225-28722M

Jan.2022

LabSolutions™ LCMS

Notice before using

Version 5.114

Read the instruction manual thoroughly before using the product. Keep this
instruction manual handy so that you can refer to it when necessary.
<< Notices >>
1) If the user or usage location changes, be sure this Instruction Manual is always kept
together with the product.
2) To ensure safe operation, contact your Shimadzu representative for installation,
adjustment, or re-installation after moving the instrument to a different site.
3) The content of this manual is subject, without notice, to modifications for the sake of
improvement.
4) Every effort has been made to ensure that the content of this manual was correct at
the time of creation. However, in the event that any mistakes or omissions are
discovered, it may not be possible to correct them immediately.
5) The contents of the hard disk in a PC can be lost due to an accident. To protect your
important data from accidents, be sure to back up your data.
6) Microsoft, Windows, Windows 10, and Windows 7 are registered trademarks of
Microsoft Corporation in the USA and other countries.
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8) Screenshots of Microsoft products are used in accordance with guidelines from
Microsoft Corporation.

The copyright of this manual is owned by Shimadzu Corporation. Reproduction and

duplication of whole or part of the content without permission of the company are strictly
prohibited.

© 2016-2022 Shimadzu Corporation. All rights reserved.

<Contents>
1. About File Compatibility with LCMSsolution Version 3 ..............................................1
1.1 About File Compatibility .......................................................................................................... 1
1.2 About the [Data Processing Settings]........................................................................................ 1
2. LC Units ............................................................................................................................2
2.1 ROM Versions ........................................................................................................................... 2
2.1.1 Nexera X3 / Nexera XS / Nexera XR / Nexera lite series .................................................. 2
2.1.2 Systems other than above ................................................................................................... 3
2.2 RS-232C Communication Settings ........................................................................................... 8
(1) SCL-10Avp/SIL-HT .............................................................................................................. 8
(2) SCL-10Asp Version 1 ............................................................................................................ 8
2.3 SPD-M10Avp Photo Diode Array Detector .............................................................................. 9
(1) Driver .................................................................................................................................... 9
(2) ROM Version......................................................................................................................... 9
(3) Wavelength Calibration ....................................................................................................... 10
3. Using the Online Manual............................................................................................... 11
3.1 Manual .................................................................................................................................... 11
3.2 Online Manual Viewer ............................................................................................................ 12
4. Sample Files and Report Template Files ....................................................................13
4.1 Sample Files ............................................................................................................................ 13
4.2 Report Template Files ............................................................................................................. 13
5. CLASS-Agent Manager .................................................................................................14
5.1 Setting the instrument information files of the CLASS-Agent Manager ................................ 14
6. Procedures for Converting CLASS-LC10 Files into LabSolutions Format .............14
6.1 Procedure for converting method files .................................................................................... 14
a. Batch conversion via Data Explorer...................................................................................... 14
b. Seamless loading from the File Menu ................................................................................... 15
6.2 Procedure for converting data files ......................................................................................... 16
6.2.1 Converting chromatograms .............................................................................................. 16
6.2.2 Conversion including a method and calculation results ................................................... 16
7. Procedures for Converting CLASS-VP Files into LabSolutions Format .................17
7.1 Handling CLASS-VP files ...................................................................................................... 18
7.2 Preparing for file conversion................................................................................................... 19
a. Installing the CLASS-VP software ....................................................................................... 19
b. Copying CLASS-VP files ..................................................................................................... 19
7.3 Procedure for converting method files .................................................................................... 20
a. Batch conversion via the Data Explorer window .................................................................. 20
b. Seamless loading via the File Menu...................................................................................... 21
7.4 Procedure for converting data files ......................................................................................... 22
 a. Batch conversion via the Data Explorer window .................................................................. 22
b. Seamless loading via the File Menu...................................................................................... 23
8. Notice for PDF File Output ...........................................................................................24
8.1 Notice for PDF Output Settings .............................................................................................. 24
8.2 About Printing when “Redirect Report to PDF file” is selected ............................................. 24
9. About the setting of Windows ......................................................................................26
9.1 Precautions for Windows Update ............................................................................................ 26
9.2 Precautions for security on folders in Windows ..................................................................... 26
9.3 Precautions for Sleep function ................................................................................................ 26
10. About installation ........................................................................................................27
10.1 Notice for installation (User Account Control) ..................................................................... 27
10.2 Notice for installation ........................................................................................................... 27
10.3 Notice for installed files and folders ..................................................................................... 28
10.4 Notice for install language .................................................................................................... 28
10.5 Notice for External Hard Drives or USB Flash Drives ......................................................... 28
11. About the (MSn) MS library search feature ...............................................................28
11.1 About the library file compatibility ....................................................................................... 28
11.2 How to convert MS library to (MSn) MS library file ............................................................ 29
11.3 About the MS library search similarity ................................................................................. 29
11.4 About Report template file .................................................................................................... 29
12. Notice for Using Windows 10 .....................................................................................29
12.1 Precautions When Removing External Storage Media ......................................................... 29
13. Others ...........................................................................................................................30
13.1 Cautions When Adding LCMS for the First Time ................................................................ 30
13.2 About License ....................................................................................................................... 30
13.3 Notice of uninstalling the software ....................................................................................... 30
1. About File Compatibility with LCMSsolution Version 3
1.1 About File Compatibility
The following files created by LCsolution [Version 1] are seamlessly opened by
LabSolutions [Version 5].
• Method files
• Data files
• Batch files
• UV spectrum files
• UV library files
• MS library files
Note. When performing Postrun batch, the manual integration settings of LC or PDA are
applied to each data file, as they are stored in the data file.
Note. These files created by LabSolutions [Version 5] cannot be opened by LCMSsolution
[Version 3].

1.2 About the [Data Processing Settings]

In LabSolutions [Version 5], [Apply] or [Not Used] of [Dilution Factor] can be selected for
the quantitative calculation formula on LC or PDA data. By default, [Apply] of [Dilution
Factor] that is compatible with LCMSsolution [Version 3] is selected.
In LabSolutions [Version 5], it is selected on the [System Settings]/[Data Proc. Settings]
window of the [Administration Tools]. Please set [Dilution Factor] to [Not Used] after the
system is installed, when using the system by the formula that [Dilution Factor] is [Not
Used].

Be advised that the same results are not printed out when a data file is reprocessed as the
quantitative calculation formula and the display format are different if the data processing
settings are different on the two PCs. Please unify the data processing settings in the
[Data Processing Settings] window and use the PCs in the laboratory.
Note. For MS data, quantitative calculation is always performed by a method with the
[Apply] setting even if a method with the [Not Used] setting is selected. Therefore,
run the calculation with the default setting (method where the dilution factor is used)
unless otherwise necessary.
To change the setting, perform the procedure described below.

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2. LC Units
2.1 ROM Versions
Please check the ROM version of each LC unit and consider an upgrade to a later
version to obtain the functionality as described in the table below.

