Digestive System
Digestive System
Esophagus. Once you begin swallowing, the process becomes automatic. Your brain signals the muscles
of the esophagus and peristalsis begins.
Lower esophageal sphincter. When food reaches the end of your esophagus, a ringlike muscle—called
the lower esophageal sphincter —relaxes and lets food pass into your stomach. This sphincter usually
stays closed to keep what’s in your stomach from flowing back into your esophagus.
Stomach. After food enters your stomach, the stomach muscles mix the food and liquid with digestive
juices. The stomach slowly empties its contents, called chyme, into your small intestine.
Small intestine. The muscles of the small intestine mix food with digestive juices from the pancreas,
liver, and intestine, and push the mixture forward for further digestion. The walls of the small intestine
absorb water and the digested nutrients into your bloodstream. As peristalsis continues, the waste
products of the digestive process move into the large intestine.
Large intestine. Waste products from the digestive process include undigested parts of food, fluid, and
older cells from the lining of your GI tract. The large intestine absorbs water and changes the waste from
liquid into stool. Peristalsis helps move the stool into your rectum.
Rectum. The lower end of your large intestine, the rectum, stores stool until it pushes stool out of your
anus during a bowel movement.
What happens to the digested food?
The small intestine absorbs most of the nutrients in your food, and your circulatory system passes them
on to other parts of your body to store or use. Special cells help absorbed nutrients cross the intestinal
lining into your bloodstream. Your blood carries simple sugars, amino acids, glycerol, and some vitamins
and salts to the liver. Your liver stores, processes, and delivers nutrients to the rest of your body when
needed.
The lymph system NIH external link, a network of vessels that carry white blood cells and a fluid called
lymph throughout your body to fight infection, absorbs fatty acids and vitamins.
Your body uses sugars, amino acids, fatty acids, and glycerol to build substances you need for energy,
growth, and cell repair.
Hormones
Cells lining your stomach and small intestine make and release hormones that control how your
digestive system works. These hormones tell your body when to make digestive juices and send signals
to your brain that you are hungry or full. Your pancreas also makes hormones that are important to
digestion.
Nerves
You have nerves that connect your central nervous system—your brain and spinal cord—to your
digestive system and control some digestive functions. For example, when you see or smell food, your
brain sends a signal that causes your salivary glands to "make your mouth water" to prepare you to eat.
You also have an enteric nervous system (ENS)—nerves within the walls of your GI tract. When food
stretches the walls of your GI tract, the nerves of your ENS release many different substances that speed
up or delay the movement of food and the production of digestive juices. The nerves send signals to
control the actions of your gut muscles to contract and relax to push food through your intestines.
Clinical Trials
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and other components of
the National Institutes of Health (NIH) conduct and support research into many diseases and conditions.