attenuation of X-ray Radiation:
Homogeneous Slab

N0

Photons will be absorbed/deflected through the slab

Let # of photons at x = N(x)
# photons lost from position x to x+dx can be approximated by
dN=N(x+dx)-N(x) = - μ N(x)dx, when dx is very small
linear attenuation coefficient: μ
μ is the fraction of photons that are lost per unit length
The above can be rewritten as
dN(x)/dx = - μ N(x). Integrate this from x=0 to ∆x yields
N(x) = N0 exp{-μ x} The fundamental photon attenuation law
Radiation Physics Yao Wang, NYU 36
 Linear Attenuation Coefficients of
Biological Tissues

Radiation Physics Yao Wang, NYU 37

 Homogeneous Slab
• Homogeneous slab: the attenuation rate is the same
over the entire slab

Radiation Physics Yao Wang, NYU 38

 Half-Value Layer (HVL)

Radiation Physics Yao Wang, NYU 39

 Example
• Consider the image taken of a bar phantom uniformly
irradiated by monoenergetic x-ray photons
– Assuming the bars are made of material that has a HVL of
0.2cm, and bars have thickness of 0.4 cm
– Assuming x-ray photons pass through the space between bars
w/o attenuation
– Assuming the intensity of the image is proportional to the
number of detected photons in a unit area
– What is the contrast of the resulting image?

• Go through in the class

Radiation Physics Yao Wang, NYU 40

Radiation Physics Yao Wang, NYU 41
 Non-Homogeneous Slab
• The attenuation coefficient depends on x

Radiation Physics Yao Wang, NYU 42

 Example: Two Layer Slab
• A slab with two homogeneous layers, with thickness d1,
d2, and attenuation coefficients μ1, μ2. If the input X-ray
intensity is N0, what is the intensity at the other end of
the slab?

Radiation Physics Yao Wang, NYU 43

 Polyenergetic Photons
• The linear attenuation coefficient depends on the medium property as
well as the energy of the incident photon (E)
• For a given material, μ can be denoted by μ(x;E)
• When the incident photons are polyenergetic, with spectrum S(E), the
outgoing photon spectrum is

{ x
S ( x; E ) = S 0 ( E ) exp − ∫ µ ( x' ; E )dx'
0
}
• In terms of intensity
∞
I = ∫ E ' S ( E ' )dE '
0
∞

0
{ 0
x
}
I ( x) = ∫ S 0 ( E ' ) E ' exp − ∫ µ ( x' ; E ' )dx' dE '

Radiation Physics Yao Wang, NYU 44

 Radiation Dosimetry
• Previous topics deal with the production of radiation and
measurement of radiation wave
• Radiation dosimetry considers the effect of radiation to
the interacting media
– Exposure
– Dose
– Kerma
– Effective dose

Radiation Physics Yao Wang, NYU 45

 Exposure (Creation of Ions)

• Exposure (X) is measured in terms of the number of ions produced

in a specific volume of air by EM radiation

• SI unit: C/kg
• Common unit: Roentgen (R)
– 1 C/kg = 3876 R
– Wilhelm Roentgen: Discovered X-ray, 1895, Nobel Prize 1901

• Exposure decreases with distance from source (d) following a

inverse square law
X (d ) = X (0) / d 2

Radiation Physics Yao Wang, NYU 46

 Dose (the deposition of energy)

Radiation Physics Yao Wang, NYU 47

 Kerma

Radiation Physics Yao Wang, NYU 48

 Dose vs. Exposure
D = fX
f - factor depends on material :
 µ 
 ρ  material
f = 0.87
 µ 
 ρ  air
 µ  : mass attenuation coefficient
 ρ
f = 0.87 for air
f ≈ 1 for soft - tissue

See Table 4.6 for the mass attenuation coefficient of typical materials

Radiation Physics Yao Wang, NYU 49

 Equivalent and Effective Dose
• Dose equivalent
– The effect of radiation depends on the source of radiation (energy)
– Dose equivalent: H = D Q
– Q: quality factor
• Q = 1 for x-ray, gamma ray, electron, beta particle (used in medical imaging)
• Q = 10 for neutrons and protons
• Q = 20 for alpha particles
• Effective dose
– Effect of a dose also depends on the tissue type
– Effective dose measures the average effect over different tissue types

Deffective = ∑w H
organs
j j

w j :weighting factor for organ j

• D can be measured in rads, H can be measured in rems
• For a dose of 1 Gy and Q =1 -> H = 1 sievert (Sv)
Radiation Physics Yao Wang, NYU 50
Radiation Physics Yao Wang, NYU 51
 Effective Dose of Different Tissues
[Smith&Webb]

Radiation Physics Yao Wang, NYU 52

 Summary
• Ionization: ejection of an orbiting electron from an atom, the affected
atom produces radiation in the process of returning to ground state
• Two types of ionizing radiation
– Particulate
– EM
• Particulate radiation transfers energy via
– Collisional transfer: resulting in heat
– Radioactive transfer: resulting in characteristic x-ray and
Bremsstrahlung x-ray
– X-ray is produced by energetic electrons accelerated in a x-ray tube,
consisting primarily Bremsstrahlung x-ray
• EM radiation transfers energy via
– Photoelectric effect: incident photons completely absorbed
– Compton scattering: incident photons are deflected
– X-ray imaging utilizes EM photoelectric effect caused by injected X-ray
photons.

Radiation Physics Yao Wang, NYU 53

 Summary (cntd)
• Attenuation of EM radiation:
– Linear attenuation coefficient is the fraction of photons that are
lost per unit length
• Depends on material property and the incident photon energy
– Fundamental photon attenuation law
• Homogeneous slab
• Heterogeneous slab

• Radiation dosimetry
– Exposure vs. dose: D=fX
– Equivalent dose: H=DQ
– Effective dose: D
effective = ∑ w j H j
organs

w j :weighting factor for organ j

Radiation Physics Yao Wang, NYU 54

 Reference
• Prince and Links, Medical Imaging Signals and Systems,
Chap 4.

Radiation Physics Yao Wang, NYU 55

 Homework
• Reading:
– Prince and Links, Medical Imaging Signals and Systems, Chap
4.
• Will be assigned at the end of lecture 3 and due on
Friday Sept 29

Radiation Physics Yao Wang, NYU 56