2.1.1 Nexera X3 / Nexera XS / Nexera XR / Nexera lite series

Model Name ROM Version Remarks
SCL-40 / CBM-40 / CBM-40lite 1.30 or later System controller
LC-40D X3 / 40B X3 / 40D XS,
1.02 or later
LC-40D XR / 40B XR / 40D
LC-40P SF 1.00 or later
SCL-40/CBM-40/CBM-40lite Ver. 1.60 or later
LC-40D XSi 1.07 or later
is necessary.
SIL-40C X3 / 40C XS, 1.04 or later Syringe unit option is available for version
SIL-40 XR / 40C XR / 40 / 40C 5.00 or later.
1.10 or later SCL-40/CBM-40/CBM-40lite Ver. 1.60 or later
SIL-40C XSi
is necessary.
PLATE CHANGER 1.04 or later
CTO-40S / 40C 1.00 or later
SPD-40 / 40V 1.03 or later
SPD-M40 2.00 or later
SFC-40P 1.00 or later
FRC-40 1.00 or later
FRC-40 SF 1.00 or later
LH-40 1.00 or later
FRS-40 1.00 or later
1.00 or later SCL-40/CBM-40/CBM-40lite Ver. 1.43 or later
CRB-40
is necessary.
pHM-40 1.00 or later

Modules listed in the table below are also controlled via system controller
SCL-40 / CBM-40 / CBM-40lite
Model Name ROM Version Remarks
LC-30AD 2.10 or later
LC-30ADSF 1.00 or later
LC-20ADXR 1.30 or later
LC-20AD 1.10 or later
LC-20AT 1.07 or later
LC-20AB 1.10 or later
LC-20AP 1.10 or later
LC-20AR 1.00 or later
LC-20Ai 3.11 or later
LC-10Ai 3.1 or later
LC-6AD/7A 1.4 or later
LC-8A 1.5 or later
SIL-30AC 3.11 or later
SCL-40/CBM-40/CBM-40lite Ver. 1.40 or later
SIL-30ACFV 3.20 or later
is necessary.
Rack Changer II 2.00 or later
SIL-30ACMP 1.00 or later
SFE-30A 1.00 or later
SIL-20AXR/20ACXR,
1.22 or later
SIL-20A/20AC

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 SIL-10Ai 3.50 or later
SIL-10AF 4.10 or later
SIL-10AP 4.10 or later
CTO-30A 2.00 or later
CTO-30AS 1.00 or later
CTO-20A/20AC 1.07 or later
CTO-10ASvp 5.28 or later
SPD-20A/20AV 1.10 or later
RF-20A/20AXS 1.00 or later
RID-20A 1.00 or later
RF-10A 3.0 or later
RF-10AXL 3.32 or later
CDD-10Avp/sp 5.00 or later
FRC-10A 3.30 or later
SFC-30A 1.00 or later
Option Box VP 5.22 or later

2.1.2 Systems other than above

a. i-Series LC-2050
Model Name ROM Version Remarks
LC-2050 3.10 or later
LC-2050C 3.10 or later
LC-2050C 3D 3.10 or later
LC-2050C LT 3.10 or later
RF-20A/20AXS 1.00 or later
RID-10A 3.0 or later
RID-20A 1.00 or later

b. i-Series LC-2060
Model Name ROM Version Remarks
LC-2060C 3.10 or later
LC-2060C 3D 3.10 or later
LC-2060C 3D MT 3.10 or later
RF-20A/20AXS 1.00 or later
RID-10A 3.0 or later
RID-20A 1.00 or later

c. i-Series LC-2030 (Prominence-i)

Model Name ROM Version Remarks
LC-2030 / LC-2030 Plus 1.10 or later
LC-2030C / LC-2030C Plus 1.10 or later
LC-2030C 3D/ LC-2030C 3D Plus 1.10 or later
LC-2030C LT / LC-2030C LT Plus 2.00 or later
RF-20A/20AXS 1.00 or later
RID-10A 3.0 or later
RID-20A 1.00 or later

d. i-Series LC-2040 (Nexera-i)

Model Name ROM Version Remarks
LC-2040C / LC-2040C Plus 1.10 or later
LC-2040C 3D/ LC-2040C 3D Plus 1.10 or later
LC-2040C LT / LC-2040C LT Plus 2.00 or later
LC-2040C MT / LC-2040C MT Plus 2.10 or later

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 LC-2040C 3D MT /
2.10 or later
LC-2040C 3D MT Plus
RF-20A/20AXS 1.00 or later
RID-10A 3.0 or later
RID-20A 1.00 or later

e. Nexera X2 series
Model Name ROM Version Remarks
LC-30AD 2.01 or later
CBM-20A/lite Ver. 2.10 or later is
LC-30AD LPGE mode 2.10 or later necessary.
Support for 10mL/min flow rate.
CBM-20A/lite Ver. 3.20 or later is
LC-30ADSF 1.00 or later
necessary.
Ver. 3.11 or later is necessary for Nexera
SIL-30AC 2.00 or later
UC.
CBM-20A/lite Ver. 3.60 or later is
SIL-30ACFV 3.20 or later
necessary.
Rack Changer II 2.00 or later
CBM-20A/lite Ver. 2.20 or later is
SIL-30ACMP 1.00 or later
necessary.
CBM-20A/lite Ver. 3.20 or later is
SFE-30A 1.00 or later
necessary.
CTO-30A 2.00 or later
CBM-20A/lite Ver. 2.20 or later is
CTO-30AS 1.00 or later
necessary.
CBM-20A/lite Ver. 2.40 or later is
SPD-M30A 3.00 or later
necessary.
CBM-20A/lite Ver. 3.30 or later is
SPD-30AM 4.00 or later
necessary.
CBM-20A/lite Ver. 3.20 or later is
SFC-30A 1.00 or later
necessary.
* Use CBM-20A/lite for the system controller.

f. Nexera XR series
Model Name ROM Version Remarks
LC-20ADXR 1.21 or later
CBM-20A/lite Ver. 2.50 or later is
LC-20ADXR LPGE mode 1.30 or later
necessary.
LC-20ADXR CBM-20A/lite Ver. 2.60 or later is
1.30 or later
Compressibility Setting necessary.
SIL-20AXR/20ACXR 1.22 or later
* Use CBM-20A/lite for the system controller.

g. Prominence series
Model Name ROM Version Remarks
CBM-20A/lite 2.02 or later
LC-20AD 1.10 or later
LC-20AT 1.07 or later
LC-20AB 1.10 or later
LC-20AP 1.00 or later
CBM-20A/lite Ver. 2.60 or later is
LC-20AP LPGE mode 1.10 or later
necessary.

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 CBM-20A/lite Ver. 2.90 or later is
LC-20AR 1.00 or later
necessary.
CBM-20A/lite Ver. 3.10 or later is
LC-20Ai 1.00 or later necessary.
LPGE mode is not supported.
SIL-20A/20AC 1.22 or later
Rack Changer/C 1.11 or later
CTO-20A/20AC 1.07 or later
SPD-20A/20AV 1.04 or later
SPD-20A/20AV 100Hz sampling 1.10 or later
SPD-M20A 1.08 or later
SPD-M20A 100Hz sampling 1.10 or later
RF-20A/20AXS 1.00 or later
CBM-20A/lite Ver. 2.80 or later is
RID-20A 1.00 or later
necessary.

h. Prominence Plus series

Model Name ROM Version Remarks
CBM-20A/lite 3.80 or later
LC-20ATXR 5.00 or later
SIL-20AXR 5.00 or later
SIL-20ACXR 5.00 or later
CTO-20A 5.00 or later
SPD-20A 5.00 or later

i. Nexera Prep
Model Name ROM Version Remarks
LH-40 1.00 or later
FRC-40 1.00 or later

j. LC-2010
Model Name ROM Version Remarks
LC-2010A/C 1.13 or later
2.11,
LC-2010AHT/CHT
3.10 or later

k. LC-VP
Model Name ROM Version Remarks
5.43, 6.22 or
SCL-10Avp
later
SCL-10Asp 6.03 or later When use the CDD-10Avp/sp
LC-10ADvp 5.31 or later
LC-10ATvp 5.31 or later
Ver. 5.35 or later is necessary when it is
SIL-10ADvp 5.34 or later
used with the CBM-20A/lite.
SCL: 6.22 or
later
SIL-HTA/C
SIL: 6.06 or
later
CTO-10Avp/10ACvp 5.27 or later
CTO-10ASvp 5.28 or later
SPD-10Avp/10AVvp 5.24 or later
SPD-M10Avp 3.30 or later Available only for 32bit Windows.
CDD-10Avp/sp 5.00 or later
Option Box VP/Subcon VP 5.22 or later

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l. LC-10A series
Model Name ROM Version Remarks
LC-10AD 3.1 or later
LC-10AT 3.1 or later
LC-10Ai 3.1 or later
LC-10AS 3.1 or later
LC-6AD/7A 1.4 or later
LC-8A 1.5 or later
When the CBM-20A is used, 4.20 cannot
SIL-10A/10Ai 3.50 or later
be used.
When the CBM-20A is used, 4.20 cannot
SIL-10AF 4.10 or later
be used.
When the CBM-20A is used, 4.20 cannot
SIL-10AP 4.10 or later
be used.
SIL-10AXL 3.61 or later
CTO-10A/10AC 3.0 or later
SPD-10A/10AV 3.0 or later
SPD-10Ai/10AVi 3.0 or later
RID-10A 3.0 or later
RF-10A 3.0 or later
RF-10AXL 3.32 or later
Option Box L, Valve I/F 3.2 or later
When the CBM-20A is used, 3.60 cannot
FRC-10A 3.30 or later be used. 3.61 or later version is
necessary.

m. Others
Model Name ROM Version Remarks
Ver. 1.5 or The analog input board (PC-55N) is
ELSD-LT II
later separately necessary.
Ver. A.0.7 or
ELSD-LT III
later
Analog input board (PC-55N) - SCL-10Avp/sp or CBM-20A is required.
Analog input board Available only for
-
(for LC-2030/2040/2050/2060) LC-2030/2040/2050/2060
The system configuration setting up
CBM-201m 1.0 or later CBM-201m and other devices together is
not supported.
Centrifugal field-flow fractionation (CF3)
FFF-C8030 1.01 or later
unit

n. ROM version required for each feature

System Controller
Item CBM-20A/lite*
ROM version of LC units
4 wavelength in RF-20A/AXS RF-20A/AXS Ver. 1.10 or later
Ver. 2.40 or later
The data can be acquired by
specifying the 4 wavelength RF-20A/AXS Ver. 1.10 or later
for the excitation and (LC-2030/2040)
(as an external detector for
fluorescence wavelength. Ver.1.10 or later
LC-2030/ 2040)
Multiple oven
Ver. 2.40 or later
4 ovens can be controlled.

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 Solvent blending LC-30AD Ver. 2.20 or later
The concentration of the mobile
phase can be controlled Ver. 2.40 or later
using the valve attached to the
pump.
Switching injection method SIL-30AC Ver. 3.15 or later
for SIL-30AC with SFC
system
Ver. 3.40 or later
The injection method (Direct or
Loop(SFC) injection) can be
specified in the method.
* When the system controller is SCL-40/CBM-40/CBM-40lite, there is no limit on the
ROM version of the system controller.
Note. We recommend that you ask Shimadzu service associate to perform ROM
upgrades.Please note that this service is not covered under warranty and is billed
separately.

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2.2 RS-232C Communication Settings
(1) SCL-10Avp/SIL-HT
LabSolutions communicates with SCL-10Avp/SIL-HT via an Enhanced Level protocol.
Use the following procedure to set the protocol mode to “Enhanced”.
1. Turn ON the power supply on the SCL-10Avp/SIL-HT.
2. From the main menu, press "F4 (SYSTEM)" and "F3 (NEXT)" to open the
COMMUNICATION SETTING screen.
3. Set the communication settings as follows.
CLASS-VP: 5.x
Interface: RS-232C
Baud rate: 19200
Level: Enhanced
4. Turn OFF the SCL-10Avp/SIL-HT power supply, then re-start.

(2) SCL-10Asp Version 1

Note. When using an SCL-10Asp Version 6, please refer to “(1) SCL-10Avp/SIL-HT”. In
this case, you select “SCL-10Asp” and “RS232C” as a communication setting for
LabSolutions. The system cannot be worked properly if the following Version 1
setting is specified.

The Enhanced mode cannot be used with the HIC-SP Suppressor Ion Chromatograph
(CDD-6A + SCL-10Asp Ver 1.xx). Please set the Level to “Standard” as described in
the procedure below.
1. Turn ON the SCL-10Asp power supply.
2. From the main menu, press "F4 (SYSTEM)" and "F3 (NEXT)" to open the
COMMUNICATION SETTING screen.
3. Set the communication settings as follows.
CLASS-VP: 5.x
Interface: RS-232C
Baud rate: 19200
Level: Standard (or Level2)
4. Turn OFF the SCL-10Asp power supply, and then re-starts.

Note. Please set “RS232C (S)”as a communication setting of theSCL-10Asp of the

[instrument] sub-window on the system configuration of LabSolutions when you use
standard mode.

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2.3 SPD-M10Avp Photo Diode Array Detector
Note. SPD-M10Avp cannot be used in Windows 10.
Note. SPD-M10Avp cannot be used with a 64-bit OS, so perform the following procedures
with a 32-bit OS.

(1) Driver
It is necessary to install SPD-M10Avp driver when using SPD-M10Avp detectors on
LabSolutions. Follow the next procedure to install the SPD-M10Avp driver.
1. Shut down the PC after LabSolutions is installed. Connect the SPD-M10Avp
detectors to the PC and turn on the power of the detectors.
2. Turn on the PC after the initialization of the SPD-M10Avp detectors is finished.
In the case of Windows 7, the installation is automatically complete by the
hardware wizard.

Note. Even if LabSolutions is not installed, the hardware wizard starts the installation of
the SPD-M10Avp driver when the Windows starts and the installation fails. In this
case please cancel the hardware wizard and close it, then install LabSolutions and
reboot PC.

(2) ROM Version

The SPD-M10Avp ROM version must be 3.3 or later.
When the SPD-M10Avp is installed in your HPLC system, please check the version
number using the following procedure.

Note. If the ROM is older than version 3.3, it is necessary to upgrade it. We recommend
that you ask Shimadzu service associate to perform ROM upgrades for
SPD-M10Avp model. Please note that this service is not covered under warranty
and is billed separately.

Procedure to check SPD-M10Avp CPU ROM Version

1. Turn on the power switch on the SPD-M10AVP main unit and wait until the LED
stops blinking.
2. Turn on the PC and start LabSolutions.
3. Select the [Operation] menu and click the [Analysis] icon to log in the Analysis
program (with user ID “admin” and no password by default).
4. Select [Instrument]-[System Configuration] menu to display the [Instrument]
sub-window. (Double click the Instrument [Communication Settings] icon to display
the [Instrument] sub-window if System Configuration window is open.)
Click the [SCSI List] button to open the [SCSI Instruments] sub-window.

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 5. Select the [SHIMADZU SPD-M10Avp] item, and click the [OK] button to close the
[SCSI Instruments] sub-window.
6. Click the [OK] button to close the [Instrument] sub-window.
7. Double click the [Detector] icon in Available Modules to open the instrument tree
and move SPD-M10Avp to Modules Used for Analysis.
8. Click the [Auto Configuration] button.
9. Double click the [SPD-M10Avp] icon to open the [PDA Detector] sub-window and
check the ROM version.
10. Click the [OK] button to close the [System Configuration] window.

(3) Wavelength Calibration

When LabSolutions is upgraded from CLASS-VP or the SPD-M10Avp is installed for
the first time, it is necessary to calibrate the wavelength on the SPD-M10Avp.

Procedure to perform the SPD-M10Avp wavelength calibration

1. Terminate all Analysis programs if they are running.
2. Select [Start]-[Programs]-[LabSolutions]-[Instrument Maintenance Tools].
3. In the [Application] drop-down box select “PDA Utility(SPD-M10Avp/M20A)” and
for the [Instrument No.] select the corresponding instrument to launch the PDA
utility program.
4. Select the Wavelength Calibration button to perform wavelength calibration.
Note. The SPD-M10Avp should be configured using LabSolutions prior to performing the
wavelength calibration.

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3. Using the Online Manual
3.1 Manual
All information necessary for using LabSolutions LCMS is provided by the documents
contained in the C:\LabSolutions\Manual folder ( on the LabSolutions LCMS Installation
disc: \LabSolutions\ManualFL\en).
*1 The LCMS-2050 software instruction manual is provided in common with the hardware.
Refer to LabSolutions LCMS Operators Guide for LCMS-2020 from LCMS-2050
instruction manual.
*2 Select [Print As Image] in [Print] dialog box before printing.
*3 In terms of applicable instruments, "LCMS-SQ" is indicated in the shared content for the
LCMS-2020/2050", LC/MS/MS" is indicated in the shared content for the
LCMS-8030/LCMS-8040/LCMS-8045/LCMS-8050/LCMS-8060(NX), and "LCMS
Q-TOF" is indicated in the content for the LCMS-9030.
*4 It is on the LabSolutions LCMS Installation disc: \BridgeSoftwareProMass.
*5 It is on the LabSolutions LCMS Installation disc:
\LabSolutions\Supplement\LogCollectionTool\Manual.
No. Documents Instruments*3 Files
LabSolutions LCMS Installation LCMS-SQ LCMS_Installation&
1 and Maintenance Manual LC/MS/MS MaintenanceGuide.pdf
LCMS Q-TOF
LabSolutions LCMS Operation LCMS-2020 LCMS_OperatorsGuide.pdf
2 Manual*1 LC/MS/MS LCMSMS_OperatorsGuide.pdf
LCMS Q-TOF
LabSolutions LCMS LCMS-SQ SystemUsersGuideFile.pdf
3 Administration Manual LC/MS/MS
LCMS Q-TOF
LabSolutions LCMS Data LCMS-SQ DataAcquisition&Processing
4 Acquisition and Processing LC/MS/MS TheoryGuide.pdf
Theory Manual LCMS Q-TOF
LabSolutions LCMS Quick LCMS-2020 LCMS_GettingStartedGuide.pd
Manual*1 f
5
LC/MS/MS LCMSMS_GettingStartedGuide
.pdf
LabSolutions LCMS Software LCMS-SQ LCMS_ReleaseNotes.pdf
6 Release Notes LC/MS/MS
LCMS Q-TOF
Software License Authentication LCMS-SQ LicenseManageToolManual.p
7 Instructions LC/MS/MS df
LCMS Q-TOF
Quick Guide for Connection of LCMS-SQ QuickGuideforConnectionof
8 CBM-20A (lite) and LC/MS/MS CBM-PDA.pdf
SPD-M20A/SPD-M30A LCMS Q-TOF
Prominence-i / Nexera-i LCMS-SQ QuickGuideforICM.pdf
9 Interactive Communication LC/MS/MS
Mode(ICM) LCMS Q-TOF
LabSolutions LCMS Readme LCMS-SQ ReadMe.pdf
10 LC/MS/MS
LCMS Q-TOF
Notice before using LabSolutions LCMS-SQ LCMS_Notice.pdf
11 LCMS (This sheet) LC/MS/MS
LCMS Q-TOF

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 LabSolutions Certificate of LCMS-SQ CertificateOfCompliance.pdf
12 Compliance*2 LC/MS/MS
LCMS Q-TOF
LabSolutions LCMS i-PeakFinder LCMS-SQ i-PeakFinder_Tips&Tricks.pdf
13 (New Peak Integration) LC/MS/MS
Guide to Adjusting Parameters LCMS Q-TOF
LabSolutions LCMS LCMS-SQ UpdateManual.pdf
14 Update Program Instruction LC/MS/MS
Manual
LabSolutions LCMS LCMS Q-TOF LCMS_Q-TOF_QuickReferenc
15 Quick Reference e.
(for LCMS Q-TOF) pdf
LabSolutions Direct Setup Guide LCMS-SQ LabSolutionsDirectSetupGuide.p
16 LC/MS/MS df
LCMS Q-TOF
LabSolutions Direct Quick Guide LCMS-SQ LabSolutionsDirectQuickGuide.p
17 LC/MS/MS df
LCMS Q-TOF
How to use ProMass Bridge LCMS-SQ ProMassBridge.pdf
18 software*4 LC/MS/MS
LCMS Q-TOF
Shimadzu Bridge program for LCMS-SQ ProMassBridge_QuickGuide.p
19 ProMass Quick Start Guide*4 LC/MS/MS df
LCMS Q-TOF
Notice before using LabSolutions LCMS-SQ GPC_Notice.pdf
20 GPC LC/MS/MS
LCMS Q-TOF
LabSolutions GPC Instruction LCMS-SQ GPC_OperatorsGuide.pdf
21 Manual LC/MS/MS
LCMS Q-TOF
LabSolutions GPC Quick Manual LCMS-SQ GPC_QuickGuide.pdf
22 LC/MS/MS
LCMS Q-TOF
LabSolutions Log Collection Tool LCMS-SQ LabSolutionsLogCollectionTool
23 Instruction Manual*5 LC/MS/MS Manual.pdf
LCMS Q-TOF

3.2 Online Manual Viewer

Viewing the online manual requires Adobe Acrobat Reader installed. If you try to use the
manual without first installing Acrobat Reader, a dialog box will appear prompting you to
install it. Adobe Acrobat Reader is stored on the LabSolutions LCMS Installation disc.
Procedure to install Adobe Acrobat Reader
1. Place the LabSolutions LCMS Installation disc into the disc drive.
2. Select the "\AdobeReader\en\AcroRdrDCXXX_en_US.exe "(“XXX” is number.) file
icon in the disc drive from the Start>Run menu.
3. Follow the instructions displayed on the screen to complete the installation.
Note. For more information about Adobe Acrobat Reader, please refer to the Adobe
Acrobat Reader software's Online User's Guide and the Adobe Corporation's
Internet Homepage.

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4. Sample Files and Report Template Files
4.1 Sample Files
The sample data files and sample report files are copied to the following folder after
installation of LabSolutions LCMS.
C:\LabSolutions\Sample\LC (for LC)
C:\LabSolutions\Sample\MS (for LCMS-2020)
C:\LabSolutions\Sample\MSMS (for LCMS-8030 / LCMS-8040 / LCMS-8045 /
LCMS-8050 / LCMS-8060(NX))
C:\LabSolutions\Sample\Q-TOF (for LCMS-9030)
(”C:\LabSolutions” means target folder for installation.)

4.2 Report Template Files

Report template files are sometimes updated if the supported models or functions are
added or changed. To use the latest report template file, perform [Initialize Format] for the
print function in each application (for example, [Print Method File] on the [File] menu of the
Realtime Analysis program).
Version No. Application Window Changed Report Template File
Ver. 5.80 Realtime [System LSS System Configuration.lsr
Analysis Configuration]
[Method Editor] LSS Method File.lsr
[Tuning] MSMS Tuning Report.lsr
MSMS Peak Monitor Report.lsr
Browser [Quant Browser] LSS Quantitative Browser MS Table.lsr
LSS Quantitative Browser MS Data.lsr
Ver. 5.82 Realtime [Method Editor] LSS Method File.lsr
Analysis
Ver. 5.86 Realtime [Method Editor] LSS Method File.lsr
SP1 Analysis
Ver. 5.89 Realtime [Tuning] MSMS Tuning Report.lsr
Analysis MSMS Peak Monitor Report.lsr
Ver. 5.91 Realtime [Method Editor] LSS Method File.lsr
Analysis
[Tuning] MSMS Tuning Report.lsr
MSMS Peak Monitor Report.lsr
Ver. 5.95 Realtime [System LSS System Configuration.lsr
Analysis Configuration]
[Method Editor] LSS Method File.lsr
Ver. 5.96 Postrun [Spectrum MS Deconvolution Results Report.lsr
Analysis Process Table] MS Deconvolution Results Multi Charge
Marks Report.lsr
Ver. 5.97 Realtime [System LSS System Configuration.lsr
Analysis Configuration]
[Method Editor] LSS Method File.lsr
[Tuning] MSMS Tuning Report.lsr
Postrun [PDA LSS PDA Spectrum Image.lsr
Analysis Data Analysis] LSS Spectrum Index.lsr
LSS UV Library Search.lsr
[UV LSS UV Library File.lsr
Library Editor]

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5. CLASS-Agent Manager
5.1 Setting the instrument information files of the CLASS-Agent Manager
Several items about LabSolutions's data are added in the CLASS-Agent Manager.
Notice the installation order of the CLASS-Agent Manager and LabSolutions.
Please install the LabSolutions after the CLASS-Agent Manager. When the CLASS-Agent
Manager is installed after the LabSolutions, please add the instrument information files of
the CLASS-Agent Manager, which set the display of LCsolution’s data in the
CLASS-Agent Manager.

Procedure
1. Please copy the new instrument information files on the LabSolutions Installation disc
folder:
“\LabSolutionsLCMS\Supplement\Agent\inf2\en”.
2. Please paste the files to the \Agent2\inf2 folder of the drive that installs the
CLASS-Agent manager.
If the instrument information files are shared in the network, please confirm where the
currently used instrument information files by selecting [Tools]-[Configuration]-[Common
Info File] in the CLASS-Agent Manager.

6. Procedures for Converting CLASS-LC10 Files into

LabSolutions Format
This document describes the procedure for converting CLASS-LC10 files into the
LabSolutions format.
• Converting method files
• Converting data files
Files may be converted by either batch conversion via the Data Explorer window or
seamless loading via the File Menu.

Batch conversion via the Data Explorer window is recommended for conversion
from the CLASS-LC10.

6.1 Procedure for converting method files

a. Batch conversion via Data Explorer
(1) Select the All Files tab of the Data Explorer window.

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 (2) Select a method file or files (xxxx.M??) for the CLASS-LC10.
(3) From the menu displayed by right-clicking in the Data Explorer window,
choose [File Conversion]-[Convert CLASS-LC10 (…) File to LabSolutions
(LC) File].
(4) Specify the destination folder and click the [OK] button.
(5) The files will be converted into the LabSolutions format as the ones named
"xxxx_M??.LCM."

b. Seamless loading from the File Menu

(1) Choose [File]-[Open Method File] in the Data Acquisition or Calibration
Curve window.
(2) Select [CLASS-LC10 Method File] as Type in the [Open Method File]
window.
(3) Select a method file from the list of files and then click the [Open] button.
(4) The method file for the CLASS-LC10 will be loaded.

Note. When method files of UV detector with dual mode are converted, data
analysis parameters of Ch1/Ch2 are converted to the parameters of
detector A (Ch1)/B (Ch1) in LabSolutions.

Note. Pretreatment program of autosampler in converted method file is set as

Standard mode. When pretreatment program is customized, set the
[Pretreatment] in [Autosampler] tab, selecting "Pretreatment Program" as
the mode of pretreatment.

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6.2 Procedure for converting data files
6.2.1 Converting chromatograms
a. Batch conversion via the Data Explorer window
(1) Select the All Files tab of the Data Explorer window.

(2) Select a chromatogram file or files (xxxx.C??) for the CLASS-LC10.

(3) From the menu displayed by right-clicking in the Data Explorer window,
choose [File Conversion]-[Convert CLASS-LC10 (…) File to LabSolutions
(LC) File].
(4) Specify the destination folder and then click [OK] button.
(5) The file(s) will be converted into the LabSolutions format as the ones
named "xxxx_C??.lcd."

b. Seamless loading via the File Menu

(1) Choose [File]-[Open Data File] in the Postrun window.
(2) Select "CLASS-LC10 Data File" as Type in the [Open Data File] window.
(3) Select a chromatogram file (xxxx.C??) from the list of files and then click
the [Open] button.
(4) The chromatogram for the CLASS-LC10 will be loaded.

6.2.2 Conversion including a method and calculation results

A calculation data file, a chromatogram data file, and a method file linked to those
data files may be converted into the LabSolutions format. For example, you
may wish to convert the calculation data file, LC10DATA.D01, the chromatogram
data file, LC10DATA.C01, and the method file (LC10DATA.M01 in the Auto Save
mode) linked to those data files into the LabSolutions format.

Note. In the conversion including methods and calculation results, files can be
converted only when there are a D-file, C-file, and M-file as a set.

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 a. Batch conversion via the Data Explorer window
(1) Select the All Files tab of the Data Explorer window.

(2) Select a calculation data file or files (xxxx.D??) for the CLASS-LC10.
(3) From the menu displayed by right-clicking in the Data Explorer window,
choose [File Conversion]-[Convert CLASS-LC10 (…) File to LabSolutions
(LC) File].
(4) Specify the destination folder and then click [OK] button.
(5) The file(s) will be converted into the LabSolutions format as the ones
named "xxxx_D??.LCD."

b. Seamless loading via the File Menu

(1) Choose [File]-[Open Data File] in the Postrun window.
(2) Select [CLASS-LC10 Data File] as Type in the [Open Data File] window.
(3) Select a calculation data file (xxxx.D??) from the list of files and then click
[Open] button.
(4) The data file for the CLASS-LC10 will be loaded.

7. Procedures for Converting CLASS-VP Files into

LabSolutions Format
This document describes the precautions and procedures for converting CLASS-VP files
into the LabSolutions format.
1. Handling CLASS-VP files
2. Preparing for file conversion
3. Converting method files
4. Converting data files
Files may be converted by either batch conversion via the Data Explorer window or
seamless loading via the File Menu.
Batch conversion via the Data Explorer window is recommended for conversion
from the CLASS-VP.
*File conversion from CLASS-VP cannot be done on 64 bit Windows OS.

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7.1 Handling CLASS-VP files
The CLASS-VP files that may be used in/converted into the LabSolutions are as
follows.
CLASS-VP file Files name on LabSolutions
Method file (*.MET) Method file (*_MET.lcm)
Data file (*.DAT, etc. ) Data file (*_DAT.lcd)
When method/data files for the CLASS-VP are used on the LabSolutions, the
following restriction will apply.
(1) The conversion or seamless loading of data files for the CLASS-VP
requires that CLASS-VP Version 5.04, Version 6.12, or later version be
installed in the computer (this is not applicable when the already converted
data is reused). In addition, CLASS-VP Version 6.13 or later version (when
using Version 5 series, Version 5.05 or later version in Version 5.X) is
necessary when converting CLASS-VP PDA data.

Note. When CLASS-VP is installed on the PC where LabSolutions is installed,

there is a case that you cannot start LabSolutions.
In this case, select [Change] of [Sentinel Protection Installer] and execute
[Repair] on [Control Panel]-[Programs and Features] or [Control Panel]-
[Add or Remove Program].
(Reboot the PC when messages to do so appeared.)

During the installation of CLASS-VP, if the following message box is

displayed, click the corresponding button in this table.
Window Message Button to click
Sentinel Driver The Sentinel Driver is running. [OK]
You must stop the driver by
entering NET STOP SENTINEL on
the command line.
Then re-install the driver.
Confirm File The target file exists and is newer [No to All]
Replace than the source.
Overwrite the newer file?

(2) The print format is different between the CLASS-VP and the LabSolutions.
Therefore, no report format information for the CLASS-VP will be converted.
A report format file for the LabSolutions must be created separately.
(3) The following data in a method file may be converted:
 Comments
 Instrument parameters
 Integration parameters (CHROMATOPAC algorithm only)
 Column performance parameters
 Compound table (described later)
No other data (properties, calibration curve information, identification/

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 quantification parameters, advanced settings, custom reports, and system
suitability) will be converted.
(4) In the conversion of a compound table from the CLASS-VP into the
LabSolutions, the following data marked with Yes will be converted from a
method file and data file. For the data that cannot be converted (marked
with No), the default values will be assumed.
Method file conversion Data file conversion
Conversion Default value Conversion Default value
Compound name Yes Yes Identified
peaks only
Type Yes No Target
Analysis channel Yes Yes
Retention time Yes Yes
Concentration (1-) Yes No 1
Bandwidth Yes No 0.01
Identified peak selection -- Closest Peak -- Closest Peak
Concentration unit Yes Yes
Calculated by Yes No Area
Calibration curve Yes No Linear
Zero Yes No Not Forced
Weighting Yes No None
Window/band -- Band -- Band
Spiked No 0 No 0

(5) In the conversion of data files for the CLASS-VP, chromatograms, the last
analysis result, and the method and configuration settings in the original
data will be converted.
(6) The original method used for data acquisition will be converted. Therefore,
if the data processing parameters or PDA multi-chromatogram settings are
modified, the settings in the method within the converted data may not
conform to the chromatograms and calculation results.
In this case, separately convert the method used for Postrun analysis into
the LabSolutions format and then create a batch table to perform Postrun
batch processing. In the LC/PDA data analysis, no method file can be
specified to make a Postrun analysis.

7.2 Preparing for file conversion

a. Installing the CLASS-VP software
(1) Supply the installation disk for the CLASS-VP.
(2) Place the installation disk into the drive and then run
ENGLISH\CLASS-VP\Disk1\Setup.exe.
(3) Select the peak purity algorithm that was selected when the CLASS-VP
was used.
b. Copying CLASS-VP files
(1) Copy the method file, data file, and configuration settings file to be used for
the LabSolutions to an appropriate folder on the PC having the

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 LabSolutions installed. If no configuration settings file is available, the
method file will not be converted properly.
7.3 Procedure for converting method files
a. Batch conversion via the Data Explorer window
(1) Select the All Files tab of the Data Explorer window.

(2) Select a method file or files (xxxx.MET) for the CLASS-VP.

(3) From the menu displayed by right-clicking the Data Explorer window,
choose [File Conversion]-[Convert CLASS-LC10 (…) File to LabSolutions
(LC) File].
(4) Specify a configuration settings file [Instrument1 (to 4).cfg] for the
CLASS-VP. This file must be the one that used the method to be
converted and corresponds to the instrument number of the CLASS-VP.
If no configuration settings file is available, one may be created by opening
a data file acquired using the above method with the <Configuration>
option selected. In this case, the configuration settings file will be given
the number of the analysis instrument on which that data file has been
opened.

Note. If the correct configuration settings file is not selected, the instrument parameters

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 will not be converted properly. Be sure to select the same configuration settings
file as the one used for data acquisition (or the one that has been similarly set
up)

(5) Specify the destination folder and then click [OK] button.
(6) The files will be converted into the LabSolutions format as the ones named
"xxxx_met.lcm."

b. Seamless loading via the File Menu

(1) Choose [Tools]-[Options] in the Data Acquisition window from the Analysis
window or in the Postrun window.
(2) Select [CLASS-VP file conversion] tab and specify the configuration
settings file [Instrument1 (to 4).cfg] for the CLASS-VP, which is to be used
for the file conversion. This file must be the one that used the above
method and corresponds to the instrument number of the CLASS-VP.

Note. If the correct configuration settings file is not selected, the instrument parameters
will not be converted properly. Be sure to select the same configuration settings
file as the one used for data acquisition (or the one that has been similarly set
up)

(3) Choose [Files]-[Open Method File] in the Data Acquisition window from the
[Analysis] window or in the [Calibration Curve] window from the Postrun
window.
(4) Select [CLASS-VP Method File] as Type on the Open Method File window.

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 (5) Select a method file from the list of files and then click the [Open] button.
(6) The method file for the CLASS-VP will be loaded.

7.4 Procedure for converting data files

a. Batch conversion via the Data Explorer window
(1) Select the All Files tab of the Data Explorer window.

(2) Select a data file or files (xxxx.dat, etc.) for the CLASS-VP.
(3) From the menu displayed by right-clicking the Data Explorer window,
choose [File Conversion]-[Convert CLASS-LC10 (…) File to LabSolutions
(LC) File].

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(4) Specify the destination folder and then click [OK] button.
(5) The file(s) will be converted into the LabSolutions format as the ones
named "xxxx_dat.lcd."

b. Seamless loading via the File Menu

(1) Choose [File]-[Open Data File] in the [LC/PDA Data Analysis] window from
the Postrun window.
(2) Select [CLASS-VP Data File] as Type in the [Open Data File] window.

(3) Select data files (xxxx.dat, etc.) from the list of files and then click the
[Open] button.
(4) The data files for the CLASS-VP will be loaded.

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8. Notice for PDF File Output
8.1 Notice for PDF Output Settings
To output PDF file, perform PDF out directly from the menu (for example, the [File]-[Data
Report]-[PDF Output] menu in the [Data Analysis] window) or select the Redirect Report to
PDF file check box in the PDF Output tab of the [Tools]-[Options] menu.
(Although SkyPDF Pro Driver is displayed in the Printer Name list box in the Printer Setup
window, do not select SkyPDF Driver in the list box.)

8.2 About Printing when “Redirect Report to PDF file” is selected

When “Redirect Report to PDF file” is selected, the PDF image is output to the following
file by the Print operation.
Operation
# Report Type Output Folder Output File Name
Window
1 System System Configuration Current project SystemConfiguratiuonN.pdf
Configuration Report folder N : Instrument number
2 System Check System Check Report Current project System Check Report.pdf
folder
3 Data Acquisition Method Report Current project {Method filename}.pdf
folder
4 Method Editor Method Report Current project {Method filename}.pdf
folder
5 Realtime Batch Batch Table Current project {Batch filename}.pdf
folder
6 Realtime Batch System Check Report Folder of batch System Check Report.pdf
file
7 Realtime Batch Summary Report Folder of batch {Batch filename}+
file _YYYYMMDDhhmmss.pdf
YYYY : Year
MM : Month
DD : Day
hh : Hour
mm : Minute
ss : Second
8 Batch Editor Batch Table Current project {Batch filename}.pdf
folder
9 Postrun Batch Batch Table Current project {Batch filename}.pdf
folder
10 Postrun Batch Summary Report Folder of batch {Batch filename}+
file _YYYYMMDDhhmmss.pdf
YYYY : Year
MM : Month
DD : Day
hh : Hour
mm : Minute
ss : Second
11 Calibration Graph Image Current project {Method filename}.pdf
folder
12 Data Comparison Graph Image Current project Data Comparison Report.pdf
folder
13 Data Analysis Graph Image Current project {Data filename}.pdf
(Chromatogram) folder
14 Data Analysis Data Report Current project {Data filename}.pdf
folder

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15 PDA Data Analysis Graph Image Current project {Data filename}.pdf
(Chromatogram) folder
16 PDA Data Analysis Graph Image Current project {Data filename}.pdf
(Spectrum) folder
17 PDA Data Analysis Spectrum Index Current project {Data filename}.pdf
folder
18 PDA Data Analysis UV Library Search Current project LSS UV Library Search.pdf
Results folder
19 PDA Data Analysis Data Report Current project {Data filename}.pdf
folder
20 MS Data Analysis Graph Image Current project {Data filename}.pdf
(Chromatogram) folder
21 MS Data Analysis Graph Image Current project {Data filename}.pdf
(Spectrum) folder
22 MS Data Analysis MS Library Search Current project {Data filename}.pdf
Results folder
23 MS Data Analysis Data Report Current project {Data filename}.pdf
folder
24 UV Library Editor Library Report Folder of UV {Library filename}.pdf
library file
25 MS Library Editor Library Report Folder of MS {Library filename}.pdf
library file
26 Quant Browser Print Table Current project (LC)
folder LSS Quantitative Browser
Table.pdf
(MS)
LSS Quantitative Browser
MS Table.pdf
27 Quant Browser Quant. Report for Current project (LC)
Current Data folder LSS Quantitative Browser
Data.pdf
(MS)
LSS Quantitative Browser
MS Data.pdf
28 Quant Browser Data Report Current project {Data filename}.pdf
folder
29 Data Browser Print Image of all cells Current project {Layout filename}.pdf
folder or Data Browser Image.pdf
30 Data Browser Graph Image Current project {Data filename}.pdf
folder
31 Data Browser Print Table Current project {Data filename}.pdf
folder
32 Data Browser Print Sample Current project {Data filename}.pdf
Information folder
33 Data Browser Data Report Current project {Data filename}.pdf
folder

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9. About the setting of Windows
9.1 Precautions for Windows Update
When PC is connected to the network, Windows can recognize, download and install
important updates(programs) for the security of Windows, by using the "Windows
Updates" function. In this function, the Windows reboot after the installation is complete
despite the status of applications, which might discard the data in analysis or files being
edited.
To prevent this sort of problem, change the “Windows Updates” setting as below.
< Windows 7 >
Specify “Check for updates (choose whether to download and install them)” as the
Windows Update setting. Do not specify “Install updates automatically”.
< Windows 10 >
On the Windows 10, it is difficult to prevent from updating automatically. Specify the time
when the PC can reboot at the settings of “Update & security” – “Notify to schedule restart”
or “Change active hours”. In addition, check on the “Defer upgrades” in the advanced
options.
There is a case that when PCs participate in a network (domain), the setting of "Windows
Updates" is forced by the domain or the network configuration. In such a case, please
check with your network administrator.

9.2 Precautions for security on folders in Windows

Depending on the OS user account control settings, it may not be possible to use data
files or method files created by another Windows user.
In order to avoid this problem, LabSolutions LCMS changes the security rights for the
LabSolutions LCMS installation folder and its subfolders when installing it, thereby sharing
data files and method files.
If a new data folder is created in any location other than the LabSolutions LCMS
installation folder (or its subfolders), you may become unable to perform some operations
such as creating a subfolder and saving a file. It is therefore necessary to change the
security settings for the folder by using the related capability of Windows.

9.3 Precautions for Sleep function

In the Windows, "Sleep (Hibernate)" function is supported which stores the working states
on the memory or hard disks and retains it in the low-power mode. When this function is
used while LabSolutions LCMS Real Time Analysis window is open, the communication
with the instrument is disconnected and it cannot acquire the data. In order to avoid this
problem, do not use Sleep (Hibernate) function when using LabSolutions LCMS.

In addition, change the settings as below when you restrict the Sleep function.

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 1) Select "Power Options" in the Control Panel.
2) Click "Change plan settings" for the current plan.
3) Click "Change advanced power settings".
4) In the tree, select "Never" for the "Sleep" setting.

10. About installation

10.1 Notice for installation (User Account Control)
In the Windows 7 or later version of the OS, when installation discs are inserted into the
drive, [AutoPlay] window appears which asks whether to "Run AUTORUN.EXE* " or to
"Open folder to view files". In order to auto-play the installer, select "Run AUTORUN.EXE".
When the [User Account Control] window is displayed, click [Allow].
*Depending on the installation discs, other names such as "SETUP.EXE" may be
displayed.

[AutoPlay] [User Account Control]

10.2 Notice for installation

While installing LabSolutions LCMS, there is a case the driver installation screens below
are displayed. In this case, wait a moment until the installation completes and these
screens close.

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10.3 Notice for installed files and folders
The installer copies the LabSolutions LCMS system files to the following folders.
LabSolutions LCMS cannot work if the files on these folders are removed, moved, or
renamed.
C:\LabSolutions\System (“C:\LabSolutions” means target folder for installation.)
（In the case of 64bit OS）
C:\Program Files (x86)\LabSolutions
C:\Program Files (x86)\Shimadzu
（In the case of 32bit OS）
C:\Program Files\LabSolutions
C:\Program Files\Shimadzu
(“C:” means target drive for installation in Windows System.)

10.4 Notice for install language

The installer recognizes the language used with OS and starts the installation.
< Windows 7 >
Please integrate the setting of “Regional and Language” and “Date and time” in the
Control Panel to the installation language.
< Windows 10 >
Please integrate the setting of “Region”, “Language” and “Date and time” in the Control
Panel to the installation language.

10.5 Notice for External Hard Drives or USB Flash Drives

When installing or uninstalling LabSolutions, be sure to disconnect external hard drives or
USB flash drives. If this is not done, install or uninstall may not complete correctly.

11. About the (MSn) MS library search feature

11.1 About the library file compatibility
MS Library file (.lib) cannot be used in (MSn) MS library search features. In (MSn) MS
library search feature, information that can be registered in the library is increasing, such
as precursor ion. Therefore it is recommended that original spectrum should be registered
into (MSn) MS library from the original data file.

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11.2 How to convert MS library to (MSn) MS library file
If you would like to use .lib library file for new (MSn) MS library feature, you can convert .lib
file to .mlb file by the following procedure.

1. Open MS library file (lib) file from MS library editor.

2. Select [File] -> [Convert MLB Library File].
3. Save it with a name.

In the .MLB file converted from .LIB file, information which is not included .LIB file (e.g.
collision energy (CE) ) is set to default value. For example, polarity information does not
include .LIB file, this value is set to [Positive] in converted .MLB file. Also, you need to set
MS stage if original .LIB spectrum was acquired MS2.

11.3 About the MS library search similarity

In (MSn) MS library search feature, algorithm for calculating the similarity score is different
from the MS library search feature. Therefore, both target spectrum and library spectrum
is same, similarity may be different from MS library search and (MSn) MS library search.
11.4 About Report template file
For supporting (MSn) MS library search feature, you need to initialize report template
format. Please perform [Initialize Format] before you use print functionality on (MSn) MS
library editor and (MSn) MS library search result window.

12. Notice for Using Windows 10

12.1 Precautions When Removing External Storage Media
When removing an external hard disk drive, USB flash drive, or other external storage
media, click [Safely Remove Hardware and Eject Media] in the task tray before proceeding.
There is a risk that files on external storage media may be lost if a device is removed
without performing this procedure, and is then connected to a PC running an OS earlier
than Windows 10, such as Windows 7.

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13. Others
13.1 Cautions When Adding LCMS for the First Time
When adding LCMS to an existing LabSolutions system for the first time, after adding the LCMS license,
click [Administration Tools]-[Customization Information] and initialize the customization information.
If you do not initialize the customization information, the LCMS item will not be displayed on the toolbar in
the [Report Format] window.

13.2 About License

The LabSolutions’s license is provided on a dongle attached to the PC or a license
certificate. When the dongle is detached, you will not be able to work with LabSolutions.
Attach the dongle on the backside of the PC to prevent it from being broken by mistake.
If the license certificate or the dongle is lost, license (USB dongle) cannot be reissued.

13.3 Notice of uninstalling the software

When uninstalling LabSolutions Ver. 5.30, please reboot PC. For LabSolutions Ver. 5.32 or
later, please reboot PC if the message dialog to reboot is displayed after uninstalling the
software.
If the LabSolutions software is re-installed without rebooting, there is a case the SkyPDF
driver is not installed properly and PDF file cannot be created. In such a case, the
LabSolutions software should be re-installed after removing the SkyPDF driver by the
following procedure.
* Do not uninstall Microsoft SQL Server because uninstalling it removes user, system, and
customized information.
Procedure to remove SkyPDF
1. Uninstall the LabSolutions software [Program and Features] in the Control Panel.
2. Open the Printer List from the [Start] menu of the Windows and then delete the [Sky
PDF].
3. Execute the “ClearSkyPDF.bat” file in the LabSolutionsLCMS\Supplement folder of
the installation disk. (Select the file and then execute [Run as administrator] from
the right-click menu.)

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